$PTI @RationalBiotech @erice579 curious if either of you had thoughts on why the 428 add-on studies with Orkambi failed to show any improvement? is it because Orkambi is just a poor drug? ir.proteostasis.com/static-... is the slide deck for that dataset I'm surprised neither PTI corrector nor amplifier benefitted it and actually seemed to cause net decreases in efficacy. I wonder if it would make sense for them to do an add-on study of trikafta and their amplifier as a worst case scenario that they deal with patients who are used to trikafta availability in clinical trials
  • 3
  • 24