$DFFN Dec. 10 results will be much better than those of Phase 2. The results seen in the Phase 2 trial were with TSC administered at 0.25 mg/kg and only in combination with RT and TMZ; TSC was not administered following the end of RT. The Phase 3 INTACT trial will be testing TSC at 1.5 mg/kg during the entire treatment period, both during the six weeks of RT/TMZ as well as during the chemotherapy portion. Because there were no safety signals seen in 19-patient trial and the DSMB recommended that the trial continue using the 1.5 mg/kg dose of TSC.
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