$AVXL All three suffer from wide-spread neurotransmitter deficiencies (D1/D2, 5-HT, GABA, Glutamate, etc.), calcium deregulation, oxidative stress, and neuroinflammation. With the M1 muscarinic affinity being extremely high in Anavex 3-71, it is very promising to see in multiple peer reviewed studies the M1 receptor playing significant historical roles in CNS disorders - and more recently, Schizophrenia & long-term depression. While the chemical issues laid out in this synopsis doesn't cover all dysfunctions within these disorders, it does give us a keen look into why Dr. Missling decided to trial them simultaneously. (Blame ST for not allowing PDF)