$XXII pubmed.ncbi.nlm.nih.gov/342... Double-blind clinical trials have shown reductions in smoking behavior when nicotine is cut from 10-15 mg nicotine/g tobacco in a regular cigarette to below 2.4 mg nicotine/g tobacco, with the largest effects seen at the lowest nicotine content (0.4 mg nicotine/g tobacco). This effect has been observed with individuals trying to quit and also with those who are not interested in quitting smoking. In these studies, when participants are not told that they are smoking low nicotine cigarettes and are not interested in stopping smoking, they smoke less and are more likely to quit when they receive cigarettes with very low nicotine content. These findings suggest that the so-called “choice” to smoke tobacco cigarettes is constrained by the pharmacology of nicotine. Qualitative data obtained from participants in very low nicotine cigarette trials supports this, in that many reported feeling less dependent and more motivation to quit smoking.
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