$TRVN Similar to other opioids, the most common adverse effects of oliceridine are nausea, vomiting, dizziness, headache, and constipation. The FDA stressed that the drug should not be administered when a patient has significant respiratory depression; acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment; or known or suspected gastrointestinal obstruction. Oliceridine has a maximum recommended daily dose limit of 27 mg. “Importantly, the FDA will only approve new drug applications, including those for opioid medications, following a rigorous review to evaluate the risks and benefits and ultimate determination that the data support safety and effectiveness. Of note, this particular medication is only indicated for use in a controlled clinical setting, meaning under medical supervision and not for use in a take-home prescription,” Throckmorton said.v........"For those saying no sales and the rest of the BS ..