$PTI $PTI @AmsterdamBioInvestor makes a good and REAL point. Look at $AXSM as an example. $1.92 - $37+ as a prime example. Only $43 mil in cash. No sales. And yet it's the #1 winner across all exchanges for this year. Why? Potential blockbuster. It's run on narcolepsy has also fueled $AVDL to run from $1 to new 52 week highs yesterday at $6.47...also on narcolepsy. If you go back far enough and look, you'll see $VRTX at $1+. What's it now? New all time highs $223s? So, things have DEFINITELY changed. Penny stocks can and should be able to go to many, many dollars. Because they are.