$TRVN Common headlines, "A Medical Worker Describes Terrifying Lung Failure From COVID-19", "What COVID-19 does to your lungs", etc. • The PK-PD analysis revealed a more than 2-fold greater potency of morphine compared to oliceridine in producing respiratory depression at doses where the two opioids were equianalgesic. • Oliceridine has a greater analgesic probability combined with a lesser probability of respiratory depression. • The clinical respiratory events occurred in clinical practice when the utility P(A NOT R) < 0.2. The experimental utility may well be translated into clinical practice. • Compared to the prototypical opioid analgesia morphine, the G-protein selective μ agonist, oliceridine, has a favorable safety profile when considering both analgesia and respiratory depression.