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Humana Inc. engages in the provision of health insurance services. It operates through the Insurance and CenterWell segments. The Insurance segment consists of Medicare benefits, marketed to individuals or directly via group Medicare accounts, as well as contract with CMS to administer the Limited Income Newly Eligible Transition, or LI-NET, prescription drug plan program and contracts with various states to provide Medicaid, dual eligible demonstration, and Long-Term Support Services benefits, which refer to as state-based contracts. The CenterWell segment represents payor-agnostic healthcare services offerings, including pharmacy dispensing services, provider services, and home services. The company was founded by David A. Jones, Sr., and Wendell Cherry on August 18, 1961 and is headquartered in Louisville, KY.

Humana Inc.

Humana Inc

Humana is trending due to a sharp sell-off in the healthcare insurance sector, following the CMS's proposed nearly flat Medicare Advantage payment rates for 2027, which sparked widespread concern over future profitability. The community is actively debating whether this represents an overreaction and a buying opportunity at multi-year lows, or if it signals a more profound, structural challenge for companies heavily reliant on Medicare Advantage.

Mattel, Inc. engages in the ownership of children's and family entertainment franchises. It operates through the following segments: North America, International, and American Girl. The North America and International segments focus on marketing and selling toys and consumer products. The American Girl segment includes marketing, retailing, and publishing dedicated to its mission to help girls grow up with confidence and character. The company was founded by Elliot Handler, Ruth Handler, and Harold Matson in 1945 and is headquartered in El Segundo, CA.

Mattel, Inc.

Mattel is trending after a significant post-earnings decline driven by a profit miss and subdued outlook, igniting community discussions about whether the sharp drop presents a buying opportunity or signals deeper challenges, even with a substantial share repurchase program announced.

Robinhood Markets, Inc is a financial services platform, which engages in the provision of retail brokerage and offers trading in U.S. listed stocks and Exchange Traded Funds, related options, and cryptocurrency trading, as well as cash management, which includes debit cards services. The company was founded by Vladimir Tenev and Baiju Prafulkumar Bhatt in 2013 and is headquartered in Menlo Park, CA.

Robinhood Markets Inc - Ordinary Shares - Class A

Robinhood Markets Inc

Robinhood is trending as its latest earnings report revealed stronger-than-expected profitability but a notable revenue miss, primarily impacted by a downturn in crypto trading activity. The community is actively debating if its "SuperApp" growth and new blockchain initiatives outweigh concerns over valuation and ongoing market sensitivity.

Vertiv Holdings Co. engages in the design, manufacture, and service of critical digital infrastructure technology for data centers, communication networks, and commercial and industrial environments. It also offers power management products, switchgear and busbar products, thermal management products, integrated rack systems, modular solutions, and management systems for monitoring and controlling digital infrastructure. It operates through the following geographical segments: Americas, Asia Pacific, and Europe, Middle East, and Africa (EMEA). The Americas segment offers products and services sold for applications within the data center, communication networks, and commercial and industrial markets in North America and Latin America. The Asia Pacific segment includes products and services sold for applications within the data center, communication networks, and commercial or industrial markets throughout Greater China, Australia and New Zealand, Southeast Asia, and India. The EMEA segment focuses on products and services sold for applications within the data center, communication networks, and commercial and industrial markets in Europe, Middle East, and Africa. The company was founded in 1946 and is headquartered in Columbus, OH.

Vertiv Holdings Co - Ordinary Shares - Class A

Vertiv Holdings Co

Vertiv Holdings is trending following its Q4 earnings, where strong long-term guidance and robust organic orders growth are overshadowing a slight current quarter miss, reinforcing its position as a critical "picks and shovels" play in the expanding AI data center infrastructure. The community is actively discussing its sustained growth, pivotal role in cooling solutions, and potential S&P 500 index inclusion amidst market volatility.

AST Spacemobile, Inc. engages in building a broadband cellular network in space to operate directly with standard, unmodified mobile devices based on an extensive IP and patent portfolio. It focuses on providing mobile broadband services with global coverage to all end-users, without the need to purchase special equipment. The company was founded by Abel Avellan on May 31, 2017 and is headquartered in Midland, TX.

AST SpaceMobile Inc - Ordinary Shares - Class A

AST SpaceMobile Inc

AST SpaceMobile is trending as the successful unfurling of its BlueBird 6 satellite, the largest commercial communications array in low Earth orbit, coupled with recent FCC approval for US beta testing with major carriers, validates its direct-to-device technology. The community is buzzing with excitement over this significant de-risking event, anticipating potential short squeezes and a clearer path to commercialization and wider partnerships.

Upstart Holdings, Inc. engages in the provision of a cloud-based artificial intelligence lending platform. It operates through the following segments: Personal Lending, Auto Lending, and Other. The Personal Lending segment focuses on unsecured personal loans and small dollar loans. The Auto Lending segment is involved in auto refinance and auto retail loans. The Other segment refers to HELOCs and other. The company was founded by David Joseph Girouard, Anna Mongayt Counselman, and Paul Gu in December 2013 and is headquartered in San Mateo, CA.

Upstart Holdings Inc

Upstart is actively discussed following its recent earnings report, which showcased significant revenue and origination growth alongside a leadership transition, yet the stock's reaction remains notably muted despite the strong operational beats. This has sparked intense community debate between those emphasizing its long-term AI lending potential and others pointing to broader fintech sector skepticism and persistent credit cycle concerns.

Lyft, Inc. engages in the provision and management of an online social rideshare community platform. It offers access to a network of shared bikes and scooters for shorter rides and first mile and last-mile legs of multimodal trips, information about nearby public transit routes, and Lyft Rentals to offer riders a view of transportation options when planning any trip. The company was founded by Marcus Cohn, John Zimmer, Rajat Suri, Matt van Horn, and Logan Green in 2007 and is headquartered in San Francisco, CA.

Lyft Inc - Ordinary Shares Cls A

Lyft Inc

Lyft is trending due to a significant stock decline following a weaker-than-anticipated Q1 profit forecast, despite reporting strong Q4 results and authorizing a $1 billion share buyback. The community is sharply divided on whether the sell-off is an overreaction by algorithms or a valid concern about competitive pressures from rivals like Uber and the long-term impact of autonomous vehicle technology.

Oatly Group AB is a holding company, which focuses on developing expertise around oats, a global power crop with inherent properties suited for sustainability and human health. It operates through the following geographical segments: Europe & International, North America and Greater China. The company was founded by Björn Öste in 1994 and is headquartered in Malmö, Sweden.

Oatly Group AB - ADR

Oatly Group

Oatly is trending as the community keenly anticipates its upcoming earnings report, with discussions focusing on expectations for sustained profitability and robust growth guidance, alongside hopes for a strategic update on its China business.

McDonald's Corp. engages in the operation and franchising of restaurants. It operates through the following segments: U.S., International Operated Markets, and International Developmental Licensed Markets and Corporate. The U.S. segment focuses its operations on the United States. The International Operated Markets segment consists of operations and the franchising of restaurants in Australia, Canada, France, Germany, Italy, the Netherlands, Russia, Spain, and the U.K. The International Developmental Licensed Markets and Corporate segment consists of developmental licensee and affiliate markets in the McDonald’s system. The firm's products include Big Mac, Quarter Pounder with Cheese, Filet-O-Fish, several chicken sandwiches, Chicken McNuggets, wraps, McDonald's Fries, salads, oatmeal, shakes, McFlurry desserts, sundaes, soft serve cones, pies, soft drinks, coffee, McCafe beverages, and other beverages. The company was founded by Raymond Albert Kroc on April 15, 1955, and is headquartered in Oak Brook, IL.

McDonald`s Corp

McDonald's Corp

McDonald's is trending following its recent mixed earnings report, where an EPS miss was offset by stronger-than-expected revenue and global comparable sales driven by value initiatives and digital engagement. The community is actively debating if its value focus can sustain growth amidst ongoing high menu prices and broader economic pressures, despite management's cautious outlook on consumer spending.

QXO, Inc. is a publicly traded distributor of roofing, waterproofing and complementary building products in the United States. It plans to become tech-enabled in the building products distribution industry and generate outsized value for shareholders. The company was founded on October 3, 2002, and is headquartered in Greenwich, CT.

QXO Inc.

QXO is trending as reports of its $2.25 billion acquisition of Kodiak Building Partners fuel community excitement, reinforced by a $3 billion financing from Apollo to accelerate its ambitious M&A roll-up strategy under CEO Brad Jacobs.

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$AMRSQ While much attention has focused on covid, there has been an interesting development elsewhere on the vaccine front. IDRI, in collaboration with Worcester HIV Vaccine and Brigham and Women’s hospital (a major hospital in Boston), has initiated a (small) phase 1 clinical trial to develop a vaccine for HIV un-infected adults. The study was first posted today. While they are testing both a DNA and protein-based formulation, the important part with respect to Amyris is that they are testing these formulations with the GLA-SE adjuvant. A description of this adjuvant can be found in the link below, but the bottom line is that SE = squalene. In other words, IDRI is bringing a squalene-containing vaccine to clinical trials a month after Eduardo confirmed that Amyris squalene exhibits comparable immunogenicity to squalene derived from sharks. 

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146372

https://www.clinicaltrials.gov/ct2/show/NCT04927585?term=Idri&amp;draw=4&amp;rank=22

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The Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant formulated in a stable emulsion (GLA-SE) promotes strong TH1 and balanced IgG1/IgG2 responses to protein vaccine antigens. This enhanced immunity is sufficient to provide protection against many diseases including tuberculosis and leishmaniasis.

Plos

The TLR4 Agonist Vaccine Adjuvant, GLA-SE, Requires Canonical and Atypical Mechanisms of Action for TH1 Induction

The purpose of the study is to evaluate the safety, tolerability, and immunogenicity of polyvalent env (A,B,C,A/E)/gag (C) DNA and gp120 (A,B,C,A/E) protein vaccines (PDPHV201401) co-administered together with or without adjuvant in repeated doses in healthy, HIV-uninfected adults.

Clinicaltrials

Evaluating the Safety and Immunogenicity of Polyvalent DNA/gp120 HIV Vaccine in Healthy, HIV-uninfected Adults - Full Text View - ClinicalTrials.gov

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Amyris Inc

$AMRS While much attention has focused on covid, there has been an interesting development elsewhere on the vaccine front. IDRI, in collaboration with Worcester HIV Vaccine and Brigham and Women’s hospital (a major hospital in Boston), has initiated a (small) phase 1 clinical trial to develop a vaccine for HIV un-infected adults. The study was first posted today. While they are testing both a DNA and protein-based formulation, the important part with respect to Amyris is that they are testing these formulations with the GLA-SE adjuvant. A description of this adjuvant can be found in the link below, but the bottom line is that SE = squalene. In other words, IDRI is bringing a squalene-containing vaccine to clinical trials a month after Eduardo confirmed that Amyris squalene exhibits comparable immunogenicity to squalene derived from sharks. 



IonQ Inc

Wiffle1

@Wiffle1 
Thanks Wiffle. This is great news for many reasons.  Not just the obvious potential for Amyris squalene sales, but hopefully a breakthrough HIV Vaccine to bring relief to impoverished 3rd world countries who suffer the most with HIV outbreaks.

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Thanks Wiffle. This is great news for many reasons.  Not just the obvious potential for Amyris squalene sales, but hopefully a breakthrough HIV Vaccine to bring relief to impoverished 3rd world countries who suffer the most with HIV outbreaks.