$AVEO @Mesaboogie @Pharmcat1 @PharmaSci I think AVEO would be best served to use a Cox regression analyses model to analyze OS & HR as it can deal with multiple variables to explain survival benefit. statisticshowto.datascience... Cox’s can analyze multiple risk factors for survival, unlike other methods (e.g. Kaplan-Meier analysis) which can only handle one. Cox’s regression also tackles the problem of participant heterogeneity. Participant heterogeneity simply means that your participants are different, which could cause issues trying to analyze your data. Ideally, your participants would have similar characteristics (i.e. they would be homogeneous). In real life, however, you rarely find homogeneous samples and Cox’s regression addresses that issue.