Bullish
$PRVB My favorite link has this type of info. The observation that anti-CD3 mAb are able to halt active autoimmunity but less efficient in preventing disease [13,38] led to an important discovery in the field of transplantation. While administration at the time of transplantation induces immunosuppression, a slightly delayed treatment can induce long-lasting remission in pancreatic islet grafts [45] and heart transplantation [46], probably due to preferential depletion of activated effector T cells, resistance of Tregs to anti-CD3 mAb-induced apoptosis and establishment of local immune privilege, factors discussed in more detail in the following paragraph. futuremedicine.com/action/c...
  • 6
  • 1