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TeraWulf, Inc. owns and operates fully integrated environmentally clean bitcoin mining facilities in the United States. It will generate domestically produced bitcoin powered by nuclear, hydro, and solar energy. It operates through the Digital Asset Mining and HPC Leasing segments. The company was founded by Paul B. Prager and Nazar M. Khan on February 8, 2021 and is headquartered in Easton, MD.

TeraWulf Inc

WULF is drawing attention amid a sharp selloff across AI-infrastructure and data-center stocks, with traders debating financing costs, leverage, and whether contracted AI/HPC demand will translate into returns. Bulls cite Morgan Stanleys positive view and CEO Paul Pragers defense of WULFs powered-shell model, while skeptics remain focused on funding and execution risks.

CoreWeave, Inc. engages in the powers of the creation and delivery of the intelligence that drives innovation. It offers a solution used by organizations of all sizes that require sophisticated AI computing, from the largest of enterprises to small, well-funded start-ups. The company was founded by Michael Intrator, Brian Venturo, Peter Salanki, and Brannin McBee on September 21, 2017 and is headquartered in Livingston, NJ.

CoreWeave Inc. - Ordinary Shares - Class A

CoreWeave Inc

CoreWeaves debt and bond-market concerns have fueled heavy volatility, with traders debating whether financing risks threaten its growth or are overstated given AI demand. Nvidia CEO Jensen Huangs confidence in the company and comments that its cost of capital is falling have bolstered dip-buyers, while skeptics remain focused on its debt burden and credit stress.

Nebius Group NV is a technology company that provides infrastructure and services to AI builders worldwide. It offers Nebius AI, an AI-centric cloud platform provides full-stack infrastructure, including large-scale GPU clusters, cloud services, and developer tools. The company also operates through specialized brands: Toloka AI, which partners in data for generative AI development; TripleTen, an edtech platform focused on re-skilling individuals for tech careers; and Avride, which develops autonomous driving technology. Nebius Group was founded by Elena Kolmanovskaya, Ilya Segalovich, Mikhail Fadeev, and Arkady Volozh in 1989 and is headquartered in Amsterdam, the Netherlands.

Nebius Group N.V. - Ordinary Shares - Class A

Nebius Group N.V. 

Nebius is being swept into a neocloud selloff as CoreWeaves debt and borrowing costs, Gartners warning about the sectors long-term viability, and inflation-driven financing concerns fuel doubts about AI infrastructure spending. Traders disagree on whether NBIS is unfairly punished despite what they view as a stronger balance sheet, with dip buyers calling the decline an overreaction and bears questioning the sectors funding and profitability.

PayPal Holdings, Inc. engages in the development of technology platforms that enable digital payments and simplifies commerce experiences on behalf of merchants and consumers worldwide. Its solutions include PayPal, PayPal Credit, Braintree, Venmo, Xoom, and Paydiant products. The firm also enables consumers to exchange funds with merchants using funding sources, which include bank account, PayPal account balance, PayPal Credit account, credit, and debit card or other stored value products. It operates through United States and Other Countries geographical segments. The company was founded in December 1998 and is headquartered in San Jose, CA.

PayPal Holdings Inc

Renewed reports of possible all-stock takeover interest from an unnamed West Coast tech company have fueled speculation that Meta could be the bidder, though no offer is confirmed. Traders are debating potential deal value while others dismiss the recurring rumors as an unsubstantiated pump; PayPals Meta Muse partnership adds context to the speculation.

Regencell Bioscience Holdings Ltd. is a early-stage bioscience company that focuses on research, development and commercialization of Traditional Chinese Medicine for the treatment of neurocognitive disorders and degeneration, specifically Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder. The company was founded by Yat-Gai Au on October 30, 2014 and is headquartered in Hong Kong.

Regencell Bioscience Holdings Ltd

RGCs sharp rally has revived speculation that the former meme-stock runner could stage another squeeze, with traders citing concentrated insider ownership and reportedly scarce, costly shares to borrow as possible amplifiers if volume builds. Others caution that a squeeze is unconfirmed and point to the companys speculative, revenue-less business and history of sharp reversals.

Verastem, Inc. is a biopharmaceutical company, which engages in the development and commercialization of drugs for the treatment of cancer. The company was founded by Richard H. Aldrich, Michelle Dipp, Piyush Gupta, Satish Jindal, Eric S. Lander, Robert F. Weinberg, and Christoph H. Westphal on August 4, 2010 and is headquartered in Needham, MA.

Verastem Inc

Verastems encouraging early clinical data for its KRAS G12D inhibitor VS-7375, including pancreatic-cancer responses and a planned Phase 3 study, are driving attention. Traders are balancing optimism about the drugs potential with concerns that the accompanying share offering dilutes shareholders; others see the financing as supporting development, while noting the results are still early.

IREN Ltd. is a vertically integrated data center business powering the future of Bitcoin, AI and beyond with renewable energy. It is strategically located in renewable-rich, fiber-connected regions across the US and Canada. IREN’s large-scale, grid-connected facilities are purpose-built for the next generation of power-dense computing applications. The company was founded by Daniel Roberts and William Roberts on November 6, 2018, and is headquartered in Sydney, Australia.

IREN Ltd.

IREN Limited

IREN is caught in a neocloud-sector selloff as concerns over CoreWeaves debt and financing costs, Gartners warning about AI infrastructure returns, and inflation-driven rate pressure weigh on the group. Traders are debating whether IRENs balance sheet and customer contracts make it less exposed than CoreWeave, while reactions range from panic over further losses to dip-buying.

Dell Technologies, Inc. is a technology company, providing customers with a broad and innovative solution portfolio to help customers modernize their information technology (IT) infrastructure, address workforce transformation, and offer critical solutions that keep people and organizations connected. It operates through the following segments: Infrastructure Solutions Group (ISG) and Client Solutions Group (CSG). The ISG segment includes servers, networking, and storage, as well as services and third-party software and peripherals that are closely tied to the sale of ISG hardware. The CSG segment includes designs for commercial and consumer customers of desktops, thin client products, and notebooks. The company was founded by Michael Saul Dell in 1984 and is headquartered in Round Rock, TX.

Dell Technologies Inc - Ordinary Shares - Class C

Dell Technologies Inc

Dells sharp selloff is being tied to Barclays downgrade, which questioned whether enterprise AI spending is accelerating and argued that higher memory pricesnot stronger unit demandmay be driving revenue growth; broader AI-infrastructure weakness and inflation concerns added pressure. Traders are split between expecting further downside and viewing the drop as an overreaction and a buying opportunity, with some blaming short sellers or market manipulation.

Vertiv Holdings Co. engages in the design, manufacture, and service of critical digital infrastructure technology for data centers, communication networks, and commercial and industrial environments. The firm also offers power management products, switchgear and busbar products, thermal management products, integrated rack systems, modular solutions, and management systems for monitoring and controlling digital infrastructure. It operates through the following geographical segments: Americas, Asia Pacific, and Europe, Middle East, and Africa (EMEA). The Americas segment includes products and services sold for applications within the data center, communication networks and commercial and industrial markets in North America and Latin America. The Asia Pacific segment consists of products and services sold for applications within the data center, communication networks and commercial and industrial markets throughout Greater China, Asia, and India. The EMEA segment focuses on products and services sold for applications within the data center, communication networks, and commercial and industrial markets in Europe, Middle East, and Africa. The company was founded in 1946 and is headquartered in Westerville, OH.

Vertiv Holdings Co - Ordinary Shares - Class A

Vertiv Holdings Co

Vertivs sharp post-earnings selloff is being debated after a revenue miss attributed to project timing and supply-chain constraints, despite raised full-year guidance and managements confidence in AI data-center demand. Bulls view the decline as an overreaction and are buying the dip, while bears remain concerned about execution, valuation, and the durability of AI infrastructure spending.

Semtech Corp. engages in the manufacture and supply of analog and mixed signal semiconductor products for high-end consumer, enterprise computing, communications, and industrial equipment. It operates through the following segments: Signal Integrity, Analog Mixed Signal and Wireless, and Internet of Things (IoT) Systems and Connectivity. The Signal Integrity segment includes designing, development, manufacturing, and marketing of a portfolio of optical and copper data communications and video transport products used in a wide variety of infrastructure and industrial applications. The Analog Mixed Signal and Wireless segment focus on designing, development, manufacturing, and marketing of transient voltage suppressors and specialized sensing products. The IoT Systems and Connectivity segment includes designing, development, operation, and marketing of a portfolio of IoT solutions that enable businesses to connect and manage devices, collect and analyze data, and improve decision-making. The company was founded in 1960 and is headquartered in Camarillo, CA.

Semtech Corp.

Semtech shares are under sharp selling pressure during its investor day, prompting traders to question whether the presentation disappointed; some also attribute the move to a broader semiconductor selloff amid rate concerns. The discussion is split between dip-buyers looking for a rebound and holders worried about the steep decline.

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$BCRX oh my. Hat tip @R8Plus 

Orphan drug trials are generally single arm (no placebo arm), nonrandomized, and open label. Safety Phase 1 trials are not usually required, and Phases 2 and 3 can be combined when the patient population is very low.

https://repository.upenn.edu/cgi/viewcontent.cgi?article=1037&amp;context=ace

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Biocryst Pharmaceuticals Inc.

 

Orphan drug trials are generally single arm (no placebo arm), nonrandomized, and open label. Safety Phase 1 trials are not usually required, and Phases 2 and 3 can be combined when the patient population is very low.



Ancora Imparo

@ancora @R8Plus And tip of the iceberg is our Phase 2 OPEN-LABEL trial has (or still recruiting) 200 PNH patients - that is a ton for not a huge patient population to chose from. 

How about we veto Phase 3 and go straight to approval???? ;)

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 And tip of the iceberg is our Phase 2 OPEN-LABEL trial has (or still recruiting) 200 PNH patients - that is a ton for not a huge patient population to chose from. 

How about we veto Phase 3 and go straight to approval???? ;)