Axsome Therapeutics Stock Slips On Bigger-Than-Feared Q4 Loss, But Retail Takes It In Stride

CEO Herriot Tabuteau struck an optimistic tone, citing strong commercial growth, a rapidly advancing pipeline, and the recent U.S. approval of Symbravo for migraine treatment.

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Last week, Wells Fargo highlighted Axsome's Auvelity patent settlement with Teva as a key de-risking event. | Image source: Getty Images

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Ramakrishnan M · Stocktwits

Published Feb 19, 2025, 1:16 AM

AXSM

Axsome Therapeutics Inc. shares dipped over 2% on Tuesday — their worst session in nearly two weeks — after the company posted a larger-than-expected quarterly loss.

The biotech firm reported an adjusted fourth-quarter (Q4) loss of $1.54 per share, missing estimates of $1.00 per share, while revenue of $118.8 million slightly topped the consensus of $117.84 million. 

Despite the earnings miss, Axsome's CEO Herriot Tabuteau struck an optimistic tone, citing strong commercial growth, a rapidly advancing pipeline, and the recent U.S. approval of Symbravo for migraine treatment.

"With potentially five marketed products across six CNS indications of great unmet need over the next 12-18 months, we are well positioned to continue delivering innovative new medicines to patients and significant near- and long-term value to shareholders," Tabuteau said. 

The company also stated that its cash reserves are sufficient to fund operations until reaching cash flow positivity.

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AXSM sentiment and message volume Feb 18 | source: Stocktwits

Retail traders on Stocktwits remained 'bullish' post-earnings, with message volume climbing. 

One user dismissed concerns over the earnings miss, noting Axsome's long-term growth.

Another emphasized the company's strong balance sheet and promising pipeline.

Axsome said its cash and cash equivalents totaled $315.4 million at the end of last year, compared to $386.2 million a year earlier.

Truist Securities reportedly raised its price target on Axsome to $200 from $190, maintaining a 'Buy' rating. 

Last week, Wells Fargo highlighted Axsome's Auvelity patent settlement with Teva Pharmaceuticals (TEVA) as a key de-risking event, according to The Fly. 

It said the IP overhang is lifted, and visibility into a second growth phase is improving with the approval of Symbravo and positive Alzheimer's data for AXS-05. 

The research firm sees further upside in 2025, driven by commercial performance and data readouts of its sleep disorder treatment, solriamfetol.

Axsome shares are up more than 50% year-to-date.

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