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The SPY is seeing increased volatility, with community chatter focused on whether a significant downturn is imminent. Mixed sentiment abounds, with some traders taking profits and anticipating a larger correction, while others are buying the dip expecting a quick recovery. News impacting AI-related stocks and broader economic concerns like inflation and government shutdowns also appear to be influencing market sentiment.

Galecto, Inc. is a clinical-stage biotechnology company, which engages in developing novel small molecule therapeutics that are designed to target the biological processes that lie at the heart of cancer and fibrotic diseases. The firm is also involved in the development of small molecule inhibitors of galectin-3 and LOXL2. The company was founded by Ulf Jörgen Nilsson, Hakon Leffler, Tariq Sethi, and Hans Thalsgård Schambye in 2011 and is headquartered in Boston, MA.

Galecto Inc

GLTO is trending due to significant pre-market price action and high trading volume, reminiscent of recent runs by other stocks like SPRB. The community is actively discussing potential reasons for the surge, including a possible short squeeze and comparing it to other high-flying tickers. Some traders are noting the lack of specific news catalysts while others speculate about possible undisclosed developments related to its oncology and liver disease treatments.

NuCana Plc is a clinical stage biopharmaceutical company. It engages in the business of developing a portfolio of new medicines to treat patients with cancer. The company was founded by Hugh Stephen Griffith and Christopher Barry Wood on January 28, 1997 and is headquartered in Edinburgh, the United Kingdom.

NuCana plc - ADR

NuCana plc

NuCana ($NCNA) is trending as traders discuss its low float and potential for a squeeze, drawing comparisons to $SPRB's recent surge. Anticipation is building around upcoming cancer treatment data presentations in October, with some speculating on merger possibilities and significant price targets. The community notes the company's strong cash runway into 2029, which further fuels optimism.

Invesco Capital Management LLC - Invesco QQQ Trust Series 1

QQQ is seeing active discussion around AI's influence and potential overextension, with some traders pointing to Oracle's recent data as a sign of hype while others cite new deals with AMD, Nvidia, and OpenAI as bullish catalysts. Community members are debating the sustainability of the rally and the impact of the government shutdown, with a focus on technical levels and potential pullbacks. Recent price action and analyst targets continue to fuel both bullish and bearish perspectives.

Rigetti Computing, Inc. provides full-stack quantum computing services. It serves global enterprise, government, and research clients through its Rigetti Quantum Cloud Services platform. The company was founded by Chad Rigetti in 2013 and is headquartered in Berkeley, CA.

Rigetti Computing Inc

RGTI is trending following an analyst upgrade and renewed interest in quantum computing stocks, with community members debating whether the sector is overheating or poised for further gains.  Bulls cite long-term potential and momentum, while bears point to valuation concerns and the possibility of a near-term correction or share offering.  The stock's volatile price action is fueling discussions around short squeezes and market manipulation.

TMC the metals co., Inc. is a deep-sea minerals exploration company focused on the collection and processing of polymetallic nodules found on the seafloor in international waters of the Clarion Clipperton Zone in the Pacific Ocean (CCZ). These nodules contain high grades of four metals (nickel, copper, cobalt, manganese) which can be used as (i) feedstock for battery cathode precursors (nickel, cobalt and manganese sulfates, or intermediate nickel-copper-cobalt matte) for electric vehicles (EV) and renewable energy storage markets, (ii) copper cathode for EV wiring, energy transmission and other applications and (iii) manganese silicate for manganese alloy production required for steel production. The company was founded in 2021 and is headquartered in Vancouver, Canada.

TMC the metals company Inc

$TMC is trending as the deep-sea mining sector gains traction, with community members discussing potential short squeezes and a possible breakout. Optimism is fueled by anticipation of government partnerships and regulatory approvals, particularly the NOAA decision. Bullish investors are focused on the company's long-term potential in the critical minerals market.

Ethereum is a global, open-source platform for decentralized applications. In other words, the vision is to create a world computer that anyone can build applications in a decentralized manner; while all states and data are distributed and publicly accessible. Ethereum supports smart contracts in which developers can write code in order to program digital value. Examples of decentralized apps (dapps) that are built on Ethereum includes tokens, non-fungible tokens, decentralized finance apps, lending protocol, decentralized exchanges, and much more.  On Ethereum, all transactions and smart contract executions require a small fee to be paid. This fee is called Gas. In technical terms, Gas refers to the unit of measure on the amount of computational effort required to execute an operation or a smart contract. The more complex the execution operation is, the more gas is required to fulfill that operation. Gas fees are paid entirely in Ether (ETH), which is the native coin of the blockchain. The price of gas can fluctuate from time to time depending on the network demand.

Ethereum

Ethereum is trending amid discussions of potential short squeezes and its struggle to break resistance, with community members debating its near-term trajectory. Bullish arguments center on institutional adoption via staking ETFs and upcoming network upgrades, while bears point to historical patterns and potential pullbacks. The conversation also touches on Ethereum's role in tokenization and its relationship with other cryptocurrencies like Bitcoin.

Bitcoin is the first successful internet money based on peer-to-peer technology; whereby no central bank or authority is involved in the transaction and production of the Bitcoin currency. It was created by an anonymous individual/group under the name, Satoshi Nakamoto. The source code is available publicly as an open source project, anybody can look at it and be part of the developmental process.  Bitcoin is changing the way we see money as we speak. The idea was to produce a means of exchange, independent of any central authority, that could be transferred electronically in a secure, verifiable and immutable way. It is a decentralized peer-to-peer internet currency making mobile payment easy, very low transaction fees, protects your identity, and it works anywhere all the time with no central authority and banks.  Bitcoin is designed to have only 21 million BTC ever created, thus making it a deflationary currency. Bitcoin uses the SHA-256 hashing algorithm with an average transaction confirmation time of 10 minutes. Miners today are mining Bitcoin using ASIC chip dedicated to only mining Bitcoin, and the hash rate has shot up to peta hashes.  Being the first successful online cryptography currency, Bitcoin has inspired other alternative currencies such as Litecoin, Peercoin, Primecoin, and so on.  The cryptocurrency then took off with the innovation of the turing-complete smart contract by Ethereum which led to the development of other amazing projects such as EOS, Tron, and even crypto-collectibles such as CryptoKitties.

Bitcoin

Bitcoin is trending as it hits new all-time highs, sparking debates about market tops and the potential for further gains. Community members are discussing strategies around leveraging altcoins and longing Bitcoin. Some analysts point to the launch of new crypto indexes and potential institutional adoption as bullish factors.

Spruce Biosciences, Inc. is a biopharmaceutical company, which engages in developing and commercializing novel therapies for rare endocrine disorders with significant unmet medical need. The company was founded on November 13, 2014 and is headquartered in South San Francisco, CA.

Spruce Biosciences Inc

SPRB is trending due to a significant price surge, driven by news of FDA breakthrough designation, leading to community excitement and discussions of potential for further gains. Some traders are comparing it to other high-flying stocks like GLTO and ZNB, while others caution about a potential pullback. The community is actively debating the stock's valuation and future prospects, with some eyeing high price targets.

Ripple is the catchall name for the cryptocurrency platform, the transactional protocol for which is actually XRP, in the same fashion as Ethereum is the name for the platform that facilitates trades in Ether. Like other cryptocurrencies, Ripple is built atop the idea of a distributed ledger network which requires various parties to participate in validating transactions, rather than any singular centralized authority. That facilitates transactions all over the world, and transfer fees are far cheaper than the likes of bitcoin. Unlike other cryptocurrencies, XRP transfers are effectively immediate, requiring no typical confirmation time.  Ripple was originally founded by a single company, Ripple Labs, and continues to be backed by it, rather than the larger network of developers that continue bitcoin’s development. It also doesn’t have a fluctuating amount of its currency in existence. Where bitcoin has a continually growing pool with an eventual maximum, and Ethereum theoretically has no limit, Ripple was created with all of its 100 billion XRP tokens right out of the gate. That number is maintained with no mining and most of the tokens are owned and held by Ripple Labs itself — around 60 billion at the latest count.  Even at the recently reduced value of around half a dollar per XRP, that means Ripple Labs is currently sitting on around $20 billion worth of the cryptocurrency (note: Ripple’s price crashed hard recently, and may be worth far less than $60 billion by time you read this). It holds 55 billion XRP in an escrow account, which allows it to sell up to a billion per month if it so chooses in order to fund new projects and acquisitions. Selling such an amount would likely have a drastic effect on the cryptocurrency’s value, and isn’t something Ripple Labs plans to do anytime soon.  In actuality, Ripple Labs is looking to leverage the technology behind XRP to allow for faster banking transactions around the world. While Bitcoin and other cryptocurrencies are built on the idea of separating financial transactions from the financial organizations of traditional currencies, Ripple is almost the opposite in every sense.  XRP by Ripple price can be found on this page alongside the market capitalization and additional stats.

Ripple

XRP is trending amid discussions around potential ETF approvals and Ripple's banking license application, though some traders express frustration with its price movement relative to Bitcoin's new all-time highs. Community members are debating the token's utility and whether it will experience a significant breakout soon, while others point to continued price suppression. Discussions also include how the potential government shutdown might affect the timeline for spot ETF launches.

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$PFSA has announced that Yann Gouëffic, MD, PhD, professor of vascular surgery in the Vascular Center at Groupe Hospitalier Paris Saint Joseph, Paris, France will adopt the company’s Lumee oxygen monitoring technology in his practice and in clinical studies, advancing application of Lumee for home monitoring 
 
https://biotuesdays.com/2025/10/01/profusa-adds-leading-clti-surgeon-to-customer-base/

Profusa (NASDAQ: PFSA) has announced that Yann Gouëffic, MD, PhD, professor of vascular surgery in the Vascular Center at Groupe Hospitalier Paris Saint