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Shiba Inu (SHIB) is a meme token which began as a fun currency and has now transformed into a decentralized ecosystem. During the initial launch, 50% of the supply was allocated into Vitalik Buterin's ethereum wallet.   As a result of that, Vitalik proceeded to donate 10% of his SHIB holdings to a COVID-19 relief effort in India and the remaining 40% is burnt forever. That donation was worth about $1 billion at that time, which makes it one of the largest donation ever in the world.  What is the Shiba Inu community working on right now? The Shiba Inu team launched a decentralized exchange called Shibaswap with 2 new tokens, LEASH and BONE. LEASH is a scarce supply token that is used to offer incentives on Shibaswap. BONE is the governance token for holders to vote on proposals on Doggy DAO.

Shiba Inu

Shiba Inu is actively trending as its community intensely discusses a potential price reversal, with many holding onto hopes for substantial gains following recent market dips. While some vocal participants express frustration and question its long-term viability, others remain confident in its community-driven momentum and look for signs of a breakout, often contrasting its appeal with more infrastructure-focused crypto projects.

Omeros Corp. operates as a biopharmaceutical company. The firm engages in the discovery, development, and commercializing of both small-molecule and protein therapeutics for large market. It also offers orphan indications targeting inflammation, coagulopathies, and disorders of the central nervous system. The company was founded by Gregory A. Demopulos and Pamela Pierce Palmer on June 16, 1994 and is headquartered in Seattle, WA.

Omeros Corporation

Omeros Corp

Omeros (OMER) is trending high after securing FDA approval for Yartemlea, marking it as the first and only approved therapy for life-threatening transplant-associated thrombotic microangiopathy (TA-TMA) in adults and children. The market is buzzing with excitement over this de-risking event, with significant community discussion around a potential short squeeze, a future valuation reset, and speculation about a buyout by Novo Nordisk, given their existing multi-billion dollar partnership.

Cardano is a blockchain platform built on academic research that enables smart contracts and decentralized applications while using significantly less energy than traditional cryptocurrencies like Bitcoin.   What sets Cardano apart is its methodical, research-driven approach — every major feature is peer-reviewed by scientists and cryptographers before being added to the network. This careful process aims to create a more secure and stable foundation compared to platforms that prioritize speed over thorough testing. The platform's native cryptocurrency, ADA, is used to send money, pay transaction fees, and participate in network governance.  Cardano uses a proof-of-stake system to process transactions, which works differently from Bitcoin's mining approach. Instead of competing to solve complex puzzles, users can "stake" their ADA — essentially locking it up temporarily — to become validators who verify transactions. The system selects validators based on how much ADA they've staked and for how long, then rewards them with additional ADA for their participation. This approach uses far less energy than traditional mining while keeping the network secure. The platform also features a two-layer design that separates basic payment transactions from smart contract operations, allowing each function to be optimized independently for better performance.   ADA holders can earn staking rewards by locking up their tokens to help secure the network, vote on proposed changes to the platform, and use ADA for international money transfers with lower fees than traditional services.  Cardano was founded in 2017 by Charles Hoskinson, who previously helped create Ethereum. Hoskinson leads Input Output Global (IOG), the technology company that builds and maintains Cardano's core software. The ecosystem operates through three organizations: IOG handles technical development, the Cardano Foundation promotes adoption and standardization, and Emurgo helps businesses integrate blockchain technology into their operations. This structure distributes responsibilities across multiple groups rather than concentrating control in a single entity.   In February 2025, major asset manager Grayscale Investments filed to create an exchange-traded fund (ETF) for Cardano with the U.S. Securities and Exchange Commission, which would allow traditional investors to buy ADA through their regular brokerage accounts without needing to set up cryptocurrency wallets.Retry

Cardano

Cardano (ADA) is a hot topic, facing significant community skepticism with many users labeling it a "scam" or "dead chain" amidst calls to sell. Conversely, proponents point to its research-driven foundation and the recent launch of ecosystem projects like Midnight ($NIGHT) as reasons for a potential rebound. The debate underscores its position as a long-term, community-focused blockchain against a market increasingly demanding high-speed, institutionally compliant solutions.

Biohaven Ltd. is a global clinical stage biopharmaceutical company, which engages in the discovery, development, and commercialization of therapies for people with neurological and neuropsychiatric diseases. The company was founded on May 2, 2022 and is headquartered in New Haven, CT.

Biohaven Ltd

Biohaven Pharmaceutical Holding Company Ltd

Biohaven is experiencing elevated discussion after its major depressive disorder candidate failed a Phase 2 trial, an outcome many investors had anticipated. Community focus has quickly pivoted to the company's epilepsy and obesity programs as the next significant catalysts, alongside positive early data for its cancer drug. This sentiment is reinforced by recent significant insider purchases, signaling strong management confidence in the company's diverse pipeline.

Dynavax Technologies Corp. is a biopharmaceutical company, which engages in the provision of discovery, development, and commercialization of novel vaccines and immuno-oncology therapeutics. Its product includes HEPLISAV-B, which prevents infection caused by all known subtypes of hepatitis B virus in adults 18 years of age and older. The company was founded by Lawrence M. Lichtenstein, Dennis A. Carson, and Eyal Raz on August 29, 1996 and is headquartered in Emeryville, CA.

Dynavax Technologies Corp.

Dynavax Technologies is surging following the announcement of its acquisition by Sanofi, which will integrate its Heplisav-B vaccine and promising shingles candidate into a major pharmaceutical pipeline. While long-term shareholders express mixed feelings about the acquisition price, the community is actively discussing whether the offer fully captures DVAX's value and the implications for its recent licensing agreements in the context of broader biotech M&A.

A project grown out of the community's love and passion for the weed culture. Launched around early 2025, $weedcoin, “Like Bitcoin but way higher,” emphasizes its alignment with cannabis culture and a laid-back vibe. Unlike other Weed communities, this project leans heavily into community engagement over technical utility, aiming to build a “stoner community” through social media presence and decentralized governance. We also aim to focus on onboarding web2 businesses and users onto web3 through the token.

Weedcoin

WEEDCOIN is trending as the community speculates on the impact of federal cannabis reclassification to Schedule III and the anticipated end of the 280E tax burden. Enthusiasts are rallying around this "Green Revolution" on the Solana ecosystem, envisioning it as a movement against traditional pharmaceutical monopolies. The prevailing sentiment among supporters is captured by the slogan, "Weedcoin - Like Bitcoin but way higher," reflecting strong belief in its potential.

USELESS

USELESS is gaining significant attention following reports of notable insider accumulation and a recent Chainlink CCIP integration enabling cross-chain transfers, signaling increased utility and adoption. The community is extremely bullish, widely discussing the potential for a massive, parabolic run for this meme coin, drawing comparisons to other major crypto success stories.

Aptos is a new, independent high-performance PoS Layer 1 project focused on delivering the safest and most scalable Layer 1 blockchain in the world. The Aptos blockchain leverages the Move programming language and the Move VM for application development, which are created and optimized for blockchain use cases.The team is comprised of the original creators, researchers, designers, and builders of Diem, the blockchain that was first built to serve this purpose. Aptos raised $200m from a16z, Multicoin, Binance and others. Aptos launched Devnet in mid March, incentivized testnet in late May and targets Q3 for mainnet launch.

Aptos

Aptos is a trending topic as discussion intensifies around its role as a high-performance Layer 1, recognized for its robust engineering and dApp capabilities. Simultaneously, significant attention is on Keeta, an emerging Layer 1 praised for its ultra-high transaction speeds, compliance-first design, and crucial fiat integration via a Stripe partnership, positioning it as a complementary, undervalued asset for global financial infrastructure alongside Aptos.

What is the project about? Pepe is a community based meme token surround the iconic meme Pepe the frog. Pepe aims to leverage the power of such an iconic meme to become the most memeable memecoin in existence.   What makes your project unique? Pepe is here to make memecoins great again. Ushering in a new paradigm for memecoins, Pepe represents the memecoin in it's purest simplicity. With zero taxes, liquidity locked forever, and contract immutable, Pepe is for the people, forever. Pepe is about culture, rallying together a community to have fun and enjoy memes, fueled purely by memetic power.   History of your project. Pepe was stealth launched on Friday, April 14th, 2023.   What’s next for your project? Pepe will focus on developing a tight-knit community around the token and building resources to enrich the communities knowledge and success in crypto through a token gated group, newsletter, and more tools.   What can your token be used for? Pepe can be used to speculate on the power of memes, and does not pretend to be anything more.

Pepe

PEPE is actively trending as a key player in the meme coin space, with its viral growth and community-driven appeal sparking significant market conversation. The community is heavily engaged in discussions around its price movements, with many expressing a mix of frustration over recent dips and optimism for future gains, actively buying the dip while observing broader market shifts. The token's performance is often contrasted with infrastructure-focused projects, highlighting the ongoing debate about the long-term viability of speculative meme assets versus utility-driven blockchain solutions in the evolving crypto ecosystem.

The KARRAT protocol is a decentralized gaming infrastructure layer, supported by $KARRAT and empowered by a truly decentralized community with a shared vision embracing gaming, entertainment and AI products catering for the new era.  To accelerate the evolution of gaming, entertainment, and AI-driven experiences with blockchain technology and a truly empowered community.  The KARRAT protocol pioneers a decentralized framework in gaming and entertainment, combining blockchain with community-driven collaboration. $KARRAT can animate ecosystems of games and products and the protocol makes tools available to support these industries and the adoption of KARRAT technology provides a unique, personalized gaming experience.

KARRAT

KARRAT is trending as a key player in the Web3 gaming and AI sectors, fueled by excitement around its upcoming AI-powered game 'My Pet Hooligan' and strategic partnerships with entities like AMGI Studios and Animoca Brands, alongside rumored collaborations. The community is actively debating its potential for a significant run, citing a "low supply, high demand" narrative and its current valuation far below previous highs, though some express concern over recent token unlocks and potential dilution.

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Bitcoin has seen massive volatility this quarter as ETFs, macro conditions, and crypto adoption continue to shape price action. As 2025 comes to a close, where do you think Bitcoin ($BTC) will finish on December 31, 2025 (EST)?

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