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Solana is a highly functional open source project that banks on blockchain technology’s permissionless nature to provide decentralized finance (DeFi) solutions. It is a layer 1 network that offers fast speeds and affordable costs. While the idea and initial work on the project began in 2017, Solana was officially launched in March 2020 by the Solana Foundation with headquarters in Geneva, Switzerland.

Solana

Solana is trending amid general crypto market volatility, with discussions focusing on its resilience relative to Bitcoin and Ethereum. The community is also actively debating the emergence of new meme coins on the Solana blockchain, with some users promoting specific projects. There are ongoing discussions around market manipulation and dubious actors within the Solana ecosystem.

Ethereum is a global, open-source platform for decentralized applications. In other words, the vision is to create a world computer that anyone can build applications in a decentralized manner; while all states and data are distributed and publicly accessible. Ethereum supports smart contracts in which developers can write code in order to program digital value. Examples of decentralized apps (dapps) that are built on Ethereum includes tokens, non-fungible tokens, decentralized finance apps, lending protocol, decentralized exchanges, and much more.  On Ethereum, all transactions and smart contract executions require a small fee to be paid. This fee is called Gas. In technical terms, Gas refers to the unit of measure on the amount of computational effort required to execute an operation or a smart contract. The more complex the execution operation is, the more gas is required to fulfill that operation. Gas fees are paid entirely in Ether (ETH), which is the native coin of the blockchain. The price of gas can fluctuate from time to time depending on the network demand.

Ethereum

Ethereum is trending amidst discussions about its potential bottom and future price action, with some traders highlighting oversold conditions and potential for a recovery. A notable point of conversation revolves around BitMine's increased ETH holdings and shift towards staking, while others express concerns about market manipulation and potential further declines. The community is actively debating ETH's performance relative to Bitcoin and the broader market, considering factors like regulatory developments and institutional investment.

Hedera is a decentralized public network where developers can build secure, fair applications with near real-time consensus. The platform is owned and governed by a council of global innovators including Avery Dennison, Boeing, Deutsche Telekom, DLA Piper, FIS (WorldPay), Google, IBM, LG Electronics, Magalu, Nomura, Swirlds, Tata Communications, University College London (UCL), Wipro, and Zain Group.   The Hedera Consensus Service (HCS) acts as a trust layer for any application or permissioned network and allows for the creation of an immutable and verifiable log of messages. Application messages are submitted to the Hedera network for consensus, given a trusted timestamp, and fairly ordered. Use HCS to track assets across a supply chain, create auditable logs of events in an advertising platform, or even use it as a decentralized ordering service.

Hedera Hashgraph

HBAR is trending as the community discusses its recent price action and potential for future growth. Bullish investors are highlighting cup and handle formations and comparing HBAR's technology to other cryptos, while some express concerns over weekend pumps and dilution. Discussion also involves the potential impact of broader market trends and regulatory developments.

The Stellar network is an open source, distributed, and community owned network used to facilitate cross-asset transfers of value. Stellar aims to help facilitate cross-asset transfer of value at a fraction of a penny while aiming to be an open financial system that gives people of all income levels access to low-cost financial services. Stellar can handle exchanges between fiat-based currencies and between cryptocurrencies. Stellar.org, the organization that supports Stellar, is centralized like XRP and meant to handle cross platform transactions and micro transactions like XRP. However, unlike Ripple, Stellar.org is non-profit and their platform itself is open source and decentralized.   Stellar was founded by Jed McCaleb in 2014. Jed McCaleb is also the founder of Mt. Gox and co-founder of Ripple, launched the network system Stellar with former lawyer Joyce Kim. Stellar is also a payment technology that aims to connect financial institutions and drastically reduce the cost and time required for cross-border transfers. In fact, both payment networks used the same protocol initially.  Distributed Exchange Through the use of its intermediary currency Lumens (XLM), a user can send any currency that they own to anyone else in a different currency.  For instance, if Joe wanted to send USD to Mary using her EUR, an offer is submitted to the distributed exchange selling USD for EUR. This submitted offer forms is known as an order book. The network will use the order book to find the best exchange rate for the transaction in-order to minimize the fee paid by a user.  This multi-currency transaction is possible because of "Anchors". Anchors are trusted entities that hold people’s deposits and can issue credit. In essence, Anchors serves as the bridge between different currencies and the Stellar network.  Lumens (XLM) Lumens are the native asset (digital currency) that exist on the Stellar network that helps to facilitate multi-currency transactions and prevent spams. For multi-currency transactions, XLM is the digital intermediary that allows for such a transaction to occur at a low cost.  In-order to prevent DoS attacks (aka spams) that would inevitably occur on the Stellar network, a small fee of 0.00001 XLM is associated with every transaction that occurs on the network. This fee is small enough so it does not significantly affect the cost of transaction, but large enough so it dissuades bad actors from spamming the network.   Prior to Protocol 12, Stellar had a built-in inflation mechanism conceived to allow account holders to collectively direct inflation-generated lumens toward projects built on Stellar.  As the network evolved and grew, it became increasingly clear that inflation wasn’t working as intended — account holders either didn’t set their inflation destination or joined inflation pools to claim the inflation themselves, and the operational costs associated with inflation payments continued to rise — and so a protocol change to disable inflation was proposed, implemented, voted on by validators, and ultimately adopted as part of a network upgrade.  The inflation operation is now deprecated. https://developers.stellar.org/docs/glossary/inflation/

Stellar Lumens

Stellar Lumens is trending as traders discuss a potential breakout and community members share their bullish sentiment. Key talking points include XLM's potential as an ISO coin and speculation around upcoming price movements. Some traders are actively "stacking" XLM while others are wary of potential downsides.

Bitcoin is the world's first decentralized cryptocurrency, created in 2009 by the pseudonymous Satoshi Nakamoto. It enables peer-to-peer electronic cash transactions without intermediaries like banks or governments, operating on a blockchain secured by Proof of Work mining and the SHA-256 cryptographic algorithm.   With a fixed supply cap of 21 million coins and programmatic halvings every four years that reduce miner rewards, Bitcoin is designed as a deflationary digital asset often called "digital gold." Its value stems from solving the double-spending problem without trusted intermediaries, creating the first truly scarce digital asset with censorship resistance and permissionless access that no government, corporation, or individual can control.  Bitcoin operates as a decentralized peer-to-peer network where transactions are recorded on a public ledger called the blockchain, distributed across thousands of computers globally. Transactions are grouped into blocks added approximately every 10 minutes through mining, where specialized computers compete to solve complex mathematical puzzles.   Bitcoin has achieved mainstream adoption through multiple vectors. The January 2024 SEC approval of 11 spot Bitcoin ETFs opened Bitcoin investment to traditional finance participants, and corporations like Strategy (formerly MicroStrategy) are using Bitcoin as a treasury reserve asset to protect against currency debasement, offering MSTR holders amplified exposure to Bitcoin.   The Bitcoin ecosystem continues to evolve with innovations like Ordinals, which emerged in January 2023 to enable NFT-like functionality directly on Bitcoin, and BRC-20 tokens, an experimental standard for creating fungible tokens using Ordinal inscriptions. BTCFi (Bitcoin Finance) represents emerging financial applications extending beyond Bitcoin's traditional role, with protocols like Babylon allowing Bitcoin holders to stake BTC to secure Proof of Stake chains.

Bitcoin

Bitcoin is trending as the crypto market attempts a recovery, sparking debates about whether it's a bull trap or a genuine turnaround. Community members are closely watching key resistance levels and anticipating potential market movements, with some pointing to a possible upcoming 'dump' while others highlight strong weekend gains.

Stonks is the first ever memecoin on the Solana blockchain.   Verifiably deployed in block 71935764 on April 02, 2021 22:10:10 UTC.  On 2024-11-24 members of the community banded together and purchased the website, Twitter, GitHub and developer coins from the original team, making it 100% community owned.  Liquidity has been locked and the community is committed to ensuring the revival of the project

Stonks

Stonks ($STNK) is trending as the first memecoin on Solana, backed by the intellectual property rights to the iconic 'Stonks' meme. Community members highlight its low market cap and potential for significant growth during the anticipated alt season, while others point to its strong community and history as a key differentiator in the memecoin space.

Sanofi engages in the research, production, and distribution of pharmaceutical products. It operates through the Biopharma segment, which comprises commercial operations and research, development and production activities relating to the specialty care, general medicines and vaccines franchises plus support and corporate functions, for all geographical territories. The company was founded in 1973 and is headquartered in Paris, France.

Sanofi - ADR

Sanofi-Aventis

Sanofi's stock is trending amidst discussions of potential acquisitions, particularly Altimmune ($ALT), driven by promising data in obesity and MASH.  The community is actively debating the likelihood of a partnership or buyout, citing connections between the companies and Sanofi's cash reserves. Some are highlighting the potential of competing companies like $GUTS, $TERN, $VKTX, and $IVA, suggesting Sanofi could pursue a broader buying spree in the weight loss and liver disease space.

GIGA is a meme token deployed on the Solana blockchain intended to honor the legend Ernest Khalimov the original “Gigachad”, by utilizing the strength of memes and “Chad” energy.  GIGA is a community run project.

GigaChad

$GIGA is trending as community members highlight its potential within the fitness industry, noting partnerships and the availability of GIGA-branded supplements in major retailers like $WMT. Many allude to its strong community, meme-based branding, and see potential for growth akin to $DOGE. The community is also discussing its association with other tokens such as $WAGMI, $SOL and $SLAP.

Clear Secure, Inc. is a secure identity company, which engages in developing biometric identity verification technology platforms. Its identity platform connects passengers to the cards in their wallet transforming the way passengers live, work, and travel, and focuses on providing verification in several areas, such as events, healthcare, and sporting stadiums. The company was founded by Caryn Seidman-Becker and Kenneth Cornick in 2010 and is headquartered in New York, NY.

Clear Secure Inc - Ordinary Shares Class A

Clear Secure is trending as investors discuss its potential beyond airport security, highlighting its expansion into healthcare and identity verification. The community is weighing analyst ratings, buyback programs, and short interest while considering the company's financial health and growth prospects. Some are speculating about a potential short squeeze and the broader implications of biometric technology.

Allora is a decentralized intelligence network that makes artificial intelligence more adaptive, collaborative, and efficient. The platform combines and coordinates thousands of specialized AI models in real time to produce superior inferences for users and applications. By enabling anyone to contribute models, data, or validation, Allora creates a self-improving market for intelligence that powers agents, DeFi systems, and AI applications across chains.

Allora

Allora (ALLO) is trending amid community chatter about potential breakouts and money rotation into the crypto. Bullish sentiment suggests an expected surge, while some traders express concern about it being a potential pump and dump. Positive news around sister crypto SPELL is also contributing to the discussion.

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$IFRX is the US ever going to invest in pandemic preparedness for Avian Flu?

There was talk about stocking drugs for COVID/ H5N1/ and others. All of which can and does cause death. 

Given ARDS (stop / difficult / distressed breathing) is *root cause* for viral / infection - does Europe / US plan to have Gohibic on hand?

Wld be nice to see Euro grant of €50m to distribute / stock Gohibic at all member locations. 

How about stocking $50m from each BARDA participant w conditional FDA approval for emergency ARDS?

$EDSA paridiprubart
$IFRX vilobelimab 
$RHHBY  bevacizumab 

Every major ER in US should have it on hand.

Likely more death had to happen before it actually occurs. Sad to see simple tools not being used.  

We’re 2-3 mutations away from a complete mess and clock is ticking. 

https://www.cnn.com/2025/11/21/health/washington-bird-flu-death

FlowerInTheCellar

Eduardo S.

avalon E

A Washington resident died of complications from an infection with a bird flu strain never before reported in humans, the state Department of Health said on Friday.

Washington resident dies of complications from bird flu strain never before reported in humans | CNN

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InflaRx N.V.

Edesa Biotech Inc

Roche Holdings AG ADR

 is the US ever going to invest in pandemic preparedness for Avian Flu?

There was talk about stocking drugs for COVID/ H5N1/ and others. All of which can and does cause death. 

Given ARDS (stop / difficult / distressed breathing) is *root cause* for viral / infection - does Europe / US plan to have Gohibic on hand?

Wld be nice to see Euro grant of €50m to distribute / stock Gohibic at all member locations. 

How about stocking $50m from each BARDA participant w conditional FDA approval for emergency ARDS?



  bevacizumab 

Every major ER in US should have it on hand.

Likely more death had to happen before it actually occurs. Sad to see simple tools not being used.  

We’re 2-3 mutations away from a complete mess and clock is ticking. 



@dogDazeSummer Hindsight is 20/20....

For those interested read my recent comments on the Edesa board, where I am also (sadly) invested.

Pari and vilo have demonstrated enough efficacy / signals with a cause agnostic MoA....they deserve a registrational pathway.

The BARDA trial is a completely unserious attempt to help bring an ARDS therapy to market. It should have been designed as an adaptive registrational P2/P3 (think like GCARs GBM Agile trial) where each IP arm had an interim analysis and allow them to graduate to a P3. Even better would have been a shared placed arm. We&#39;re talking an acute unmet medical need.

Never trust in government work. Not to say I&#39;m not grateful but the timeline here for any of the participants is absurd. We&#39;re talking 7-10 years at least before any approval. Worthless.

Maybe there&#39;s some regulatory angle here that will materialize but as of right now I&#39;m seeing it.

 Hindsight is 20/20....

For those interested read my recent comments on the Edesa board, where I am also (sadly) invested.

Pari and vilo have demonstrated enough efficacy / signals with a cause agnostic MoA....they deserve a registrational pathway.

The BARDA trial is a completely unserious attempt to help bring an ARDS therapy to market. It should have been designed as an adaptive registrational P2/P3 (think like GCARs GBM Agile trial) where each IP arm had an interim analysis and allow them to graduate to a P3. Even better would have been a shared placed arm. We're talking an acute unmet medical need.

Never trust in government work. Not to say I'm not grateful but the timeline here for any of the participants is absurd. We're talking 7-10 years at least before any approval. Worthless.

Maybe there's some regulatory angle here that will materialize but as of right now I'm seeing it.

@TheGhostOfEd disagree and think the FDA is genuinely trying to get best drugs to market now —-and speed process substantially. 

Push out on BARDA cld be optics desire to drain more $ from US GOVT. 

If clear efficacy in P2, expect full approval 2 years. 

This is a robust p2 and while I don’t know “how they” exactly speed it up, the desire is there from all parties - not something we’ve seen historically.  

The only party who might wanna slow walk is PPG a  $TMO company. 

Before Trumps term ends - politics / fda/ knows they need results.  Results = approvals before another administration comes w different plans.

Thermo Fisher Scientific Inc.

 disagree and think the FDA is genuinely trying to get best drugs to market now —-and speed process substantially. 

Push out on BARDA cld be optics desire to drain more $ from US GOVT. 

If clear efficacy in P2, expect full approval 2 years. 

This is a robust p2 and while I don’t know “how they” exactly speed it up, the desire is there from all parties - not something we’ve seen historically.  

The only party who might wanna slow walk is PPG a  

 company. 

Before Trumps term ends - politics / fda/ knows they need results.  Results = approvals before another administration comes w different plans.

@dogDazeSummer The P2 now looks like it&#39;s going to be completing sometime in 2028. They said specifically that it&#39;s a non registrational trial. So what&#39;s your pitch to me on how any of the participants can get approval w/o a larger registrational P3? Conditional approval for IFRX in the EMA with a commitment to do a P3? Maybe. Potentially same deal for Edesa in Canada via the NOC/c pathway. But not a fully approved label. Of someone can convince me otherwise I&#39;m all ears.

 The P2 now looks like it's going to be completing sometime in 2028. They said specifically that it's a non registrational trial. So what's your pitch to me on how any of the participants can get approval w/o a larger registrational P3? Conditional approval for IFRX in the EMA with a commitment to do a P3? Maybe. Potentially same deal for Edesa in Canada via the NOC/c pathway. But not a fully approved label. Of someone can convince me otherwise I'm all ears.

@TheGhostOfEd Nothing to sell- rather observation FDA is open to highly creative ideas on safe drugs getting to market faster. 

Even $AMGN doing pre clinical branding on avacopan better than steroids.  

A Gohibic conversion from EMA to full approval may also open doors we can’t fully understand.  

Prior post:

****I don’t know “how they” exactly speed it up, the desire is there from all parties - not something we’ve seen historically.  

The only party who might wanna slow walk is PPG a  $TMO company. 

Before Trumps term ends - politics / fda/ knows they need results.  Results = approvals before another administration comes w different plans.****

AMGEN Inc.

 Nothing to sell- rather observation FDA is open to highly creative ideas on safe drugs getting to market faster. 

Even 

 doing pre clinical branding on avacopan better than steroids.  

A Gohibic conversion from EMA to full approval may also open doors we can’t fully understand.  

Prior post:

****I don’t know “how they” exactly speed it up, the desire is there from all parties - not something we’ve seen historically.  

The only party who might wanna slow walk is PPG a  

 company. 

Before Trumps term ends - politics / fda/ knows they need results.  Results = approvals before another administration comes w different plans.****