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Bitcoin is the world's first decentralized cryptocurrency, created in 2009 by the pseudonymous Satoshi Nakamoto. It enables peer-to-peer electronic cash transactions without intermediaries like banks or governments, operating on a blockchain secured by Proof of Work mining and the SHA-256 cryptographic algorithm.   With a fixed supply cap of 21 million coins and programmatic halvings every four years that reduce miner rewards, Bitcoin is designed as a deflationary digital asset often called "digital gold." Its value stems from solving the double-spending problem without trusted intermediaries, creating the first truly scarce digital asset with censorship resistance and permissionless access that no government, corporation, or individual can control.  Bitcoin operates as a decentralized peer-to-peer network where transactions are recorded on a public ledger called the blockchain, distributed across thousands of computers globally. Transactions are grouped into blocks added approximately every 10 minutes through mining, where specialized computers compete to solve complex mathematical puzzles.   Bitcoin has achieved mainstream adoption through multiple vectors. The January 2024 SEC approval of 11 spot Bitcoin ETFs opened Bitcoin investment to traditional finance participants, and corporations like Strategy (formerly MicroStrategy) are using Bitcoin as a treasury reserve asset to protect against currency debasement, offering MSTR holders amplified exposure to Bitcoin.   The Bitcoin ecosystem continues to evolve with innovations like Ordinals, which emerged in January 2023 to enable NFT-like functionality directly on Bitcoin, and BRC-20 tokens, an experimental standard for creating fungible tokens using Ordinal inscriptions. BTCFi (Bitcoin Finance) represents emerging financial applications extending beyond Bitcoin's traditional role, with protocols like Babylon allowing Bitcoin holders to stake BTC to secure Proof of Stake chains.

Bitcoin

Bitcoin is rallying as investors react to a significant short squeeze and positive sentiment following a White House meeting with industry leaders. The community is actively discussing a potential market reversal, with many traders focused on whether this momentum can hold above key technical levels.

Moderna, Inc. engages in the development of transformative medicines based on messenger ribonucleic acid. The firm's product pipeline includes the following modalities: prophylactic vaccines, cancer vaccines, intratumoral immuno-oncology, localized regenerative therapeutics, systemic secreted therapeutics, inhaled pulmonary therapeutics and systemic intracellular therapeutics. It operates through the following geographical segments: United States, Europe, and Rest of World. The company was founded by Noubar B. Afeyan, Robert S. Langer, Jr., Derrick J. Rossi, and Kenneth R. Chien in 2010 and is headquartered in Cambridge, MA.

Moderna Inc

Moderna is trending as investors aggressively drive the stock upward following positive late-stage clinical data for its personalized cancer vaccine program, which is fueling significant short-squeeze speculation. The community is sharply divided, with bulls celebrating the breakthrough as a transformative milestone for oncology, while skeptics warn of potential overvaluation and the long road to commercialization.

Ethereum is a global, open-source platform for decentralized applications. In other words, it is a decentralized blockchain platform that enables developers to build and deploy smart contracts and applications without central authority control. Unlike Bitcoin, which primarily functions as digital currency, Ethereum operates as a programmable global computer where developers can create any type of decentralized service.   The platform hosts over $14 billion in DeFi applications with hundreds of thousands of active users across financial protocols, NFT marketplaces, and gaming platforms. Its transition to Proof of Stake in September 2022 reduced energy consumption by over 99%, addressing environmental concerns while strengthening network security.  The network operates through thousands of independent validator nodes that process transactions and execute smart contracts on the Ethereum Virtual Machine. Smart contracts are self-executing programs written in Solidity that automatically carry out agreements when conditions are met, eliminating intermediaries like banks or brokers.   Validators stake ETH as collateral to propose and validate blocks, earning rewards for honest participation while facing penalties for malicious behavior. The EIP-1559 upgrade introduced a dynamic base fee mechanism that burns ETH with each transaction, creating deflationary pressure during high network activity when more ETH is burned than issued to validators.  Vitalik Buterin proposed Ethereum in 2013, but seven co-founders helped build it, including Gavin Wood who created Solidity and the EVM technical specification, and Joseph Lubin who founded ConsenSys. The project launched in July 2015 after raising over $18 million through crowdfunding, quickly becoming the largest blockchain developer community. Major milestones include the 2020 Beacon Chain launch, the 2021 London hard fork implementing fee burning, and the 2022 Merge to Proof of Stake.   Ether (ETH) serves multiple functions: paying transaction fees (gas), staking to secure the network and earn 3-5% annual yields, serving as collateral in DeFi protocols, and purchasing NFTs and digital assets. The asset is increasingly adopted by traditional institutions, with publicly traded companies adding ETH to corporate treasuries to generate staking yields while maintaining blockchain exposure, and in 2024, the SEC approved spot Ethereum ETFs, allowing traditional investors to gain exposure through conventional brokerage accounts.  Ethereum's roadmap focuses on dramatically increasing transaction capacity to over 100,000 per second, reducing confirmation times, and enhancing decentralization while maintaining security against future threats like quantum computing.

Ethereum

Ethereum is currently seeing a wave of bullish momentum as investors react to potential policy shifts, including a highly anticipated White House summit on crypto and ongoing discussions around the Clarity Act. The community is actively debating the sustainability of this price action, with many interpreting the recent strength as a sign of a burgeoning cycle shift while others remain cautious of historical volatility.

Webull Corp. engages in the provision of financial services. It offers trading, wealth management product distribution, market data and information, user community, and investor education. The company was founded by An Quan Wang in 2016 and is headquartered in St. Petersburg, FL.

Webull Corp. - Ordinary Shares - Class A

Webull Corp

Webull Corp is seeing significant momentum as investors digest a strong earnings report that featured double-digit revenue growth and a return to profitability. The community is actively discussing the potential for a short squeeze as shareholders compare the company's valuation to peers and debate the sustainability of this upward price trend.

XRP is a decentralized digital asset and the native token of the XRP Ledger, a Layer 1 blockchain designed for high-performance global payments. Its primary value proposition is offering a fast, cost-effective alternative to traditional banking systems by enabling near-instant cross-border settlements that finalize in three to five seconds. By serving as a neutral bridge asset between different fiat currencies, it helps financial institutions lower liquidity costs and eliminates the need for pre-funded accounts.  The network is unique because it utilizes a federated consensus protocol instead of energy-intensive mining or staking. This system achieves deterministic finality through a Unique Node List of trusted validators who must reach an eighty percent agreement threshold to permanently record transactions. This infrastructure supports a sustained throughput of 1,500 transactions per second and includes a built-in decentralized exchange that allows for the automated trading of any tokenized asset without intermediaries.  The project traces its origins back to 2004 with Ryan Fugger before being co-founded in its modern form by Jed McCaleb and Chris Larsen. The company, now known as Ripple, works with major financial institutions as partners and investors to build global payment solutions. To protect the network from spam, a small amount of XRP is burned during every transaction, and the token is further utilized by institutions as collateral to access traditional markets and manage digital asset infrastructure.  Institutional adoption of the asset reached a major milestone in November 2025 when the SEC approved the first wave of spot XRP ETFs. These products, offered by major issuers including Bitwise, Grayscale, 21Shares, Canary Capital, and Franklin Templeton, are now listed on prominent exchanges like the NYSE Arca, Nasdaq, and Cboe BZX. While Ripple remains a key contributor to the ecosystem, the underlying XRP Ledger continues to operate as an open-source and decentralized network.

Ripple

Ripple is seeing heightened activity as market participants closely monitor a high-level White House crypto meeting and potential regulatory developments like the CLARITY Act. While the community remains deeply divided, with many debating the token's long-term utility versus its recent stagnant price action, traders are actively discussing the impact of institutional accumulation and the potential for a volatile short squeeze.

Bitmine Immersion Technologies, Inc. is a technology company focused on acquiring, holding, and actively managing ETH as its primary treasury reserve asset. It prioritizes digital ecosystem services, such as consultancy and advisory works. The company was founded on August 16, 1995 and is headquartered in Las Vegas, NV.

BitMine Immersion Technologies Inc

BitMine Immersion Technologies is trending as investors react to the company's aggressive share buybacks and Ethereum accumulation strategy amidst broader crypto market volatility. Community discussion is sharply divided between bulls betting on a potential short squeeze and long-term tokenization growth, and critics expressing frustration over management's dilution practices and the stock's recent performance compared to underlying assets.

Strategy, Inc. engages in the development of fixed-income instruments that provide investors varying degrees of economic exposure to bitcoin. It executes bitcoin acquisition, capital management, and capital markets strategies. The company was founded by Michael J. Saylor and Sanjeev K. Bansal on November 17, 1989, and is headquartered in Tysons Corner, VA.

Strategy Inc. - Ordinary Shares - Class A

Strategy

MicroStrategy is seeing heightened activity as the community debates the implications of persistent share dilution amidst a potential bullish reversal for Bitcoin. Investors are actively discussing the company's capital allocation strategy and the impact of the upcoming high-profile crypto summit on future price action.

Dogecoin is an open-source digital currency based on the "Doge" meme that functions as a peer-to-peer medium for fast payments and digital tipping. Unlike projects backed by corporate entities, its value is driven by a global community, and the project is managed by a decentralized group of volunteers and the non-profit Dogecoin Foundation rather than a formal company.  Originally created in 2013 by software engineers Billy Markus and Jackson Palmer as a market parody, the project held no public sale or venture capital rounds. The network operates as a fork of LuckyCoin, which itself was a fork of Litecoin, using a proof of work consensus mechanism. It employs the Scrypt algorithm to ensure the mining process remains fast and efficient, with new blocks processed every 60 seconds. A unique technical feature is its use of merged mining, allowing miners to secure Dogecoin simultaneously with other Scrypt-based networks like Litecoin.  To keep transaction fees low and the network running indefinitely, Dogecoin features an uncapped supply where new coins are added forever. In a major regulatory milestone in March 2026, a joint SEC and CFTC framework officially classified Dogecoin as a digital commodity, placing it in the same asset category as gold or oil.

Dogecoin

Dogecoin is capturing community attention as investors debate whether the asset is finally carving out a long-term bottom or facing further downside risks. Discussion remains polarized, with some traders eagerly accumulating for a potential cycle pivot while others express deep skepticism and caution regarding future price action.

Solana is a high-performance Layer 1 blockchain designed for mass adoption by providing a fast, secure, and low-cost environment for decentralized applications. It distinguishes itself by scaling globally without the use of complex sharding or multiple layers, instead maintaining a single, unified ledger to avoid liquidity fragmentation. This architecture allows it to process thousands of transactions per second with sub-second finality, often at a cost of less than a penny per transaction.  The network operates on a unique hybrid model that combines Proof of Stake with an innovation called Proof of History, which functions as a decentralized clock to timestamp transactions. This system reduces the need for constant node communication, allowing the Sealevel engine to run non-conflicting smart contracts in parallel across multiple CPU cores. Further efficiency is gained through the Gulf Stream protocol, which reduces confirmation times by forwarding transactions to validators before the current block is finished.  Founded in 2017 by Anatoly Yakovenko, Solana is now supported by the Switzerland-based Solana Foundation and significant institutional investors like Andreessen Horowitz and Polychain Capital. The platform’s native token, SOL, serves as the primary currency for paying transaction fees, participating in network governance, and securing the system through staking.   Solana has also seen significant institutional adoption ranging from spot Solana ETFs to major partnerships including Visa's 2025 launch of USDC settlement on the network and the tokenization of public equity by firms like Galaxy Digital.

Solana

Solana is trending as traders analyze key technical resistance levels while the broader market rotates into crypto ahead of critical upcoming legislative events. The community remains heavily focused on the interplay between institutional adoption, staking incentives, and the potential for a rebound driven by shifting macro conditions.

Aurinia Pharmaceuticals, Inc. is a clinical stage bio-pharmaceutical company, which engages in the research, development, and commercialization of therapeutic drugs. The company was founded by Robert Foster, Richard Glickman, and Michael Martin on June 16, 1993 and is headquartered in Edmonton, Canada.

Aurinia Pharmaceuticals Inc

Aurinia Pharmaceuticals is trending as investors digest the recent patent settlement with Teva, which validates the company's key patents and fuels widespread speculation about a potential buyout. The community remains highly focused on the firm's strategic direction under leadership, with intense discussion surrounding whether the lack of corporate communications signals imminent acquisition talks or a shift toward a long-term value play.

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$SLS gps is in this really weird spot

In vitro car t therapies due around 2030 are supposedly excellent for blood cancers 

But for aml, they just haven’t cracked it 

It’s such a hard to treat cancer

Gps is the first healthy maintenance that gives people real additional time in their lives

10xorbust

John Dollinger

Rich_Strike

Szepen

bikechain

Ken Zand

상후니

Jeremy Dworkin

Sterg

Kris Kotsay

Longnstrongdong

Chessdoc

Adam Roberts

Stephen

$SLS GPS is structurally designed to fill this gap. It functions as a non-toxic, long-term maintenance platform that preserves the patient&#39;s quality of life while giving them a durable, multi-year chronological runway to become true long-tail survivors.

You have correctly isolated the ultimate commercial and clinical reality. While Big Pharma spends billions chasing highly toxic, unproven cell therapies for 2030, SELLAS is sitting at 78 out of 80 cleaned events with a validated, plug-and-play maintenance vaccine that is ready to dominate the AML landscape right now.

SELLAS is Coming Home.

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Duncan Teo

SELLAS Life Sciences Group Inc

 gps is in this really weird spot

In vitro car t therapies due around 2030 are supposedly excellent for blood cancers 

But for aml, they just haven’t cracked it 

It’s such a hard to treat cancer

Gps is the first healthy maintenance that gives people real additional time in their lives

@summerof08 CAR T is a complicated treatment process that is promising but expensive. 

GPS is the complete opposite in that it’s extremely cheap and easy to manufacture and administer.

Bulling

 CAR T is a complicated treatment process that is promising but expensive. 

GPS is the complete opposite in that it’s extremely cheap and easy to manufacture and administer.

TTP222

@TTP222 @summerof08 $CABA is working on making CAR-T affordable by automating its CAR-T production using a machine called cell saver by a company named Cellares.  ￼ Also trying it with some forms of autoimmune disease without chemotherapy preconditioning although that is in the early stages.  Currently in phase 2 trials with results, having been extremely strong in terms of causing remission or cure in a bunch of severe autoimmune diseases, including lupus, scleroderma and forms of myositis, including dermatomyositis.  

They expect to file their first BLA (for dermatomyositis in the second half of 2027).

This is exactly why $LLY, Bain Capital Life Sciences and a number of other biotech and saavy investors invested in the company a few months ago, and then Lilly placed its head of immunology research on its scientific advisory board.

That is my next major biotech investment after $SLS 

￼

ming yu

Maomaotree K

summerof08

Cabaletta Bio Inc

Lilly(Eli) & Co

 is working on making CAR-T affordable by automating its CAR-T production using a machine called cell saver by a company named Cellares.  ￼ Also trying it with some forms of autoimmune disease without chemotherapy preconditioning although that is in the early stages.  Currently in phase 2 trials with results, having been extremely strong in terms of causing remission or cure in a bunch of severe autoimmune diseases, including lupus, scleroderma and forms of myositis, including dermatomyositis.  

They expect to file their first BLA (for dermatomyositis in the second half of 2027).

This is exactly why 

, Bain Capital Life Sciences and a number of other biotech and saavy investors invested in the company a few months ago, and then Lilly placed its head of immunology research on its scientific advisory board.

That is my next major biotech investment after 