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Solana is a high-performance Layer 1 blockchain designed for mass adoption by providing a fast, secure, and low-cost environment for decentralized applications. It distinguishes itself by scaling globally without the use of complex sharding or multiple layers, instead maintaining a single, unified ledger to avoid liquidity fragmentation. This architecture allows it to process thousands of transactions per second with sub-second finality, often at a cost of less than a penny per transaction.  The network operates on a unique hybrid model that combines Proof of Stake with an innovation called Proof of History, which functions as a decentralized clock to timestamp transactions. This system reduces the need for constant node communication, allowing the Sealevel engine to run non-conflicting smart contracts in parallel across multiple CPU cores. Further efficiency is gained through the Gulf Stream protocol, which reduces confirmation times by forwarding transactions to validators before the current block is finished.  Founded in 2017 by Anatoly Yakovenko, Solana is now supported by the Switzerland-based Solana Foundation and significant institutional investors like Andreessen Horowitz and Polychain Capital. The platform’s native token, SOL, serves as the primary currency for paying transaction fees, participating in network governance, and securing the system through staking.   Solana has also seen significant institutional adoption ranging from spot Solana ETFs to major partnerships including Visa's 2025 launch of USDC settlement on the network and the tokenization of public equity by firms like Galaxy Digital.

Solana

A sharp Solana rally and breakout is drawing attention, with traders citing strong spot ETF inflows, planned Charles Schwab access for brokerage clients, and governance approvals for faster disinflation and higher fee burns that could tighten supply. Sentiment is broadly bullish, though some traders view the move as overbought or a potential fakeout and expect a pullback.

UNI is the governance token for Uniswap, an Automated Market Marker DEX on the Ethereum blockchain. The UNI token allows token holders to participate in the governance of the protocol. Key decisions such as usage of the treasury or future upgrades can be decided through a governance vote.

UniSwap

The UNIfication governance proposal to activate Uniswaps fee switch and introduce ongoing UNI burns is driving attention, with traders focused on potential revenue capture and reduced supply. The community is broadly bullish, though some remain skeptical because the proposals implementation and the impact of the Robinhood integration on actual volume and token value remain uncertain.

Cash Cat

Robinhoods listing and the tokens positioning as the platforms flagship meme coin are driving attention, with traders highlighting potential exposure to Robinhoods user base, launchpad fees, and buyback-and-burn activity. Bullish participants view it as a possible BONK- or DOGE-style winner, while others point to sell-the-news pressure, wide Robinhood spreads, volatility, and concerns about manipulation.

Revolution Medicines, Inc. is a clinical-stage precision oncology company, which engages in developing novel targeted therapies. It engages in the discovery and development of cancer treatment by pioneering novel combination and monotherapy treatment regimens to maximize the depth and durability of clinical benefit and circumvent adaptive resistance mechanisms for patients which are dependent on the RAS and mTOR pathway. The company was founded by Mark A. Goldsmith, Kevan Shokat, Martin D. Burke, David L. Pompliano and Michael Fischbach in October 2014 and is headquartered in Redwood City, CA.

Revolution Medicines Inc

FDA approval of Rasonque (daraxonrasib), Revolution Medicines first-in-class oral RAS inhibitor for metastatic pancreatic cancer, is driving attention after pivotal data showed a substantial survival benefit versus chemotherapy. Traders are bullish on its commercial potential and broader oncology pipeline, though some debate whether the approval was already priced in and cite launch access, side effects, valuation, and sell-the-news pressure.

Zebec's integrated products - real time payroll apps, on-chain payments infrastructure and networked DePIN - serve companies of all sizes, merchants and individuals and help transcend the boundaries of traditional banking and diminish the role of financial intermediaries.

Zebec Network

Attention is focused on Zebecs SuperApp rollout and reported payments-adoption progress, including enterprise payroll expansion, card usage, and European stablecoin benefits initiatives. Traders are divided over whether these milestones and potential regulatory clarity will translate into token demand, with bullish holders emphasizing long-term utility while skeptics cite weak price performance, dilution, and limited proven usage.

Ethereum is a global, open-source platform for decentralized applications. In other words, it is a decentralized blockchain platform that enables developers to build and deploy smart contracts and applications without central authority control. Unlike Bitcoin, which primarily functions as digital currency, Ethereum operates as a programmable global computer where developers can create any type of decentralized service.   The platform hosts over $14 billion in DeFi applications with hundreds of thousands of active users across financial protocols, NFT marketplaces, and gaming platforms. Its transition to Proof of Stake in September 2022 reduced energy consumption by over 99%, addressing environmental concerns while strengthening network security.  The network operates through thousands of independent validator nodes that process transactions and execute smart contracts on the Ethereum Virtual Machine. Smart contracts are self-executing programs written in Solidity that automatically carry out agreements when conditions are met, eliminating intermediaries like banks or brokers.   Validators stake ETH as collateral to propose and validate blocks, earning rewards for honest participation while facing penalties for malicious behavior. The EIP-1559 upgrade introduced a dynamic base fee mechanism that burns ETH with each transaction, creating deflationary pressure during high network activity when more ETH is burned than issued to validators.  Vitalik Buterin proposed Ethereum in 2013, but seven co-founders helped build it, including Gavin Wood who created Solidity and the EVM technical specification, and Joseph Lubin who founded ConsenSys. The project launched in July 2015 after raising over $18 million through crowdfunding, quickly becoming the largest blockchain developer community. Major milestones include the 2020 Beacon Chain launch, the 2021 London hard fork implementing fee burning, and the 2022 Merge to Proof of Stake.   Ether (ETH) serves multiple functions: paying transaction fees (gas), staking to secure the network and earn 3-5% annual yields, serving as collateral in DeFi protocols, and purchasing NFTs and digital assets. The asset is increasingly adopted by traditional institutions, with publicly traded companies adding ETH to corporate treasuries to generate staking yields while maintaining blockchain exposure, and in 2024, the SEC approved spot Ethereum ETFs, allowing traditional investors to gain exposure through conventional brokerage accounts.  Ethereum's roadmap focuses on dramatically increasing transaction capacity to over 100,000 per second, reducing confirmation times, and enhancing decentralization while maintaining security against future threats like quantum computing.

Ethereum

Expectations around Fed Chair Kevin Warshs Jackson Hole speech are driving Ethereum attention, with traders split over whether a hawkish tone will trigger a pullback or a dovish, crypto-friendly message will extend the recent rally. Bullish participants also cite persistent spot-ETF inflows, institutional accumulation and declining exchange supply, while technical traders warn of resistance and potential consolidation.

Direxion Shares ETF Trust - Direxion Daily Junior Gold Miners Index Bull 2X ETF

A sharp pullback in gold, silver and junior gold miners is driving attention, with JNUGs leveraged exposure amplifying the decline. Traders attribute the weakness to rising oil-driven inflation, Treasury yields and real rates, while others view the move as a technical correction and continue to cite debt, currency debasement, central-bank buying and geopolitical risk as longer-term bullish factors.

BlackRock, Inc. engages in the provision of investment, advisory, and risk management solutions. Its products include single-asset and multi-asset portfolios. The company was founded by Laurence Douglas Fink and Robert Steven Kapito in 1988 and is headquartered in New York, NY.

Blackrock Inc.

Strong second-quarter results, record assets under management and robust client inflows are driving bullish discussion around BlackRock, with traders also highlighting analyst upgrades and the firms expanding ETF, crypto and private-markets businesses. Debate remains over private-credit exposure and whether the recent rally is sustainable, with some traders expecting consolidation or further downside.

Onyx is an infrastructure for a multi-asset, scalable, and cryptographically secure ledger. Onyx functions as a blockchain-based technology that enhances financial ecosystems by enabling a more efficient and interconnected economy, with a mission to develop cryptographic ledgers that optimize security, scalability, and usability. XCN is native to the Onyx XCN Ledger Blockchain as well as the Onyx Goliath Blockchain. XCN is also used as an ERC-20 token for Staking and Governance.

Onyxcoin

An Upbit listing and expanded South Korean trading have drawn attention to XCN, with traders highlighting a sharp increase in volume and market access. The reaction is divided between bullish expectations for sustained momentum and skepticism that the move is another short-lived pump-and-dump.

$4CHAN is a meme token on the Ethereum Network.   4ChanToken represents a global crypto community that pays homage to the memetic powerhouses of the internet as Pepe, Doge, Shib and all major memes inventor combining them all into one super meme token that is $4CHAN. At its core, 4ChanToken embodies the untamed spirit of the notorious 4chan imageboard, where iconic memes are born, nurtured, and unleashed upon the world. With an unyielding spirit of irreverence and a touch of mischief, $4CHAN has emerged as the darling of meme enthusiasts, internet dwellers, and crypto aficionados alike.   The foundation of 4ChanToken lies in its community. We’ve harnessed the chaotic energy of this digital realm to create a currency that celebrates the power of memetic expression, empowering users to engage in a truly unique and decentralized economy. As a passionate supporter, you’ll join a vibrant ecosystem where dank memes and viral sensations are the lifeblood of commerce. 4ChanToken is more than just a digital currency – it’s the place where memes are born.  The ultimate playground for memelords and crypto degens. Based on the simplicity of holdrs/volume operating a store of value.  The identification of this value is best described as 'digital gold'. That $4chan can ultimately represent a superior store of value relative to all other forms of memecoins by embodying all memes in one token as the factual birthplace of all popular memes.

4Chan

Positive price momentum and visibility are driving attention to 4CHAN as traders promote it as a community-backed Ethereum memecoin with an unusually large token supply and speculative upside. Supporters highlight its meme-culture ties, liquidity and apparent resilience while broader crypto markets weaken, whereas critics point to the massive supply, limited utility and potential pump-and-dump risk.

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$SLS $MRK $JNJ Big Pharma is in a massive pipeline crisis, and they desperately need Sellas. Inside the VDR under strict NDAs, the industry is split in two:

🏢 CAMP A: THE SCALERS (Merck/AZ) Pipelines are top-heavy and near-term revenue engines are stalling. They NEED advanced Phase 3 oncology anchors right now to protect market share.

🧬 CAMP B: THE STREAMLINERS (J&amp;J/Roche) Internal discovery engines are completely OFF after slashing early R&amp;D. They MUST buy external, de-risked assets because they outsourced innovation.

Why is management holding through this strict SEC Quiet Period? To completely eliminate the risk-discount before the 80th REGAL event unblinds. Forget complicated CVR milestone nonsense—we want a straight, heavy Upfront Cash + Liquid Stock buyout for immediate monetization.

Let them fight it out to see who writes the biggest upfront check for a total monopoly. SELLAS is not desperate. The BP facing patent cliff is.

Tilted

Christy Morgan

Jeremy Dworkin

jhk35611

CMSP

Stephen

Steve call

Gebinator

$SLS Who is still running clinical trials in America? 
 
We compared how many new clinical trials each major sponsor started at US sites in 2019-2021 versus 2023-2025 (all interventional studies, counted by lead sponsor, at least one US site). 
 
The source is ClinicalTrials(.)gov (the public registry the FDA requires sponsors to file to). 
 
The industry split in two: 
 
Scaling up: 
1. Merck +50% 
2. AstraZeneca +21% 
3. Novo Nordisk +21% 
4. Eli Lilly +20% 
5. Bristol Myers Squibb +11% 
 
Pulling back: 
1. Johnson &amp; Johnson -42% 
2. Roche -40% 
3. Novartis -30% 
4. Pfizer -13% 
 
So, why is this happening? 
 
1) J&amp;J cut early research hardest. Its Phase 1 starts at US sites fell from 52 to 20, while Phase 3 held steady at 42 to 41. 
 
2) Merck&#39;s surge is almost all new pipeline. Phase 1 starts went from 35 to 117, more than tripled. Over half of every new Merck trial is now first-stage research. 
 
3) Lilly&#39;s growth is concentrated in one disease. Its obesity and type 2 diabetes trials went from 44 to 92, more than doubled.

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Merck & Co Inc

Johnson & Johnson

 Big Pharma is in a massive pipeline crisis, and they desperately need Sellas. Inside the VDR under strict NDAs, the industry is split in two:

🏢 CAMP A: THE SCALERS (Merck/AZ) Pipelines are top-heavy and near-term revenue engines are stalling. They NEED advanced Phase 3 oncology anchors right now to protect market share.

🧬 CAMP B: THE STREAMLINERS (J&J/Roche) Internal discovery engines are completely OFF after slashing early R&D. They MUST buy external, de-risked assets because they outsourced innovation.

Why is management holding through this strict SEC Quiet Period? To completely eliminate the risk-discount before the 80th REGAL event unblinds. Forget complicated CVR milestone nonsense—we want a straight, heavy Upfront Cash + Liquid Stock buyout for immediate monetization.

Let them fight it out to see who writes the biggest upfront check for a total monopoly. SELLAS is not desperate. The BP facing patent cliff is.

Duncan Teo

@Duncan74 more liquid stock than cash preferred.