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Agios Pharmaceuticals, Inc. is a biopharmaceutical company, which engages in a research engine, multiple novels, and investigational therapies in preclinical development. It focuses on cellular metabolism and classical hematology. The company was founded by Lewis Clayton Cantley, Tak W. Mak, Craig B. Thompson and Shin-Shan Michael Su on August 7, 2007 and is headquartered in Cambridge, MA.

Agios Pharmaceuticals Inc

Agios Pharmaceuticals is trending following its recent FDA approval for Aqvesme, positioning it as the sole approved treatment for alpha- and beta-thalassemia. This significant regulatory milestone is sparking community discussion around its market potential and expected impact, driving considerable trading activity despite past investor concerns regarding other pipeline developments.

The Compound Governance Token is a governance token on the Compound Finance lending protocol, COMP allows the owner to delegate voting rights to the address of their choice; the owner’s wallet, another user, an application, or a DeFi expert. Anybody can participate in Compound governance by receiving delegation, without needing to own COMP.  Anybody with 1% of COMP delegated to their address can propose a governance action; these are simple or complex sets of actions, such as adding support for a new asset, changing an asset’s collateral factor, changing a market’s interest rate model, or changing any other parameter or variable of the protocol that the current administrator can modify.

Compound

Compound (COMP) is drawing significant attention as its circulating supply nears its maximum cap, fueling expectations of a potential 'supply shock' and treasury buybacks among bullish investors. This optimism is sharply contrasted by widespread community concerns regarding the Compound Foundation's financial health, governance challenges, and strong competition within the DeFi lending space.

Avantis is the largest RWA perps DEX in DeFi, built on and backed by Base. Avantis allows users to trade crypto and real-world assets (RWAs), including FX, commodities, indices, and equities. Backed by Pantera and Coinbase, Avantis is the largest DEX on Base by volumes, and brings institutional-grade products to DeFi, letting users trade with up to 500x leverage in a transparent, permissionless environment.  Avantis is best known for launching zero-fee perpetuals (ZFP) — a first-of-its-kind primitive where traders only pay fees if they profit. They've also brought leveraged RWAs onchain. This has driven explosive growth: over $20B+ in cumulative volume and 15M+ run-rate revenues since Febrruary 2024.

Avantis

AVNT CRYPTO is actively trending with heightened discussion and trading volume, significantly fueled by its recent listing on Robinhood and strategic backing by Coinbase's Base app. Community sentiment is deeply divided, with many anticipating a substantial price rally due to these developments, while a vocal segment expresses skepticism over perceived "rug pulls," token unlocks, and concerns about leadership, intensifying the debate around its market trajectory. Investors are weighing its potential as a leading perp DEX against rivals, highlighting a dynamic and contentious trading environment.

Dynavax Technologies Corp. is a biopharmaceutical company, which engages in the provision of discovery, development, and commercialization of novel vaccines and immuno-oncology therapeutics. Its product includes HEPLISAV-B, which prevents infection caused by all known subtypes of hepatitis B virus in adults 18 years of age and older. The company was founded by Lawrence M. Lichtenstein, Dennis A. Carson, and Eyal Raz on August 29, 1996 and is headquartered in Emeryville, CA.

Dynavax Technologies Corp.

Dynavax Technologies is seeing a significant surge and high trading volume following the announcement that Sanofi will acquire the company for $15.50 per share in cash to bolster its adult immunization portfolio. While many long-term shareholders are celebrating much-anticipated gains, a notable segment of the community expresses disappointment, believing the offer undervalues the company given its vaccine assets and prior market discussions. This acquisition brings to a head ongoing conversations about the company's valuation and strategic direction.

Omeros Corp. operates as a biopharmaceutical company. The firm engages in the discovery, development, and commercializing of both small-molecule and protein therapeutics for large market. It also offers orphan indications targeting inflammation, coagulopathies, and disorders of the central nervous system. The company was founded by Gregory A. Demopulos and Pamela Pierce Palmer on June 16, 1994 and is headquartered in Seattle, WA.

Omeros Corporation

Omeros Corp

Omeros (OMER) is trending following the FDA approval of YARTEMLEA, its first-in-class therapy for transplant-associated thrombotic microangiopathy (TA-TMA). Investors are celebrating this significant milestone, anticipating substantial upside potential given the drug's unique market position and the company's strengthened financial outlook from a major licensing deal. The community is actively discussing a potential re-rating of the stock and speculation around a possible acquisition.

RaveDAO is a global community uniting music, technology, and purpose. Since their first sold-out event at Dubai 2024, they have expanded across Europe, the Middle East, North America, and Asia, hosting world-class experiences with over 100,000 total attendees and 3,000+ attendees for each event.  RaveDAO has worked with top-tier artists like Vintage Culture, Don Diablo, Chris Avantgarde, Lilly Palmer, MORTEN, Bassjackers, and GENESI and has support from Binance, OKX, Bitget, and Polygon. RaveDAO is redefining live entertainment in Web3 and has active partnerships with 1001Tracklists, AMF, and Warner Music.  Beyond the dance floor, RaveDAO channels energy and attention toward impact. In 2025 alone, proceeds from its events helped restore sight to 400+ cataract patients in Nepal and fund over 150 meditation programs across the U.S.

RaveDAO

RaveDAO (RAVE CRYPTO) is a trending topic, primarily fueled by a news report detailing Trumps World Liberty Financial's integration of Aster Trade into its USD1 expansion, coinciding with the RAVE token achieving a record high. The community is actively discussing its breakout potential, with many expressing enthusiasm to participate in what they view as a significant rally and a potential for substantial upside, noting considerable recent trading volume.

Citigroup, Inc. is a holding company, which engages in the provision of financial products and services. It operates through the following segments: Services, Markets, Banking, Wealth, U.S. Personal Banking (USPB), and All Other. The Services segment includes Treasury and Trade Solutions (TTS) which provides an integrated suite of tailored cash management, trade, and working capital solutions to multinational corporations, financial institutions and public sector organizations, and Securities Services, which offers cross-border support for clients, providing on-the-ground local market expertise, post-trade technologies, customized data solutions, and a wide range of securities services solutions that can be tailored to meet client needs. The Markets segment provides corporate, institutional, and public sector clients around the world with a full range of sales and trading services across equities, foreign exchange, rates, spread products, and commodities. The Banking segment offers Investment Banking and Corporate Lending services. The Wealth segment includes Private Bank, Wealth at Work, and Citigold and provides financial services to a range of client segments through banking, lending, mortgages, investment, custody, and trust product offerings. The USPB segment includes Branded Cards and Retail Services, which have proprietary card portfolios and co-branded card portfolios within Branded Cards, and co-brand and private label relationships within Retail Services. The All Other segment consists of activities not assigned to the reportable operating segments, including certain unallocated costs of global functions, other corporate expenses, and net treasury results. The company was founded in 1812 and is headquartered in New York, NY.

Citigroup Inc

Citigroup is currently trending as a leading bank stock, driven by significant regulatory progress and ongoing strategic initiatives, including a major wealth management partnership and advancements in digital assets. The community is actively discussing its substantial price appreciation and perceived undervaluation, while some caution about its rapid ascent and overbought technical indicators.

Arm Holdings Plc engages in the licensing, marketing, research, and development of microprocessors, systems IP, graphics processing units, physical IP and associated systems IP, software, and tools. It operates through the following geographical segments: United Kingdom, United States, and Other Countries. The company was founded on November 12, 1990 and is headquartered in Cambridge, the United Kingdom.

Arm Holdings plc. - ADR

Arm Holdings Plc.

Arm Holdings is actively trending due to its expanding strategic partnerships with industry giants like Nvidia and Meta, positioning its energy-efficient architecture as a crucial foundation for AI advancements in data centers, robotics, and edge computing. The community is sharply divided, with many bullish on its long-term potential as an "AI power-efficiency engine" despite its high valuation, while others express frustration over recent price volatility and alleged market manipulation. This ongoing debate highlights the challenge of reconciling strong fundamental developments with short-term market action in the semiconductor sector.

Philip Morris International, Inc. is a holding company, which engages in the business of delivering a smoke-free future and evolving a portfolio for the long term to include products outside of the tobacco and nicotine sector. It operates through the following geographical segments: Europe Region (Europe), South and Southeast Asia, Commonwealth of Independent States, Middle East, and Africa Region (SSEA, CIS, and MEA), East Asia, Australia, and PMI Duty Free Region (EA, AU, and PMI DF), and Americas Region (Americas). The Europe segment includes all the European Union countries, Switzerland, the United Kingdom, Ukraine, Moldova, and Southeast Europe. The SSEA, CIS, and MEA segment focuses on South and Southeast Asia, the African continent, the Middle East, Turkey, Israel, Central Asia, Caucasus, and Russia. The EA, AU, and PMI DF segment is involved in the consolidation of international duty-free business with East Asia and Australia. The Americas segment is comprised of the United States, Canada, and Latin America. The company was founded by Philip Morris in 1847 and is headquartered in Stamford, CT.

Philip Morris International Inc

Philip Morris International is gaining significant traction from its rapidly expanding smoke-free product portfolio, particularly IQOS and ZYN, driving strong financial performance. The company's strategic pivot away from traditional combustibles, coupled with recent regulatory news regarding expedited nicotine pouch reviews, is fueling market conversation. Community discussion highlights PM as a defensive growth opportunity, though some debate the sustainability of ZYN's momentum and the market's reaction to earnings reports.

AIRO Group Holdings, Inc. engages in the purpose of acquiring and integrating various companies engaged in the aerospace and defense industry. It operates through the following segments: Avionics and Electronics, Electric Air Mobility, Drones, and Training. The Avionics and Electronics segment refers to its brand, Aspen Avionics, designs, certifies, and manufactures critical navigation, communication, and display components and integrated systems. The Electric Air Mobility segment transforms urban transportation with its development of an electric vertical take-off and landing (eVTOL) aircraft. The Drones perform crucial missions such as ISR and target tracking, mapping, surveying, inspection, and localization, enhancing military, and commercial operational efficiency worldwide. The Training segment relates to its brand, Coastal Defense, delivers specialized professional training services to the military and commercial aviation communities. The company was founded by Chirinjeev Kathuria on August, 30, 2021 and is headquartered in Albuquerque, NM.

AIRO Group Holdings Inc.

Airo Group Holdings Inc

AIRO Group Holdings is generating significant discussion after forming a joint venture to produce combat-proven UAV technology for defense markets and its recent inclusion in major market indexes. While some in the community view the stock as deeply undervalued amidst a surging drone sector, others voice skepticism stemming from past earnings surprises, insider actions, and recent dilution. The potential for substantial defense contracts, driven by evolving geopolitical demands and a shift towards domestic drone manufacturing, continues to drive active debate around its long-term prospects despite recent volatility.

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Bitcoin has seen massive volatility this quarter as ETFs, macro conditions, and crypto adoption continue to shape price action. As 2025 comes to a close, where do you think Bitcoin ($BTC) will finish on December 31, 2025 (EST)?

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