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Shares of Q32 Bio (QTTB) jumped 91% on Monday after the company reported strong 36-week results from the second part of its early-stage trial of bempikibart in patients with severe or very severe alopecia areata.
The stock clocked its best day since July 2025 before slipping 5% after-hours.
Patients treated with bempikibart for 36 weeks saw a 35% average reduction in scalp hair loss severity. In the main group, 40% achieved at least 80% scalp hair coverage. The drug worked in both treatment-naïve patients and those who had previously tried certain drugs belonging to the class of JAK inhibitors. Early follow-up suggested benefits may last after stopping treatment, the company said.
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Bempikibart was well tolerated with no serious treatment-related side effects, the company added. The most common issue was mild injection-site reactions.
Following the update, Wells Fargo analyst Derek Archila upgraded Q32 Bio to ‘Overweight’ from ‘Equal Weight’ and raised the price target to $66 from $10. He said the positive data boosts the odds of success for bempikibart and expects the stock to move toward a roughly $2 billion market cap once the company addresses its capital needs.
Oppenheimer raised its price target to $40 from $20 and kept an ‘Outperform’ rating. The firm called the data an “overwhelmingly positive derisking event” that validates the dosing regimen and shows competitive efficacy with approved JAK inhibitors.
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Mizuho analyst Joseph Catanzaro, meanwhile, lifted the price target to $36 from $14 while keeping an ‘Outperform’ rating. He highlighted bempikibart’s “JAK-like to better” efficacy and “very favorable” safety profile.
The new price targets imply a potential upside of 68% to 209% from the stock’s closing price on Monday.
Q32 Bio also announced a proposed public offering of $200 million in common stock and pre-funded warrants after-hours. The company plans to use the net proceeds to support the advancement of bempikibart into future clinical trials and for general corporate purposes.
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On Stocktwits, retail sentiment around QTTB stock stayed within the ‘extremely bullish’ territory over the past 24 hours, while message volume stayed at ‘extremely high’ levels.
A Stocktwits user said that the stock will crash in light of the $200-million offering announcement.
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Another, however, highlighted that the stock didn’t crash too much after-hours despite the offering announcement, and termed it a “great sign.”
QTTB stock has risen over 500% year-to-date.
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