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Solana is a highly functional open source project that banks on blockchain technology’s permissionless nature to provide decentralized finance (DeFi) solutions. It is a layer 1 network that offers fast speeds and affordable costs. While the idea and initial work on the project began in 2017, Solana was officially launched in March 2020 by the Solana Foundation with headquarters in Geneva, Switzerland.

Solana

Solana is trending as community members express bullish sentiment and anticipate a breakout, particularly around the $200 mark. Discussions also involve various Solana-based meme coins like $WAGMI and $SOLYCAT, reflecting interest in the Solana ecosystem. Some traders are eyeing potential short squeezes and retesting of resistance levels.

$WAGMI is a community-driven meme token built on the Solana blockchain, designed to bring positivity, unity, and humor into the crypto space. The project encourages community engagement through memes, social interaction, and token-based activities. It leverages Solana’s fast and low-cost infrastructure to allow for smooth on-chain interactions, such as token transfers, community games, and NFT integration. The goal is to foster a fun, inclusive ecosystem where holders feel they are part of a larger movement – "We Are Gonna Make It."

WAGMI

WAGMI is trending as community members highlight its resilience and stable market capitalization within the Solana ecosystem. Talk centers on the token's potential for significant revaluation, driven by strong holder growth and expanding visibility. The community emphasizes a long-term vision, focusing on building and holding.

Pump.fun

$PUMP is gaining attention, with community members actively buying and expressing enthusiasm. Much of the discussion revolves around the $SOL ecosystem and the sentiment that 'We Are All Gonna Make It' ($WAGMI). Some users believe $PUMP has the potential for significant growth, drawing comparisons to other successful tokens.

The 401jk (just kidding) meme is a satirical punch in the gut in the face of the concept of retirement and also the 401k. The 401k total holdings are valued at around $12 trillion USD and it is the most popular retirement savings plan in the US. As time passes forevermore true retirement, or as we like to call it real freedom will only become much harder and harder for people to attain.  Through meme fueled laser focus and cyperphunk ideology the 401jK meme retirement fund token and community aim to point out the absurdities of how rigged our current system is, and how only insiders and those with power are starting the benefit from the increased centralization of cryptocurrency.........while also aiming to flip the $12 trillion USD 401k system to achieve freedom before our backs and knees are breaking.

401jK

$401JK is trending due to its community's focus on challenging traditional retirement systems and promoting the idea of financial freedom through crypto. Community members are actively discussing the token's potential to disrupt conventional 401(k) plans and create a new path to early retirement, emphasizing its strong community and organic growth on the Solana blockchain.

Trump For President

The $TRUMP crypto token is trending amid renewed focus on political hype coins, spurred by recent poll headlines, leading to increased volatility. The community's discussion varies wildly, ranging from strong support tied to the 'MAGA' movement and the upcoming election to harsh criticism, including accusations of being a 'creepy PEDO cult stock' or a 'scam'. Additionally, potential consensus between U.S. and China officials regarding rare earth elements and tariffs, involving Trump and Xi, may also be contributing to the current interest.

Avidity Biosciences, Inc. engages in the development of a new class of oligonucleotide-based therapies called Antibody Oligonucleotide Conjugates (AOC). It utilizes its AOC platform to design, engineer, and develop therapeutics that combine the tissue selectivity of monoclonal antibodies and the precision of oligonucleotide-based therapies in order to access previously undruggable tissue and cell types and more effectively target underlying genetic drivers of diseases. The company was founded by Troy E. Wilson, Kent Hawryluk, Mark E. Davis, and Francis Patrick McCormick on November 13, 2012 and is headquartered in San Diego, CA.

Avidity Biosciences Inc

Avidity Biosciences ($RNA) is trending amid speculation of a potential acquisition, with community members highlighting positive trial data and a strong cash position. The stock is seeing increased interest and unusual options activity, leading to discussions about a possible buyout by Novartis ($NVS) or other major pharmaceutical players. Despite some skepticism and recent insider selling, many investors remain bullish, citing analyst price targets and the potential for significant gains in the muscular dystrophy treatment space.

Shibmas was launched on the 9th Of December. The project is a meme token and gives homage to Shiba Inu the token. The token is a playful character who is bringing the Christmas spirit to token holders all around the world. We plan on getting many listings on various exchanges in the coming days. We have over 1000 holders in 24 hours and we aim on getting over 10000 holders within the next week and in the run up to Christmas

Shibmas

Shibmas ($SMAS) is gaining attention, particularly within the Phantom Wallet community, as traders discuss its potential for a breakout. Bullish sentiment is fueled by perceived positive chart patterns and strong momentum, with many highlighting its potential for rapid gains. The crypto is currently testing resistance levels, leading to increased monitoring of volume.

BlackRock Institutional Trust Company N.A. - iShares S&P 100 ETF

iShares S&P 100 ETF

The iShares S&P 100 ETF ($OEF) is trending as investors assess the market's concentration in top stocks and debate whether large caps can sustain their outperformance. Recent inclusion of Uber is also a hot topic. Additionally, rising inflation is shaking up expectations for future Fed rate cuts, potentially impacting the ETF.

iShares Trust - iShares Top 20 U.S. Stocks ETF

iShares Top 20 U.S. Stocks ETF

The iShares Top 20 U.S. Stocks ETF ($TOPT) is trending as investors assess its concentration in mega-cap stocks and potential for long-term growth. Community discussions include comparing $TOPT to other ETFs, analyzing its expense ratio, and evaluating its performance in the current market environment, with some noting its recent all-time highs.

Invesco Capital Management LLC - Invesco S&P 500 Top 50 ETF

Invesco S&P 500 Top 50 ETF

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Wall Street's top analyst calls for the week of October 20, 2024

Yahoo Finance looks at Wall Street's top analyst call for the week of October 20, 2024. 0:00 Ebay, Deckers Outdoor, Intel October 24, 2025 1:37 Tesla, Zions Bancorp, Moderna October 23, 2025 3:25...

Moderna (MRNA) Outperforms Broader Market: What You Need to Know

Moderna (MRNA) reached $26.74 at the closing of the latest trading day, reflecting a +1.87% change compared to its last close.

<ul class="summary-bullets"><li>Moderna said its cytomegalovirus (CMV) vaccine, mRNA-1647, failed to prevent infection in women of childbearing age in a large Phase 3 trial, prompting the company to end its congenital CMV program.</li><li>The biotech will continue testing the vaccine in bone marrow transplant patients, where CMV reactivation can cause serious complications, and said no safety concerns were identified.</li><li>Moderna reaffirmed its 2025 guidance and breakeven goal for 2028, noting the vaccine was expected to be cash-flow negative that year.</li></ul>Moderna Inc. shares fell 4% in after-hours trading on Wednesday after the biotech company said its investigational cytomegalovirus (CMV) vaccine, mRNA-1647, failed to meet its primary efficacy endpoint in a late-stage trial.<h2 class="st-heading-2">Phase 3 Trial Misses Target</h2>The Phase 3 trial was designed to determine if the vaccine can prevent CMV infection among seronegative women aged 16-40. Moderna stated that the vaccine efficacy was substantially below the company's expectations and fell between 6 and 23% depending on the case definition used. The company will not continue the development of mRNA-1647 for the prevention of congenital CMV.“Today's announcement is disappointing for families and healthcare professionals who have been eagerly awaiting a CMV vaccine to prevent congenital CMV,” said CEO Stephane Bancel in a statement. “We will share full results with the scientific community in hopes that our learnings contribute to the continued pursuit of a CMV vaccine.”<h2 class="st-heading-2">Focus Shifts To Transplant Patients</h2>Moderna will further evaluate mRNA-1647 in a Phase 2 trial for bone marrow transplant recipients, who can experience serious complications when CMV is reactivated. The company said it will investigate the vaccine’s ability to suppress CMV reactivation in this high-risk population.The company said mRNA-1647 was well-tolerated with no safety concerns identified by the trial’s monitoring board.<h2 class="st-heading-2">No Impact On Financial Outlook</h2>Moderna said the setback is not expected to impact its 2025 financial guidance or its path to breakeven in 2028. The company had expected low revenue for the CMV vaccine in the near term before investments in the market and for the product to be cash-flow negative in 2028.<h2 class="st-heading-2">Stocktwits Users Debate Cash Burn, Oncology Focus After Vaccine Failure</h2>On Stocktwits, retail sentiment for Moderna was ‘bearish’ amid ‘normal’ message volume.<figure class="image"><img style="aspect-ratio:978/137;" src="https://news.stocktwits-cdn.com/mrna_ss_jpg_45aec4f522.webp" alt="mrna ss.jpg" width="978" height="137"><figcaption>MRNA sentiment and message volume as of October 22 | Source: Stocktwits</figcaption></figure>One user suggested the company’s decision to discontinue the CMV program might actually help reduce its cash burn, saying the move could allow Moderna to concentrate more effectively on its oncology pipeline.<stembedurl>https://stocktwits.com/pfh_investing/message/633326630</stembedurl>Another user expressed concern that the company’s spending remained unsustainable, describing its cash burn as “endless.”<stembedurl>https://stocktwits.com/KK_KK/message/633344767</stembedurl>A third bearish user took a harsher view, warning that the stock could fall below $5, after revealing they held two sold naked calls expiring this week.<stembedurl>https://stocktwits.com/georgeyann/message/633359261</stembedurl><a href="https://stocktwits.com/symbol/MRNA">Moderna’s stock</a> has declined 35% so far in 2025.For updates and corrections, email newsroom[at]stocktwits[dot]com.

Moderna headquarters, exterior view, Cambridge, Massachusetts, USA. (Photo by: Plexi Images/GHI/UCG/Universal Images Group via Getty Images)

Moderna Stock Slides After-Hours On CMV Vaccine Failure In Phase 3 Trial — Retail Traders Warn Of ‘Endless’ Cash Burn

The biotech will continue testing the vaccine in bone marrow transplant patients, where CMV reactivation can cause serious complications, and said no safety concerns were identified.

Equity

Market Wrap- Top Stocks: Tesla, Intuitive Surgical

The earnings season has sent the market into a scramble. Strong reports from major banks last week sent the market soaring, followed by Tuesday's estimate miss from Netflix and electric-vehicle...

Moderna (MRNA) Dips More Than Broader Market: What You Should Know

Moderna (MRNA) closed at $26.85 in the latest trading session, marking a -2.33% move from the prior day.

Moderna (MRNA) Registers a Bigger Fall Than the Market: Important Facts to Note

In the closing of the recent trading day, Moderna (MRNA) stood at $26.25, denoting a -1.83% move from the preceding trading day.

R&D spending now can have big payoffs later for companies

Just how long have people been saying you have to spend money to make money"?Historians maintain that this particular proverb goes all that way back to the Roman playwright Titus Maccius Plautus, who...

Pfizer Left COVID-19 Vaccine Data Out Of Submissions To FDA, Documents Show

Pfizer Left COVID-19 Vaccine Data Out Of Submissions To FDA, Documents Show Data on how parts of a Pfizer-BioNTech COVID-19 vaccine spread in the bodies of mice were withheld from regulatory...

Moderna (MRNA) Surpasses Market Returns: Some Facts Worth Knowing

In the closing of the recent trading day, Moderna (MRNA) stood at $27.92, denoting a +2.12% move from the preceding trading day.

Moderna (MRNA) Beats Stock Market Upswing: What Investors Need to Know

Moderna (MRNA) concluded the recent trading session at $28.38, signifying a +2.83% move from its prior day's close.

Moderna, Inc. engages in the development of transformative medicines based on messenger ribonucleic acid. The firm's product pipeline includes the following modalities: prophylactic vaccines, cancer vaccines, intratumoral immuno-oncology, localized regenerative therapeutics, systemic secreted therapeutics, inhaled pulmonary therapeutics and systemic intracellular therapeutics. It operates through the following geographical segments: United States, Europe, and Rest of World. The company was founded by Noubar B. Afeyan, Robert S. Langer, Jr., Derrick J. Rossi, and Kenneth R. Chien in 2010 and is headquartered in Cambridge, MA.

Moderna Inc

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