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Advanced Micro Devices, Inc. engages in the provision of semiconductor businesses. It operates through the following segments: Data Center, Client, Gaming, and Embedded. The Data Center segment includes server-class CPUs, GPUs, AI accelerators, DPUs, FPGAs, SmartNICs, and Adaptive SoC products. The Client segment refers to the computing platforms, which are a collection of technologies that are designed to work together to provide a more complete computing solution. The Gaming segment is a fundamental component across many products and can be found in APU, GPU, SoC or a combination of a discrete GPU with another product working in tandem. The Embedded segment focuses on the embedded CPUs, GPUs, APUs, FPGAs, and Adaptive SoC products. The company was founded by W. J. Sanders III on May 1, 1969 and is headquartered in Santa Clara, CA.

Advanced Micro Devices Inc.

Advanced Micro Devices Inc

AMD is trending as the community discusses the potential impact of a recent deal with OpenAI, particularly regarding revenue projections and AMD's position relative to Nvidia. Some believe the deal validates AMD's technology and could drive the share price higher, while others express concerns about valuation and potential overbought conditions. The overall sentiment is bullish, with many anticipating further gains, though some caution a possible pullback is coming.

Webull Corp. engages in the provision of financial services. It offers trading, wealth management product distribution, market data and information, user community, and investor education. The company was founded by An Quan Wang in 2016 and is headquartered in St. Petersburg, FL.

Webull Corp. - Ordinary Shares - Class A

Webull Corp

Webull ($BULL) is trending as the lock-up period expired, leading to a significant drop that some community members believe was overdone, presenting a "buy the dip" opportunity. Discussions revolve around a potential short squeeze, comparisons to similar plays like $HOOD, and the possibility of a reversal to previous levels. Some traders are also looking at options activity and technical indicators to determine potential price movements.

Quantum Computing, Inc. engages in developing novel algorithms and solutions utilizing quantum and quantum-inspired computing to solve difficult problems in various industries. It leverages its expertise in finance, computing, security, mathematics, and physics to develop commercial applications for the financial, security, and government sectors. The company was founded on July 25, 2001 and is headquartered in Hoboken, NJ.

Quantum Computing Inc

QUBT is trending amid discussions around a recent private placement and its potential impact on the stock's future. The community is debating whether this influx of capital will fuel growth or dilute shareholder value, with some highlighting the company's potential in the quantum computing sector while others express concerns about valuation and profitability. Technical analysis and potential government contracts are also being heavily discussed.

Universe Pharmaceuticals, Inc. is a pharmaceutical company. The firm is focused on the manufacturing, marketing, sales, and distribution of traditional Chinese medicine derivative products. It also sells biomedical drugs, medical instruments, traditional Chinese medicine Pieces, and dietary supplements manufactured by third-party pharmaceutical companies. The company was founded on March 2, 1998 and is headquartered in Ji'an, China.

Universe Pharmaceuticals INC

Universe Pharmaceuticals INC ($UPC) is trending due to its low float and strong cash position, leading to speculation about potential buybacks or strategic moves. The community is actively discussing its potential for a short squeeze, drawing comparisons to other recent low-float runners in the biotech sector. Traders are closely watching for news, particularly related to potential cryptocurrency ventures, that could drive further momentum.

Invesco Capital Management LLC - Invesco QQQ Trust Series 1

QQQ is trending as the market rallies, fueled by optimism around potential rate cuts and continued AI hype, though some community members express concern about a possible bubble. Discussions revolve around the sustainability of the current pump, potential overvaluation, and the influence of government policies. The Invesco QQQ Trust is hitting new all-time highs, prompting debates about market manipulation and whether a significant pullback is on the horizon.

Rigetti Computing, Inc. provides full-stack quantum computing services. It serves global enterprise, government, and research clients through its Rigetti Quantum Cloud Services platform. The company was founded by Chad Rigetti in 2013 and is headquartered in Berkeley, CA.

Rigetti Computing Inc

RGTI is trending amid volatility and debate over its valuation relative to revenue, with discussions focusing on potential catalysts like a possible upcoming offering. Community members are actively debating whether the stock's momentum can be sustained or if a significant pullback is imminent, especially in light of comparisons to other quantum computing companies and broader market conditions. The stock's high trading volume and rapid price appreciation have intensified the discussions.

UiPath, Inc. engages in the development and provision of a software platform to automate business processes. The firm serves the public, healthcare, telecommunication, finance, and banking industries. It also offers accounts payable automation, claims processing automation, contact center automation, and finance and accounting automation. The company was founded by Daniel Dines and Marius Tirca in 2005 and is headquartered in New York, NY.

UiPath Inc - Ordinary Shares - Class A

UiPath Inc

UiPath is trending as investors discuss its potential as a leader in AI-powered automation, particularly within the agentic economy. Bullish sentiment is fueled by recent partnerships with major players like Nvidia, OpenAI, and Google, sparking speculation about a possible breakout and short squeeze. The community highlights UiPath's strong fundamentals and undervaluation compared to other AI stocks, viewing it as a long-term growth opportunity.

Xenetic Biosciences, Inc. is a biopharmaceutical company engaged in the advancement of cell-based therapeutics to target the B-cell receptor on the surface of an individual patient’s malignant tumor cells. Its product pipeline includes XCart Platform and Polyxen. The company was founded on August 9, 2011 and is headquartered in Framingham, MA.

Xenetic Biosciences Inc

XBIO is trending due to discussions around its low float and potential for a short squeeze, with traders actively pinpointing it as the next potential runner. Community chatter highlights the stock's potential to mirror the moves of other low float bio stocks. Some traders point to the company's expanded R&D collaboration as a possible catalyst.

D-Wave Quantum, Inc. engages in the development and delivery of quantum computing systems, software, and services. It provides customers with access to the company’s quantum computing systems via the cloud in the form of quantum computing as a service. It offers professional services such as customer assistance in identifying and implementing quantum-computing applications. The company was founded on January 25, 2022 and is headquartered in Palo Alto, CA.

D-Wave Quantum Inc

D-Wave Quantum ($QBTS) is trending amidst a debate over its valuation and long-term potential in the quantum computing sector. Bulls cite potential government contracts, big tech partnerships and the company's quantum supremacy as reasons for optimism, while bears point to high valuations and a new 2x short ETF ($QBTZ) as signs of a possible correction. Community members are actively discussing whether this surge is sustainable or a bubble about to burst.

SU Group Holdings Ltd. engages in the provision of security-related engineering services, and security guarding and screening services. It operates through the Security-Related Engineering Services and Security Guarding and Screening Services segments. The company was founded by Ming Chan in 1998 and is headquartered in Hong Kong.

SU Group Holdings Ltd. - Ordinary Shares - Class A

SU Group Holdings Ltd.

SUGP is trending due to its recent contract news, which has sparked significant interest in the stock's potential. The community is actively discussing its low float and potential for a substantial run, while also noting the stock's volatility and trading patterns. Some traders believe the stock is undervalued, while others are wary of potential dilution.

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Shares of Spruce Biosciences (SPRB) surged to a 19-month high of $240 in Tuesday morning trading, prompting two trading halts due to extreme volatility.Trading was halted at 9:32 a.m. ET and again at 9:48 a.m. ET, according to data from Nasdaq Trader, citing a ‘Volatility Trading Pause’.<a href="http://stocktwits.com/symbol/SPRB">SPRB’s stock</a> was up 74%, trading around $229 at the time of writing. It ranked among the top trending tickers on Stocktwits, with retail sentiment climbing higher within ‘extremely bullish’ territory amid ‘extremely high’ chatter – recording the highest levels of retail activity seen this year. Data also showed that the number of retail traders monitoring SPRB shares jumped 76% over the past day.<figure class="image"><img style="aspect-ratio:1259/133;" src="https://news.stocktwits-cdn.com/Screenshot_2025_10_07_101031_png_dc3a1a3a6c.webp" alt="Screenshot 2025-10-07 101031.png" width="1259" height="133"><figcaption>SPRB retail sentiment and message volume on October 7 as of 10:00 a.m. ET | Source: Stocktwits</figcaption></figure>The rally follows Spruce Biosciences’ shares jumping 1,378% to close at $130.4 on Monday after the U.S. Food and Drug Administration (FDA)&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/spruce-biosciences-stock-more-than-quadruples-after-breakthrough-therapy-designation-to-therapy-for-rare-fatal-genetic-disease/ch6R7WfR3gl">granted</a> Breakthrough Therapy Designation to tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanfilippo Syndrome Type B (MPS IIIB).Martin Shkreli also&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/spruce-biosciences-stock-nearly-doubles-premarket-pharma-bro-martin-shkreli-sees-280-upside/ch6PEVhR3Wj">disclosed</a> his long position in Spruce and expressed a bullish outlook. In a&nbsp;<a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://x.com/MartinShkreli/status/1975241784369262649">post</a> on X, Shkreli said he believes the treatment “will be approved” and become “the new standard of care,” predicting that Spruce’s stock could rise to $500. Shkreli, a former hedge fund manager and pharmaceutical executive who&nbsp;<a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.justice.gov/usao-edny/pr/martin-shkreli-sentenced-seven-years-imprisonment-multi-million-dollar-fraud-scheme">served time</a> for securities fraud, did not provide a timeline for the forecast.MPS IIIB is a rare, inherited lysosomal storage disease that causes a gradual decline in motor skills and cognition, as well as hyperactivity with aggressive behavior. CEO Javier Szwarcberg said on Monday that the company is preparing to submit an application for approval of the therapy in MPS IIIB in the first quarter of 2026.&nbsp;Read also:&nbsp;<a href="https://stocktwits.com/news-articles/markets/cryptocurrency/bnb-token-surges-to-record-high-overtakes-xrp-as-third-largest-cryptocurrency/ch6PaXTR3Wy">BNB Token Surges To Record High, Overtakes XRP As Third-Largest Cryptocurrency</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Representative image of abstract numbers amid rising stock market prices. (Photo by SEAN GLADWELL/Getty Images)

SPRB Stock Hits 19-Month High Amid Trading Halts

The rally follows Spruce Biosciences’ shares jumping 1,378% to close at $130.4 on Monday.

Equity

The rally follows Spruce Biosciences’ shares jumping 1,378% to close at $130.4 on Monday.


Spruce Biosciences' stock&nbsp;leaped over 90% in early premarket trading on Tuesday, topping the Stocktwits trending list,&nbsp;hours after investor Martin Shkreli disclosed his long position on the stock and discussed his optimistic outlook.That's after SPRB stock gained a staggering 1,378% to $130.4 in Monday's session, following the company's announcement that it&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/spruce-biosciences-stock-more-than-quadruples-after-breakthrough-therapy-designation-to-therapy-for-rare-fatal-genetic-disease/ch6R7WfR3gl">received</a> the FDA's 'Breakthrough Therapy Designation' for its new therapy for a rare neurological disease.Spruce's tralesinidase alfa enzyme replacement therapy (TA-ERT) is designed to treat Sanfilippo syndrome type B (MPS IIIB), a rare, inherited lysosomal storage disease that causes a gradual decline in motor skills and cognition, as well as hyperactivity with aggressive behavior.Shkreli said in an&nbsp;<a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://x.com/MartinShkreli/status/1975241784369262649">X post</a> early Tuesday he believes the said treatment "will be approved" and become "the new standard of care," forecasting that it would push Spruce's stock to $500.&nbsp;Shkreli, a former hedge fund manager and pharmaceutical executive who has served time in jail for securities fraud, did not provide a timeline."I was working on a presentation when the news was scooped. but this drug restores the abnormally high levels of heparan sulfate to normal. without this drug, patients will die at 18. with normal ranges of HS, they may live a normal life," he said in a follow-up post.CEO Javier Szwarcberg&nbsp;<a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.businesswire.com/news/home/20251006024469/en/Spruce-Biosciences-Receives-U.S.-FDA-Breakthrough-Therapy-Designation-for-Tralesinidase-Alfa-Enzyme-Replacement-Therapy-TA-ERT-in-Sanfilippo-Syndrome-Type-B-MPS-IIIB">said</a> on Monday that the company is preparing to submit an application for approval of the therapy in MPS IIIB in the first quarter of 2026. According to Spruce, Sanfilippo Syndrome Type B affects one in 200,000 people in the U.S.FDA's 'Breakthrough Therapy Designation' expedites the development and regulatory review of promising therapies for serious or life-threatening conditions, with intensive FDA guidance.Notably, Shkreli also recently&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/pharma-bro-martin-shkreli-bets-against-opendoor-but-retail-traders-call-it-an-obvious-long-backed-by-eric-jackson/chw0M0bRdsE">revealed a short position</a> in Opendoor Technologies' shares, a widely watched meme stock.For updates and corrections, email newsroom[at]stocktwits[dot]com.

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Spruce Biosciences Stock Nearly Doubles Premarket: 'Pharma Bro' Martin Shkreli Sees 280% Upside

SPRB stock surged by over 1,300% on Monday after the biotech firm received the FDA's 'Breakthrough Therapy Designation' for its new therapy for a rare neurological disease.

Spruce Biosciences (SPRB) on Monday said that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation to tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanfilippo Syndrome Type B.Sanfilippo syndrome type B (MPS IIIB) is a rare, inherited lysosomal storage disease caused by a deficiency in the enzyme alpha-N-acetylglucosaminidase, leading to the accumulation of heparan sulfate in cells, particularly neurons. It causes progressive neurological symptoms like cognitive and developmental impairment, hyperactivity with aggressive and destructive behavior, delayed speech, hearing loss, and motor skill deficits.Tralesinidase Alfa Enzyme Replacement Therapy is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB. The Breakthrough Therapy Designation is designed to expedite the development and regulatory review of promising therapies for serious or life-threatening conditions. It enables intensive FDA guidance and eligibility for rolling submission and priority review.Shares of SPRB traded 314% higher at the time of writing on Monday. On Stocktwits, retail sentiment around <a href="https://stocktwits.com/symbol/SPRB">SPRB stock</a> jumped from ‘bullish’ to ‘extremely bullish’ territory over the past 24 hours while message volume stayed at ‘extremely high’ levels.CEO Javier Szwarcberg <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.businesswire.com/news/home/20251006024469/en/Spruce-Biosciences-Receives-U.S.-FDA-Breakthrough-Therapy-Designation-for-Tralesinidase-Alfa-Enzyme-Replacement-Therapy-TA-ERT-in-Sanfilippo-Syndrome-Type-B-MPS-IIIB">said</a> that the company is preparing to submit an application for approval of the therapy in MPS IIIB in the first quarter of 2026. According to Spruce, Sanfilippo Syndrome Type B affects one in 200,000 people in the U.S.Currently, there are no FDA-approved therapies for the disease, which drastically brings down the life expectancy of individuals to 15-19 years of age.SPRB stock rose over 200% over the past 12 months.&nbsp;Read also:&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/us-listed-nyxoah-shares-soar-on-first-genio-system-implants-in-patients-with-sleep-disorder/ch6R4LYR3g1">US-Listed Nyxoah Shares Soar On First Genio System Implants In Patients With Sleep Disorder</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Why Did Spruce Biosciences Stock Quadruple Today?

The FDA’s Breakthrough Therapy Designation is designed to expedite the development and regulatory review of promising therapies for serious or life-threatening conditions.

Puma Biotech (PBYI) Surpasses Q2 Earnings and Revenue Estimates

Puma Biotech (PBYI) delivered earnings and revenue surprises of +36.36% and +4.42%, respectively, for the quarter ended June 2025. Do the numbers hold clues to what lies ahead for the stock?

Curis (CRIS) Reports Q2 Loss, Beats Revenue Estimates

Curis (CRIS) delivered earnings and revenue surprises of +65.83% and +14.54%, respectively, for the quarter ended June 2025. Do the numbers hold clues to what lies ahead for the stock?

Illumina (ILMN) Q2 Earnings and Revenues Surpass Estimates

Illumina (ILMN) delivered earnings and revenue surprises of +16.67% and +1.11%, respectively, for the quarter ended June 2025. Do the numbers hold clues to what lies ahead for the stock?

Spruce Biosciences Announces Topline Results from CAHmelia-204 in Adult CAH and CAHptain-205 in Adult and Pediatric CAH

Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological and endocrine disorders with significant...

Spruce Biosciences Reports Third Quarter 2024 Financial Results and Provides Corporate Updates

Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for endocrine and neurological disorders with significant...

Spruce Biosciences to Participate in the Guggenheim Securities Healthcare Innovation Conference

Spruce Biosciences to Participate in the H.C. Wainwright 26th Annual Global Investment Conference

Spruce Biosciences, Inc. is a biopharmaceutical company, which engages in developing and commercializing novel therapies for rare endocrine disorders with significant unmet medical need. The company was founded on November 13, 2014 and is headquartered in South San Francisco, CA.

Spruce Biosciences Inc

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Current Price	$160.08
Prev Close	$182.60
Open	$140.00
Dividend Yield	0.00%
50-Day Moving Average	$14.65
Beta	1.27
Avg. Volume	14,691.48
PE Ratio	-2.13

52-Week High	$240.00
52-Week Low	$4.28
Market Capitalization	$102.81M
EPS (Annual)	-$96.39
Price to Book	7.80
Revenue Per Employee	$233,857.14
Enterprise Value/EBITDA	N/A

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