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Click Holdings Ltd. operates as a holding company which provides temporary and permanent personnel solutions. Its services include professional solution services, nursing solution services, and logistics and other solution services. The company was founded by Chan Chun Sing on January 31, 2024 and is headquartered in Hong Kong.

Click Holdings Ltd. - Ordinary Shares - Class A

Click Holdings Limited

CLIK is trending due to a sharp after-hours surge, fueled by a strong fiscal year revenue report showing significant year-over-year growth. The community is actively discussing its low float and potential for a substantial move, with some anticipating a short squeeze. Traders are watching for volume confirmation to validate further upside potential.

GameStop Corp. engages in offering games and entertainment products through its ecommerce properties and stores. The firm’s stores and ecommerce sites operate primarily under the names GameStop, EB Games, and Micromania. It operates through the following geographical segments: United States, Canada, Australia, and Europe. The company was founded by Daniel A. DeMatteo in 1996 and is headquartered in Grapevine, TX.

Gamestop Corporation - Ordinary Shares - Class A

GameStop Corp

GameStop is trending as the community discusses potential catalysts stemming from activity surrounding the White House's social media, drawing comparisons to the stock's previous surges. Community members are debating the potential impact of this activity and its implications for a possible short squeeze. The stock's movement is also being compared to other meme stocks like BYND, with some suggesting a rotation of interest.

BioCryst Pharmaceuticals, Inc. is a biotechnology company. It engages in the provision of structure-guided drug design with the goal of developing oral small-molecule and protein therapeutics to target difficult-to-treat rare diseases. The company was founded by William M. Spencer III, Charles E. Bugg, and John A. Montgomery in 1986 and is headquartered in Durham, NC.

Biocryst Pharmaceuticals Inc.

BioCryst Pharmaceuticals (BCRX) is trending amid discussions around its strategic acquisition of Astria Therapeutics to bolster its hereditary angioedema (HAE) portfolio, although some investors express concern about the deal's financial implications and dilution. Community talking points include the potential of navenibart, Astria's late-stage drug, and its impact on the competitive landscape, while others question management's decision-making and the company's future growth trajectory. Analysts have weighed in with revised price targets, adding to the ongoing conversation.

Avidity Biosciences, Inc. engages in the development of a new class of oligonucleotide-based therapies called Antibody Oligonucleotide Conjugates (AOC). It utilizes its AOC platform to design, engineer, and develop therapeutics that combine the tissue selectivity of monoclonal antibodies and the precision of oligonucleotide-based therapies in order to access previously undruggable tissue and cell types and more effectively target underlying genetic drivers of diseases. The company was founded by Troy E. Wilson, Kent Hawryluk, Mark E. Davis, and Francis Patrick McCormick on November 13, 2012 and is headquartered in San Diego, CA.

Avidity Biosciences Inc

Avidity Biosciences ($RNA) is trending amid rumors of a potential acquisition by Novartis ($NVS), sending the stock soaring. The community speculates on the deal's likelihood and potential value, while noting positive clinical data and a strengthened pipeline. Discussions also involve the impact on the broader RNA therapeutics sector and comparisons to other companies in the space.

SoFi Technologies, Inc. is a financial service platform, which engages in the provision of student loan refinancing options to the private student loan market. It operates through the following segments: Lending, Technology Platform, and Financial Services. The Lending segment offers personal loans, student loans, home loan products, and related servicing activities. The Technology Platform segment focuses on technology products and solutions revenue. The Financial Services segment includes the SoFi Money product, SoFi Invest product, SoFi Credit Card product, SoFi Relay personal finance management product, and other financial services such as lead generation and content for other financial services institutions. The company was founded in 2011 and is headquartered in San Francisco, CA.

SoFi Technologies Inc

SoFi is trending as investors anticipate upcoming earnings and potential catalysts like rate cuts and S&P 500 inclusion. The community is closely watching for a breakout above the $30 resistance level, with many expecting a significant move post-earnings. Bullish sentiment is fueled by strong growth metrics and the company's position as a disruptor in the fintech sector.

Circle Internet Group, Inc. is a financial technology company that enables businesses of all sizes to harness the power of digital currencies and public blockchains for payments, commerce and financial applications worldwide. The company was founded by Jeremy J. Allaire and Patrick Sean Neville in August 2013 and is headquartered in New York, NY.

Circle Internet Group Inc. - Ordinary Shares - Class A

Circle

Circle ($CRCL) is trending due to a mix of bullish sentiment and unusual options activity, specifically large volumes of out-of-the-money calls expiring in November, leading to speculation about a potential short squeeze or upcoming news. Community members are actively discussing breakout potential, key price levels, and the impact of a potential lockup expiry, with some eyeing ambitious price targets. Recent analyst ratings and broader trends in the crypto and digital asset space also appear to be fueling the conversation.

POET Technologies, Inc. engages in the designing, developing, manufacturing and sale of opto-electronic solutions for the sensing, data communications and telecommunications markets. It developed POET Optical Interposer platform, which allows the integration of electronic and photonic devices into a single multi-chip module. The company was founded on November 14, 1985 and is headquartered in Toronto, Canada.

POET Technologies Inc

POET Technologies is trending amid discussions about a recent $150 million capital raise and its potential impact on the company's growth within the AI infrastructure market; the community views the raise as a strategic move to scale production and capitalize on the booming demand for AI optical components, as its technology addresses critical power and cost challenges in AI data centers. Some traders are closely watching options activity and potential gamma squeeze scenarios.

HIVE Digital Technologies Ltd. engages in building a bridge between the digital currency and blockchain sector and traditional capital markets. It operates data centers for computing and mining cryptocurrencies, including Bitcoin and other coins. The firm owns and operates green energy-powered data center facilities in Canada, Sweden, and Iceland. Its project includes Iceland Cryptocurrency Mining. HIVE Digital Technologies was founded on June 24, 1987 and is headquartered in San Antonio, TX.

HIVE Digital Technologies Ltd.

HIVE Digital Technologies Ltd

HIVE Digital Technologies is trending as investors react to news of expansion into hydroelectric-powered data centers and a strategic partnership with Bell Canada for AI operations. The community is discussing the potential for HIVE to leverage its renewable energy infrastructure for both Bitcoin mining and AI cloud services. Some see HIVE as undervalued compared to peers, citing its growing hash rate and pivot towards high-performance computing.

Phathom Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company, which engages in the development and commercialization of novel treatments for gastrointestinal diseases. The company was founded by Tadataka Yamada, David Socks, Azmi Nabulsi, Aditya Kohli, and Roger Ulrich on January 9, 2018 and is headquartered in Florham Park, NJ.

Phathom Pharmaceuticals Inc

Phathom Pharmaceuticals is trending due to the FDA's correction confirming VOQUEZNA's market exclusivity through 2032, driving optimism about the drug's long-term potential. The community is also discussing the upcoming earnings report and potential for a short squeeze, given the high short interest. Bullish sentiment is fueled by strong analyst ratings and the drug's superior profile compared to existing GERD treatments.

ETHZilla Corp. operates as a clinical-stage biotechnology company, which engages in the development of novel drugs that fulfill unmet needs in inflammatory diseases, fibrosis and pain by leveraging the combined expertise of luminaries in therapeutics from Oxford University, the Hebrew University and Stanford University. The company was founded by Marc Feldmann, Lawrence J. Steinman, and Jonathan B. Rothbard on September 7, 2016 and is headquartered in Palm Beach, FL.

ETHZilla Corp

ETHZilla Corporation

ETHZilla is trending as community members discuss its relationship to the price of Ethereum and potential for a short squeeze, with some drawing comparisons to other meme stocks. Despite positive movement in ETH, ETHZ is struggling to follow, leading to frustration and questions around dilution and management strategy. Discussions also include the upcoming reverse stock split and its potential impact on institutional investment.

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$PRTC PureTech Health presents deupirfenidone data at ATS conference 
 
PureTech Health delivered a late-breaking, oral presentation at the 2025 American Thoracic Society international conference in San Francisco. The presentation provided further insights into the Phase 2b ELEVATE IPF trial of deupirfenidone, highlighting the strength and durability of deupirfenidone&#39;s treatment effect through at least 52 weeks while maintaining favorable tolerability in patients living with idiopathic pulmonary fibrosis. Data presented from PureTech&#39;s global Phase 2b randomized, double-blind, active- and placebo-controlled, dose-ranging ELEVATE IPF trial demonstrated the potential for deupirfenidone to offer a differentiated treatment option for patients with IPF.  
 
In the trial, patients treated with deupirfenidone 825 mg three times a day experienced a slower rate of lung function decline, as measured by Forced Vital Capacity, at 26 weeks versus those who were treated with placebo. This statistically significant difference represents a robust treatment effect versus placebo of 80.9% for deupirfenidone 825 mg TID as a monotherapy. This result compares favorably against the rate of decline in FVC observed in the trial among patients treated with pirfenidone 801 mg TID versus placebo, which was consistent with previously reported pirfenidone clinical trial data and represents a treatment effect of 54.1%.  
 
Taken together, these results indicate that the treatment effect with deupirfenidone 825 mg TID was approximately 50% greater than that of pirfenidone 801 mg TID, based on their respective reductions in lung function decline versus placebo. In addition to these findings, deupirfenidone 825 mg TID also demonstrated a statistically significant benefit in delaying time to IPF progression4 compared to placebo, further supporting the clinical relevance of the treatment effect. Importantly, the rate of FVC decline observed over 26 weeks with deupirfenidone 825 mg TID was similar to the expected natural decline in lung function in healthy older adults. Furthermore, preliminary data from the ongoing open-label extension study suggest that this treatment effect is durable out to at least 52 weeks.  
 
As of May 9, a total of 101 patients had received at least 52 weeks of treatment with deupirfenidone. Those in the deupirfenidone 825 mg TID arm experienced a decline in FVC of -32.8 mL over the 52-week period, which is similar to the expected natural decline in lung function in healthy older adults over one year. These new data provide additional support for the durability of the treatment effect observed with this dose and reinforce its potential to stabilize lung function decline over time, while maintaining favorable safety and tolerability. Additional details from the ongoing OLE are expected to be shared in a future scientific forum. These results are further supported by preliminary pharmacokinetic data, which underscore the differentiated profile of deupirfenidone.  
 
Compared to pirfenidone 801 mg TID, deupirfenidone 825 mg TID resulted in an approximately 50% increase in drug exposure. Notably, the dramatically increased drug exposure did not result in an increase in tolerability challenges, suggesting that the deuterated structure of deupirfenidone may overcome the dose-limiting adverse events associated with pirfenidone. PureTech believes these PK results are consistent with the enhanced efficacy and favorable tolerability seen with deupirfenidone 825 mg TID in the trial. Deupirfenidone was well tolerated at both doses studied. Safety analyses included identification of the 16 most common treatment-emergent adverse events, defined as occurring in more than 5% of participants in at least one treatment group, and characterized the arm with the highest relative incidence of each of these 16 TEAEs.  
 
The pirfenidone 801 mg treatment group had the highest relative incidence for 9 of these TEAEs, followed by deupirfenidone 825 mg (5), placebo (2), and deupirfenidone 550 mg. PureTech is targeting a meeting with the U.S. Food and Drug Administration by the end of the third quarter of 2025 to discuss the results of the Phase 2b trial and align on a potential registrational pathway, with the goal of initiating a Phase 3 trial by the end of 2025. PureTech anticipates providing further guidance later this year following the finalization of the trial design and FDA interactions.

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Puretech Health

 PureTech Health presents deupirfenidone data at ATS conference 
 
PureTech Health delivered a late-breaking, oral presentation at the 2025 American Thoracic Society international conference in San Francisco. The presentation provided further insights into the Phase 2b ELEVATE IPF trial of deupirfenidone, highlighting the strength and durability of deupirfenidone's treatment effect through at least 52 weeks while maintaining favorable tolerability in patients living with idiopathic pulmonary fibrosis. Data presented from PureTech's global Phase 2b randomized, double-blind, active- and placebo-controlled, dose-ranging ELEVATE IPF trial demonstrated the potential for deupirfenidone to offer a differentiated treatment option for patients with IPF.  
 
In the trial, patients treated with deupirfenidone 825 mg three times a day experienced a slower rate of lung function decline, as measured by Forced Vital Capacity, at 26 weeks versus those who were treated with placebo. This statistically significant difference represents a robust treatment effect versus placebo of 80.9% for deupirfenidone 825 mg TID as a monotherapy. This result compares favorably against the rate of decline in FVC observed in the trial among patients treated with pirfenidone 801 mg TID versus placebo, which was consistent with previously reported pirfenidone clinical trial data and represents a treatment effect of 54.1%.  
 
Taken together, these results indicate that the treatment effect with deupirfenidone 825 mg TID was approximately 50% greater than that of pirfenidone 801 mg TID, based on their respective reductions in lung function decline versus placebo. In addition to these findings, deupirfenidone 825 mg TID also demonstrated a statistically significant benefit in delaying time to IPF progression4 compared to placebo, further supporting the clinical relevance of the treatment effect. Importantly, the rate of FVC decline observed over 26 weeks with deupirfenidone 825 mg TID was similar to the expected natural decline in lung function in healthy older adults. Furthermore, preliminary data from the ongoing open-label extension study suggest that this treatment effect is durable out to at least 52 weeks.  
 
As of May 9, a total of 101 patients had received at least 52 weeks of treatment with deupirfenidone. Those in the deupirfenidone 825 mg TID arm experienced a decline in FVC of -32.8 mL over the 52-week period, which is similar to the expected natural decline in lung function in healthy older adults over one year. These new data provide additional support for the durability of the treatment effect observed with this dose and reinforce its potential to stabilize lung function decline over time, while maintaining favorable safety and tolerability. Additional details from the ongoing OLE are expected to be shared in a future scientific forum. These results are further supported by preliminary pharmacokinetic data, which underscore the differentiated profile of deupirfenidone.  
 
Compared to pirfenidone 801 mg TID, deupirfenidone 825 mg TID resulted in an approximately 50% increase in drug exposure. Notably, the dramatically increased drug exposure did not result in an increase in tolerability challenges, suggesting that the deuterated structure of deupirfenidone may overcome the dose-limiting adverse events associated with pirfenidone. PureTech believes these PK results are consistent with the enhanced efficacy and favorable tolerability seen with deupirfenidone 825 mg TID in the trial. Deupirfenidone was well tolerated at both doses studied. Safety analyses included identification of the 16 most common treatment-emergent adverse events, defined as occurring in more than 5% of participants in at least one treatment group, and characterized the arm with the highest relative incidence of each of these 16 TEAEs.  
 
The pirfenidone 801 mg treatment group had the highest relative incidence for 9 of these TEAEs, followed by deupirfenidone 825 mg (5), placebo (2), and deupirfenidone 550 mg. PureTech is targeting a meeting with the U.S. Food and Drug Administration by the end of the third quarter of 2025 to discuss the results of the Phase 2b trial and align on a potential registrational pathway, with the goal of initiating a Phase 3 trial by the end of 2025. PureTech anticipates providing further guidance later this year following the finalization of the trial design and FDA interactions.