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Shiba Inu (SHIB) is a decentralized, community-led cryptocurrency ecosystem built on the Ethereum blockchain. Originally launched as a meme-based project, it has evolved into a comprehensive financial ecosystem designed to offer a decentralized alternative to traditional banking. Its main value proposition lies in its transition from a social phenomenon into a functional utility network, supported by a vast global community known as the ShibArmy and a commitment to 100% community ownership with no central leadership.  The ecosystem features its own decentralized exchange, ShibaSwap, where users can trade, provide liquidity, and earn rewards. To address Ethereum’s high costs and slow speeds, the project utilizes Shibarium, a Layer 2 scaling solution that processes transactions faster and more affordably.  The project employs a unique three-token model to manage its economy and governance. SHIB serves as the primary currency for trading and payments, while LEASH offers scarcity-based incentives for dedicated supporters. BONE acts as the governance token, allowing holders to vote on proposals through the Doggy DAO and serving as the native gas token for the Shibarium network.

Shiba Inu

Shiba Inu is currently a focal point for intense debate, as investors weigh its potential for a speculative rebound against deep-seated concerns regarding its lack of utility and stagnant price performance. The community remains sharply divided between loyalists anticipating a future bull cycle and vocal skeptics who view the asset as an exhausted meme coin with no path to recovery.

Dogecoin is an open-source digital currency based on the "Doge" meme that functions as a peer-to-peer medium for fast payments and digital tipping. Unlike projects backed by corporate entities, its value is driven by a global community, and the project is managed by a decentralized group of volunteers and the non-profit Dogecoin Foundation rather than a formal company.  Originally created in 2013 by software engineers Billy Markus and Jackson Palmer as a market parody, the project held no public sale or venture capital rounds. The network operates as a fork of LuckyCoin, which itself was a fork of Litecoin, using a proof of work consensus mechanism. It employs the Scrypt algorithm to ensure the mining process remains fast and efficient, with new blocks processed every 60 seconds. A unique technical feature is its use of merged mining, allowing miners to secure Dogecoin simultaneously with other Scrypt-based networks like Litecoin.  To keep transaction fees low and the network running indefinitely, Dogecoin features an uncapped supply where new coins are added forever. In a major regulatory milestone in March 2026, a joint SEC and CFTC framework officially classified Dogecoin as a digital commodity, placing it in the same asset category as gold or oil.

Dogecoin

Dogecoin is facing intense debate as community members weigh the potential for a speculative rally against skepticism regarding its long-term utility. Investors are actively discussing the influence of celebrity endorsements and market speculation while some pivot to newer meme coins in search of higher volatility.

TRUMP is a politics-themed digital coin built on the Solana blockchain that uses the brand of Donald Trump to foster a community-driven ecosystem. As a community-focused asset, it is designed to bridge political support with web ownership, operating within the PolitiFi sector to blend political movements with decentralized finance tools. The project's main value proposition lies in its official ties to Donald Trump’s media and business brands, which allows it to provide unique physical utility such as invitations to gala dinners and meetings at Mar-a-Lago.  The token serves as the primary currency for the officially licensed Trump Billionaires Club mobile and web game, where it is used for in-game purchases and unlocking features. By leveraging the Solana blockchain, the project ensures that these in-game actions and token transfers remain fast and cost-effective. The ecosystem remains stable through a programmatic release schedule that introduces new tokens slowly to prevent supply shocks, alongside the use of specialized market makers to maintain consistent liquidity for traders.  Holders can also participate in liquidity sharing by providing their tokens to automated systems to facilitate trading for others, often earning rewards or prizes in return. Beyond digital utility, holding a specific amount of the token is a requirement for attending exclusive real-world events, including VIP parties at Mar-a-Lago. The project is managed by the Trump Meme Team and is linked with Trump Media, with an investor base that includes a wide range of retail buyers and large holders who utilize secure custody services for their assets.

Trump For President

The TRUMP CRYPTO memecoin is trending as community members voice sharp criticism over its significant loss in value, with many investors labeling the project a "scam" or "rug pull" that enriched insiders at the expense of retail traders. Discussions are heavily polarized, featuring heated political debates, frustration over the asset's performance, and ongoing skepticism regarding its long-term viability in the broader crypto market.

PENGU is the official coin of Pudgy Penguins.  Pudgy Penguins has become the face of crypto with one of the most influential communities in the industry. From large companies wearing the Penguin, to being featured in ETF commercials, to garnering millions of followers and over 100 billion views, the Pengu has become a cultural icon making PENGU the world’s social currency.  PENGU allows for the ever-expanding Pudgy Penguin fanbase and the hundreds of millions of people outside of crypto that see and share the Pudgy Penguin everyday, to join The Huddle. PENGU is a symbol for community, memes, and good vibes.  Believe in Pengu. Believe in the Prophecy.

Pudgy Penguins

Pudgy Penguins is trending as investors debate its potential for a massive breakout, with many in the community accumulating the token while contrasting its brand-based IP against traditional memecoin volatility. While some participants express frustration over recent price stagnation and sell-offs, others remain focused on long-term accumulation, citing the project's retail partnerships and potential to mirror the growth of legacy memecoins in a broader crypto bull run.

Tidal Trust II - Defiance Daily Target 2x Long MSTR ETF

Defiance Daily Target 2x Long MSTR ETF

MSTX is experiencing significant volatility as market participants debate its viability as a leveraged play on MicroStrategy's Bitcoin strategy, with the community polarized between those loading up on the dip and others warning about the structural risks of volatility decay. Discussions are dominated by active swing traders navigating rapid price swings, while concerns regarding potential reverse splits and the fund's long-term performance remain central to the conversation.

Ethena

Ethena is currently trending as investors discuss its potential for a major breakout, driven by institutional partnerships and speculation surrounding its role in new stablecoin treasury initiatives. The community remains divided between bullish sentiment fueled by technical chart patterns like golden crosses and accumulation, and skepticism from those concerned about recent token unlocks and price volatility.

Upwork, Inc. is an online marketplace which engages in the provision of businesses to find, hire, and pay freelancers for short-term and longer-term projects. Its marketplace offerings include Upwork Basic, Upwork Plus, Upwork Business, Upwork Enterprise, and Upwork Payroll. The company was founded by Odysseas Tsatalos and Efstratios Karamanlakis in December 2013 and is headquartered in Palo Alto, CA.

Upwork Inc

Upwork is trending as investors weigh its potential for AI-driven revenue growth against concerns over workforce reductions and client retention. The community remains actively focused on whether the company's efficiency initiatives will spark a breakout or if broader market shifts in the gig economy will continue to pressure the stock.

Grayscale Ethereum Trust (ETH) operates as open-end investment company. Its investment objective is for the shares to reflect the value of ETH held by the trust. The company was founded on December 13, 2017 and is headquartered in Stamford, CT.

Grayscale Ethereum Staking Mini ETF - Common units of fractional undivided beneficial interest

Grayscale Ethereum Mini Trust

Investors are actively debating the impact of upcoming regulatory developments, including the Digital Asset Market CLARITY Act, on ETH's long-term valuation. The community is focused on institutional adoption and accumulation patterns while monitoring how ETH performs relative to BTC as the market approaches major macroeconomic policy decisions.

The Ondo Foundation was founded in 2022 as an independently governed and nonprofit Cayman Islands Foundation Company with no beneficial owners. The Ondo Foundation assisted in the launch of the Ondo DAO, which deployed and currently governs Flux Finance, the first lending protocol supporting tokenized securities as collateral.  ONDO token holders are entrusted with shaping the future of the Ondo DAO so that it continues to pursue its mission to democratize access to institutional-grade finance. The Ondo DAO gives ONDO holders specific rights pertaining to Flux Finance, which is currently governed by the Ondo DAO.

Ondo

Ondo is trending as investors monitor ongoing governance discussions regarding a potential fee switch, which the community views as a critical catalyst for driving direct value to token holders. While the project remains a primary leader in the real-world asset (RWA) tokenization space, market participants are actively debating whether its current valuation reflects the long-term potential of institutional adoption or if further regulatory clarity is needed to spark sustained momentum.

Keeta is a high-performance layer-1 blockchain designed to unify transactions across different blockchains and fiat payment systems, eliminating the need for costly intermediaries, reducing fees, and enabling near-instant settlements. With 400-millisecond transaction finality and the ability to process 10 million transactions per second, Keeta sets a new industry benchmark for speed and scalability.  Founded in 2022 and backed by Eric Schmidt, the former CEO of Google, Keeta has been engineered to meet the stringent regulatory and operational requirements of financial institutions. Its advanced on-chain compliance protocols, including KYC and AML, ensure security and regulatory adherence. Keeta’s architecture natively supports asset tokenization and digital identity, making it an ideal platform for stablecoins and real-world asset transfers.  By facilitating cross-chain transactions and interoperability with existing payment systems, Keeta bridges the gap between cryptocurrencies and fiat, enabling a secure, efficient, and compliant global financial ecosystem.

Keeta

Keeta is trending as investors digest news of its integration into the x402 ecosystem and its ongoing efforts to tokenize real-world assets through high-profile partnerships. The community remains deeply divided, with some highlighting significant infrastructure milestones as a foundation for long-term growth, while others express frustration over stagnant price action and the speculative nature of its upcoming roadmap.

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@DeadInvestor  
 
Attached are formally updated $TVTX multiples versus all other commercial-stage non-oncology bios with pre-12/31/23 approvals. 
 
All Others 
 
We&#39;re a tad surprised to see $ALNY on our trackers, at what appear reasonable multiples versus peers. ALNY specific comments? 
 
We also thought $XERS would be more expensive 
 
As always, this is not investment advice. 
 
$ARQT $XBI

Flamingo Jack

Kevin Haborak

Joseph Alonso

PSR Development

Whiz Kid

R Ellies

TymeTryethTroth

Jürgen Willing

jack p

Kelly Sheppard

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Travere Therapeutics Inc

Alnylam Pharmaceuticals Inc

Xeris Biopharma Holdings Inc

Arcutis Biotherapeutics Inc

SPDR S&P Biotech ETF

 multiples versus all other commercial-stage non-oncology bios with pre-12/31/23 approvals. 
 
All Others 
 
We're a tad surprised to see 

 on our trackers, at what appear reasonable multiples versus peers. ALNY specific comments? 
 
We also thought 

 would be more expensive 
 
As always, this is not investment advice. 
 


Night Owl Biotech Research

@Night_Owl_Biotech @DeadInvestor - The five year multiple says everything about XERS. Especially sitting in a group of small caps.

xersdave

StockTwits for iOS

 - The five year multiple says everything about XERS. Especially sitting in a group of small caps.