SPDR Dow Jones Industrial Average ETF

SPDR S&P 500 ETF Trust

Invesco QQQ Trust Series 1

Super Micro Computer, Inc. engages in the distribution and manufacture of information technology solutions and other computer products. Its products include twin solutions, MP servers, GPU and coprocessor, MicroCloud, AMD solutions, power supplies, SuperServer, storage, motherboards, chassis, super workstations, accessories, SuperRack and server management products. The company was founded by Charles Liang, Yih-Shyan Liaw, Sara Liu, and Chiu-Chu Liu Liang in September 1993 and is headquartered in San Jose, CA.

Super Micro Computer Inc

Super Micro Computer is experiencing intense volatility and sell-side pressure following a federal indictment of company insiders, including a co-founder, for allegedly smuggling restricted AI servers to China. While community members are polarized between those viewing the stock as a distressed deep-value opportunity and those concerned about long-term institutional trust and potential delisting, the primary focus remains on the distinction that the company itself has not been charged as a defendant.

AleAnna, Inc. operates as a technology-driven energy company, which engages in supplying low-carbon natural gas and renewable natural gas to Italy. The company was founded in 2007 and is headquartered in Dallas, TX.

AleAnna Inc. - Ordinary Shares - Class A

AleAnna Inc. is seeing intense community interest as traders target the stock's low float and potential role as a key European natural gas provider amidst heightened geopolitical instability. Investors are actively debating the stock's momentum, potential for a short squeeze, and its alignment with efforts to achieve regional energy independence following significant updates to its reserves and production prospects.

Planet Labs PBC provides daily data and insights about earth. It offers a web-geo platform with satellite data available and foundational analytics to derive insights to make decisions. The company is founded by William S. Marshall and Robert H. Schingler in 2010 and is headquartered in San Francisco, CA.

Planet Labs PBC - Ordinary Shares - Class A

Planet Labs PBC

Planet Labs is gaining significant market attention following a robust quarterly earnings beat, strong guidance, and an expanding multi-million dollar backlog, driving bullish sentiment among investors who view the stock as a key player in the space data and AI infrastructure sector. Community discourse is heavily focused on the company's deepening strategic partnerships with major tech entities and its pivotal role in defense-related geospatial intelligence, with many traders drawing parallels to other high-momentum space names and eyeing potential long-term growth as the broader sector matures.

iShares Trust - iShares 20+ Year Treasury Bond ETF

iShares 20+ Year Treasury Bond ETF

TLT is currently navigating extreme market volatility driven by an intensifying energy shock and regional conflict, fueling widespread community debate over whether Treasury bonds offer genuine safety or are trapped in a stagflationary spiral. Investors are closely monitoring spiking oil prices and shifting interest rate expectations, as traders grapple with the tension between safe-haven demand and the risk of rising inflation.

Applied Materials, Inc. engages in provision of materials engineering solutions used to produce semiconductors. The firm also focuses on design, development, production, and servicing of the critical wafer fabrication tools used for customers to manufacture semiconductors. It operates through the following segments: Semiconductor Systems and Applied Global Services (AGS). The Semiconductor Systems segment includes designing, development, manufacturing and sale of equipment used to fabricate semiconductor chips referred to as integrated circuits. The AGS segment engages in provision of services, spares, and factory automation software to customer fabrication plants globally. The company was founded on November 10, 1967 and is headquartered in Santa Clara, CA.

Applied Materials Inc.

Applied Materials is currently trending as investors weigh strong AI-driven infrastructure demand against concerns over semiconductor export restrictions to China. Community discussion is focused on the stock's resilience during sector-wide volatility and ongoing debates about whether the company is overvalued or remains a long-term play on the AI capex cycle.

Unusual Machines, Inc. is a development stage technology company, which engages in the provision of drone solutions with a focus on first-person view (FPV) technology. It offers products to entertainment, recreation, and competitive racing industries. The company was founded on July 11, 2019, and is headquartered in Orlando, FL.

Unusual Machines Inc

Unusual Machines is currently trending following a significant public offering of common stock priced at $17 per share, which includes a strategic investment from Ondas Inc. Investors are actively debating the long-term potential of the company's U.S.-based drone components expansion against community concerns regarding frequent share dilution and leadership governance.

Cadence Design Systems, Inc. engages in the provision of design and development of integrated circuits and electronic devices. It operates through the following geographical segments: Americas, Asia, EMEA, and Japan. The company was founded by Alberto Sangiovanni-Vincentelli, Gudmundur A. Hjartarson, K. Bobby Chao, and K. Charles Janac in June 1988 and is headquartered in San Jose, CA.

Cadence Design Systems, Inc.

Cadence Design Systems is trending as investors debate the impact of potential US export restrictions on its sales to China and analyze the company's mixed earnings report, which featured record backlogs and AI-driven growth alongside cautious 2025 guidance. The community is actively discussing whether the recent pullback represents a buying opportunity for a long-term compounder or a signal of broader valuation concerns in the EDA sector.

Tidal Trust II - Defiance Daily Target 2x Long SMCI ETF

Defiance Daily Target 2X Long SMCI ETF

The Defiance Daily Target 2X Long SMCI ETF (SMCX) is currently facing intense volatility as the community reacts to a sharp decline in the underlying stock (SMCI) following serious news regarding alleged AI chip export violations. Investors are actively debating the merits of "buying the dip" on this leveraged ETF, with many highlighting the risks of compounding decay while others remain optimistic that the company's fundamental market position remains strong despite the current legal and governance uncertainty.

FedEx Corp. is a holding company, which engages in the provision of transportation, e-commerce, business services, and business solutions. It operates through the following segments: FedEx Express, FedEx Freight, Corporate, Other, and Eliminations. The FedEx Express segment offers transportation and delivery services. The FedEx Freight segment refers to freight transportation services to business and residences. The FedEx Services segment includes sales, marketing, information technology, communications, customer service, technical support, billing and collection services, and certain back-office functions that support the company's operating segments. The Corporate, Other, and Eliminations segment is involved in the corporate headquarters costs for executive officers and certain legal and finance functions, as well as certain other costs and credits not attributed to the firm's core business. The company was founded by Frederick Wallace Smith on June 18, 1971, and is headquartered in Memphis, TN.

Fedex Corp

FedEx is trending as investors weigh strong fiscal second-quarter earnings and a raised full-year outlook against concerns over aircraft groundings and ongoing geopolitical trade complexities. The community is actively debating the company's ability to navigate high fuel costs and operational headwinds while capitalizing on B2B demand and transformation-driven cost efficiencies.

Shiba Inu (SHIB) is a decentralized, community-led cryptocurrency ecosystem built on the Ethereum blockchain. Originally launched as a meme-based project, it has evolved into a comprehensive financial ecosystem designed to offer a decentralized alternative to traditional banking. Its main value proposition lies in its transition from a social phenomenon into a functional utility network, supported by a vast global community known as the ShibArmy and a commitment to 100% community ownership with no central leadership.  The ecosystem features its own decentralized exchange, ShibaSwap, where users can trade, provide liquidity, and earn rewards. To address Ethereum’s high costs and slow speeds, the project utilizes Shibarium, a Layer 2 scaling solution that processes transactions faster and more affordably.  The project employs a unique three-token model to manage its economy and governance. SHIB serves as the primary currency for trading and payments, while LEASH offers scarcity-based incentives for dedicated supporters. BONE acts as the governance token, allowing holders to vote on proposals through the Doggy DAO and serving as the native gas token for the Shibarium network.

Shiba Inu

Shiba Inu is seeing heightened social activity as community members debate the asset's long-term utility versus its history as a speculative meme token. Investors are actively discussing rumors of potential supply reductions and monitoring whale movements, while broader market sentiment remains divided between those calling for a renewed breakout and those skeptical of the project's performance.

statis crypto Watchlist

Bitcoin

Ethereum

Solana

Ripple

Dogecoin

Cardano

statis IN Watchlist

Nifty 50

Nifty Bank

Reliance Industries Ltd.

Zomato Ltd.

Tata Consultancy Services

Tata Motors Ltd.

HDFC Bank Ltd.

ITC Ltd.

Adani Enterprises Ltd

Axis Bank Ltd

Bajaj Finance Ltd

statis US Watchlist

SPDR S&P 500 ETF

Apple Inc.

Tesla Inc

Microsoft Corporation

NVIDIA Corp

 Hey, I want to invite you to join Stocktwits. It’s the largest global community of active traders. You’ll get access to the real-time market insights, news, discussion and much more! You can sign up using my unique link below 
 


 has invited you to join Stocktwits

$OKUR This is from a SABCS poster with LOXO-783, a H1047R inhibitor. The data suggest that this inhibitor likely has on-target inhibition of H1047R and that the efficacy looks to be dose dependend. What the poster also shows is that 600mg BID should be the minimum dosis, cause that seemed to have the largest effect on ctDNA reduction, which correlated with reduced tumor burden. The development however was stopped because side effects where too high with 600mg BID. Selectivity over wild type was not high enough. IMO we can conclude from this, that the approach can lead to tumor shrinkage when u can get enough drug into the system. If you have to reduce dose or stop treatment then u cant combine it with more toxic stuff thats SOC in BC.  So u need very high selectivity, which results in better tolerability. They seem to have the highest selectivity, so there is a chance that it works out well as triplet in 1L BC.

Akaradetch Detadulsak

Toby Thompson

George G

Uknowwho

StockTwits Web

Onkure Therapeutics Inc

 This is from a SABCS poster with LOXO-783, a H1047R inhibitor. The data suggest that this inhibitor likely has on-target inhibition of H1047R and that the efficacy looks to be dose dependend. What the poster also shows is that 600mg BID should be the minimum dosis, cause that seemed to have the largest effect on ctDNA reduction, which correlated with reduced tumor burden. The development however was stopped because side effects where too high with 600mg BID. Selectivity over wild type was not high enough. IMO we can conclude from this, that the approach can lead to tumor shrinkage when u can get enough drug into the system. If you have to reduce dose or stop treatment then u cant combine it with more toxic stuff thats SOC in BC.  So u need very high selectivity, which results in better tolerability. They seem to have the highest selectivity, so there is a chance that it works out well as triplet in 1L BC.

IO Biotech Inc

Notnotshort

@Notnotshort it’s not just selectivity as you mentioned.  The combinability of the drug is also important and that’s related to whether the drug can have drug-drug interactions with combination therapy.

StockTwits for iOS

 it’s not just selectivity as you mentioned.  The combinability of the drug is also important and that’s related to whether the drug can have drug-drug interactions with combination therapy.

Drrayng

@Drrayng we already know that PI3K inhibitors work well in combination with fulvestrant, which is a SERD and SERDs will remain SOC for a very long time it seems, as there is barely any progress in BC. Even if only used in 2nd or 3rd or even later lines BC market is huge. Thats why CEO stressed that their inhibitor has to show tolerability in combination, cause that will lead to longer treatment and less dosing interruptions or discontinuations, which reduce efficacy and OS.  
https://www.nejm.org/doi/full/10.1056/NEJMoa1813904

Nejm

 we already know that PI3K inhibitors work well in combination with fulvestrant, which is a SERD and SERDs will remain SOC for a very long time it seems, as there is barely any progress in BC. Even if only used in 2nd or 3rd or even later lines BC market is huge. Thats why CEO stressed that their inhibitor has to show tolerability in combination, cause that will lead to longer treatment and less dosing interruptions or discontinuations, which reduce efficacy and OS.  
