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Bitcoin is the world's first decentralized cryptocurrency, created in 2009 by the pseudonymous Satoshi Nakamoto. It enables peer-to-peer electronic cash transactions without intermediaries like banks or governments, operating on a blockchain secured by Proof of Work mining and the SHA-256 cryptographic algorithm.   With a fixed supply cap of 21 million coins and programmatic halvings every four years that reduce miner rewards, Bitcoin is designed as a deflationary digital asset often called "digital gold." Its value stems from solving the double-spending problem without trusted intermediaries, creating the first truly scarce digital asset with censorship resistance and permissionless access that no government, corporation, or individual can control.  Bitcoin operates as a decentralized peer-to-peer network where transactions are recorded on a public ledger called the blockchain, distributed across thousands of computers globally. Transactions are grouped into blocks added approximately every 10 minutes through mining, where specialized computers compete to solve complex mathematical puzzles.   Bitcoin has achieved mainstream adoption through multiple vectors. The January 2024 SEC approval of 11 spot Bitcoin ETFs opened Bitcoin investment to traditional finance participants, and corporations like Strategy (formerly MicroStrategy) are using Bitcoin as a treasury reserve asset to protect against currency debasement, offering MSTR holders amplified exposure to Bitcoin.   The Bitcoin ecosystem continues to evolve with innovations like Ordinals, which emerged in January 2023 to enable NFT-like functionality directly on Bitcoin, and BRC-20 tokens, an experimental standard for creating fungible tokens using Ordinal inscriptions. BTCFi (Bitcoin Finance) represents emerging financial applications extending beyond Bitcoin's traditional role, with protocols like Babylon allowing Bitcoin holders to stake BTC to secure Proof of Stake chains.

Bitcoin

Bitcoin is drawing significant attention as it shows strong upward momentum, fueled by sustained bullish ETF inflows and a prevailing community sentiment that anticipates further appreciation. There's active discussion around a potential supply shock from geopolitical events, contributing to the widespread belief that bears are facing heavy pressure and significant liquidations.

Ripple is the catchall name for the cryptocurrency platform, the transactional protocol for which is actually XRP, in the same fashion as Ethereum is the name for the platform that facilitates trades in Ether. Like other cryptocurrencies, Ripple is built atop the idea of a distributed ledger network which requires various parties to participate in validating transactions, rather than any singular centralized authority. That facilitates transactions all over the world, and transfer fees are far cheaper than the likes of bitcoin. Unlike other cryptocurrencies, XRP transfers are effectively immediate, requiring no typical confirmation time.  Ripple was originally founded by a single company, Ripple Labs, and continues to be backed by it, rather than the larger network of developers that continue bitcoin’s development. It also doesn’t have a fluctuating amount of its currency in existence. Where bitcoin has a continually growing pool with an eventual maximum, and Ethereum theoretically has no limit, Ripple was created with all of its 100 billion XRP tokens right out of the gate. That number is maintained with no mining and most of the tokens are owned and held by Ripple Labs itself — around 60 billion at the latest count.  Even at the recently reduced value of around half a dollar per XRP, that means Ripple Labs is currently sitting on around $20 billion worth of the cryptocurrency (note: Ripple’s price crashed hard recently, and may be worth far less than $60 billion by time you read this). It holds 55 billion XRP in an escrow account, which allows it to sell up to a billion per month if it so chooses in order to fund new projects and acquisitions. Selling such an amount would likely have a drastic effect on the cryptocurrency’s value, and isn’t something Ripple Labs plans to do anytime soon.  In actuality, Ripple Labs is looking to leverage the technology behind XRP to allow for faster banking transactions around the world. While Bitcoin and other cryptocurrencies are built on the idea of separating financial transactions from the financial organizations of traditional currencies, Ripple is almost the opposite in every sense.  XRP by Ripple price can be found on this page alongside the market capitalization and additional stats.

Ripple

XRP is drawing significant investor attention amid growing optimism for an approaching regulatory clarity act and reports of substantial escrow lockups tightening its supply. The community is actively discussing its fundamental utility in global finance and real-world asset tokenization, with an eye on broader market movements and geopolitical events, while some anticipate a potential decoupling from major crypto trends.

Memecoin on Cronos launched by the Cro Crow community

crow with knife

$CAW, or "crow with knife," is generating significant community buzz, with supporters touting it as a potential life-changing investment akin to early Bitcoin. The narrative highlights its multi-chain presence, deflationary burn mechanism, and organic community strength, aiming to bring substantial volume to the Cronos chain and beyond. Many are actively discussing its potential to rival other popular meme coins.

Strategy, Inc. engages in the provision of enterprise analytics and mobility software. The firm designs, develops, markets, and sells software platforms through licensing arrangements and cloud-based subscriptions and related services. Its product packages include Hyper. The company was founded by Michael J. Saylor and Sanjeev K. Bansal on November 17, 1989, and is headquartered in Vienna, VA.

Strategy Inc. - Ordinary Shares - Class A

Strategy

MicroStrategy is trending as Bitcoin's recent price action sparks debate on its valuation. The community is sharply divided on whether its perceived discount to its Bitcoin exposure represents an opportunity or is justified by ongoing share dilution and the impending MSCI index decision.

Ethereum is a global, open-source platform for decentralized applications. In other words, it is a decentralized blockchain platform that enables developers to build and deploy smart contracts and applications without central authority control. Unlike Bitcoin, which primarily functions as digital currency, Ethereum operates as a programmable global computer where developers can create any type of decentralized service.   The platform hosts over $14 billion in DeFi applications with hundreds of thousands of active users across financial protocols, NFT marketplaces, and gaming platforms. Its transition to Proof of Stake in September 2022 reduced energy consumption by over 99%, addressing environmental concerns while strengthening network security.  The network operates through thousands of independent validator nodes that process transactions and execute smart contracts on the Ethereum Virtual Machine. Smart contracts are self-executing programs written in Solidity that automatically carry out agreements when conditions are met, eliminating intermediaries like banks or brokers.   Validators stake ETH as collateral to propose and validate blocks, earning rewards for honest participation while facing penalties for malicious behavior. The EIP-1559 upgrade introduced a dynamic base fee mechanism that burns ETH with each transaction, creating deflationary pressure during high network activity when more ETH is burned than issued to validators.  Vitalik Buterin proposed Ethereum in 2013, but seven co-founders helped build it, including Gavin Wood who created Solidity and the EVM technical specification, and Joseph Lubin who founded ConsenSys. The project launched in July 2015 after raising over $18 million through crowdfunding, quickly becoming the largest blockchain developer community. Major milestones include the 2020 Beacon Chain launch, the 2021 London hard fork implementing fee burning, and the 2022 Merge to Proof of Stake.   Ether (ETH) serves multiple functions: paying transaction fees (gas), staking to secure the network and earn 3-5% annual yields, serving as collateral in DeFi protocols, and purchasing NFTs and digital assets. The asset is increasingly adopted by traditional institutions, with publicly traded companies adding ETH to corporate treasuries to generate staking yields while maintaining blockchain exposure, and in 2024, the SEC approved spot Ethereum ETFs, allowing traditional investors to gain exposure through conventional brokerage accounts.  Ethereum's roadmap focuses on dramatically increasing transaction capacity to over 100,000 per second, reducing confirmation times, and enhancing decentralization while maintaining security against future threats like quantum computing.

Ethereum

Ethereum is experiencing a strong wave of bullish sentiment, fueled by significant institutional interest, including increased staking activity and anticipation of potential ETF inflows. The community is actively discussing the onset of an "alt season," with many anticipating ETH to lead the broader crypto market to retest and surpass key resistance levels.

Dogecoin is a cryptocurrency based on the popular "Doge" Internet meme and features a Shiba Inu on its logo. Dogecoin is a Litecoin fork. Introduced as a "joke currency" on 6 December 2013, Dogecoin quickly developed its own online community and reached a capitalization of US$60 million in January 2014. Compared with other cryptocurrencies, Dogecoin had a fast initial coin production schedule: 100 billion coins were in circulation by mid-2015, with an additional 5.256 billion coins every year thereafter. As of 30 June 2015, the 100 billionth Dogecoin had been mined.   Dogecoin was created by Billy Markus from Portland, Oregon and  Jackson Palmer from Sydney, Australia. Both wanted to create a fun cryptocurrency that will appeal beyond the core Bitcoin audience. Dogecoin is primarily used as a tipping system on Reddit and Twitter where users tip each other for creating or sharing good content. The community is very active in organising fundraising activities for deserving causes.  The developers of Dogecoin haven’t made any major changes to the coin since 2015. This means that Dogecoin could get left behind and is why Shibas are leaving Dogecoin to join more advanced platforms like Ethereum. One of Dogecoin strengths is its relaxed and fun-loving community. However, this is also a weakness because other currencies are way more professional.  To purchase Dogecoin, it involves downloading a crypto wallet, setting up a crypto exchange account and then trading away for your desired crypto currency. Once we have set up an account with a DOGE currency exchange and deposited some funds, you are ready to start trading.

Dogecoin

Dogecoin is trending with significant bullish momentum, driven by a broad crypto market rally and renewed community enthusiasm. Investors are actively discussing its potential for substantial gains, fueled by its position as a prominent meme coin and speculation around "ETF power" and institutional interest. Despite some mixed sentiment, a strong conviction for continued upward movement prevails amidst the broader "meme season."

Applied Digital Corp. is a technology company, which engages in the provision of development and operation of data centers which provide computing power. It operates through the Data Center Hosting Business and HPC Hosting Business segments. The Data Center Hosting Business segment provides energized infrastructure services to crypto mining customers. The HPC Hosting Business segment focuses on the designing, constructing, and operating data centers tailored to support high power density applications like HPC and AI. The company was founded by Wesley Carl Cummins and Jason Zhang in May 2001 and is headquartered in Dallas, TX.

Applied Digital Corporation

Applied Digital is seeing heightened community discussion leading into its upcoming earnings report, with investors keenly awaiting confirmation of operational data center capacity and potential hyperscaler contract updates. This event is widely viewed as a crucial moment to validate the company's strategic positioning within the rapidly expanding AI infrastructure sector. Talk of potential market reactions and short-covering activity further fuels the current enthusiasm surrounding the stock.

Keeta is a high-performance layer-1 blockchain designed to unify transactions across different blockchains and fiat payment systems, eliminating the need for costly intermediaries, reducing fees, and enabling near-instant settlements. With 400-millisecond transaction finality and the ability to process 10 million transactions per second, Keeta sets a new industry benchmark for speed and scalability.  Founded in 2022 and backed by Eric Schmidt, the former CEO of Google, Keeta has been engineered to meet the stringent regulatory and operational requirements of financial institutions. Its advanced on-chain compliance protocols, including KYC and AML, ensure security and regulatory adherence. Keeta’s architecture natively supports asset tokenization and digital identity, making it an ideal platform for stablecoins and real-world asset transfers.  By facilitating cross-chain transactions and interoperability with existing payment systems, Keeta bridges the gap between cryptocurrencies and fiat, enabling a secure, efficient, and compliant global financial ecosystem.

Keeta

KTA is trending due to its robust, compliance-first blockchain infrastructure, now featuring operational fiat on/off-ramps through its partnership with Stripe-owned Bridge. The community is actively discussing its validated capacity for over 11 million transactions per second, positioning KTA as an undervalued asset ready to serve as essential financial plumbing for institutional adoption and cross-chain settlement.

BigBear.ai Holdings, Inc. engages in data-driven decision dominance and advanced analytics that provide its customers with a competitive advantage in a world driven by data that is growing in terms of volume, variety, and velocity. The firm operationalizes artificial intelligence and machine learning at scale through its end-to-end data analytics platform. It deploys its observe, orient and dominate products to customers throughout the defense, intelligence, and commercial markets. The company was founded in 2020 and is headquartered in McLean, VA.

BigBear.ai Holdings Inc

BigBear.ai is actively trending following its strategic acquisition of Ask Sage, a generative AI platform for secure environments, coupled with a significant debt reduction initiative. The community is buzzing with anticipation for potential large government contracts in defense and national security, despite ongoing discussions around share dilution. Investors are closely watching if these strategic moves solidify BigBear.ai's position as a crucial AI infrastructure provider in critical sectors.

CleanSpark, Inc. is a bitcoin mining technology company, which engages in the management of data centers. Its operations include College Park, Norcross, Washington, Sandersville, Dalton, and Massena. The company was founded by S. Matthew Schultz and Bryan Huber on October 15, 1987 and is headquartered in Henderson, NV.

Cleanspark Inc

CleanSpark is trending as Bitcoin momentum strengthens, fueling investor discussions about its high short interest and potential for a significant squeeze. The community is buzzing with anticipation for developments regarding its strategic pivot into AI and high-performance computing, with many awaiting confirmations of new contracts. This dual focus on crypto mining and emerging AI infrastructure is driving active conversation and debate around its future trajectory.

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Cardano

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Nifty 50

Nifty Bank

Reliance Industries Ltd.

Zomato Ltd.

Tata Consultancy Services

Tata Motors Ltd.

HDFC Bank Ltd.

ITC Ltd.

Adani Enterprises Ltd

Axis Bank Ltd

Bajaj Finance Ltd

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SPDR S&P 500 ETF

Apple Inc.

Tesla Inc

Microsoft Corporation

NVIDIA Corp

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INmune Bio (NASDAQ:INMB) Rating Increased to Hold at Wall Street Zen

Wall Street Zen raised INmune Bio from a "sell" rating to a "hold" rating in a research note on Sunday...

Praetorian PR LLC Sells 863,000 Shares of INmune Bio, Inc. $INMB

Praetorian PR LLC lowered its stake in INmune Bio, Inc. (NASDAQ:INMB - Free Report) by 99.3% in the second quarter, according to the company in its most recent disclosure with the Securities and...

INmune Bio (INMB) Could Find a Support Soon, Here's Why You Should Buy the Stock Now

INmune Bio (INMB) appears to have found support after losing some value lately, as indicated by the formation of a hammer chart. In addition to this technical chart pattern, strong agreement among Wall Street analysts in revising earnings estimates higher enhances the stock's potential for a turnaround in the near term.

INmune Bio (INMB) Loses 23.8% in 4 Weeks, Here's Why a Trend Reversal May be Around the Corner

INmune Bio (INMB) is technically in oversold territory now, so the heavy selling pressure might have exhausted. This along with strong agreement among Wall Street analysts in raising earnings estimates could lead to a trend reversal for the stock.

INmune  slides again as Scotiabank, RJ cut ratings after Alzheimer’s drug miss

Investing.com --  INmune Bio  (NASDAQ:INMB) shares fell another 6% to about $2.17 on Tuesday after brokerages downgraded the stock, saying failure of the company’s experimental Alzheimer’s drug XPro in a mid‑stage trial sharply weakens its investment case.

INmune Bio Inc. (INMB) on Monday said that its experimental drug XPro did not show any effects in the intent-to-treat population in a mid-stage study evaluating its effectiveness in early Alzheimer’s Disease (AD) with biomarkers of inflammation.INmune’s stock fell about 59% in morning trade at the time of writing.The <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2025/06/30/3107380/0/en/INmune-Bio-Reports-Key-Findings-from-Phase-2-MINDFuL-Trial-of-XPro-in-Early-Alzheimer-s-Disease.html">trial </a>enrolled 208 participants with early-stage Alzheimer’s to asses the drug’s potential in slowing cognitive decline by tackling neuroinflammation.The primary endpoint of the study was a change in cognition over 6 months on the Early Mild Alzheimer’s Cognitive Composite (EMACC). EMACC is a tool used in clinical trials and research to assess cognitive changes in individuals with early or mild Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI).The primary endpoint was not met in the intent-to-treat population.However, changes in clinical measures of cognition, behavior, and an AD-related biomarker demonstrated a benefit in a subpopulation of 100 early Alzheimer's patients with inflammation biomarkers who were treated with XPro, compared to patients treated with placebo, the company said.CEO RJ Tesi said that the findings lay the foundation for advancing XPro as a “promising treatment option” for Alzheimer’s.XPro treatment was safe and well-tolerated, the company added.<a href="https://stocktwits.com/symbol/INMB">INmune</a> now intends to schedule an end-of-mid-stage meeting with the U.S. Food and Drug Administration (FDA) in the last quarter of 2025 to define the path forward for a pivotal trial to support XPro approval in early Alzheimer’s.Despite the drop in INMune stock during Monday’s trading session, retail sentiment around the stock is trending in the ‘extremely bullish’ territory on Stocktwits.INMB stock is down by about 53% this year and by about 74% over the past 12 months.Read Next: <a href="https://stocktwits.com/news-articles/markets/equity/moderna-flu-vaccine-show-positive-results-in-late-stage-trial/chmZitPRR72">Moderna Stock Surges Pre-Market As Flu Vaccine Shows Positive Results In Late-Stage Trial</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Stock market down on a black background. | Image source: Yuichiro Chino via Getty Images

INmune Bio Stock Slumps After Alzheimer’s Drug Falls Short In Mid-Stage Trial

The primary endpoint of the study was not met in the intent-to-treat population, the company said. 

Equity

INmune Bio stock plummets after mixed Phase 2 Alzheimer’s trial results

Investing.com --  INmune Bio  Inc. (NASDAQ:INMB) stock fell 60% in pre-market trading Monday after the company reported mixed results from its Phase 2 MINDFuL trial of XPro in early Alzheimer’s disease patients.

INmune Bio Inc. (INMB) on Friday said that it entered into securities purchase agreements with two healthcare-focused institutional investors for the purchase and sale of 3 million shares of its common stock.The company <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2025/06/27/3106725/0/en/INmune-Bio-Inc-Announces-Approximately-19-Million-Registered-Direct-Offering-Priced-At-the-Market-Under-Nasdaq-Rules.html">said</a> that it would sell 3 million shares of its common stock in a registered direct offering at a purchase price of $6.30 per share. The proceeds from the offering are expected to be about $19 million, excluding costs such as fees to the placement agency Alliance Global Partners.<a href="https://stocktwits.com/symbol/INMB">INmune Bio</a> said that it intends to use the proceeds from the offering for working capital purposes and general corporate purposes.The closing of the offering is expected to occur on or about June 20.INMB shares are down 19% on Friday afternoon.&nbsp;On Stocktwits, retail sentiment around INmune Bio is unmoved within the ‘extremely bullish’ territory over the past 24 hours, while retail chatter stayed at ‘extremely high’ levels.<figure class="image"><img style="aspect-ratio:625/64;" src="https://news.stocktwits-cdn.com/Screenshot_2025_06_27_at_2_24_21_PM_png_cb3ab03d42.webp" alt="INMB's Sentiment Meter and Message Volume as of 2:25 p.m. ET on June 27, 2025 | Source: Stocktwits" width="625" height="64"><figcaption>INMB's Sentiment Meter and Message Volume as of 2:25 p.m. ET on June 27, 2025 | Source: Stocktwits</figcaption></figure> A Stocktwits user opined that the company is headed to a year-long downtrend.<stembedurl>https://stocktwits.com/CharlesIV/message/619287462</stembedurl>Another user opined that a stock offering before data results is “sketchy.”<stembedurl>https://stocktwits.com/EddieGon/message/619286742</stembedurl>INmune Bio is slated to present topline results from its mid-stage Alzheimer’s trial, the MINDFuL study, on Monday. The trial is testing its lead drug candidate XPro in patients with mild cognitive impairment or Alzheimer’s disease with brain inflammation.The MINDFuL study will compare XProTM to placebo to find out whether XPro affects memory, functioning, and behavior. The study will also evaluate whether XPro is safe and tolerable.INMB stock is up by 9% this year and down by about 41% over the past 12 months.Read Next: <a href="https://stocktwits.com/news-articles/markets/equity/gilead-stock-rises-on-us-supreme-court-ruling-in-favor-of-health-insurers-covering-preventive-care/chmWPN2RRe5">Gilead Stock Rises On US Supreme Court Ruling In Favor Of Health Insurers Covering Preventive Care</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

INmune Bio Stock Slumps On 3M Share Offering Ahead Of Mid-stage Trial Data, But Retail Remains Bullish 

The company said that it would sell 3 million shares of its common stock in a registered direct offering at a purchase price of $6.30 per share.

INmune Bio saw its stock surge 75% in after-hours trading Thursday after disclosing plans to unveil topline results from its Phase 2 Alzheimer’s trial on Monday.The company will present findings from its MINDFuL study, a placebo-controlled trial testing its lead drug candidate XPro in patients showing early signs of Alzheimer’s.&nbsp;The study participants consisted of 208 patients diagnosed with mild cognitive impairment or mild Alzheimer's disease.&nbsp;The average age of the participants was 72 years. In all of the participants, biomarkers of inflammation were present.&nbsp;The inflammatory biomarkers observed were elevated C-reactive protein levels, along with increased ESR and higher HbA1c values and genetic markers such as the APOE ε4 allele.&nbsp;Participants were randomized 2-to-1 to receive weekly doses of XPro or a placebo for just under six months.The main goal of the study is to assess cognitive change using a custom measurement tool called the early and mild Alzheimer's cognitive composite&nbsp;(EMACC), designed to detect subtle shifts in early-stage Alzheimer’s.&nbsp;Previous data showed the EMACC aligns well with other standard assessments like MMSE and CDR-SB.The company reported that over two-thirds of participants carried the APOE ε4 gene, and nearly two-thirds qualified through more than one biomarker.&nbsp;Roughly 72% of patients screened for the trial were not enrolled, mostly due to more advanced disease.In addition to cognitive scoring, the study includes secondary measures such as evaluations of daily living, neuropsychiatric symptoms, and biological markers.XPro is part of the company’s broader immune-targeting drug platform, which focuses on conditions believed to stem from chronic inflammation.&nbsp;<a href="https://stocktwits.com/symbol/INMB">INmune</a> is also exploring XPro for use in depression, alongside other programs for cancer and rare skin disorders.On Stocktwits, retail sentiment was ‘extremely bullish’ amid a 344% surge in 24-hour message volume.One user said that the timing of the announcement indicated confidence from the company, noting that results slated for early Monday were unlikely to disappoint.<stembedurl>https://stocktwits.com/winefan/message/619189685</stembedurl>They also referenced commentary from&nbsp;“pharma bro”&nbsp;Martin&nbsp;Shkreli, who previously stated that if the drug proves effective, the stock could surge dramatically, possibly even reaching triple-digit levels.Another user noted the pre-market Monday scheduling as a potentially encouraging signal but said they wouldn’t celebrate until the actual data is released.<stembedurl>https://stocktwits.com/BoilerKing/message/619167991</stembedurl>The stock has risen 27.4% so far in 2025.For updates and corrections, email newsroom[at]stocktwits[dot]com.

INmune Bio Skyrockets After-Hours On Alzheimer’s Trial Buzz; Retail Bulls Bet Big Before Data Reveal Next Week

INmune is also developing XPro for treatment-resistant depression and exploring other immune-driven conditions like cancer and rare skin disorders.

<ul><li>Alzheimer’s Drug Market Faces Urgent Need for Innovative Therapies Beyond Big Pharma</li><li>Small Biotech Companies Lead the Charge with Disruptive Approaches to Treating Alzheimer’s</li></ul>Alzheimer’s disease has been one of the most challenging conditions for the pharmaceutical industry to address. While companies like&nbsp;Biogen (BIIB) and&nbsp;Eli Lilly (LLY) have made notable strides with drugs like&nbsp;Aduhelm and&nbsp;Donanemab, which target amyloid plaques, breakthrough treatments that offer substantial cognitive improvements remain elusive. Despite these advancements, many of these drugs focus on slowing disease progression rather than providing a cure, and their impact has been limited.Historically, much of the innovation in Alzheimer’s research has come from smaller biotech companies, many of which are eventually acquired by larger pharmaceutical firms like BIIB and LLY. However, the results from these acquisitions have often not met expectations, leaving room for new players to disrupt the market with more innovative approaches.For investors looking for broader exposure to the biotech sector, the&nbsp;XBI ETF (SPDR S&amp;P Biotech ETF) offers a more diversified way to play the space. XBI tracks an equal-weighted index of U.S. biotech stocks, providing exposure to both large players like Biogen and smaller upstarts working on novel treatments. The ETF has seen strong performance recently, driven by optimism around biotech innovation in areas like Alzheimer’s, oncology, and rare diseases. While individual biotech stocks can be volatile, XBI spreads the risk across a broader portfolio, making it a compelling option for those looking to invest in the sector without taking on the higher risk of single-stock picks.The Alzheimer’s drug market is projected to reach $13.7 billion by 2029, and despite the presence of big pharma, there remains a significant opportunity for companies with novel therapies to address this unmet need. In this article, we examine three small-cap biotech players —&nbsp;Cassava Sciences (SAVA),&nbsp;INmune Bio (INMB), and&nbsp;Annovis Bio (ANVS) — that are working on breakthrough Alzheimer’s therapies. We will break down their potential by analyzing the good, the bad, the ugly, and their overall investability.&nbsp;<h4>Read Now:&nbsp;<a href="https://wealthyvc.com/featured/20m-healthcare-stock-breaks-out-after-rising-1700-on-medicare-and-medicaid-clearance-heres-whats-being-announced-in-the-coming-months-in-a-25x-larger-market/">This $20m Company Soars 1,700% on Medicare &amp; Medicaid Clearance— Find out What’s Being Announced in the Coming Months in a Market 25X Larger</a></h4>&nbsp;<h3>Cassava Sciences (SAVA)&nbsp;<a href="https://stocktwits.com/symbol/SAVA">[Follow on Stocktwits.com]</a></h3><h4>The Lowdown:</h4>Cassava Sciences is developing Simufilam, a drug that targets a unique protein misfolding pathway in Alzheimer’s disease. Unlike traditional therapies that focus solely on amyloid plaques, Simufilam aims to correct the shape of the protein Filamin A, which may influence multiple Alzheimer’s disease processes. This innovative approach could potentially address multiple aspects of the disease.Cassava has faced a mix of positive and negative news. Its Phase 2 trial results showed cognitive improvement in Alzheimer’s patients, generating optimism. However, allegations of data manipulation have cast a cloud over the company’s achievements, leading to regulatory scrutiny and volatility in the stock.<h4>The Good:</h4>Simufilam’s unique approach could disrupt the Alzheimer’s drug market if Phase 3 trials confirm its efficacy. With Alzheimer’s treatments falling short of significant impact, a drug that improves cognitive function would undoubtedly capture massive attention. Additionally, Cassava’s high short interest could lead to a short squeeze if positive news emerges, providing an opportunity for investors to capitalize on sharp price movements. Notably, if the drug succeeds, the company’s stock could skyrocket, presenting massive upside potential for investors.<img src="https://st-everywhere-cms-prod.s3.us-east-1.amazonaws.com/Screenshot_2024_10_03_at_11_27_24_AM_67dc564cb2.png" alt="Screenshot 2024-10-03 at 11.27.24 AM.png"><h4>The Bad:</h4>The allegations of data manipulation have raised questions about the integrity of Cassava’s research. Although the company has denied wrongdoing, the concerns could weigh heavily on investor confidence until the Phase 3 data is released. Moreover, Alzheimer’s disease is notoriously difficult to treat, and even promising drugs can fail in late-stage trials.<h4>The Ugly:</h4>Cassava’s main challenge is that it’s a one-trick pony. The company’s future is almost entirely dependent on the success of Simufilam. If the Phase 3 trials show negative results, the stock could plummet, potentially wiping out investors. Cassava lacks diversification in its pipeline, and failure could be disastrous for the company’s long-term viability.<h4>Investability:</h4>Cassava Sciences is a high-risk, high-reward stock. For investors willing to take on significant risk, the potential upside of Simufilam is enormous. However, given the controversies surrounding the company, a cautious approach is warranted. Those looking for long-term gains should monitor the Phase 3 results closely before making any major investments.&nbsp;<h3>INmune Bio (INMB)&nbsp; <a href="https://stocktwits.com/symbol/inmb">[Follow on Stocktwits.com]</a></h3><h4>The Lowdown:</h4>INmune Bio is taking a unique approach to treating Alzheimer’s by focusing on neuroinflammation rather than the traditional amyloid or tau pathways. The company’s lead drug, XPro1595, is designed to reduce brain inflammation by neutralizing soluble TNF (sTNF), a cytokine that drives chronic inflammation in Alzheimer’s patients. This could potentially offer a complementary treatment to existing therapies. In addition to its Alzheimer’s focus, INmune Bio has a strong oncology portfolio, which includes its INKmune platform aimed at improving cancer immunotherapy.Recent clinical data on XPro1595 has been promising, with the drug showing efficacy in reducing neuroinflammation. The company is preparing for larger trials in 2025, which could solidify its position in the Alzheimer’s space.<h4>The Good:</h4>INmune Bio’s focus on neuroinflammation sets it apart from other Alzheimer’s treatments. Reducing inflammation has shown to be a crucial factor in preventing cognitive decline, and XPro1595’s early data suggests it could be a game-changer in this area. Furthermore, INmune Bio’s diversified portfolio, including its oncology platform, gives it additional avenues for growth beyond Alzheimer’s, reducing its risk compared to Cassava Sciences.<h4>The Bad:</h4>Despite the promise of XPro1595, the drug is still in early-stage trials, and it could take years before it reaches the market. The road to FDA approval is long and fraught with challenges, and investors will need to be patient as the company moves through its clinical development phases.<img src="https://st-everywhere-cms-prod.s3.us-east-1.amazonaws.com/Screenshot_2024_10_03_at_11_28_27_AM_bf6e45fe54.png" alt="Screenshot 2024-10-03 at 11.28.27 AM.png"><h4>The Ugly:</h4>One of the biggest risks for INmune Bio is its reliance on early-stage data. While XPro1595 has shown promise, it has not yet demonstrated long-term efficacy in larger trials. Any setbacks in the trial process could delay the drug’s development and hurt the company’s stock.<h4>Investability:</h4>INmune Bio offers the best reward-to-risk ratio among the three companies. With a diversified portfolio and a promising Alzheimer’s treatment, INmune Bio is well-positioned to capitalize on breakthroughs in both neuroinflammation and oncology. Investors looking for a biotech stock with high upside potential but less concentrated risk compared to Cassava Sciences may find INmune Bio to be a compelling option.<h4>Read Now:&nbsp;<a href="https://wealthyvc.com/featured/20m-healthcare-stock-breaks-out-after-rising-1700-on-medicare-and-medicaid-clearance-heres-whats-being-announced-in-the-coming-months-in-a-25x-larger-market/">This $20m Company Soars 1,700% on Medicare &amp; Medicaid Clearance— Find out What’s Being Announced in the Coming Months in a Market 25X Larger</a></h4>&nbsp;<h3>Annovis Bio (ANVS)&nbsp;&nbsp;<a href="https://stocktwits.com/symbol/ANVS">[Follow on Stocktwits.com]</a></h3><h4>The Lowdown:</h4>Annovis Bio is targeting Alzheimer’s with Buntanetap, a drug that aims to reduce multiple neurotoxic proteins, including amyloid, tau, and alpha-synuclein. By taking a multi-pronged approach, Annovis hopes to provide a more comprehensive treatment for neurodegenerative diseases like Alzheimer’s and Parkinson’s.The company recently reported positive early-stage trial results, showing that Buntanetap improved cognition in patients with Alzheimer’s. With a Phase 2 trial in progress, Annovis Bio is positioning itself as a serious contender in the Alzheimer’s space.<h4>The Good:</h4>Buntanetap’s ability to target multiple neurotoxic proteins gives it an advantage over single-target therapies. The early data showing cognitive improvement has bolstered investor confidence, and the drug’s potential to address both Alzheimer’s and Parkinson’s opens up additional market opportunities. If Buntanetap continues to perform well in clinical trials, Annovis Bio could see substantial growth.<img src="https://st-everywhere-cms-prod.s3.us-east-1.amazonaws.com/Screenshot_2024_10_03_at_11_29_39_AM_fafa150775.png" alt="Screenshot 2024-10-03 at 11.29.39 AM.png"><h4>The Bad:</h4>However, Annovis Bio is still in the early stages of its clinical trials, and the road to commercialization is long. The company will need to demonstrate consistent efficacy in larger trials before it can become a serious player in the Alzheimer’s market. Additionally, competition from other multi-target therapies could limit its market share.<h4>The Ugly:</h4>Like many small biotech companies, Annovis Bio is reliant on the success of a single drug candidate. If Buntanetap fails in its clinical trials, the company could struggle to recover. Investors should be aware of the high risk associated with this stock.<h4>Investability:</h4>Annovis Bio presents a speculative but potentially rewarding investment. The company’s multi-target approach could offer greater efficacy than traditional Alzheimer’s treatments, but it remains a high-risk bet. Investors should monitor the progress of its clinical trials closely before making any significant investments.<h3>Conclusion</h3>The Alzheimer’s drug market is poised for disruption, and companies like Cassava Sciences, INmune Bio, and Annovis Bio are leading the charge with innovative treatments. While these stocks come with substantial risks, the potential rewards could be life-changing — both for patients and investors. For those willing to take a gamble on the future of Alzheimer’s treatment, these companies offer a unique opportunity to not only achieve significant financial gains but also to contribute to a cause that could improve millions of lives.Of the three, INmune Bio stands out for its diversified portfolio and promising early data, making it a potentially safer bet. Cassava Sciences offers the most dramatic upside but comes with higher risks due to its single-drug focus. Annovis Bio, while speculative, offers intriguing potential with its multi-targeted approach.As always, investors should weigh the risks and rewards carefully but know that their investments could make a profound difference in the fight against one of the most challenging diseases of our time.&nbsp;<h4>Read Now:&nbsp;<a href="https://wealthyvc.com/featured/20m-healthcare-stock-breaks-out-after-rising-1700-on-medicare-and-medicaid-clearance-heres-whats-being-announced-in-the-coming-months-in-a-25x-larger-market/">This $20m Company Soars 1,700% on Medicare &amp; Medicaid Clearance— Find out What’s Being Announced in the Coming Months in a Market 25X Larger</a></h4>&nbsp;This author or the principals of WVC do not hold any of the stocks mentioned in this article.&nbsp;<ul><li><a href="http://www.stocktwits.com/wealthyvc">Follow us on Stocktwits</a>&nbsp;</li><li><a href="https://www.facebook.com/groups/WealthyVC">Join the Discussion in the WVC Facebook Investor Group</a></li><li>Have a Stock Tip or New&nbsp; Story Suggestion? Email us at&nbsp;Invest@WealthyVC.com</li></ul>

Big Pharma’s $13.7B Alzheimer’s Drug Market Has a Progress Problem: Here Are Three Small-Cap Biotech Stocks That Could Disrupt the Market

Discover how small-cap biotech companies like Cassava Sciences, INmune Bio, and Annovis Bio are shaking up the $13.7 billion Alzheimer’s drug market with innovative treatments. Explore their potential for high-risk, high-reward gains

Small biotech firms like Cassava Sciences, INmune Bio, and Annovis Bio are developing innovative Alzheimer’s treatments, disrupting big pharma’s dominance in the $13.7B market. For those targeting groundbreaking therapies, high-risk, high-reward investments lie ahead.


INmune Bio, Inc. is a clinical stage biotechnology company, which engages in developing new immunotherapies that reprogram the immune system to fight cancer and Alzheimer’s disease. Its product pipeline includes INKMUNE-Cancer, INB03-Cancer, XPRO1595-Alzheimer and TRD, and LIVNate. The company was founded by Mark Lowdell on September 25, 2015 and is headquartered in Boca Raton, FL.

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