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Memecoin on Cronos launched by the Cro Crow community

crow with knife

The community is rallying behind the multichain meme project crow with knife, highlighting its deflationary burn mechanism and organic growth as primary drivers of their bullish sentiment. Discussions are dominated by high-energy engagement and a strong conviction that the token serves as a unique asset within the current meme coin landscape.

Back in 2011, long before “crypto Twitter”, NFTs, or VC-backed chains existed, users of the BitcoinTalk forum came up with a new currency - not to launch a network, but to make fun of btc.... and so: The first memecoin/memecurrency was born.  On May 23, 2011, a Something Awful poster cracked, “Has anyone called them buttcoins yet?”. It was sophomoric and perfect. Within weeks the gag metastasized into Buttcoin.org, a parody blog that described a “peer to peer butt” economy while cataloging mining fiascos, exchange blowups, and MLM-adjacent “innovations”.

Buttcoin

Buttcoin is surging in popularity as the community rallies around its status as a long-standing parody of Bitcoin, with users debating whether its satirical roots give it staying power as a legitimate asset. Supporters are actively pointing to its unique lore, growing holder count, and high-profile endorsements as catalysts, while others remain skeptical, fueling a polarized discussion about its long-term potential in the meme coin space.

VanEck ETF Trust - VanEck Semiconductor ETF

VanEck Semiconductor ETF

The VanEck Semiconductor ETF (SMH) is trending as institutional investors debate whether the sector's aggressive AI-driven rally is facing a distribution phase or a continuation setup. The community is heavily focused on the disconnect between soaring AI infrastructure capex and mounting concerns over data center cancellations, power grid constraints, and valuation premiums.

Avalanche is a high throughput smart contract blockchain&nbsp;platform. Validators secure the network through a proof-of-stake consensus protocol. It is said to be fast, low cost, and environmental friendly.

Avalanche

Avalanche is currently facing intense selling pressure and negative sentiment as investors express frustration over prolonged stagnant price action and its consistent underperformance compared to other assets. The community is actively debating the project's long-term utility versus its speculative nature, while many are focused on the impact of upcoming legislative developments and potential accumulation opportunities during this period of high volatility.

Fresenius Medical Care AG engages in the provision of products and services for individuals with renal diseases. It operates through the Care Enablement and Care Delivery segments. The Care Enablement segment is involved in the healthcare products business including research and development, manufacturing, supply chain, and commercial operations as well as supporting functions, such as regulatory and quality management. The Care Delivery segment focuses on the health care services for the treatment of CKD, ESRD, and other extracorporeal therapies, including value and risk-based care programs. The company was founded on August 5, 1996 and is headquartered in Bad Homburg, Germany.

Fresenius Medical Care AG - ADR

Fresenius Medical Care AG & Co. KGAA

Fresenius Medical Care (FMS) is trending as the community debates the competitive landscape for infection prevention in dialysis, specifically regarding the adoption and impact of antimicrobial catheter lock solutions like Defencath. Investors are actively tracking potential partnerships and the strategic implications of these technologies on facility-level infection metrics as operators strive to improve patient safety outcomes.

DaVita, Inc. engages in the provision of medical care services. It operates through the US Dialysis and Related Lab Services, and Other-Ancillary Services and Strategic Initiatives segments. The US Dialysis and Related Lab Services segment offer kidney dialysis services in the United States for patients suffering from chronic kidney failure. The Other-Ancillary Services and Strategic Initiatives segment consists primarily of pharmacy services, disease management services, vascular access services, clinical research programs, physician services, direct primary care, end stage renal disease seamless care organizations, and comprehensive care. The company was founded in 1994 and is headquartered in Denver, CO.

DaVita Inc

DaVita is currently trending as investors weigh the potential long-term impact of GLP-1 weight-loss drugs on the demand for dialysis services, leading to significant market volatility. While some community members view the sharp price drop as a major overreaction based on distant speculation, others are actively debating the sustainability of the company's business model and debt load in light of emerging medical treatments.

Maulcoin

Maulcoin is trending as its community aggressively rallies behind the project's organic growth and 'join the dark side' branding, with members actively pushing for social engagement and new listings to drive the next wave of price appreciation. Investors are heavily focused on holding through dips and hitting specific market cap milestones that trigger community-wide airdrops, highlighting a strong collective sentiment centered on long-term accumulation rather than short-term gains.

Bitcoin is the world's first decentralized cryptocurrency, created in 2009 by the pseudonymous Satoshi Nakamoto. It enables peer-to-peer electronic cash transactions without intermediaries like banks or governments, operating on a blockchain secured by Proof of Work mining and the SHA-256 cryptographic algorithm.   With a fixed supply cap of 21 million coins and programmatic halvings every four years that reduce miner rewards, Bitcoin is designed as a deflationary digital asset often called "digital gold." Its value stems from solving the double-spending problem without trusted intermediaries, creating the first truly scarce digital asset with censorship resistance and permissionless access that no government, corporation, or individual can control.  Bitcoin operates as a decentralized peer-to-peer network where transactions are recorded on a public ledger called the blockchain, distributed across thousands of computers globally. Transactions are grouped into blocks added approximately every 10 minutes through mining, where specialized computers compete to solve complex mathematical puzzles.   Bitcoin has achieved mainstream adoption through multiple vectors. The January 2024 SEC approval of 11 spot Bitcoin ETFs opened Bitcoin investment to traditional finance participants, and corporations like Strategy (formerly MicroStrategy) are using Bitcoin as a treasury reserve asset to protect against currency debasement, offering MSTR holders amplified exposure to Bitcoin.   The Bitcoin ecosystem continues to evolve with innovations like Ordinals, which emerged in January 2023 to enable NFT-like functionality directly on Bitcoin, and BRC-20 tokens, an experimental standard for creating fungible tokens using Ordinal inscriptions. BTCFi (Bitcoin Finance) represents emerging financial applications extending beyond Bitcoin's traditional role, with protocols like Babylon allowing Bitcoin holders to stake BTC to secure Proof of Stake chains.

Bitcoin

Bitcoin is experiencing heightened volatility as the market reacts to shifting geopolitical tensions between the U.S. and Iran, with traders intensely debating whether current diplomatic stalemate signals a deeper correction or a massive short squeeze. Community sentiment is deeply polarized, with bulls pointing to robust institutional ETF inflows and long-term accumulation as a floor, while bears are focused on potential macroeconomic fallout from prolonged conflict and the risk of a breakdown in technical support levels.

Algorand is a scalable, secure, and decentralized digital currency and smart contract platform. Its protocol uses a variation of Proof-of-Stake (PoS) called Pure PoS (PPoS) to secure the network and reach consensus on block production. Developers can build decentralized applications (dApps) using familiar programming languages, including Python, which Algorand supports natively. Its infrastructure enables various use cases, including payment systems, digital identity solutions, supply-chain tracking, and financial services. The protocol's architecture allows for tokenization of assets and the development of smart contracts, while its technical specifications support both retail users seeking basic transaction capabilities and enterprises requiring more, complex, blockchain solutions.

Algorand

Algorand is seeing heightened social engagement as the community reacts to a recent Google research paper that cites its protocol as a benchmark for quantum-resistant security, while investors remain split between long-term optimism regarding its enterprise utility and frustration over extended price volatility.

TON (The Open Network) is a general-purpose&nbsp;blockchain that allows developers to build decentralized apps and tokens.

Toncoin

Toncoin is capturing market attention as its integration with Telegram reaches a massive user base, with traders highlighting recent sub-second network upgrades and high APY staking opportunities. Community discussion is currently centered on increased institutional adoption, including new ETP listings and strategic whale accumulation despite recent price volatility.

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<ul class="summary-bullets"><li>Jefferies had predicted that IOVA could see a 5%-15% move on Replime’s drug getting rejected.&nbsp;</li><li>According to Chardan analyst Geulah Livshits, RP1’s rejection is a positive for Iovance's Amtagvi's near-term competitive position.</li><li>Iovance story "remains centered on" Amtagvi's sales acceleration and margin expansion in 2026, according to Jefferies.</li></ul>Shares of Iovance Biotherapeutics Inc. (IOVA) garnered retail attention on Friday in light of an aspiring rival’s drug failing to get the nod from the U.S. Food and Drug Administration.IOVA shares closed down 8% on Friday, surprising retail investors and analysts alike. Jefferies had predicted that IOVA could see a 5%-15% move on Replimune’s drug getting rejected.Earlier on Friday, the FDA <a href="https://stocktwits.com/news-articles/markets/equity/repl-stock-dives-after-fda-refuses-approval-for-skin-cancer-drug/cZJ0Kb3RIto">refused</a> to approve Replimune’s (REPL) investigational melanoma drug RP1. The agency said in a letter to the company that the data submitted by Replimune as part of its application seeking approval of the drug is “insufficient to conclude substantial evidence of effectiveness” in the treatment of unresectable advanced cutaneous melanoma.Iovance’s Amtagvi cellular therapy is already approved as a treatment for people with previously treated melanoma that has spread or cannot be removed by surgery. The drug was granted accelerated approval in February 2024. The company recorded Amtagvi revenue of about $220 million for the full year 2025 in the U.S.<h2 class="st-heading-2">How Did Retail Traders React?</h2>A Stocktwits user expressed surprise at the stock closing down on the good news.<stembedurl>https://www.stocktwits.com/KingCuerv0/message/649991039</stembedurl>Yet another echoed the sentiment.<stembedurl>https://www.stocktwits.com/lebranjames/message/649990274</stembedurl>Another user opined that the stock may be down over concerns about FDA raising the bar for trials.<stembedurl>https://www.stocktwits.com/mlftt/message/649991395</stembedurl>Yet another user sounded optimism for clarity on sentiment around the stock on Monday. &nbsp;“Good news after good news lately, don’t let the price action tell you otherwise,” they said.<stembedurl>https://www.stocktwits.com/Morrito23/message/649985521</stembedurl>Overall retail sentiment around IOVA jumped from ‘bullish’ to ‘extremely bullish’ territory over the past 24 hours, while message volume increased from ‘normal’ to ‘high’ levels. Retail chatter around IOVA rose 75%, according to platform data.<h2 class="st-heading-2">Analyst Take</h2>According to data from Koyfin, eight of the 11 analysts covering IOVA rate it ‘Buy’ or higher, while three rate it ‘Hold’. There are no ‘Sell’ ratings of the stock.The average 12-month price target on the stock is $9, representing a potential upside of about 144%.According to Jefferies analyst Andrew Tsai, the rejection for RP1 means one less competitor for Iovance in the near term though Replimune was “technically not an overhang.” Iovance story "remains centered on" Amtagvi's sales acceleration and margin expansion in 2026, he said. The analyst has a ‘Buy’ rating and $12 price target on the shares.Chardan analyst Geulah Livshits also kept &nbsp;a ‘Buy’ rating on Iovance Biotherapeutics (IOVA) with a $16 price target after Replimune (REPL) update. RP1’s rejection is a positive for Iovance's Amtagvi's near-term competitive position, the analyst told investors in a research note. However, the firm added that more direct competition from cell therapies "could be on the horizon" in 2027.<a href="https://stocktwits.com/symbol/IOVA">IOVA stock</a> has gained 21% over the past 12 months.&nbsp;Read More: <a href="https://stocktwits.com/news-articles/markets/equity/cue-stock-on-track-for-best-day-in-history-why-is-retail-optimistic/cZJ0N5KRItC">CUE Stock On Track For Best Day In History — Why Is Retail Optimistic?</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, the IOVANCE BIOTHERAPEUTICS logo is displayed on the screen of a tablet computer. (Photo Illustration by Sheldon Cooper/SOPA Images/LightRocket via Getty Images)

IOVA Stock Slump Takes Wall Street, Retail By Surprise — Here’s Why

Earlier on Friday, the FDA refused to approve Replimune’s investigational melanoma drug RP1, which was a likely contender for Iovance’s Amtagvi. 

Equity

Earlier on Friday, the FDA refused to approve Replimune’s investigational melanoma drug RP1, which was a likely contender for Iovance’s Amtagvi. 


Iovance Biotherapeutics' (IOVA) Buy Rating Reiterated at Chardan Capital

Chardan Capital reissued a "buy" rating and set a $16.00 target price on shares of Iovance Biotherapeutics in a report on Friday...

Promising Biotech Stocks To Follow Today - April 10th

Danaher, Vertex Pharmaceuticals, Iovance Biotherapeutics, argenex, and Moderna are the five Biotech stocks to watch today, according to MarketBeat's stock screener tool. Biotech stocks are shares of publicly traded companies whose primary business is developing, manufacturing, or commercializing bi...

Iovance Biotherapeutics (NASDAQ:IOVA)  Shares Down 6.6%   - Here's Why

Iovance Biotherapeutics (NASDAQ:IOVA) Stock Price Down 6.6% - Should You Sell...

Investors Purchase High Volume of Call Options on Iovance Biotherapeutics (NASDAQ:IOVA)

Iovance Biotherapeutics, Inc. (NASDAQ:IOVA - Get Free Report) was the recipient of unusually large options trading activity on Friday. Traders acquired 23,006 call options on the company. This is an...

Zacks Research Brokers Boost Earnings Estimates for IOVA

Iovance Biotherapeutics, Inc. (NASDAQ:IOVA - Free Report) - Equities researchers at Zacks Research boosted their Q1 2026 EPS estimates for shares of Iovance Biotherapeutics in a report issued on Wednesday, April 8th. Zacks Research analyst Team now expects that the biotechnology company will earn...

<ul class="summary-bullets"><li>Analysts estimate about 116% upside for REPL, compared to a 124% upside for IOVA from current levels.</li><li>Amtagvi, already approved for melanoma, helped Iovance generate about $264 million in product revenue in 2025.</li><li>RP1, in combination with Nivolumab, shrank tumors in about one-third of PD-1-failed melanoma patients.</li></ul>Shares of Replimune Group, Inc. (REPL) and Iovance Biotherapeutics, Inc. (IOVA) are back in focus on Friday ahead of an FDA decision on the former's lead immunotherapy candidate RP1, as investors compare a near-term approval catalyst with an already approved melanoma therapy.<a href="https://stocktwits.com/symbol/REPL">REPL stock</a> is on track for its worst weekly decline in nearly seven months after logging its biggest single-session drop in over six months on Wednesday. Meanwhile,&nbsp;<a href="https://stocktwits.com/symbol/IOVA">IOVA shares</a> are poised to snap a four-week losing streak after jumping 16% on Thursday, marking their best session in over a month.Koyfin estimates give Iovance the early lead on upside, but today’s RP1 verdict could determine whether Replimune closes the gap in a single catalyst move.<h2 class="st-heading-2">RP1 Decision Looms For Replimune</h2>Replimune’s lead candidate RP1, in combination with Nivolumab, an immunotherapy that helps the immune system attack cancer cells, is under U.S. Food and Drug Administration (FDA) review for patients with advanced melanoma whose disease has progressed after prior PD-1 therapy, with the Prescription Drug User Fee Act (PDUFA) decision due Friday.The company’s commercial readiness activities are already underway to support the launch if approval is granted. Trial results from last year showed that RP1 combined with Nivolumab shrank tumors in about one-third of patients whose melanoma had already stopped responding to standard PD-1 immunotherapy, including complete tumor disappearance in 15% of patients.Consensus estimates tracked by Koyfin place Replimune’s average price target at $12.86, implying a 116% upside from current levels. The stock is covered by seven analysts, with one rating it ‘Strong Buy’, four ‘Buy’, and two ‘Hold’, resulting in an overall consensus rating of ‘Strong Buy’.Several analysts turned bullish after the FDA accepted the BLA resubmission in October. H.C. Wainwright raised its probability of approval to 85% from 50%, while Piper Sandler expects a potential mid-2026 launch. JPMorgan added that the “totality of the RP1 data in the refractory melanoma setting is compelling and warrants approval.”<h2 class="st-heading-2">Amtagvi Gives Iovance Commercial Edge</h2>Unlike Replimune, Iovance already has an approved therapy on the market. The FDA approved Amtagvi in 2024 as the first therapy made from a patient’s own tumor-fighting immune cells for people with advanced melanoma that cannot be removed with surgery or has spread after earlier PD-1 immunotherapy stopped working.The company reported $264 million in total product revenue in 2025, including $220 million from Amtagvi, marking its first full calendar year of launch. The company flagged increasing treatment-center adoption and manufacturing improvements expected to continue this year.Consensus estimates place Iovance’s average analyst price target at $9, representing a 124% upside from the stock’s last close. The stock is covered by 11 analysts, with two rating it ‘Strong Buy’, six ‘Buy’, and three ‘Hold’, supporting a consensus rating of ‘Strong Buy’.Iovance is also expanding its tumor-infiltrating lymphocyte, or TIL, therapy platform into several cancers beyond melanoma. Updated data in February showed that 44% of melanoma patients responded to Amtagvi, while additional trials are underway in non-small-cell lung cancer, sarcoma and frontline melanoma combinations. The FDA has also granted Fast Track designation to Amtagvi in advanced non-small-cell lung cancer.<h2 class="st-heading-2">How Do Retail Traders Feel About REPL, IOVA?</h2>On Stocktwits, retail sentiment for REPL was ‘bearish’ amid ‘extremely high’ message volume, while sentiment toward IOVA was ‘bullish’ amid ‘high’ message volume.One user&nbsp;<a href="https://stocktwits.com/Bob_Whitley/message/649897269">warned</a> that approval appeared unlikely ahead of the decision, saying "Take off the blinders, the stock [REPL] tanked this week on no news, IOVA had a surge, the trial design was basically picked apart at the joints in the last CRL."<stembedurl>https://stocktwits.com/Bob_Whitley/message/649897269</stembedurl>Another user&nbsp;<a href="https://stocktwits.com/RunnersOnly4/message/649889153">said</a>, “Why gamble with REPL when you have a sure thing with IOVA at a lower price?”<stembedurl>https://stocktwits.com/RunnersOnly4/message/649889153</stembedurl>Over the past year, shares of REPL have fallen 19%, while IOVA stock has risen 23%.For updates and corrections, email newsroom[at]stocktwits[dot]com.Read Next:&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/nio-stock-dips-hk-after-es9-debut-what-went-wrong/cZJ0cCeRIsD">Nio Stock Dips In HK After ES9 Debut: What Went Wrong?</a>

Over the past year, shares of REPL have fallen 19%, while IOVA stock has risen 23%. (Photo credit: Getty Images)

REPL Vs IOVA: FDA Decision Day Could Test Biotech Bulls’ Conviction On These Melanoma Plays

REPL stock is heading for its worst weekly loss in nearly seven months ahead of the FDA decision on RP1.

<ul class="summary-bullets"><li>FDA is slated to decide on potential rival Replimune’s application for RP1 in the treatment of advanced melanoma by April 10.</li><li>Iovance’s Amtagvi cellular therapy is already approved as a treatment for people with previously treated melanoma that has spread or cannot be removed by surgery.</li><li>The company recorded Amtagvi revenue of about $220 million for the full year 2025 in the U.S.</li></ul> Shares of Iovance Biotherapeutics (IOVA) closed up 16% on Thursday as investors await the U.S. Food and Drug Administration’s decision on its aspiring competitor Replimune’s (REPL) skin cancer drug.IOVA stock has closed in the green for three consecutive days and recorded its best single-day gain on Thursday since late February.The FDA is slated to decide on Replimune’s application for RP1 in the treatment of advanced melanoma by April 10. RP1 is Replimune’s lead product candidate.Iovance’s Amtagvi cellular therapy is already approved as a treatment for people with previously treated melanoma that has spread or cannot be removed by surgery. The drug was granted accelerated approval in February 2024. &nbsp;The company recorded Amtagvi revenue of about $220 million for the full year 2025 in the U.S.<h2 class="st-heading-2">Retail Chimes In</h2>A Stocktwits user said that rejection for Replimune’s drug will be the “end of the last anchor” holding IOVA down.<stembedurl>https://www.stocktwits.com/EvrytIsNothingWithaTwist/message/649873087</stembedurl>Another expressed anticipation for the decision.<stembedurl>https://www.stocktwits.com/medinapj/message/649874467</stembedurl><h2 class="st-heading-2">RP1’s Past Issues</h2>In late July 2025, the FDA issued a complete response letter regarding the application for RP1 in combination with Nivolumab for the treatment of advanced melanoma.The agency said in the letter that it is unable to approve the application in its present form, and indicated that the trial conducted by the company for the drug is not considered to be an adequate and well-controlled clinical investigation that provides substantial evidence of effectiveness.Following months of engagement between the company and the FDA, Replimune subsequently resubmitted its application in October with additional information, data, and analyses.<h2 class="st-heading-2">How Did Retail Traders React?</h2>On Stocktwits, retail sentiment around IOVA stock jumped from ‘bearish’ to ‘bullish’ territory over the past 24 hours, while message volume increased from ‘low’ to ‘normal’ levels.Meanwhile, sentiment around REPL trended in ‘extremely bearish’ territory at the time of writing. &nbsp;<a href="https://stocktwits.com/symbol/IOVA">IOVA stock</a> has gained 23% over the past 12 months while <a href="https://stocktwits.com/symbol/REPL">REPL stock</a> fell 19%.&nbsp;Read More: <a href="https://stocktwits.com/news-articles/markets/equity/why-is-gemi-stock-up-eleven-percent/cZJWX2VRIsh">GEMI Stock On Track To Record Best Session In Over A Month On Acquisition Interest</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

IOVA Stock Clocks Best Session Since February As Retail Awaits FDA Decision On Rival Drug

IOVA stock closed in the green for the past three days and recorded its best single-day gain on Thursday since late February.

Iovance Biotherapeutics (NASDAQ:IOVA) Trading Up 7.1% - Time to Buy?

Iovance Biotherapeutics (NASDAQ:IOVA) Trading 7.1% Higher - Here's What Happened...

Iovance Biotherapeutics (NASDAQ:IOVA) Shares Cross Below 50 Day Moving Average - Here's What Happened

Iovance Biotherapeutics (NASDAQ:IOVA) Stock Crosses Below 50 Day Moving Average - Here's What Happened...

Iovance Biotherapeutics, Inc. is a biopharmaceutical company, which engages in the development and commercialization of cell therapies as novel cancer immunotherapy products. Its lead product candidate, LN-144 for metastatic melanoma, is an autologous adoptive cell therapy utilizing tumor-infiltrating lymphocytes (TIL), which are T cells derived from patients' tumors. The company was founded by Robert T. Brooke on September 17, 2007 and is headquartered in San Carlos, CA.

Iovance Biotherapeutics Inc

Warranted - fundamentals justify the decline

Overdone - the market is overreacting

Too early to tell

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The denial of a key competitor's BLA clears the field, leaving the firm as the dominant player in the advanced melanoma market.

Recruiting high-caliber ex-FDA leaders provides a strategic advantage for navigating the stringent regulatory landscape for cell therapies.

Massive short interest coupled with positive sentiment from competitor failures is sparking intense debate over potential near-term price surges.

Accelerating expansion and deeper utilization within the Authorized Treatment Center network serves as a key catalyst for projected 2026 growth.

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