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Bitcoin is the world's first decentralized cryptocurrency, created in 2009 by the pseudonymous Satoshi Nakamoto. It enables peer-to-peer electronic cash transactions without intermediaries like banks or governments, operating on a blockchain secured by Proof of Work mining and the SHA-256 cryptographic algorithm.   With a fixed supply cap of 21 million coins and programmatic halvings every four years that reduce miner rewards, Bitcoin is designed as a deflationary digital asset often called "digital gold." Its value stems from solving the double-spending problem without trusted intermediaries, creating the first truly scarce digital asset with censorship resistance and permissionless access that no government, corporation, or individual can control.  Bitcoin operates as a decentralized peer-to-peer network where transactions are recorded on a public ledger called the blockchain, distributed across thousands of computers globally. Transactions are grouped into blocks added approximately every 10 minutes through mining, where specialized computers compete to solve complex mathematical puzzles.   Bitcoin has achieved mainstream adoption through multiple vectors. The January 2024 SEC approval of 11 spot Bitcoin ETFs opened Bitcoin investment to traditional finance participants, and corporations like Strategy (formerly MicroStrategy) are using Bitcoin as a treasury reserve asset to protect against currency debasement, offering MSTR holders amplified exposure to Bitcoin.   The Bitcoin ecosystem continues to evolve with innovations like Ordinals, which emerged in January 2023 to enable NFT-like functionality directly on Bitcoin, and BRC-20 tokens, an experimental standard for creating fungible tokens using Ordinal inscriptions. BTCFi (Bitcoin Finance) represents emerging financial applications extending beyond Bitcoin's traditional role, with protocols like Babylon allowing Bitcoin holders to stake BTC to secure Proof of Stake chains.

Bitcoin

Bitcoin is experiencing a steep decline amid a weekend sell-off, largely attributed to leveraged liquidations and thin liquidity, with some connecting it to recent movements in precious metals. The community is sharply divided between those predicting further collapse and advocating aggressive shorting, and those viewing it as a manipulated "shakeout" and a significant long-term buying opportunity.

Ethereum is a global, open-source platform for decentralized applications. In other words, it is a decentralized blockchain platform that enables developers to build and deploy smart contracts and applications without central authority control. Unlike Bitcoin, which primarily functions as digital currency, Ethereum operates as a programmable global computer where developers can create any type of decentralized service.   The platform hosts over $14 billion in DeFi applications with hundreds of thousands of active users across financial protocols, NFT marketplaces, and gaming platforms. Its transition to Proof of Stake in September 2022 reduced energy consumption by over 99%, addressing environmental concerns while strengthening network security.  The network operates through thousands of independent validator nodes that process transactions and execute smart contracts on the Ethereum Virtual Machine. Smart contracts are self-executing programs written in Solidity that automatically carry out agreements when conditions are met, eliminating intermediaries like banks or brokers.   Validators stake ETH as collateral to propose and validate blocks, earning rewards for honest participation while facing penalties for malicious behavior. The EIP-1559 upgrade introduced a dynamic base fee mechanism that burns ETH with each transaction, creating deflationary pressure during high network activity when more ETH is burned than issued to validators.  Vitalik Buterin proposed Ethereum in 2013, but seven co-founders helped build it, including Gavin Wood who created Solidity and the EVM technical specification, and Joseph Lubin who founded ConsenSys. The project launched in July 2015 after raising over $18 million through crowdfunding, quickly becoming the largest blockchain developer community. Major milestones include the 2020 Beacon Chain launch, the 2021 London hard fork implementing fee burning, and the 2022 Merge to Proof of Stake.   Ether (ETH) serves multiple functions: paying transaction fees (gas), staking to secure the network and earn 3-5% annual yields, serving as collateral in DeFi protocols, and purchasing NFTs and digital assets. The asset is increasingly adopted by traditional institutions, with publicly traded companies adding ETH to corporate treasuries to generate staking yields while maintaining blockchain exposure, and in 2024, the SEC approved spot Ethereum ETFs, allowing traditional investors to gain exposure through conventional brokerage accounts.  Ethereum's roadmap focuses on dramatically increasing transaction capacity to over 100,000 per second, reducing confirmation times, and enhancing decentralization while maintaining security against future threats like quantum computing.

Ethereum

Ethereum is experiencing a significant weekend sell-off, driven by thin liquidity and concerns from ETF holders unable to trade, sparking intense community debate between those identifying a manipulation-driven buying opportunity and others predicting further market collapse.

Themes ETF Trust - Leverage Shares 2X Long BBAI Daily ETF

Leverage Shares 2X Long BBAI Daily ETF

Leverage Shares 2X Long BBAI Daily ETF ($BAIG) is trending as traders leverage its 2x exposure to BigBear.ai ($BBAI), with strong community sentiment around strategic entries on dips and the potential for a significant short squeeze on increasing volume.

Trump For President

TRUMP CRYPTO is trending as community members discuss the recent capture of Maduro in Venezuela, with enthusiasts celebrating perceived presidential influence, while a strong counter-narrative labels the token a "scam" amidst ongoing debates about its long-term viability and various controversies including the Epstein files.

VenHub Global, Inc. engages in the management of fully autonomous and robotic-operated convenience stores. It is involved in utilizing technologies such as artificial intelligence (AI) and smart inventory management systems for shopping experience of customers. The company was founded by Shahan Ohanessian and Shoushana Ohanessian on January 31, 2023 and is headquartered in Pasadena, CA.

Venhub Global Inc.

Venhub Global Inc. (VHUB) is trending following its direct listing on NASDAQ, which saw significant after-hours trading volume and a notable price surge, leading to community speculation about its potential as a multi-day runner.

UNI is the governance token for Uniswap, an Automated Market Marker DEX on the Ethereum blockchain. The UNI token allows token holders to participate in the governance of the protocol. Key decisions such as usage of the treasury or future upgrades can be decided through a governance vote.

UniSwap

Uniswap is trending as its community overwhelmingly supports the 'UNIfication Proposal,' poised to activate a fee switch for protocol revenue and burn 100 million UNI tokens, a move many believe will significantly enhance token value and create a deflationary ecosystem.

Bankr is an advanced AI agent focused on simplifying the process of buying and selling digital assets. Bankr was the first AI agent on Farcaster to help you quickly buy all your favorites coins directly in the social. BankrCoin is the official coin of the agent and was deployed by Bankr itself directly in the Farcaster social feed. Fees from swaps go to support BankrCoin. Bankr is available on Farcaster and will soon be launching a private terminal, token recs, and limit orders on Base.

BankrCoin

BNKR CRYPTO is trending with high volatility and divided community sentiment as it navigates broader crypto market pullbacks. Its association with the "AI Agent tokens on Base" narrative, ongoing ecosystem developments, and strong holder growth are fueling bullish discussions, while others caution about its "pump and dump" nature.

Ripple is the catchall name for the cryptocurrency platform, the transactional protocol for which is actually XRP, in the same fashion as Ethereum is the name for the platform that facilitates trades in Ether. Like other cryptocurrencies, Ripple is built atop the idea of a distributed ledger network which requires various parties to participate in validating transactions, rather than any singular centralized authority. That facilitates transactions all over the world, and transfer fees are far cheaper than the likes of bitcoin. Unlike other cryptocurrencies, XRP transfers are effectively immediate, requiring no typical confirmation time.  Ripple was originally founded by a single company, Ripple Labs, and continues to be backed by it, rather than the larger network of developers that continue bitcoin’s development. It also doesn’t have a fluctuating amount of its currency in existence. Where bitcoin has a continually growing pool with an eventual maximum, and Ethereum theoretically has no limit, Ripple was created with all of its 100 billion XRP tokens right out of the gate. That number is maintained with no mining and most of the tokens are owned and held by Ripple Labs itself — around 60 billion at the latest count.  Even at the recently reduced value of around half a dollar per XRP, that means Ripple Labs is currently sitting on around $20 billion worth of the cryptocurrency (note: Ripple’s price crashed hard recently, and may be worth far less than $60 billion by time you read this). It holds 55 billion XRP in an escrow account, which allows it to sell up to a billion per month if it so chooses in order to fund new projects and acquisitions. Selling such an amount would likely have a drastic effect on the cryptocurrency’s value, and isn’t something Ripple Labs plans to do anytime soon.  In actuality, Ripple Labs is looking to leverage the technology behind XRP to allow for faster banking transactions around the world. While Bitcoin and other cryptocurrencies are built on the idea of separating financial transactions from the financial organizations of traditional currencies, Ripple is almost the opposite in every sense.  XRP by Ripple price can be found on this page alongside the market capitalization and additional stats.

Ripple

XRP is trending amid a significant crypto market downturn, fueled by expectations of impending regulatory clarity for digital assets and intense community debate over its centralization and the impact of Ripple's monthly token unlocks. Many investors are grappling with sharp price declines, with bears predicting further collapse, while staunch bulls view the current volatility as a strategic 'shakeout' by larger players and a prime opportunity to accumulate for future institutional adoption.

Reactive Network is the first parallelized interoperability execution layer, utilising a new form of smart contract we call reactive smart contracts.   Reactive smart contracts are able to react to on-chain events autonomously and execute their own user defined logic to initiate new transactions. This allows a virtually limitless number of use cases to achieve fully decentralized on-chain automation.

Reactive Network

Reactive Network ($REACT) is currently trending as the crypto community buzzes about its foundational utility in Web3 automation, underscored by its integration with Ethereum's EIL testnet and strategic partnerships for AI-driven DeFi and Real-World Asset execution. With its token migration nearing completion and new exchange listings on the horizon, many view it as a severely undervalued 'hidden gem' with significant growth potential.

Terra is a decentralized financial payment network that rebuilds the traditional payment stack on the blockchain. Luna is the reserve currency of the Terra platform. It has three core functions: i) mine Terra transactions through staking, ii) ensure the price stability of Terra stablecoins and iii) provide incentives for the platform’s blockchain validators.

Terra Luna Classic

Terra Luna Classic is trending due to renewed community focus on significant LUNC burns by Binance and the recent sentencing of Do Kwon, fueling discussions about its potential resurgence as a community-driven project with ongoing ecosystem development.

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Janux Therapeutics, Inc. (NASDAQ:JANX) Given Consensus Rating of "Moderate Buy" by Brokerages

Shares of Janux Therapeutics, Inc. (NASDAQ:JANX - Get Free Report) have received a consensus recommendation of "Moderate Buy" from the fifteen research firms that are currently covering the stock...

Janux Therapeutics (NASDAQ:JANX) Shares Gap Down - Should You Sell?

Janux Therapeutics (NASDAQ:JANX) Shares Gap Down - Here's Why...

Janux Therapeutics Appoints William Go, M.D., Ph.D., as Chief Medical Officer

Janux Therapeutics, Inc., a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies based on its proprietary Tumor Activated T Cell Engager (TRACTr), Tumor...

JANX Enters Global Oncology Collaboration With BMY, Stock Rises

Janux Therapeutics struck a global licensing deal for its tumor-activated platforms, sending shares higher and expanding its reach in solid tumors.

Janux Therapeutics (NASDAQ:JANX) Sees Strong Trading Volume - Here's Why

Janux Therapeutics (NASDAQ:JANX) Sees Unusually-High Trading Volume - Still a Buy...

Janux Therapeutics Strikes Bristol Myers Biotech Deal Worth $800 Million

Janux Therapeutics signs a global licensing deal with Bristol Myers Squibb worth up to $800 million.read more...

<ul class="summary-bullets"><li>Under the agreement, Janux will manage preclinical development through IND submission.</li><li>Bristol Myers Squibb will hold the IND, oversee subsequent clinical development, and lead global commercialization efforts.</li><li>The deal provides Janux with up to $50 million in upfront and near-term milestone payments.</li></ul>Janux Therapeutics, Inc. (JANX) announced on Thursday that it has entered a strategic collaboration with Bristol Myers Squibb to advance the development of a new tumor-activated therapy.&nbsp;The partnership focuses on a yet-to-be-disclosed solid tumor target expressed across multiple cancer types, aiming to expand treatment options for patients worldwide.<h2 class="st-heading-2">Collaboration Details</h2>Under the agreement, Janux will manage preclinical development through IND submission, whileBristol Myers Squibb will hold the IND, oversee subsequent clinical development, and lead global commercialization efforts.&nbsp;The collaboration ensures Janux remains actively engaged, supporting the completion of the first Phase 1 clinical study alongside Bristol Myers Squibb.<blockquote>“This collaboration marks a significant milestone for Janux, validating the strength of our tumor-activated platforms and expanding our reach in solid tumor oncology.”&nbsp;- David Campbell, President and CEO, Janux</blockquote>Following the announcement,&nbsp;<a href="https://stocktwits.com/symbol/JANX">Janux Therapeutics’ stock</a> traded over 8% higher in Thursday’s premarket.&nbsp;On Stocktwits, retail sentiment around the stock jumped to ‘bullish’ from ‘bearish’ territory the previous day. Message volume shifted to ‘high’ from ‘low’ levels in 24 hours.&nbsp;<h2 class="st-heading-2">Financial Terms</h2>The deal provides Janux with up to $50 million in upfront and near-term milestone payments. Additional development, regulatory, and commercial milestones could total roughly $800 million. Additionally, Janux will receive tiered royalties on worldwide product sales, giving the company potential long-term revenue streams if the therapy succeeds.This tie-up will use Janux’s proprietary technologies, including its Tumor Activated T Cell Engager (TRACTr), Tumor Activated Immunomodulator (TRACIr), and Adaptive Immune Response Modulator (ARM) platforms. These platforms are designed to enhance the immune system targeting of tumors while minimizing off-target effects.Also See:&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/netflix-warner-bros-deal-paramount-seeks-wbd-shareholder-suppot/cmUzzULR4QC">Netflix-Warner Bros. Deal: Paramount Seeks WBD Shareholder Support To Counter Amended NFLX Transaction, Extends Tender Offer</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

 A staff member of the Baden-Württemberg State Health Authority is pipetting corona samples during an experiment.

Janux Stock Is Rising Pre-Market After A New Oncology Deal With Bristol Myers Squibb

The company, along with Bristol Myers Squibb, will develop a new tumor-activated therapy.

Equity

The company, along with Bristol Myers Squibb, will develop a new tumor-activated therapy.


Janux Therapeutics Announces Collaboration and Exclusive Worldwide License Agreement with Bristol Myers Squibb to Develop a Novel Tumor-Activated Therapeutic for Solid Tumors

Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technologies to its Tumor...

Clear Str Downgrades Janux Therapeutics (NASDAQ:JANX) to Hold

Clear Str cut shares of Janux Therapeutics from a "strong-buy" rating to a "hold" rating in a research note on Tuesday...

Janux Therapeutics (NASDAQ:JANX) Reaches New 1-Year Low - What's Next?

Janux Therapeutics (NASDAQ:JANX) Hits New 1-Year Low - Here's Why...

Janux Therapeutics, Inc. operates a preclinical stage biopharmaceutical company which engages in developing therapeutics based on the Tumor Activated T Cell Engager platform technology. The company was founded by David Campbell in June 2017 and is headquartered in San Diego, CA.

Fiscal Period	Estimated	Reported	Surprise	Result
Q4 '25	-$0.62	--	--	N/A
Q3 '25	-$0.61	-$0.39	36.32%	BEAT
Q2 '25	-$0.46	-$0.55	-20.76%	MISSED
Q1 '25	-$0.37	-$0.38	-2.91%	MISSED
Q4 '24	-$0.46	-$0.36	21.85%	BEAT

JANX
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