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Karyopharm Therapeutics, Inc. is a commercial-stage pharmaceutical company, which engages in the discovery, development, and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. The company was founded by Joseph Araujo, Ronald A. DePinho, Pamela A, Silver, Giulio Draetta, Michael G. Kauffman, and Sharon Shacham on December 22, 2008, and is headquartered in Newton, MA.

Karyopharm Therapeutics Inc

KPTI is trending due to concerns around the company's leadership and financial management. Community discussions focus on the performance of the CEO, potential mismanagement, and the need for strategic changes. Upcoming phase 3 results are a key factor for the company's future, amid discussions about its cash runway and potential need for further financing.

Caesars Entertainment, Inc. engages in the management of casinos and resorts under the Caesars, Harrah's, Horseshoe, and Eldorado brands. It operates through the following segments: Las Vegas, Regional, Caesars Digital, Managed and Branded, and Corporate and Other. The company was founded in 1937 and is headquartered in Reno, NV.

Caesars Entertainment Inc

CZR is trending as investors digest recent earnings results and debate the company's future prospects, particularly its debt load and growth strategy in a competitive market. Community discussions revolve around the impact of tariffs, potential for a recession, and the attractiveness of the stock's valuation relative to its digital assets and real estate. Some traders are closely watching for a potential bottom and possible actions from activist investors like Carl Icahn.

Zevra Therapeutics, Inc. is a commercial-stage rare disease company that combines science, data and patient needs to create therapies for diseases with limited or no treatment options. The firm focuses on the treatment of rare neurological and sleep conditions such as certain Urea Cycle Disorders, Niemann Pick Disease Type C and Idiopathic Hypersomnia. The company receives royalties for AZSTARYS from its commercial partner Corium. The company was founded by Christal M. M. Mickle and Travis C. Mickle on October 30, 2006 and is headquartered in Celebration, FL.

Zevra Therapeutics Inc

ZVRA is trending as rumors of potential acquisition swirl, with the community buzzing about a potential buyout after reports of a failed financing attempt from a smaller company.  Enthusiasm is building for the upcoming earnings report and the potential for a positive outcome, while some investors express skepticism toward management. Bullish sentiment is further fueled by high short interest, leading to speculation about a possible short squeeze.

Internet Computer (IC) is the world’s first blockchain that is capable of running at web speed at unrestrictive capacities. Built by the DFINITY Foundation, IC aims to recreate the web by supporting smart contract development at scale and changing the way people can interact using web services. Internet Computer aims to extend the public internet, so that it can be the world’s computing platform, in a decentralized manner. Internet Computer sets to revolutionalize the design of the crypto economy, with an aim to overhaul traditional software services.   The project was founded in October 2016 by Dominic WIllams and have raised a total of $121 million from investors such as Adreessen Horowitz, Polychain Capital, Multicoin Capital and such. On May 10, 2021, DFINITY launched the Internet Computer into the public domain, marking it a major milestone for ICP as it means the internet now functions as a decentralised global computer. This is marked by the release of all of the Internet Computer’s source code into the public domain, as well as ICP utility token that allows tens of thousands of community members to govern the Internet Computer network.  ICP is Internet Computer's native token. It plays three prominent roles:  1. Network Governance: Users that participate in the governance will be rewarded with ICPI 2. Production of Cycles for Compute: ICP can be converted into cycles where it is used as the transaction fee to access the network. Cycles are burned after used. 3. Rewarding Users: ICP is used as the rewards to incentivize users to participate in the network such as securing the network.

Internet Computer

Internet Computer (ICP) is trending amidst discussions about its underlying technology and potential for growth, with some community members highlighting its long-term vision to decentralize the internet and challenge established cloud providers. Bullish sentiment centers on its strong technology, recent launch of Caffeine AI, and staking rewards, while bears cite concerns about its historical performance, tokenomics, and adoption rates. Speculation about increased volume, potential partnerships, and integration of Bitcoin DeFi are also circulating within the community.

Hertz Global Holdings, Inc. engages in the vehicle rental business through the Hertz, Dollar, and Thrifty brands. It operates under the Americas Rental Car (RAC) and International Rental Car (RAC) segments. The Americas RAC segment focuses on operations in the United States, Canada, Latin America, and the Caribbean. The International RAC segment includes the provision of rental and sales of vehicles and value-added services in other locations. The company was founded in 1918 and is headquartered in Estero, FL.

Hertz Global Holdings Inc. - Ordinary Shares (New)

HTZ is trending due to a partnership with Amazon to sell used cars online, sparking discussions about its potential to challenge competitors like Carvana and boost retail visibility. The community is analyzing the potential for a short squeeze, fueled by high short interest and Ackman's involvement, while also considering the company's debt and upcoming earnings.

Altria Group, Inc. is a holding company, which engages in the manufacture and sale of cigarettes in the United States. It operates through the following segments: Smokeable Products, Oral Tobacco Products, and All Other. The Smokeable Products segment consists of cigarettes manufactured and sold by PM USA, and machine-made large cigars and pipe tobacco manufactured and sold by Middleton. The Oral Tobacco Products segment includes MST and snus products manufactured and sold by USSTC, and oral nicotine pouches manufactured and sold by Helix. The All Other segment refers to the financial results of NJOY, Helix ROW, and the IQOS System heated tobacco business. The company was founded in 1919 and is headquartered in Richmond, VA.

Altria Group Inc.

Altria Group ($MO) is trending as investors weigh its future amid shifting consumer habits and regulatory pressures. The community is discussing the growth potential of its oral tobacco segment, particularly the on! nicotine pouches, and evaluating its valuation relative to peers. Discussions also involve the company's dividend yield and its attractiveness as a defensive stock in a volatile market.

BioMarin Pharmaceutical, Inc. engages in the development and commercialization of therapies for people with serious and life-threatening rare diseases and medical conditions. Its pipeline products include Valoctocogene roxaparvovec, Vosoritide, and BMN 307. The company was founded by John C. Klock, Christopher M. Starr and Grant W. Denison on March 21, 1997, and is headquartered in San Rafael, CA.

Biomarin Pharmaceutical Inc. - Registered Shares

Biomarin Pharmaceutical is trending as traders discuss its deep-value territory and potential for call LEAPS. The community is weighing the risk-reward ratio and catalysts, including potential news or FDA activity, with some focusing on long-term opportunities while others express bearish sentiment due to concerns about momentum and lackluster performance.

Polkadot is a platform that allows diverse blockchains to transfer messages, including value, in a trust-free fashion; sharing their unique features while pooling their security. In brief, Polkadot is a scalable heterogeneous multi-chain technology.  Polkadot is heterogeneous because it is entirely flexible and makes no assumption about the nature or structure of the chains in the network. Even non-blockchain systems or data structures can become parachains if they fulfill a set of criteria.  Polkadot may be considered equivalent to a set of independent chains (e.g. a set containing Ethereum, Ethereum Classic, Namecoin and Bitcoin) except with important additions: pooled security and trust-free interchain transactability.  Many of the native parachains of Polkadot will be written using a Polkadot Runtime Environment SDK (e.g. Parity Technologies' Substrate).

Polkadot

Polkadot (DOT) is trending amid mixed sentiments, with some traders eyeing potential gains from staking and anticipating a broader altcoin rally, while others express frustration with the project's performance and leadership. Discussions include potential catalysts such as ETF approvals and interoperability solutions, alongside debates about its long-term viability and tokenomics. Community members are actively weighing the risks and opportunities surrounding DOT within the current market cycle.

DexCom, Inc. is a medical device company, which engages in the design, development, and commercialization of glucose monitoring systems for ambulatory use by people with diabetes. Its products include Dexcom G6, Dexcom G7, Dexcom Stelo, Dexcom Share, Dexcom Real-Time API, and Dexcom ONE. The company was founded by John F. Burd on May 13, 1999 and is headquartered in San Diego, CA.

Dexcom Inc

DXCM is trending downwards amidst concerns regarding the accuracy and reliability of its G7 continuous glucose monitor, highlighted in a recent short report. The community is discussing the potential impact of these issues on Dexcom's market share and the possibility of a class action lawsuit. Some traders believe the stock is oversold and presents a buying opportunity, while others are wary of negative sentiment and potential for further decline.

Trump For President

The Trump Crypto token is trending amid fluctuating prices, with community members debating its correlation to Bitcoin's movements and speculating on potential upside. Some traders are expressing bullish sentiment, while others cite the token's YTD performance and broader associations with political figures and meme coins. Discussions also include mentions of potential lawsuits, market manipulation, and the token's use in fundraising efforts.

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Shares of Nio, Inc. fell over 2% on Friday, on course to mark the fourth consecutive session of losses.&nbsp;In Hong Kong and Singapore, Nio’s stock dropped nearly 4% earlier in the day, reflecting a broad negative sentiment.&nbsp;The company on Thursday hosted its 2024 year-end media event in Shanghai, but that appears to have failed to impress investors, contributing to the stock’s decline.According to Reuters, during the event, CEO William Li outlined Nio’s strategy to accelerate sales through better efficiency and cost control.&nbsp;He set a target of delivering 20,000 units of the Onvo L60 model by March next year. He also announced plans for the company’s third factory to begin production in the latter half of 2025.&nbsp;Despite these plans, Li acknowledged that the company’s growth of 30-40% over the past three years was unsatisfactory, which raised concerns.Deliveries of Nio’s main brand models have declined sequentially over the last two months, with Onvo growth not fully compensating for the dip in Nio branded vehicles, according to CNEVpost.&nbsp;Li reportedly denied that the Onvo brand was cannibalizing the main brand’s sales, attributing the decline to a reduction in promotions by at least RMB 10,000 ($1,380).In the third quarter, Nio missed both revenue and profit estimates due to weaker demand for its core brand, slower production ramp for Onvo, and rising operating costs.&nbsp;<figure class="image"><img style="aspect-ratio:1318/324;" src="https://st-everywhere-cms-prod.s3.us-east-1.amazonaws.com/NIO_sentiment_and_message_volume_Dec_13_0a8c02c5f8.png" alt="NIO sentiment and message volume Dec 13.png" width="1318" height="324"><figcaption>NIO sentiment and message volume Dec 13 as of 11:45 am ET | source: Stocktwits</figcaption></figure>Retail sentiment has turned more cautious on Stocktwits, to a ‘neutral’ score, as investors continue to digest the company’s struggles and uncertain growth trajectory.Optimists focused on Li’s commentary about delivery targets next year.<stembedurl>https://stocktwits.com/HonestJoe/message/596285856</stembedurl>Some bullish watchers even claimed that investing in the stock at current levels could boost returns tenfold by 2025.<stembedurl>https://stocktwits.com/sivkas/message/596338880</stembedurl>However, skeptics questioned the reliability of the CEO’s statements, arguing that the company has repeatedly failed to live up to promises in the past.<stembedurl>https://stocktwits.com/We__will__see/message/596374819</stembedurl><stembedurl>https://stocktwits.com/ForeverUSA/message/596380405</stembedurl>Shares of Chinese EV makers surged earlier this week after China’s Politburo <a href="https://stocktwits.com/news-articles/markets/5/xpev-nio-li-stocks-surge-after-china-vows-more-stimulus/cJaGDnfRi4">announced</a> plans for “more proactive fiscal policies and moderately loose monetary policies.”&nbsp;They also drew attention last week, reporting record November deliveries, with third-quarter guidance hinting at another record in December.Nio shares have lost more than 46% year-to-date, underscoring investor disappointment.For updates and corrections, email newsroom[at]stocktwits[dot]com.

Li Bin, founder and CEO of NIO, attends the closing ceremony of 2024 China Auto Chongqing Summit on June 8, 2024 in Chongqing, China. (Photo by VCG/VCG via Getty Images)

Nio Stock Drops After Year-End Media Meet Fails To Impress: Retail Turns Cautious

CEO William Li reportedly acknowledged that the company’s growth of 30-40% over the past three years was unsatisfactory, which raised concerns.

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CEO William Li reportedly acknowledged that the company’s growth of 30-40% over the past three years was unsatisfactory, which raised concerns.


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