In the Phase 3 REIMAGINE 5 trial, adults w/ type 2 diabetes taking the 1 mg/ 1 mg dose of CagriSema lost an est’d 12.4% of their body weight after 60 weeks, compared w/ 9.1% for patients receiving 5 mg of tirzepatide, which is the active ingredient in
$LLY Mounjaro & Zepbound. $NVO CariSema delivered non-inferior blood-sugar reduction
For Novo investors, the timing holds significance since CagriSema is one of the company&
#39;s most important next-gen obesity assets, & the FDA is expected to decide on its weight-mgmt application in 4Q25, w/ the company targeting a launch early next year
In the separate Phase 3 REDEFINE 9 study, the same 1 mg/1 mg dose produced est’d weight loss of 21% after 68 weeks in adults w/ overweight or obesity, compared w/ 2.0% for placebo. The drug combines cagrilintide, a long-acting amylin receptor agonist, w/ semaglutide, the GLP-1 ingredient in Wegovy.