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Papa John's International, Inc. engages in the operation and franchise of pizza delivery and carryout restaurants. It operates through the following segments: Domestic Company-owned Restaurants, North America Franchising, North America Commissaries, International Operations, and All Others. The Domestic Company-Owned Restaurants segment consists of retail sales of pizza and side items, breadsticks, cheese sticks, chicken poppers and wings, dessert items, and canned and bottled beverages. The North America Franchising segment involves the offering of sales and support activities, development rights, and collection of royalties from franchisees located in the United States and Canada. The North America Commissaries segment includes the eleven full-service regional dough production and distribution and quality control centers. The International Operations segment represents all restaurant operations outside of the United States and Canada. The All Others segment focuses on franchise contributions to marketing funds and sale, company-owned and franchised restaurants, information systems and related services used in restaurant operations, point-of-sale system, online and other technology-based ordering platforms, printing, and promotional items. The company was founded by John H. Schnatter in 1984 and is headquartered in Louisville, KY.

Papa John`s International, Inc.

Attention is centered on reports that Papa Johns largest U.S. franchisee has joined Irth Capitals effort to take the company private, reviving buyout hopes. Traders see the franchisees involvement as strengthening the proposal, while others remain skeptical that the board will approve a deal or that negotiations will produce a signed transaction.

Amgen, Inc. is a biotechnology company, which engages in the discovery, development, manufacture, and marketing of human therapeutics. The company was founded by William K. Bowes, Jr., Franklin Pitcher Johnson, Jr., George B. Rathmann, and Joseph Rubinfeld on April 8, 1980 and is headquartered in Thousand Oaks, CA.

AMGEN Inc.

Phase 3 results for Amgens IMDELLTRA-plus-IMFINZI combination in extensive-stage small-cell lung cancerreported to reduce the risk of death by 58%are driving discussion, with traders viewing the data as a potential growth opportunity. Some also point to Repathas sales growth as a key business driver and debate whether the lung-cancer program can become a major contributor.

TOSHI

TOSHI is drawing attention around a hoped-for breakout after bursts of volume and a modest rebound, with traders repeatedly watching a stubborn resistance zone and speculating about a short squeeze. Bulls are accumulating and anticipating a run, while skeptics point to repeated rejections, weak price action, and broader crypto-market risk; rumors of listings or an announcement remain unconfirmed.

Palo Alto Networks, is a cybersecurity company that provides cybersecurity platforms and services to enterprises, organizations, service providers, and government entities. Its offerings include network and AI security, cloud security, security operations, and identity security solutions. The company was founded by Nir Zuk in March 2005 and is headquartered in Santa Clara, CA.

Palo Alto Networks Inc

Palo Alto Networks rallied with cybersecurity peers as traders focused on an Evercore ISI survey indicating enterprise security budgets are firming and on escalating vulnerability and AI-driven cyberthreat concerns. The move drew bullish momentum commentary, while some traders questioned whether the sectors gains are justified given lofty valuations.

Celcuity, Inc. operates as a cellular analysis company. The company discovers new cancer sub-types and commercializing diagnostic tests designed to improve the clinical outcomes of cancer patients treated with targeted therapies. The firm's proprietary CELx diagnostic platform is the commercially ready technology that uses a patient's living tumor cells to identify the specific abnormal cellular process driving a patient's cancer and the targeted therapy that treats it. The company was founded by Brian F. Sullivan and Lance G. Laing in January 2012 and is headquartered in Minneapolis, MN.

Celcuity Inc

Updated ESMO subgroup analyses from Celcuitys Phase 3 VIKTORIA-1 breast-cancer study are driving discussion, with traders highlighting favorable efficacy for gedatolisib and the potential for a PIK3CA-mutant label expansion. The reaction is split between enthusiasm for the data and concern that CELC still needs to demonstrate commercial uptake and revenue; some posts also debate whether the share price reflects the clinical results.

iShares Trust - iShares Biotechnology ETF

iShares Biotechnology ETF

A broad biotech-sector pullback is the main focus, with IBB hovering near its 50-day moving average after a strong run. Traders describe the dip as a pause while others remain cautious about sector weakness, and several note that large-cap biotech is holding up better than smaller names.

Cloudflare, Inc. engages in the provision of cloud-based services to secure websites. The firm offers various products for application security, performance and reliability, network services, Zero Trust, developer platform, media delivery, insights, domain registration, and consumer services. It operates through the United States and Rest of the World geographical segments. The company was founded by Matthew Prince, Michelle Zatlyn, and Lee Holloway in July 2009 and is headquartered in San Francisco, CA.

Cloudflare Inc - Ordinary Shares - Class A

Cloudflare Inc

Cloudflare shares are drawing attention after a sharp gain tied to the PHP2Shell web-software vulnerabilities: traders see its web application firewall as a potential beneficiary as site operators seek protection, alongside a broader cybersecurity-stock rally. Some participants are bullish on the security-demand angle, while others focus on the stocks high valuation and trade the move cautiously.

Merck & Co., Inc. is a health care company, which engages in the provision of health solutions through its prescription medicines, vaccines, biologic therapies, animal health, and consumer care products. It operates through the following segments: Pharmaceutical, Animal Health, and Other. The Pharmaceutical segment includes human health pharmaceutical and vaccine products. The Animal Health segment discovers, develops, manufactures, and markets animal health products, such as pharmaceutical and vaccine products, for the prevention, treatment and control of disease in livestock, and companion animal species. The Other segment consists of sales for the non-reportable segments of healthcare services. The company was founded in 1891 and is headquartered in Rahway, NJ.

Merck & Co Inc

Attention centers on Merck and Modernas Phase 3 melanoma-vaccine results: the personalized vaccine combined with Keytruda met trial endpoints, but traders debate whether the benefit and future commercial potential justify expectations, with some viewing the share pullback as a sell the news reaction. The treatment is not yet approved, and its broader use remains uncertain.

BioNTech SE operates as immunotherapy company, which engages therapies for cancer and other serious diseases. Its product pipeline include BNT162b2, BNT161, BNT164, FixVac, iNeST, RiboMabs, CAR-T Cells, TCRs and Next-Gen CP Immunomodulators. The company was founded by Christopher Huber, Oezlem Tuereci, and Ugur Sahin on June 2, 2008 and is headquartered in Mainz, Germany.

BioNTech SE - ADR

Promising lung-cancer trial updates for BioNTechs oncology pipeline, including pumitamig and gotistobart, are drawing attention, with traders highlighting encouraging response and survival data. The reaction is bullish but tempered by questions about how durable the results are and lingering concerns over earlier clinical setbacks and leadership changes.

The GEO Group, Inc. engages in the design, financing, development, and support services for secure facilities, processing centers, and community re-entry facilities. It operates through the following segments: U.S. Secure, Electronic Monitoring and Supervision, Reentry, and International Services. The U.S. Secure Services segment encompasses the United States-based public-private partnership corrections and detention business. The Electronic Monitoring and Supervision Services segment conducts its services in the U.S. The Reentry Services Segment consists of various community-based and reentry services. The International Services segment consists of public-private partnership secure services operations in Australia and South Africa. The company was founded by George C. Zoley in 1984 and is headquartered in Boca Raton, FL.

Geo Group, Inc.

GEOs sale of its Adelanto facilities to DHS and the resulting debt-reduction and buyback flexibility are driving discussion. Traders see the transaction as a balance-sheet positive, while others question the stocks weakness and weigh the benefits against giving up ownership economics; many are looking for clarity on further sales.

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NVNO's Shares Decline on Unfavorable FDA Review Outcome for VenoValve

enVVeno Medical shares plunge after the FDA rejects its VenoValve PMA, citing insufficient trial data and safety concerns tied to the surgical procedure.

This Medical Device Stock Just Plunged A Whopping 71% Today – Do You Own It?

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enVVeno Medical Corporation CEO Robert Berman said that the company will continue to work with the FDA on new criteria to demonstrate the safety and effectiveness of its VenoValve device. 

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enVVeno Medical

enVVeno Medical Corp. is a development stage medical device company, which develops tissue based solutions that are designed to be life sustaining or life enhancing for patients with cardiovascular disease, and peripheral arterial and venous disease. Its products include VenoValve and enVVe. The company was founded by Norman Jaffe on December 22, 1999 and is headquartered in Irvine, CA.

enVVeno Medical Corporation

Neutral Sentiment

Medical device company enVVeno Medical Corporation (NVNO) on Wednesday announced that the U.S. Food &amp; Drug Administration (FDA) has refused to approve its application for its lead product, VenoValve, a surgical replacement venous valve for treating severe deep chronic venous insufficiency (CVI).Following the announcement, NVNO shares plunged 71% by Wednesday afternoon, at the time of writing.Severe deep chronic venous insufficiency (CVI) is a long-term condition where the veins in the legs have difficulty returning blood to the heart, leading to blood pooling and various symptoms like swelling, aching, and skin changes. This occurs primarily due to damaged or weakened valves within the deep leg veins.On Stocktwits, retail sentiment around <a href="https://stocktwits.com/symbol/NVNO">NVNO</a> rose from ‘neutral’ to ‘extremely bullish’ territory over the past 24 hours, while retail chatter rose from ‘low’ to ‘extremely high’ levels.<figure class="image"><img style="aspect-ratio:563/61;" src="https://news.stocktwits-cdn.com/Screenshot_2025_08_20_at_12_41_02_PM_png_bca2208bb7.webp" alt="NVNO's Sentiment Meter and Message Volume as of 12:40 p.m. ET on Aug. 20, 2025 | Source: Stocktwits" width="563" height="61"><figcaption>NVNO's Sentiment Meter and Message Volume as of 12:40 p.m. ET on Aug. 20, 2025 | Source: Stocktwits</figcaption></figure>A Stocktwits user expressed optimism for the company renegotiating with the FDA.<stembedurl>https://stocktwits.com/Flying_Trader2/message/625960642</stembedurl>Another user said that they see no value in the company with the VenoValve rejection.<stembedurl>https://stocktwits.com/kmx_swing/message/625941525</stembedurl>The FDA <a target="_blank" rel="noopener noreferrer nofollow" href="https://envveno.com/envveno-receives-not-approvable-letter-from-the-fda-for-the-venovalve/">said</a> in a letter that it completed its review of the company’s application for VenoValve but has decided that it is unable to approve it in its current form. The agency said that data generated by the company for the application was not sufficient on its own to determine the favorability of the benefit-risk profile for VenoValve.The FDA also raised concerns about bias and the possibility that clinical improvement occurred as a result of the patients being enrolled in a study. The agency further raised safety concerns, which were attributed to the VenoValve open surgical procedure, and which required re-hospitalizations.CEO Robert Berman said that the company is disappointed by the FDA’s decision and highlighted that a high percentage of patients in a study showed significant clinical improvement after receiving VenoValve. Berman added that the company will continue to work with the FDA on new criteria to demonstrate the safety and effectiveness of the device.The firm’s next steps may include a meeting with the FDA to discuss requirements for a potential resubmission of the VenoValve or appeal of the decision, along with appropriate next steps.NVNO stock is down by 59% this year and by about 77% over the past 12 months.&nbsp;Read also: <a href="https://stocktwits.com/news-articles/markets/equity/elon-musk-says-tesla-model-yl-might-not-ever-come-to-us-markets/chsitLlRdhq">Elon Musk Said Tesla’s Model Y L Might Not Ever Come To US Markets – Here’s Why</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

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What do you think the S&amp;P 500&#39;s ($SPY) return will be next week?

Current Price	$6.65
Prev Close	$6.91
Open	$6.72
Dividend Yield	0.00%
50-Day Moving Average	$9.37
Beta	1.51
Avg. Volume	28,867.69
PE Ratio	-0.27

52-Week High	$26.25
52-Week Low	$6.55
Market Capitalization	$4.62M
EPS (Annual)	-$33.06
Price to Book	0.22
Revenue Per Employee	$0.00

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