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Bitcoin is the world's first decentralized cryptocurrency, created in 2009 by the pseudonymous Satoshi Nakamoto. It enables peer-to-peer electronic cash transactions without intermediaries like banks or governments, operating on a blockchain secured by Proof of Work mining and the SHA-256 cryptographic algorithm.   With a fixed supply cap of 21 million coins and programmatic halvings every four years that reduce miner rewards, Bitcoin is designed as a deflationary digital asset often called "digital gold." Its value stems from solving the double-spending problem without trusted intermediaries, creating the first truly scarce digital asset with censorship resistance and permissionless access that no government, corporation, or individual can control.  Bitcoin operates as a decentralized peer-to-peer network where transactions are recorded on a public ledger called the blockchain, distributed across thousands of computers globally. Transactions are grouped into blocks added approximately every 10 minutes through mining, where specialized computers compete to solve complex mathematical puzzles.   Bitcoin has achieved mainstream adoption through multiple vectors. The January 2024 SEC approval of 11 spot Bitcoin ETFs opened Bitcoin investment to traditional finance participants, and corporations like Strategy (formerly MicroStrategy) are using Bitcoin as a treasury reserve asset to protect against currency debasement, offering MSTR holders amplified exposure to Bitcoin.   The Bitcoin ecosystem continues to evolve with innovations like Ordinals, which emerged in January 2023 to enable NFT-like functionality directly on Bitcoin, and BRC-20 tokens, an experimental standard for creating fungible tokens using Ordinal inscriptions. BTCFi (Bitcoin Finance) represents emerging financial applications extending beyond Bitcoin's traditional role, with protocols like Babylon allowing Bitcoin holders to stake BTC to secure Proof of Stake chains.

Bitcoin

Bitcoin is experiencing heightened volatility and bullish momentum as community members discuss a massive wave of short liquidations and the potential for a breakout above psychological resistance levels. The conversation remains heavily focused on institutional accumulation strategies and shifting macro sentiment, with many traders closely watching for sustained support to confirm a path toward future highs.

GameStop Corp. engages in offering games and entertainment products through its ecommerce properties and stores. The firm’s stores and ecommerce sites operate primarily under the names GameStop, EB Games, and Micromania. It operates through the following geographical segments: United States, Canada, Australia, and Europe. The company was founded by Daniel A. DeMatteo in 1996 and is headquartered in Grapevine, TX.

Gamestop Corporation - Ordinary Shares - Class A

GameStop Corp

GameStop is trending following reports that the company has initiated an unsolicited bid to acquire eBay, sparking intense debate among investors over the feasibility of a deal that would involve significant financing and share dilution. The community remains deeply divided, with bulls eyeing a potential short squeeze and long-term transformation, while bears warn of the massive debt burden and the risks of a whimsical strategic pivot.

SoundHound AI, Inc. engages in the development, owning, and commercialization of voice, sound, and natural language artificial intelligence technologies and related activities. The company was founded on September 2, 2005 and is headquartered in Santa Clara, CA.

SoundHound AI Inc - Ordinary Shares - Class A

SoundHound AI Inc

SoundHound AI is experiencing significant market interest and bullish sentiment as investors position for a potential short squeeze ahead of upcoming earnings. The community is actively discussing the stock's high short interest and heavy institutional buying, with many traders viewing the current price action as a setup for a major breakout.

Ethereum is a global, open-source platform for decentralized applications. In other words, it is a decentralized blockchain platform that enables developers to build and deploy smart contracts and applications without central authority control. Unlike Bitcoin, which primarily functions as digital currency, Ethereum operates as a programmable global computer where developers can create any type of decentralized service.   The platform hosts over $14 billion in DeFi applications with hundreds of thousands of active users across financial protocols, NFT marketplaces, and gaming platforms. Its transition to Proof of Stake in September 2022 reduced energy consumption by over 99%, addressing environmental concerns while strengthening network security.  The network operates through thousands of independent validator nodes that process transactions and execute smart contracts on the Ethereum Virtual Machine. Smart contracts are self-executing programs written in Solidity that automatically carry out agreements when conditions are met, eliminating intermediaries like banks or brokers.   Validators stake ETH as collateral to propose and validate blocks, earning rewards for honest participation while facing penalties for malicious behavior. The EIP-1559 upgrade introduced a dynamic base fee mechanism that burns ETH with each transaction, creating deflationary pressure during high network activity when more ETH is burned than issued to validators.  Vitalik Buterin proposed Ethereum in 2013, but seven co-founders helped build it, including Gavin Wood who created Solidity and the EVM technical specification, and Joseph Lubin who founded ConsenSys. The project launched in July 2015 after raising over $18 million through crowdfunding, quickly becoming the largest blockchain developer community. Major milestones include the 2020 Beacon Chain launch, the 2021 London hard fork implementing fee burning, and the 2022 Merge to Proof of Stake.   Ether (ETH) serves multiple functions: paying transaction fees (gas), staking to secure the network and earn 3-5% annual yields, serving as collateral in DeFi protocols, and purchasing NFTs and digital assets. The asset is increasingly adopted by traditional institutions, with publicly traded companies adding ETH to corporate treasuries to generate staking yields while maintaining blockchain exposure, and in 2024, the SEC approved spot Ethereum ETFs, allowing traditional investors to gain exposure through conventional brokerage accounts.  Ethereum's roadmap focuses on dramatically increasing transaction capacity to over 100,000 per second, reducing confirmation times, and enhancing decentralization while maintaining security against future threats like quantum computing.

Ethereum

Ethereum is currently a focal point for investors as it grapples with market volatility and ongoing debate regarding the upcoming Clarity Act, which many believe could serve as a catalyst for institutional adoption and price movement. Community sentiment is deeply divided, with many traders closely monitoring support levels and reacting to broader macroeconomic indicators like interest rate expectations and energy costs.

Sandisk Corp. engages in the development, manufacture, and provision of storage devices and solutions based on NAND flash technology. Its products include solid state drives, memory cards, and USB flash drives. The company was founded on February 5, 2024 and is headquartered in Milpitas, CA.

Sandisk Corp

Sandisk (SNDK) is experiencing a historic surge fueled by an extreme, AI-driven shortage of NAND flash memory and high-performance SSDs, with investors betting on long-term contracts to sustain growth. While bullish sentiment is bolstered by massive analyst target hikes and a significant share buyback program, the community remains intensely divided between those anticipating a continued parabolic run and others warning of a potential bubble-like pullback.

eBay, Inc. is a commerce company, whose platforms include an online marketplace and its localized counterparts, including off-platform businesses in South Korea, Japan, and Turkey, as well as eBay’s suite of mobile apps. It offers a platform for various product categories, including parts and accessories, collectibles, fashion, electronics, and home & garden. eBay generates revenue mainly through fees from sales, payment processing, and advertising. The company was founded by Pierre Morad Omidyar in September 1995 and is headquartered in San Jose, CA.

EBay Inc.

eBay Inc

eBay shares are trending following a high-profile, unsolicited acquisition offer from GameStop that has sparked intense debate among retail traders regarding the deal's viability and potential dilution. While some community members are highlighting the strategic potential for a combined retail and e-commerce giant, others are expressing significant skepticism about the financing and the fundamental logic behind the proposal.

Ethereum Classic

Ethereum Classic is seeing increased community engagement as traders speculate on its potential for a breakout, driven by discussions around its proof-of-work utility and its historical correlation with other altcoins. Despite frustration over long-term price stagnation, investors are actively debating accumulation strategies while monitoring broader market momentum for signs of a reversal.

Applied Optoelectronics, Inc. engages in the design and manufacture of optical communications products. Its products include optical devices, such as laser diodes, photodiodes, related modules and circuitry, and equipment for applications in fiber-to-the-home, cable television, point to point communications, and wireless. The company was founded by Chih Hsiang Lin on February 28, 1997 and is headquartered in Sugar Land, TX.

Applied Optoelectronics Inc

Applied Optoelectronics is experiencing intense investor interest driven by a massive data center infrastructure super-cycle, with community discussion centering on its critical role in supplying 800G and 1.6T optical transceivers to major hyperscalers. While bulls are excited by the company's aggressive expansion and recent grant-backed manufacturing growth, many market participants are actively debating whether the stock's parabolic climb reflects legitimate fundamental growth or unsustainable speculative exuberance.

Solana is a high-performance Layer 1 blockchain designed for mass adoption by providing a fast, secure, and low-cost environment for decentralized applications. It distinguishes itself by scaling globally without the use of complex sharding or multiple layers, instead maintaining a single, unified ledger to avoid liquidity fragmentation. This architecture allows it to process thousands of transactions per second with sub-second finality, often at a cost of less than a penny per transaction.  The network operates on a unique hybrid model that combines Proof of Stake with an innovation called Proof of History, which functions as a decentralized clock to timestamp transactions. This system reduces the need for constant node communication, allowing the Sealevel engine to run non-conflicting smart contracts in parallel across multiple CPU cores. Further efficiency is gained through the Gulf Stream protocol, which reduces confirmation times by forwarding transactions to validators before the current block is finished.  Founded in 2017 by Anatoly Yakovenko, Solana is now supported by the Switzerland-based Solana Foundation and significant institutional investors like Andreessen Horowitz and Polychain Capital. The platform’s native token, SOL, serves as the primary currency for paying transaction fees, participating in network governance, and securing the system through staking.   Solana has also seen significant institutional adoption ranging from spot Solana ETFs to major partnerships including Visa's 2025 launch of USDC settlement on the network and the tokenization of public equity by firms like Galaxy Digital.

Solana

Solana is generating significant community engagement and buzz as retail traders discuss its potential for a bullish breakout, with many highlighting its role as a core asset alongside Bitcoin. The community is actively debating staking strategies, long-term holding prospects, and comparing the network's performance to broader market trends while monitoring various emerging projects within the ecosystem.

Direxion Shares ETF Trust - Direxion Daily S&P Biotech Bull 3X ETF

Direxion Daily S&P Biotech Bull 3X Shares

LABU is trending as biotech stocks ride a wave of M&A activity and positive momentum from the XBI index's recent breakout. Community discourse is heavily focused on whether the sector's current parabolic rally can sustain its highs or if a technical retracement is imminent.

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 Hey, I want to invite you to join Stocktwits. It’s the largest global community of active traders. You’ll get access to the real-time market insights, news, discussion and much more! You can sign up using my unique link below 
 


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$SLS Just a reminder that there are 99.99% chances of success for REGAL.  Failure is a statistical impossibility. 
 
For context, before the mixed-cure model, I built several different models.  I&#39;ve attached the convergence and divergence between 6 models, that all lead to the same/similar result during the trial duration.  
 
Pure Cure: S(t) = p + (1-p)·exp(-λt) 67.9% cured forever  
Leaky Cure: &quot;cured&quot; patients relapse at 1-10% per year  
Weibull: S(t) = exp(-(t/η)^β) decelerating hazard, no plateau  
Log-Normal: heavy right tail, no true cure  
Piecewise Exponential: fast early decline, slow late decline  
 
The straight HR when BAT = 11.5m across all, 0.179–0.186. P(success) = 100% for every one (stratified topline HR will be higher of course, but in the 0.31-.50 range, 99.99% chances) 
 
The only reason model choice does matter is for long term predictions.  But they all agree on what happens within the trial&#39;s observation window, which is all the HR needs.  
 
Fortunes will be made with sizeable positions.

Chris

Jeff Freedman

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Roger Rabbit $5,56

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_level_m_

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$SLS Three top ML models for Regal, which probably also uses &#39;yG19&#39;.) Gemini) =

&#39;​1. DeepSurv (Deep Cox Proportional Hazards)

​What it is: A state-of-the-art deep learning model specifically designed for survival analysis.

​Why it&#39;s best for REGAL: It excels at modeling non-linear relationships between patient data and survival time. Unlike traditional stats, it can &quot;learn&quot; complex immune system responses to GPS, making it the most accurate tool for predicting when the final 8 events will occur.

​2. Cure-Fraction Model (Mixture Model)

​What it is: A specialized model that assumes a portion of the treated group might be &quot;functionally cured&quot; (the survival curve reaches a permanent plateau).

​Why it&#39;s best for REGAL: Current data (72 events/126 patients) shows a significant &quot;event deceleration.&quot; This model is the only mathematical way to explain why so many patients are still alive after 5 years, suggesting a high cure rate for GPS.

​3. Bayesian Monte Carlo Simulation

...

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Ehrenhardt

$SLS 80TH REGAL P3 WILL HAPPEN. AND WHEN FAILURE IS A STATISTICAL IMPOSSIBILITY - THE ONLY QUESTION IS HOW MUCH $40B

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Duncan Teo

$SLS A Question... Remember I&#39;m A Nail Bender🤣 
SLS Has To Know If Things Are Going Well By Simply Continuing Demand For The Drug . Right ?

StockTwits Web

nick

$SLS anyone else trying to learn science overnight so they aren&#39;t left out? Finals week all over again. Maybe I&#39;ll just stick to the chart and trust the science bros.

GalacticCognitionShip

Partal

$SLS Reminder for all people, we cannot fail

Morten Skov Schiellerup

$SLS Thank you very much and congratulations for your dedication and expertise. &lt;3

EasyLode

Jesse101

The_Horologist

$SLS 🎯🎯🎯 I said it around 2 weeks ago!!! The longer event 80 takes to achieve the more blockbuster this ticker is!!! 😎😎😎

Ferdinand Baudet

Stephen Rustom

$SLS it’s a lock folks. This is a money printing machine. Just hold

Sarah

$SLS This is why I full ported and am up over $400K since last year, it’s free money 😆

SELLAS Life Sciences Group Inc

 Just a reminder that there are 99.99% chances of success for REGAL.  Failure is a statistical impossibility. 
 
For context, before the mixed-cure model, I built several different models.  I've attached the convergence and divergence between 6 models, that all lead to the same/similar result during the trial duration.  
 
Pure Cure: S(t) = p + (1-p)·exp(-λt) 67.9% cured forever  
Leaky Cure: "cured" patients relapse at 1-10% per year  
Weibull: S(t) = exp(-(t/η)^β) decelerating hazard, no plateau  
Log-Normal: heavy right tail, no true cure  
Piecewise Exponential: fast early decline, slow late decline  
 
The straight HR when BAT = 11.5m across all, 0.179–0.186. P(success) = 100% for every one (stratified topline HR will be higher of course, but in the 0.31-.50 range, 99.99% chances) 
 
The only reason model choice does matter is for long term predictions.  But they all agree on what happens within the trial's observation window, which is all the HR needs.  
 
Fortunes will be made with sizeable positions.

Corsair Gaming Inc

@yG19  I love the analysis and have been running some of my own. Do you have any recently published evidence that gives a strong insight into the BAT’s median OS so that I can get better statistical certainty for the parameters I am setting for BAT OS rates that are driven by stronger real world data. Happy to DM if it’s preferred

Kat Tastrophe

Tristan Davis

Mr Bob

NuoriHarrastelija

  I love the analysis and have been running some of my own. Do you have any recently published evidence that gives a strong insight into the BAT’s median OS so that I can get better statistical certainty for the parameters I am setting for BAT OS rates that are driven by stronger real world data. Happy to DM if it’s preferred

Venus Concept Inc

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Brett Thomas

@yG19 I’m all in!
I went from 7000 to 80,000 shares in 2 weeks.  Now I can sleep well knowing every passing day without an 80th event, drops that HR number even more making the BO war even more extreme!!!

I_Buy_Stock

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 I’m all in!
I went from 7000 to 80,000 shares in 2 weeks.  Now I can sleep well knowing every passing day without an 80th event, drops that HR number even more making the BO war even more extreme!!!

Altimmune Inc

Ricko4

@Bladetrader4965 Thank you, and certainly, if you look at the October 29th R&amp;D call, Dr. Jamy goes over this in detail.  In the Part 2 of the DD I shared, I have 7 sources as well for AML CR2 (not eligible for transplant) 
 
The biological cap from study after study is 6 to 10 (assume 6 to 12), or 8 to 10 (up to 12) 
 
In the Part 1 and Part 2 DD I shared, the machine learning models tested all the way up to 23 for BAT mOS. 
 
BAT mOS would have to be above 18 for the trial to fail, which is impossible. 
 
https://www.reddit.com/r/TheRaceTo10Million/comments/1repf0k/sls_part_2_and_final_deepest_due_diligence_for/

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$SLS Part 2 and FINAL (Deepest Due Diligence for REGAL Trial) (From a Deep Value Investor) (Predicting BAT mOS from Predictive Model)

 Thank you, and certainly, if you look at the October 29th R&D call, Dr. Jamy goes over this in detail.  In the Part 2 of the DD I shared, I have 7 sources as well for AML CR2 (not eligible for transplant) 
 
The biological cap from study after study is 6 to 10 (assume 6 to 12), or 8 to 10 (up to 12) 
 
In the Part 1 and Part 2 DD I shared, the machine learning models tested all the way up to 23 for BAT mOS. 
 
BAT mOS would have to be above 18 for the trial to fail, which is impossible. 
 


Keith Thompson

Nobody

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CMSP

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Gilead Sciences, Inc.

Merck & Co Inc

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Abbvie Inc

Forty Seven, Inc.

Revolution Medicines Inc

Abivax - ADR

5,500% ROI this quarter

@yG19 please send this to Dr. Fleming.. Great stuff.

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 please send this to Dr. Fleming.. Great stuff.

Capricor Therapeutics Inc

Cingulate Inc

SeaStar Medical Holding Corp

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Joby Aviation Inc

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Peter Chester

@YosemiteSam7 REGAL is the Phase 3 Trial for GPS, in AML CR2 (not eligible for transplant).  It is extending lives by 3x to 4x, along with creating a cure fraction/extremely long survival tail/&quot;cure&quot; 
 
On reddit, I posted a Part 1 and Part 2 DD (due diligence).  If you google it, you should come across it.  Read through that and the comments/Q&amp;A and it will be very helpful and insightful. 
 
Upside from $5 a share is 5.5X to 32X

Alan

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awesome sauce

 REGAL is the Phase 3 Trial for GPS, in AML CR2 (not eligible for transplant).  It is extending lives by 3x to 4x, along with creating a cure fraction/extremely long survival tail/"cure" 
 
On reddit, I posted a Part 1 and Part 2 DD (due diligence).  If you google it, you should come across it.  Read through that and the comments/Q&A and it will be very helpful and insightful. 
 
Upside from $5 a share is 5.5X to 32X

Callen

@yG19 wow, any of these models far outpaces the 21 month mOS seen in p2. Is this due to unlimited GPS dosing and healthier trial population compared to p2? Or do you have other explanations?

 wow, any of these models far outpaces the 21 month mOS seen in p2. Is this due to unlimited GPS dosing and healthier trial population compared to p2? Or do you have other explanations?