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Bitcoin is the world's first decentralized cryptocurrency, created in 2009 by the pseudonymous Satoshi Nakamoto. It enables peer-to-peer electronic cash transactions without intermediaries like banks or governments, operating on a blockchain secured by Proof of Work mining and the SHA-256 cryptographic algorithm.   With a fixed supply cap of 21 million coins and programmatic halvings every four years that reduce miner rewards, Bitcoin is designed as a deflationary digital asset often called "digital gold." Its value stems from solving the double-spending problem without trusted intermediaries, creating the first truly scarce digital asset with censorship resistance and permissionless access that no government, corporation, or individual can control.  Bitcoin operates as a decentralized peer-to-peer network where transactions are recorded on a public ledger called the blockchain, distributed across thousands of computers globally. Transactions are grouped into blocks added approximately every 10 minutes through mining, where specialized computers compete to solve complex mathematical puzzles.   Bitcoin has achieved mainstream adoption through multiple vectors. The January 2024 SEC approval of 11 spot Bitcoin ETFs opened Bitcoin investment to traditional finance participants, and corporations like Strategy (formerly MicroStrategy) are using Bitcoin as a treasury reserve asset to protect against currency debasement, offering MSTR holders amplified exposure to Bitcoin.   The Bitcoin ecosystem continues to evolve with innovations like Ordinals, which emerged in January 2023 to enable NFT-like functionality directly on Bitcoin, and BRC-20 tokens, an experimental standard for creating fungible tokens using Ordinal inscriptions. BTCFi (Bitcoin Finance) represents emerging financial applications extending beyond Bitcoin's traditional role, with protocols like Babylon allowing Bitcoin holders to stake BTC to secure Proof of Stake chains.

Bitcoin

Bitcoin's recent drop below a key psychological level, fueled by continued ETF outflows and concerns over major institutional holdings like MicroStrategy, has polarized the community between extreme bearishness and conviction in a cyclical buying opportunity, amplified by controversial "pedo coin" narratives.

Ripple is the catchall name for the cryptocurrency platform, the transactional protocol for which is actually XRP, in the same fashion as Ethereum is the name for the platform that facilitates trades in Ether. Like other cryptocurrencies, Ripple is built atop the idea of a distributed ledger network which requires various parties to participate in validating transactions, rather than any singular centralized authority. That facilitates transactions all over the world, and transfer fees are far cheaper than the likes of bitcoin. Unlike other cryptocurrencies, XRP transfers are effectively immediate, requiring no typical confirmation time.  Ripple was originally founded by a single company, Ripple Labs, and continues to be backed by it, rather than the larger network of developers that continue bitcoin’s development. It also doesn’t have a fluctuating amount of its currency in existence. Where bitcoin has a continually growing pool with an eventual maximum, and Ethereum theoretically has no limit, Ripple was created with all of its 100 billion XRP tokens right out of the gate. That number is maintained with no mining and most of the tokens are owned and held by Ripple Labs itself — around 60 billion at the latest count.  Even at the recently reduced value of around half a dollar per XRP, that means Ripple Labs is currently sitting on around $20 billion worth of the cryptocurrency (note: Ripple’s price crashed hard recently, and may be worth far less than $60 billion by time you read this). It holds 55 billion XRP in an escrow account, which allows it to sell up to a billion per month if it so chooses in order to fund new projects and acquisitions. Selling such an amount would likely have a drastic effect on the cryptocurrency’s value, and isn’t something Ripple Labs plans to do anytime soon.  In actuality, Ripple Labs is looking to leverage the technology behind XRP to allow for faster banking transactions around the world. While Bitcoin and other cryptocurrencies are built on the idea of separating financial transactions from the financial organizations of traditional currencies, Ripple is almost the opposite in every sense.  XRP by Ripple price can be found on this page alongside the market capitalization and additional stats.

Ripple

XRP is trending heavily amidst a significant downturn, sparking intense community debate over whether this deep dip is a prime buying opportunity or a signal of further decline, as many attribute the market's weakness to institutional manipulation and recent 'Epstein files' conspiracy theories. Adding to the volatility, the token is also notably 'decoupling' from Bitcoin, polarizing holders on its immediate future and long-term utility.

Strategy, Inc. engages in the provision of enterprise analytics and mobility software. The firm designs, develops, markets, and sells software platforms through licensing arrangements and cloud-based subscriptions and related services. Its product packages include Hyper. The company was founded by Michael J. Saylor and Sanjeev K. Bansal on November 17, 1989, and is headquartered in Vienna, VA.

Strategy Inc. - Ordinary Shares - Class A

Strategy

MSTR is trending amidst a significant Bitcoin price correction, fueling community concerns over its substantial leveraged crypto holdings falling into an unrealized loss and widespread speculation about potential liquidation risks ahead of its earnings report.

Alphabet, Inc. is a holding company, which engages in software, health care, transportation, and other technologies. It operates through the following segments: Google Services, Google Cloud, and Other Bets. The Google Services segment includes products and services, such as ads, Android, Chrome, devices, Google Maps, Google Play, Search, and YouTube. The Google Cloud segment refers to infrastructure and platform services, collaboration tools, and other services for enterprise customers. The Other Bets segment relates to the sale of healthcare-related services and internet services. The company was founded by Lawrence E. Page and Sergey Mikhaylovich Brin on October 2, 2015 and is headquartered in Mountain View, CA.

Alphabet Inc - Ordinary Shares - Class A

Alphabet Inc Class A

Alphabet is trending after surpassing earnings estimates, though its projected $175B-$185B capital expenditure for 2026 AI infrastructure has sparked immediate debate. While some view the massive spending with concern, the community is actively discussing its bullish implications for Google's AI and cloud dominance and a surge in demand for chip suppliers.

Robinhood Markets, Inc is a financial services platform, which engages in the provision of retail brokerage and offers trading in U.S. listed stocks and Exchange Traded Funds, related options, and cryptocurrency trading, as well as cash management, which includes debit cards services. The company was founded by Vladimir Tenev and Baiju Prafulkumar Bhatt in 2013 and is headquartered in Menlo Park, CA.

Robinhood Markets Inc - Ordinary Shares - Class A

Robinhood Markets Inc

Robinhood is experiencing a significant downturn, largely driven by the broader crypto market's weakness and Bitcoin's recent dip, leading to extensive community debate on whether the stock is now oversold or poised for further decline as earnings approach.

Dogecoin is a cryptocurrency based on the popular "Doge" Internet meme and features a Shiba Inu on its logo. Dogecoin is a Litecoin fork. Introduced as a "joke currency" on 6 December 2013, Dogecoin quickly developed its own online community and reached a capitalization of US$60 million in January 2014. Compared with other cryptocurrencies, Dogecoin had a fast initial coin production schedule: 100 billion coins were in circulation by mid-2015, with an additional 5.256 billion coins every year thereafter. As of 30 June 2015, the 100 billionth Dogecoin had been mined.   Dogecoin was created by Billy Markus from Portland, Oregon and  Jackson Palmer from Sydney, Australia. Both wanted to create a fun cryptocurrency that will appeal beyond the core Bitcoin audience. Dogecoin is primarily used as a tipping system on Reddit and Twitter where users tip each other for creating or sharing good content. The community is very active in organising fundraising activities for deserving causes.  The developers of Dogecoin haven’t made any major changes to the coin since 2015. This means that Dogecoin could get left behind and is why Shibas are leaving Dogecoin to join more advanced platforms like Ethereum. One of Dogecoin strengths is its relaxed and fun-loving community. However, this is also a weakness because other currencies are way more professional.  To purchase Dogecoin, it involves downloading a crypto wallet, setting up a crypto exchange account and then trading away for your desired crypto currency. Once we have set up an account with a DOGE currency exchange and deposited some funds, you are ready to start trading.

Dogecoin

Dogecoin is heavily trending amid a sharp market-wide downturn, fueling widespread bearish sentiment with many investors expressing deep losses and predicting further price drops. The community remains divided between those despairing over the declines and a defiant faction urging others to buy the dip.

Snap, Inc. operates as a technology company, which engages in the provision of a visual messaging application that was created to help people communicate through short videos and images. The company was founded by Frank Reginald Brown IV, Evan Thomas Spiegel, and Robert C. Murphy in 2010 and is headquartered in Santa Monica, CA.

Snap Inc - Ordinary Shares - Class A

Snap Inc

Snap is trending as bullish analyst upgrades and a strong Q4 earnings report, featuring positive net income and free cash flow, fuel speculation of a turnaround and potential short squeeze, despite ongoing community debate regarding executive compensation and long-term profitability.

Ethereum is a global, open-source platform for decentralized applications. In other words, it is a decentralized blockchain platform that enables developers to build and deploy smart contracts and applications without central authority control. Unlike Bitcoin, which primarily functions as digital currency, Ethereum operates as a programmable global computer where developers can create any type of decentralized service.   The platform hosts over $14 billion in DeFi applications with hundreds of thousands of active users across financial protocols, NFT marketplaces, and gaming platforms. Its transition to Proof of Stake in September 2022 reduced energy consumption by over 99%, addressing environmental concerns while strengthening network security.  The network operates through thousands of independent validator nodes that process transactions and execute smart contracts on the Ethereum Virtual Machine. Smart contracts are self-executing programs written in Solidity that automatically carry out agreements when conditions are met, eliminating intermediaries like banks or brokers.   Validators stake ETH as collateral to propose and validate blocks, earning rewards for honest participation while facing penalties for malicious behavior. The EIP-1559 upgrade introduced a dynamic base fee mechanism that burns ETH with each transaction, creating deflationary pressure during high network activity when more ETH is burned than issued to validators.  Vitalik Buterin proposed Ethereum in 2013, but seven co-founders helped build it, including Gavin Wood who created Solidity and the EVM technical specification, and Joseph Lubin who founded ConsenSys. The project launched in July 2015 after raising over $18 million through crowdfunding, quickly becoming the largest blockchain developer community. Major milestones include the 2020 Beacon Chain launch, the 2021 London hard fork implementing fee burning, and the 2022 Merge to Proof of Stake.   Ether (ETH) serves multiple functions: paying transaction fees (gas), staking to secure the network and earn 3-5% annual yields, serving as collateral in DeFi protocols, and purchasing NFTs and digital assets. The asset is increasingly adopted by traditional institutions, with publicly traded companies adding ETH to corporate treasuries to generate staking yields while maintaining blockchain exposure, and in 2024, the SEC approved spot Ethereum ETFs, allowing traditional investors to gain exposure through conventional brokerage accounts.  Ethereum's roadmap focuses on dramatically increasing transaction capacity to over 100,000 per second, reducing confirmation times, and enhancing decentralization while maintaining security against future threats like quantum computing.

Ethereum

Ethereum is trending amidst a significant price decline, mirroring Bitcoin's recent struggles and leading to widespread liquidations. The community is sharply divided between those seeing a "lifetime buying opportunity" and others fearing further capitulation, with sentiment intensified by regulatory uncertainty over a US crypto bill and recent token sales by its co-founder.

Brand Engagement Network, Inc. engages in the provision of conversational artificial intelligence assistants with the purpose of transforming engagement and analytics for businesses through security-focused, multimodal communication and human-like artificial intelligence assistants. The firm is also involved in delivering highly personalized, multi-modal artificial intelligence engagement with a focus on industries where there is a massive workforce gap and an opportunity to transform how consumers engage with networks, providers, and brands. The company is founded on March 14, 2024 and is headquartered in Jackson, WY.

Brand Engagement Network Inc

Brand Engagement Network (BNAI) is trending due to news of terminating its $50 million standby equity purchase agreement, which strengthens its balance sheet and reduces potential dilution; this, combined with extremely high short interest and a low float, has ignited community speculation about a significant short squeeze.

Alphabet Inc - Ordinary Shares - Class C

Alphabet is trending after reporting strong earnings that were immediately met with investor concern over its significantly increased capital expenditure outlook for AI infrastructure, igniting debate within the community on whether this aggressive spending is a prudent investment for future growth or a sign of potential margin compression.

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ITC Ltd.

Adani Enterprises Ltd

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 Hey, I want to invite you to join Stocktwits. It’s the largest global community of active traders. You’ll get access to the real-time market insights, news, discussion and much more! You can sign up using my unique link below 
 


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$ORMP And finally... after so many months and without any hope, we can see the application number CXSS2300021 listed on the NMPA drugs list https://www.nmpa.gov.cn/zwfw/sdxx/sdxxyp/yppjfb/20251229162739197.html 
what are the repercussions for Oramed now? as the joint venture with Hefei was cancelled not long ago

Vittoria Colonna

Thomas Leimenstoll

Nmpa

StockTwits Web

Oramed Pharmaceuticals, Inc

 And finally... after so many months and without any hope, we can see the application number CXSS2300021 listed on the NMPA drugs list 

 
what are the repercussions for Oramed now? as the joint venture with Hefei was cancelled not long ago

David

@_Deivid_ Hard to believe almost 3 years passed since the failed trial. This was a major part of my daily routine the years prior. Still pains me to think of Nadav and company. 
 
I see you still do your DD on this. All the hours spent on this, got me nothing but frustration.

 Hard to believe almost 3 years passed since the failed trial. This was a major part of my daily routine the years prior. Still pains me to think of Nadav and company. 
 
I see you still do your DD on this. All the hours spent on this, got me nothing but frustration.

TransCode Therapeutics Inc

Ah, the hell with it.

more on this 
https://www.medvalley.cn/yiyao/78390.html 
https://finance.eastmoney.com/a/202512303606033561.html

12月29日，国家药监局公布药品通知件送达信息，合肥天汇生物科技有限公司申报的重组人胰岛素肠溶胶囊位列其中。一般而言，拿到药品通知件，有可能是药品上市申请"不予批准"，或者是企业因预判无法过审而主动撤回上市申请，这也意味着该药上市申请目前未获通过。

Medvalley

全球首款口服胰岛素上市申请未获成功

【首个口服胰岛素未能获批 回应称是主动撤回申报】12月29日，国家药监局官网显示，合肥天汇生物的重组人胰岛素肠溶胶囊（ORMD-0801）位列当日药品通知件送达信息列表。这意味着该药物未能成功获批。

Eastmoney

首个口服胰岛素未能获批 回应称是主动撤回申报 _ 东方财富网

@_Deivid_ pardon my ignorance but could you please explain what this drug listing could mean for ormp. Thanks

StockTwits For Android 

 pardon my ignorance but could you please explain what this drug listing could mean for ormp. Thanks