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Omeros Corp. operates as a biopharmaceutical company. The firm engages in the discovery, development, and commercializing of both small-molecule and protein therapeutics for large market. It also offers orphan indications targeting inflammation, coagulopathies, and disorders of the central nervous system. The company was founded by Gregory A. Demopulos and Pamela Pierce Palmer on June 16, 1994 and is headquartered in Seattle, WA.

Omeros Corporation

Omeros Corp

Omeros (OMER) is experiencing extreme volatility and intense investor focus as the market eagerly awaits an imminent FDA PDUFA decision for its life-saving drug, Narsoplimab, to treat TA-TMA. Following a trading halt for news pending, community sentiment is largely optimistic for approval, anticipating a significant price surge fueled by high short interest and the drug's first-in-class status for a condition with no existing treatment. The broader context of the recent de-risking deal with Novo Nordisk and previous regulatory hurdles fuels speculation of substantial long-term value and even a potential buyout, making this a pivotal moment for the company.

AST Spacemobile, Inc. engages in building a broadband cellular network in space to operate directly with standard, unmodified mobile devices based on an extensive IP and patent portfolio. It focuses on providing mobile broadband services with global coverage to all end-users, without the need to purchase special equipment. The company was founded by Abel Avellan on May 31, 2017 and is headquartered in Midland, TX.

AST SpaceMobile Inc - Ordinary Shares - Class A

AST SpaceMobile Inc

AST SpaceMobile is trending following the successful orbital launch of its BlueBird 6 satellite, which is touted as the largest commercial communications array ever deployed in low Earth orbit. This achievement is fueling significant bullish sentiment, with many anticipating the validation of its direct-to-device cellular broadband vision and rapid network expansion. However, discussions also reflect skepticism around the company's long-term profitability and current valuation, even as the community focuses on future scaling and execution milestones.

Intel Corp. engages in the design, manufacture, and sale of computer products and technologies. It delivers computer, networking, data storage, and communications platforms. The firm operates through the following segments: Client Computing Group (CCG), Data Center and AI (DCAI), Network and Edge (NEX), Mobileye, Accelerated Computing Systems and Graphics (AXG), Intel Foundry Services (IFS), and All Other. The CCG segment consists of platforms designed for notebooks, 2-in-1 systems, desktops, tablets, phones, wireless and wired connectivity products, and mobile communication components. The DCAI segment delivers solutions to cloud service providers and enterprise customers, along with silicon devices for communications service providers and high-performance computing customers. The NEX segment offers computing system solutions from inflexible fixed-function hardware to general-purpose compute, acceleration, and networking devices running cloud native software on programmable hardware. The Mobileye segment develops driving assistance and self-driving solutions. The AXG segment provides products and technologies designed to help customers solve the toughest computational problems. Its products include CPUs for high-performance computing and GPUs targeted for a range of workloads and platforms, from gaming and content creation on client devices to delivering media and gaming in the cloud, and the most demanding high-performance computing and AI workloads on supercomputers. The IFS segment refers to full stack solutions created from the foundry industry ecosystem. The All Other segment represents results from other non-reportable segments and corporate-related charges. The company was founded by Robert Norton Noyce and Gordon Earle Moore on July 18, 1968 and is headquartered in Santa Clara, CA.

Intel Corp.

Intel Corp

Intel is trending amid a contentious Reuters report suggesting Nvidia halted 18A chip process testing, which many in the community dismiss as 'fake news' or 'FUD' designed for market manipulation. Investors are actively discussing the true implications, with many viewing recent price dips as a buying opportunity given Intel's long-term foundry strategy and the recent FTC approval of Nvidia's $5 billion investment. The broader context of Intel's manufacturing turnaround and US government support for domestic chip production remains a key talking point.

Novavax, Inc. Is a biotechnology company, which engages in the discovery, development, and commercialization of recombinant vaccines. The company was founded in 1987 and is headquartered in Gaithersburg, MD.

Novavax, Inc.

Novavax Inc

Novavax is actively trending as investors voice deep frustration with management's perceived inaction to secure partnerships, especially for its combination flu/COVID vaccine, a sentiment exacerbated by a competitor's recent acquisition. The community debates whether leadership's prolonged silence signals advanced buyout discussions or a strategic misstep, particularly as potential regulatory scrutiny on mRNA vaccines could highlight Novavax's protein-based platform as a differentiated alternative.

Dynavax Technologies Corp. is a biopharmaceutical company, which engages in the provision of discovery, development, and commercialization of novel vaccines and immuno-oncology therapeutics. Its product includes HEPLISAV-B, which prevents infection caused by all known subtypes of hepatitis B virus in adults 18 years of age and older. The company was founded by Lawrence M. Lichtenstein, Dennis A. Carson, and Eyal Raz on August 29, 1996 and is headquartered in Emeryville, CA.

Dynavax Technologies Corp.

Dynavax is trending as Sanofi has announced an all-cash agreement to acquire the company, offering a significant premium for its leading hepatitis B vaccine and promising shingles pipeline. The community is actively celebrating the immediate gains for shareholders, though some express sentiment that the valuation is conservative, fueling speculation about potential competing bids. This acquisition highlights Sanofi's strategic expansion in adult vaccines and reflects the ongoing M&A activity within the biotech sector.

NIKE, Inc. engages in the design, development, marketing, and sale of athletic footwear, apparel, accessories, equipment, and services. It operates through the following segments: North America, Europe, Middle East, and Africa (EMEA), Greater China, Asia Pacific and Latin America (APLA), Global Brand Divisions, Converse, and Corporate. The North America, EMEA, Greater China, and APLA segments refer to the design, development, marketing, and selling of athletic footwear, apparel, and equipment. The Global Brand Divisions segment represents its NIKE Brand licensing businesses. The Converse segment designs, markets, licenses, and sells casual sneakers, apparel, and accessories. The Corporate segment is composed of unallocated general and administrative expenses. The company was founded by William Jay Bowerman and Philip Hampson Knight on January 25, 1964 and is headquartered in Beaverton, OR.

Nike, Inc. - Ordinary Shares - Class B

Nike Inc

Nike is trending as Apple CEO Tim Cook's recent stock purchase sparks significant community discussion, viewed by many as a strong vote of confidence in the company. While some dismiss the insider buy as insignificant, others believe it signals a potential turnaround for the sportswear giant, which has faced headwinds from China sales and tariff concerns.

Zeta Global Holdings Corp. operates as a marketing technology software company, which engages in the provision of enterprises with consumer intelligence and marketing automation software. It enables its customers to target, connect and engage consumers through software that delivers marketing across all addressable channels, including email, social media, web chat, connected TV and video among others. The company was founded by David A. Steinberg and John Sculley on May 9, 2012 and is headquartered in New York, NY.

Zeta Global Holdings Corp - Ordinary Shares - Class A

Zeta Global Holdings Corp

Zeta Global is a focal point of market discussion following its Marigold acquisition and upcoming CES 2026 showcase, where its AI-powered Athena platform is expected to lead future marketing innovations. Despite analysts raising price targets and impressive growth metrics, the community expresses strong sentiment that the stock remains significantly undervalued and poised for a major re-rating, with many anticipating an explosive move driven by further AI developments.

Agios Pharmaceuticals, Inc. is a biopharmaceutical company, which engages in a research engine, multiple novels, and investigational therapies in preclinical development. It focuses on cellular metabolism and classical hematology. The company was founded by Lewis Clayton Cantley, Tak W. Mak, Craig B. Thompson and Shin-Shan Michael Su on August 7, 2007 and is headquartered in Cambridge, MA.

Agios Pharmaceuticals Inc

Agios Pharmaceuticals is trending following the FDA's expanded approval of AQVESME (mitapivat) for adults with alpha- or beta-thalassemia, establishing it as the first and only oral treatment for this condition. The community is actively discussing the commercial implications and the drug's high cost, while also reflecting on broader concerns about management's communication style and historical execution.

UiPath, Inc. engages in the development and provision of a software platform to automate business processes. The firm serves the public, healthcare, telecommunication, finance, and banking industries. It also offers accounts payable automation, claims processing automation, contact center automation, and finance and accounting automation. The company was founded by Daniel Dines and Marius Tirca in 2005 and is headquartered in New York, NY.

UiPath Inc - Ordinary Shares - Class A

UiPath Inc

UiPath is experiencing significant buzz following its announced inclusion in the S&P MidCap 400 index, a move the community views as a major catalyst for increased institutional buying and enhanced market visibility. Investors are actively discussing its potential as a leader in Agentic AI automation, drawing comparisons to other high-growth tech plays, while some caution about near-term profit-taking.

Regencell Bioscience Holdings Ltd. is a early-stage bioscience company that focuses on research, development and commercialization of Traditional Chinese Medicine for the treatment of neurocognitive disorders and degeneration, specifically Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder. The company was founded by Yat-Gai Au on October 30, 2014 and is headquartered in Hong Kong.

Regencell Bioscience Holdings Ltd

Regencell Bioscience is trending amidst reports of significant insider buying from its CEO, fueling discussions around its extremely low float and potential for a short squeeze. Despite concerns regarding fundamental valuation and a past DOJ investigation into its volatility, the community is actively debating if its current momentum could replicate prior parabolic surges seen in similar speculative microcaps.

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<ul><li>A single wallet lost nearly 89% after liquidating AI agent tokens on Base.</li><li>The trades were flagged by Akhram Intelligence and Lookonchain.</li><li>The selloff coincided with broad weakness across the AI agent token category.&nbsp;</li></ul>A crypto whale suffered a loss of more than $20 million after a failed bet on AI agent tokens.As per&nbsp;<a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://intel.arkm.com/explorer/address/0x29AAC0d8A7dA68EB549f8E9649F18775870e5082">data</a> from Akhram Intelligence,&nbsp;<a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://x.com/lookonchain/status/2000850214350110944">flagged</a> by Lookonchain, the wallet spent roughly $23 million buying AI-related tokens on Base before liquidating the entire position on Monday for about $2.58 million, locking in a loss of $20.43 million, or nearly 89%. The on-chain analytics firm said this was “one of the worst investments ever.”&nbsp;<figure class="image"><a class="st-link-external" href="https://x.com/lookonchain/status/2000850214350110944" target="_blank" rel="noopener noreferrer nofollow"><img style="aspect-ratio:821/1065;" src="https://news.stocktwits-cdn.com/Screenshot_2025_12_16_043003_png_2a9595fcba.webp" alt="Screenshot 2025-12-16 043003.png" width="821" height="1065"></a><figcaption>Source: @lookonchain/X</figcaption></figure><h2 class="st-heading-2">Whale Trade Turns Into Steep AI Token Loss</h2>The trades spanned several AI agent tokens, including Freysa AI (FAI), aixbt (AIXBT), Botto (BOTTO), nftxbt (NFTXBT), and maicrotrader (MAICRO).The selloff coincided with broad weakness across the AI agent token category. The&nbsp;<a href="https://stocktwits.com/coins/botto">BOTTO token</a> led losses among AI agent coins early Tuesday, falling more than 32% over the past 24 hours, according to CoinGecko. On Stocktwits, retail sentiment around the token remained in ‘neutral’ territory over the past day.Freysa AI also ranked about the top losers among AI agent coins on Tuesday morning, with&nbsp;<a href="https://stocktwits.com/coins/freysa-ai">FAI’s price</a> down 14% in the last 24 hours. However, retail sentiment around the coin on Stocktwits remained in ‘bullish’ territory over the past day, with chatter at ‘extremely high’ levels.&nbsp;Meanwhile,&nbsp;<a href="https://stocktwits.com/coins/aixbt">AIXBT’s price</a> fell more than 11% in the last 24 hours. On Stocktwits, retail sentiment around the coin trended in ‘bearish’ territory over the past day but saw chatter at ‘high’ levels.<h2 class="st-heading-2">The Biggest Loss Making Investments On Record</h2>The biggest&nbsp;<a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://x.com/lookonchain/status/1899741688689463342">verifiable</a> individual crypto trading losses are clustered around a few recent, ultra‑levered whale blow‑ups on Ethereum (ETH) and Hyperliquid (HYPE), led by a March 2025 ETH whale who lost over $308 million in a single liquidation. Another trader turned $125,000 into roughly $43 million through leveraged ETH trades before that position collapsed to under $1 million.Earlier this year, Lookonchain also&nbsp;<a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://x.com/lookonchain/status/1971200206994833721">flagged</a> a Hyperliquid address that lost over $45.3 million in 40 days of trading, calling it the platform’s largest loser. The account withdrew only about $450,000 after the drawdown.​ The broader crypto market <a href="https://stocktwits.com/news-articles/markets/cryptocurrency/bitcoin-dips-below-86-000-while-xrp-leads-in-losses-among-major-tokens/cLe7U1VREoz">remained</a> under pressure on Tuesday morning. Total market capitalization fell more than 4.2% over the past 24 hours to about $3 trillion. Ethereum and Ripple’s XRP (XRP) led declines among major tokens, while Bitcoin (BTC) fell nearly 4% to trade around $86,300.Read also:&nbsp;<a href="https://stocktwits.com/news-articles/markets/cryptocurrency/bitcoin-retail-traders-split-on-timing-of-next-all-time-high/cLeJGnHREYc">Bitcoin Retail Traders Split On Timing Of Next All-Time High While Sentiment Turns ‘Extremely Bearish’</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Repsentative image of a cryptcurrency. (Photo by OsakaWayne Studios/Getty Images)

Crypto Whale Loses $20 Million On ‘Worst Investments Ever’ In AI Token Trade

Arkham Intelligence data showed the trades spanned several AI agent tokens, including Freysa AI, aixbt, Botto, nftxbt, and maicrotrader.

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Bitcoin has seen massive volatility this quarter as ETFs, macro conditions, and crypto adoption continue to shape price action. As 2025 comes to a close, where do you think Bitcoin ($BTC) will finish on December 31, 2025 (EST)?

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