OpenAI, Nvidia Join Trump’s ‘Genesis Mission’ To Power AI-Driven Science And Energy

• The initiative aims to integrate AI with national lab supercomputing to accelerate research and innovation.
• OpenAI and Nvidia will support collaboration between government, industry, and scientific institutions.
• The effort reflects a broader U.S. push to strengthen leadership in advanced computing and energy technologies.

OpenAI and Nvidia have joined U.S. President Donald Trump’s Genesis Mission, a sweeping public-private effort to put AI at the centre of U.S. scientific research and energy innovation, as Washington ramps up efforts to secure technological edge.

The Department of Energy said companies including OpenAI, Nvidia, Microsoft, Google, Amazon Web Services, Oracle, AMD, Intel, Dell Technologies, Hewlett Packard Enterprise, IBM, Palantir and others have signed memorandums of understanding or expressed interest in collaborating on the initiative, which aims to accelerate scientific discovery through large-scale AI and supercomputing.

White House And DOE Launch Public-Private AI Push

The White House said a meeting between industry participants, Energy Secretary Chris Wright, DOE Under Secretary for Science and Genesis Mission Director Dario Gil, and White House Office of Science and Technology Policy Director Michael Kratsios helped formally launch the public-private partnerships underpinning the initiative.

Michael Kratsios, Assistant to the President and OSTP Director, said the 24 research partnerships announced so far represent an initial phase of a broader national effort to bring companies, universities, non-profits and federal agencies into a shared AI-driven research platform.

What The Genesis Mission Seeks To Do

Inspired by the Apollo programme, the Genesis Mission is a nationwide effort to speed scientific breakthroughs by combining AI with the computing power of U.S. national laboratories. 

The Department of Energy has been tasked with integrating “world-class supercomputers and datasets into a unified, closed-loop AI platform” that can automate experiment design, accelerate simulations and generate predictive models. The effort is expected to involve coordination with agencies including the National Science Foundation, the National Institute of Standards and Technology and the National Institutes of Health.

OpenAI Expands Work With National Laboratories

OpenAI said the agreement builds on its existing work with DOE national laboratories, where its AI models have already been deployed in research environments. The company has worked directly with scientists on high-impact problems, deployed advanced reasoning models on the Venado supercomputer at Los Alamos National Laboratory, and convened large-scale collaborations such as a “1,000 Scientist AI Jam Session” across multiple labs.

Kevin Weil, vice president of OpenAI for Science, said the collaboration would help researchers explore ideas, test hypotheses faster and move more quickly from insight to validated results.

Nvidia Brings Supercomputing 

Nvidia said its participation in the Genesis Mission builds on recent collaborations with the DOE, including work with Oracle to build the department’s largest supercomputer for scientific research at Argonne National Laboratory. The company also said it will support additional systems at Argonne and Los Alamos to expand the use of accelerated computing across the national lab network.

How Did Stocktwits Users React?

On Stocktwits, retail sentiment was ‘bearish’ across OpenAI and Nvidia, with ‘low’ message volume for Nvidia and ‘extremely high’ message volume for OpenAI.

Nvidia’s stock has risen 30% so far in 2025.

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