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Bitcoin is the world's first decentralized cryptocurrency, created in 2009 by the pseudonymous Satoshi Nakamoto. It enables peer-to-peer electronic cash transactions without intermediaries like banks or governments, operating on a blockchain secured by Proof of Work mining and the SHA-256 cryptographic algorithm.   With a fixed supply cap of 21 million coins and programmatic halvings every four years that reduce miner rewards, Bitcoin is designed as a deflationary digital asset often called "digital gold." Its value stems from solving the double-spending problem without trusted intermediaries, creating the first truly scarce digital asset with censorship resistance and permissionless access that no government, corporation, or individual can control.  Bitcoin operates as a decentralized peer-to-peer network where transactions are recorded on a public ledger called the blockchain, distributed across thousands of computers globally. Transactions are grouped into blocks added approximately every 10 minutes through mining, where specialized computers compete to solve complex mathematical puzzles.   Bitcoin has achieved mainstream adoption through multiple vectors. The January 2024 SEC approval of 11 spot Bitcoin ETFs opened Bitcoin investment to traditional finance participants, and corporations like Strategy (formerly MicroStrategy) are using Bitcoin as a treasury reserve asset to protect against currency debasement, offering MSTR holders amplified exposure to Bitcoin.   The Bitcoin ecosystem continues to evolve with innovations like Ordinals, which emerged in January 2023 to enable NFT-like functionality directly on Bitcoin, and BRC-20 tokens, an experimental standard for creating fungible tokens using Ordinal inscriptions. BTCFi (Bitcoin Finance) represents emerging financial applications extending beyond Bitcoin's traditional role, with protocols like Babylon allowing Bitcoin holders to stake BTC to secure Proof of Stake chains.

Bitcoin

Bitcoin is experiencing a powerful rally as institutional buying and massive short liquidations propel the price past key psychological resistance levels. The community is actively discussing the potential for a sustained bull run, with many investors debating whether this breakout is a genuine trend reversal or a temporary liquidity squeeze.

Dogecoin is an open-source digital currency based on the "Doge" meme that functions as a peer-to-peer medium for fast payments and digital tipping. Unlike projects backed by corporate entities, its value is driven by a global community, and the project is managed by a decentralized group of volunteers and the non-profit Dogecoin Foundation rather than a formal company.  Originally created in 2013 by software engineers Billy Markus and Jackson Palmer as a market parody, the project held no public sale or venture capital rounds. The network operates as a fork of LuckyCoin, which itself was a fork of Litecoin, using a proof of work consensus mechanism. It employs the Scrypt algorithm to ensure the mining process remains fast and efficient, with new blocks processed every 60 seconds. A unique technical feature is its use of merged mining, allowing miners to secure Dogecoin simultaneously with other Scrypt-based networks like Litecoin.  To keep transaction fees low and the network running indefinitely, Dogecoin features an uncapped supply where new coins are added forever. In a major regulatory milestone in March 2026, a joint SEC and CFTC framework officially classified Dogecoin as a digital commodity, placing it in the same asset category as gold or oil.

Dogecoin

Dogecoin is trending as investors react to a renewed sense of optimism, with the community actively discussing potential price movements and drawing parallels to broader market activity. Discussions are heavily focused on technical chart formations and hopes that the coin will regain its momentum as a major crypto asset.

Strategy, Inc. engages in the development of fixed-income instruments that provide investors varying degrees of economic exposure to bitcoin. It executes bitcoin acquisition, capital management, and capital markets strategies. The company was founded by Michael J. Saylor and Sanjeev K. Bansal on November 17, 1989, and is headquartered in Tysons Corner, VA.

Strategy Inc. - Ordinary Shares - Class A

Strategy

MicroStrategy is trending as investors rally behind Bitcoin's surge past the $70,000 level and renewed optimism surrounding potential U.S. crypto legislation. The community is actively debating the stock's divergence from Bitcoin's price action, with bulls pointing to the potential for a short squeeze and institutional momentum, while bears highlight concerns over share dilution and the stock's performance relative to its underlying assets.

Ethereum is a global, open-source platform for decentralized applications. In other words, it is a decentralized blockchain platform that enables developers to build and deploy smart contracts and applications without central authority control. Unlike Bitcoin, which primarily functions as digital currency, Ethereum operates as a programmable global computer where developers can create any type of decentralized service.   The platform hosts over $14 billion in DeFi applications with hundreds of thousands of active users across financial protocols, NFT marketplaces, and gaming platforms. Its transition to Proof of Stake in September 2022 reduced energy consumption by over 99%, addressing environmental concerns while strengthening network security.  The network operates through thousands of independent validator nodes that process transactions and execute smart contracts on the Ethereum Virtual Machine. Smart contracts are self-executing programs written in Solidity that automatically carry out agreements when conditions are met, eliminating intermediaries like banks or brokers.   Validators stake ETH as collateral to propose and validate blocks, earning rewards for honest participation while facing penalties for malicious behavior. The EIP-1559 upgrade introduced a dynamic base fee mechanism that burns ETH with each transaction, creating deflationary pressure during high network activity when more ETH is burned than issued to validators.  Vitalik Buterin proposed Ethereum in 2013, but seven co-founders helped build it, including Gavin Wood who created Solidity and the EVM technical specification, and Joseph Lubin who founded ConsenSys. The project launched in July 2015 after raising over $18 million through crowdfunding, quickly becoming the largest blockchain developer community. Major milestones include the 2020 Beacon Chain launch, the 2021 London hard fork implementing fee burning, and the 2022 Merge to Proof of Stake.   Ether (ETH) serves multiple functions: paying transaction fees (gas), staking to secure the network and earn 3-5% annual yields, serving as collateral in DeFi protocols, and purchasing NFTs and digital assets. The asset is increasingly adopted by traditional institutions, with publicly traded companies adding ETH to corporate treasuries to generate staking yields while maintaining blockchain exposure, and in 2024, the SEC approved spot Ethereum ETFs, allowing traditional investors to gain exposure through conventional brokerage accounts.  Ethereum's roadmap focuses on dramatically increasing transaction capacity to over 100,000 per second, reducing confirmation times, and enhancing decentralization while maintaining security against future threats like quantum computing.

Ethereum

Ethereum is surging alongside the broader crypto market, fueled by optimism over the potential passage of the Clarity Act and a favorable macroeconomic shift involving government bond buybacks. Community sentiment has flipped aggressively bullish, with many traders celebrating a historic short squeeze and expressing high conviction in long-term price appreciation.

Aurinia Pharmaceuticals, Inc. is a clinical stage bio-pharmaceutical company, which engages in the research, development, and commercialization of therapeutic drugs. The company was founded by Robert Foster, Richard Glickman, and Michael Martin on June 16, 1993 and is headquartered in Edmonton, Canada.

Aurinia Pharmaceuticals Inc

Aurinia Pharmaceuticals is trending after reaching a patent settlement with Teva that secures exclusivity for its flagship drug until 2036, fueling community speculation about a potential buyout. Investors are actively discussing the company's strong financial profile and the strategic impact of resolving litigation on its long-term valuation.

Tidal Trust II - YieldMax MSTR Option Income Strategy ETF

YieldMax MSTR Option Income Strategy ETF

MSTY is trending as investors monitor weekly dividend payouts and the fund's correlation with the recent volatility of MicroStrategy and Bitcoin. Community sentiment remains split between those focused on high-yield income strategies and others concerned about long-term NAV erosion.

iShares Trust - iShares 20+ Year Treasury Bond ETF

iShares 20+ Year Treasury Bond ETF

TLT is trending as investors weigh persistent concerns over high government debt and fiscal deficits against the latest inflation data, fueling debate on whether the bond market has reached a bottom or if yields will continue their ascent. The community is actively discussing the impact of potential Treasury interventions and the broader macroeconomic implications of the current deficit environment on long-term bond pricing.

Walmart, Inc. engages in the retail and wholesale business. The company offers an assortment of merchandise and services at everyday low prices. It operates through the following segments: Walmart U.S., Walmart International, and Sam's Club U.S. The Walmart U.S. segment operates as a mass merchandiser of consumer products, operating under the Walmart and Walmart Neighborhood Market brands, including walmart.com. The Walmart International segment includes operations of wholly-owned subsidiaries in Canada, Chile, China, and Africa, and majority-owned subsidiaries in India, as well as Mexico and Central America. The Sam's Club U.S. segment manages membership-only warehouse clubs and operates samsclub.com. The company was founded by Samuel Moore Walton and James Lawrence Walton on July 2, 1962 and is headquartered in Bentonville, AR.

Walmart Inc

Walmart shares are facing significant selling pressure as investors react to a rare miss on U.S. comparable sales and cautious third-quarter guidance, which triggered concerns regarding consumer resilience. While the company remains a dominant retail force, community discussion highlights a divide between those viewing the decline as an overreaction to temporary headwinds and those concerned that the stock's premium valuation is being reset amid shifting economic conditions.

Tempus AI, Inc. is a healthcare technology company, which engages in bringing artificial intelligence and machine learning to healthcare. It focuses on building platforms for oncology, neuropsychiatry, cardiology, infectious disease, and radiology. The company was founded by Eric Paul Lefkofsky in August 2015 and is headquartered in Chicago, IL.

Tempus AI Inc. - Ordinary Shares - Class A

Tempus AI Inc

Tempus AI shares are trending as investors digest the strategic rationale behind the company's planned $1.5 billion acquisition of Personalis, viewing the deal as a significant expansion of its precision oncology and cancer monitoring platform. Community sentiment is mixed as market participants debate the immediate impact of potential share dilution versus the long-term growth opportunity within the cancer recurrence monitoring market.

Cipher Digital, Inc. operates as a Bitcoin mining ecosystem in the United States. The firm is developing a cryptocurrency business. The company was founded in 2021 and is headquartered in New York, NY.

Cipher Digital Inc.

Cipher Mining is trending as investors react to positive regulatory developments in Texas, including the company's confirmed compliance with state data center standards, alongside increased institutional buying from firms like Bank of America. Market participants are actively discussing the stock's significant potential as a major data center operator with a valuable power pipeline.

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$BCTX Further, it looks there are late line TPC therapy achieving 9-13 months mOS, as per below link. If Bria-IMT achieves say 2-4 months higher mOS, how could they succeed 0.70 HR at P3 interim analysis?

https://www.theinvestmentlog.com/posts/bctx/2026-03-10

Deep dive into BriaCell Therapeutics (BCTX) stock: Bria-IMT whole-cell cancer vaccine mechanism, Phase 2 survival data, Phase 3 trial design, the January 2026 offering that cratered the stock, financial position, share structure, competitive landscape, and probability-weighted valuation ahead of the interim overall survival readout.

Theinvestmentlog

BriaCell Therapeutics: A Cash-Value Biotech With a Phase 3 Cancer Vaccine Readout Months Away

$BCTX thanks for sharing the link. I am very deep in SLS (~200,000 stocks worth calls after booking $400K+ profit), and learn BCTX first time from your cross post. 

As per the video presentation, the CPI Phase 2 data VS Trodelvy shows Bria-IMT achieved only 13.4 months mOS compared to 14.4 months for HR+ patients. While HR doesn’t entirely based on mOS ratio, but if an ADC drug shows 14.4 months mOS, to clear the 0.70 HR Bria-IMT mOS would need to come in 19-21 months. 

SLS P3 had a similar mOS target — GPS needs to demonstrate ~1.57x mOS of BAT.. in their clinical trial SLS assumed 8M BAT mos, so target GPS mos &gt; 12.6M. How could then Bria-IMT P3 at interim analysis can demonstrate a 0.70 HR with an inferior mOS for some patients subgroup?

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BriaCell Therapeutics Corp

Shopno

 Further, it looks there are late line TPC therapy achieving 9-13 months mOS, as per below link. If Bria-IMT achieves say 2-4 months higher mOS, how could they succeed 0.70 HR at P3 interim analysis?



@shopno The comparison arm is not Trodelvy, it&#39;s physician&#39;s choice of therapy and many physicians don&#39;t choose Trodelvy due to its horrible side effects (BriaCell therapy has shown NO side effects). Also, BriaCell can get approved for patients with intracranial disease or some of the subtypes of cancer. The Phase 3 BriaCell formulation achieved 16.6 months survival vs about 7-9 months in the physician&#39;s choice arm thus far.

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 The comparison arm is not Trodelvy, it's physician's choice of therapy and many physicians don't choose Trodelvy due to its horrible side effects (BriaCell therapy has shown NO side effects). Also, BriaCell can get approved for patients with intracranial disease or some of the subtypes of cancer. The Phase 3 BriaCell formulation achieved 16.6 months survival vs about 7-9 months in the physician's choice arm thus far.

@shopno I also looked up the study protocol - Trodelvy is not one of the physician&#39;s choice options

 I also looked up the study protocol - Trodelvy is not one of the physician's choice options