$ABBV $KURA $SNDX
This is a hematologist prescriber survey embedded within the recent SNDX note, focused on NPM1 mutant AML (the largest subset of adult AML, ~30% of all AML).
Core survey findings
1. Diagnosis & testing behavior
Virtually all responding leukemia specialists now routinely test newly diagnosed AML patients for NPM1 mutation at baseline.
Previously, many viewed revumenib only as a KMT2Ar drug; survey shows this perception has shifted after NPM1 label approval + real-world data.
2. Treatment preference for R/R NPM1 AML (already approved setting)
◦ Efficacy / deep MRD response is the
#1 decision factor (ranked far above safety, oral convenience, or price).
◦ HCPs say revumenib’s ability to drive MRD negativity is its biggest differentiator vs older salvage regimens.
◦ Survey uptake expectation: Respondents expect Revuforj to capture a dominant share of eligible R/R NPM1 patients, even with competing menin inhibitor now on market.