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Microsoft Corp. engages in the development and support of software, services, devices, and solutions. It operates through the following segments: Productivity and Business Processes, Intelligent Cloud, and More Personal Computing. The Productivity and Business Processes segment is composed of products and services relating to productivity, communication, and information services such as Office Commercial, Office Consumer, LinkedIn, and Dynamics business solutions. The Intelligent Cloud segment consists of public, private, and hybrid server products and cloud services for businesses and developers, as well as enterprise and partner services. The More Personal Computing segment refers to products and services including Windows operating system, Windows cloud services, Surface, HoloLens, personal computer accessories, Xbox hardware, Xbox Cloud Gaming, Microsoft News, and Microsoft Edge. The company was founded by Paul Gardner Allen and William Henry Gates, III in 1975 and is headquartered in Redmond, WA.

Microsoft Corporation

Microsoft Corp

Microsoft is trending due to recent service outages affecting its 365 suite and ongoing debate surrounding its AI strategy and investment in OpenAI, amplified by Elon Musk's lawsuit. While some investors see current price levels as an opportune moment to buy a fundamentally strong company, others point to broader mega-cap tech weakness and competitive pressures as key drivers of the decline ahead of its earnings report.

PAVmed, Inc. is a multi-product life sciences company, which engages in the innovation, development, acquisition, and commercialization of products that target unmet medical needs with large addressable market opportunities. Its products include Lucid Diagnostics and Veris Health. The company was founded by Lishan Aklog and Brian J. deGuzman on June 26, 2014 and is headquartered in New York, NY.

PAVmed Inc

PAVmed (PAVM) is trending due to news that its subsidiary, Lucid Diagnostics, secured a contract with the U.S. Department of Veterans Affairs for its EsoGuard Esophageal DNA Test, expanding access across the VA healthcare system. This has ignited intense market activity and debate, with some investors anticipating significant further upside given the contract's potential and the company's low share float, while others express caution regarding extreme price volatility and the potential for future share offerings.

Oracle Corp. engages in the provision of products and services that address aspects of corporate information technology environments, including applications and infrastructure technologies. It operates through the following business segments: Cloud and License, Hardware, and Services. The Cloud and License segment markets, sells, and delivers enterprise applications and infrastructure technologies through cloud and on-premise deployment models including cloud services and license support offerings. The Hardware segment provides infrastructure technologies including Oracle Engineered Systems, servers, storage, industry-specific hardware, operating systems, virtualization, management, and other hardware-related software. The Services segment offers consulting, advanced support, and education services. The company was founded by Lawrence Joseph Ellison, Robert Nimrod Miner, and Edward A. Oates on June 16, 1977 and is headquartered in Austin, TX.

Oracle Corp.

Oracle is experiencing significant volatility amid intense community debate, driven by reports of potential lawsuits from bondholders concerning the financing of its large-scale AI infrastructure projects and substantial debt. While some investors view the recent price action as a major buying opportunity given Oracle's strategic position in cloud and AI, others are wary of the financial liabilities and the long-term impact on the company. The ongoing speculation regarding a significant TikTok deal is also a key point of discussion, contributing to divergent market sentiment.

Hims & Hers Health, Inc. operates a telehealth consultation platform. It connects consumers to healthcare professionals, enabling them to access medical care for mental health, sexual health, dermatology and primary care. The company was founded in 2017 and is headquartered in San Francisco, CA.

Hims & Hers Health Inc - Ordinary Shares - Class A

Hims & Hers Health Inc

Hims & Hers Health Inc. is experiencing a notable sell-off, generating intense community discussion over its future. While many express strong bearish sentiment citing competition in the GLP-1 market and perceived threats from Amazon, others view the downturn as an oversold buying opportunity, emphasizing the company's expanding personalized healthcare platform and vertical integration.

Invesco Capital Management LLC - Invesco QQQ Trust Series 1

The Invesco QQQ Trust is a focal point for intense market volatility, driven by shifting geopolitical narratives concerning presidential statements on Greenland and evolving US-EU trade relations. Community sentiment is sharply divided, with some anticipating continuous "V-shape" rallies and "buy the dip" opportunities fueled by perceived pro-market stances, while others remain highly skeptical, warning of orchestrated pump-and-dump scenarios and a looming market decline. This tug-of-war reflects deep uncertainty within the tech-heavy Nasdaq, where bullish convictions clash with cautious perspectives on broader economic stability.

BigBear.ai Holdings, Inc. engages in data-driven decision dominance and advanced analytics that provide its customers with a competitive advantage in a world driven by data that is growing in terms of volume, variety, and velocity. The firm operationalizes artificial intelligence and machine learning at scale through its end-to-end data analytics platform. It deploys its observe, orient and dominate products to customers throughout the defense, intelligence, and commercial markets. The company was founded in 2020 and is headquartered in McLean, VA.

BigBear.ai Holdings Inc

BigBear.ai (BBAI) is trending due to an upcoming pivotal shareholder vote on increasing authorized shares, which has polarized the community. While some investors fear potential dilution, many anticipate the approval will unlock significant growth, enabling future contracts and strategic moves in the government AI and defense sectors that could drive a substantial re-rating.

USA Rare Earth, Inc. is domestic supplier of rare earth magnets and heavy rare earth elements. It is developing a vertically integrated, domestic supply chain for rare earth element magnet production, with a facility in Stillwater, Oklahoma, and mining rights to the Round Top heavy rare earth and critical minerals deposit in West Texas. The company was founded in May 2019 and is headquartered in Stillwater, OK.

USA Rare Earth Inc. - Ordinary Shares - Class A

USA Rare Earth Inc

USA Rare Earth is trending following news of a significant French government-backed deal to establish a rare earth metals and alloys production facility in Europe, aiming to bolster the integrated supply chain for the U.S. and its allies. This development, alongside broader sector momentum driven by geopolitical dynamics and the launch of new leveraged ETFs, is fueling community discussions about the company's long-term potential and notable price volatility. Traders are actively discussing the broader implications of securing critical minerals supply chains and the company's "mine-to-magnet" strategy amidst ongoing market swings.

Innodata, Inc. is a data engineering company, which engages in providing artificial intelligence software platforms and management of its services. It operates through the following business segments: Digital Data Solutions (DDS), Synodex, and Agility. The DDS segment combines deep neural networks and human expertise in multiple domains to make unstructured information useable. The Synodex segment enables clients in the insurance and healthcare sectors to transform medical records into useable digital data and to apply technologies to the digital data to augment decision support. The Agility segment provides tools and related professional services that enable public relations and communications professionals to discover influencers, amplify messages, monitor coverage, and measure the impact of campaigns. The company was founded by Todd H. Solomon in 1988 and is headquartered in Ridgefield Park, NJ.

Innodata Inc

Innodata Inc. is trending following its selection for the U.S. Missile Defense Agency's SHIELD contract, a significant validation of its capabilities in defense AI that positions it for substantial 'Golden Dome' task orders. The community is actively discussing the company's expanding footprint into sovereign AI initiatives, particularly in the Middle East, with many viewing recent price dips as strategic buying opportunities. This perceived shift toward high-value government and international AI contracts is fueling anticipation for a significant re-rating of INOD's valuation.

Netflix, Inc. engages in providing entertainment services. It also offers activities for leisure time, entertainment video, video gaming, and other sources of entertainment. It operates through the United States and International geographic segments. The company was founded by Marc Randolph and Wilmot Reed Hastings on August 29, 1997 and is headquartered in Los Gatos, CA.

Netflix Inc.

Netflix Inc

Netflix is trending after reporting strong Q4 results driven by subscriber and ad revenue growth, though its stock faces downward pressure from softer Q1 guidance and ongoing speculation around a potential Warner Bros. Discovery acquisition. The community is sharply divided, with many viewing the dip as a prime buying opportunity for a market leader, while others anticipate further declines given the acquisition's perceived risks and potential for market manipulation.

United States Antimony Corp. engages in the extraction, processing and sale of antimony, zeolite, silver, and gold products. It operates through the following segments: United States Antimony Operations, Mexican Antimony Operations, Precious Metals Recovery, and United States Zeolite Operations. The company was founded by John C. Lawrence in June 1968 and is headquartered in Thompson Falls, MT.

United States Antimony Corp.

United States Antimony Corp

United States Antimony is trending following its recent acquisition of a critical minerals flotation facility, strengthening its integrated processing capabilities amidst a heightened national security focus. The community is actively discussing the company's unique position as a domestic antimony producer, anticipating significant government investment in critical mineral supply chains and potential for substantial upside. Many are closely watching for further strategic announcements as geopolitical tensions underscore the importance of securing domestic resource supply.

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<ul class="summary-bullets"><li>It is now unclear when the company would apply for approval of the gene therapy, it said.</li><li>uniQure, however, added that it intends to communicate with the FDA to determine a path forward toward approval of the therapy.&nbsp;</li><li>uniQure CEO termed the meeting outcome “unexpected.”<br>&nbsp;</li></ul><p>uniQure N.V. (QURE) no longer believes that the U.S. Food and Drug Administration considers data from an early-to mid-stage trial of its investigational gene therapy for Huntington’s disease sufficient for approval, the company said on Monday.</p><p>The company recently met with the agency, and although the minutes of the meeting have not been received, the company <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2025/11/03/3179114/0/en/uniQure-Provides-Regulatory-Update-on-AMT-130-for-Huntington-s-Disease.html">believes</a> that the FDA no longer considers the data from the AMT-130 trial adequate to provide primary evidence in support of an application for approval.</p><p>As a result, it is now unclear when the company would apply for approval of the gene therapy, it said. uniQure, however, added that it intends to communicate with the FDA to determine a path forward toward approval of the therapy.</p><h2 class="st-heading-2">CEO Reacts</h2><p>uniQure CEO termed the meeting outcome “unexpected.”</p><p>“We are surprised by the FDA’s feedback at the recent pre-BLA meeting, which is a drastic change from the guidance the FDA provided in November 2024 that data from the ongoing Phase I/II studies, compared to a natural history external control, may serve as the primary basis for a BLA submission under the Accelerated Approval pathway,” CEO Matt Kapusta said.</p><p>The company also stated that it intends to engage in further communications with other regulatory agencies while working with the FDA.</p><h2 class="st-heading-2">Expert Take</h2><p>Stifel analyst Annabel Samimy said that the news regarding the FDA's reversal on the approvability of uniQure's AMT-130 based on early to mid-stage trial data on the surface injects another layer of uncertainty into the workings of the FDA and their receptivity to gene therapy, more specifically.</p><p>The analyst, however, does not expect this to impact Regenxbio’s (RGNX) rare disease programs. Meanwhile, Raymond James added that it does not expect the meeting outcome to impact Biohaven (BHVN) either.</p><h2 class="st-heading-2">How Did Stocktwits Users React?</h2><p>QURE stock traded 55% lower at the time of writing. On Stocktwits, retail sentiment around <a href="https://stocktwits.com/symbol/QURE">QURE stock</a> fell from ‘neutral’ to ‘bearish’ territory over the past 24 hours, while message volume stayed at ‘low’ levels.</p><p>QURE stock is up 72% this year and approximately 445% over the past 12 months.&nbsp;</p><p>Read also: <a href="https://stocktwits.com/news-articles/markets/equity/tg-therapeutics-stock-soars-after-company-ups-guidance-for-multiple-sclerosis-drug/cL2NEPSR3zl">TG Therapeutics Stock Soars After Company Ups Guidance For Multiple Sclerosis Drug</a></p><p><i>For updates and corrections, email newsroom[at]stocktwits[dot]com.</i></p>

In this photo illustration, the uniQure logo is seen displayed on a smartphone screen. (Photo Illustration by Thomas Fuller/SOPA Images/LightRocket via Getty Images)

uniQure Stock Tumbled 55% Today: What’s The FDA Angle?

The company recently met with the FDA and believes that the agency no longer considers the data from an early-to-mid-stage trial of its investigational gene therapy sufficient for approval.

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