• Reported GAAP EPS of -$1.02 up 63.18% YoY • Reported revenue of $35.07M up 16.83% YoY • Karyopharm reaffirms full-year 2026 total revenue guidance of $130 million to $150 million, including U.S. XPOVIO net product revenue of $115 million to $130 million for Karyopharm.
Bullish
Karyopharm achieved increased total and XPOVIO net product revenue in Q1 2026, completed enrollment for a key endometrial cancer trial, and saw global royalty revenue growth from selinexor.
Bearish
Karyopharm experienced lower XPOVIO demand due to new competitive entrants and increased interest expense. The SENTRY trial also missed a co-primary endpoint, impacting Karyopharm's clinical progress.