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Ethereum is a global, open-source platform for decentralized applications. In other words, the vision is to create a world computer that anyone can build applications in a decentralized manner; while all states and data are distributed and publicly accessible. Ethereum supports smart contracts in which developers can write code in order to program digital value. Examples of decentralized apps (dapps) that are built on Ethereum includes tokens, non-fungible tokens, decentralized finance apps, lending protocol, decentralized exchanges, and much more.  On Ethereum, all transactions and smart contract executions require a small fee to be paid. This fee is called Gas. In technical terms, Gas refers to the unit of measure on the amount of computational effort required to execute an operation or a smart contract. The more complex the execution operation is, the more gas is required to fulfill that operation. Gas fees are paid entirely in Ether (ETH), which is the native coin of the blockchain. The price of gas can fluctuate from time to time depending on the network demand.

Ethereum

Ethereum is experiencing volatility, prompting discussions around potential government shutdowns and the impact of overnight liquidations. Community members are debating whether this is a buying opportunity or a sign of deeper issues, with some pointing to market manipulation and others awaiting key price levels. Tom Lee's previous predictions are being questioned amidst the current price action.

Bitcoin is the first successful internet money based on peer-to-peer technology; whereby no central bank or authority is involved in the transaction and production of the Bitcoin currency. It was created by an anonymous individual/group under the name, Satoshi Nakamoto. The source code is available publicly as an open source project, anybody can look at it and be part of the developmental process.  Bitcoin is changing the way we see money as we speak. The idea was to produce a means of exchange, independent of any central authority, that could be transferred electronically in a secure, verifiable and immutable way. It is a decentralized peer-to-peer internet currency making mobile payment easy, very low transaction fees, protects your identity, and it works anywhere all the time with no central authority and banks.  Bitcoin is designed to have only 21 million BTC ever created, thus making it a deflationary currency. Bitcoin uses the SHA-256 hashing algorithm with an average transaction confirmation time of 10 minutes. Miners today are mining Bitcoin using ASIC chip dedicated to only mining Bitcoin, and the hash rate has shot up to peta hashes.  Being the first successful online cryptography currency, Bitcoin has inspired other alternative currencies such as Litecoin, Peercoin, Primecoin, and so on.  The cryptocurrency then took off with the innovation of the turing-complete smart contract by Ethereum which led to the development of other amazing projects such as EOS, Tron, and even crypto-collectibles such as CryptoKitties.

Bitcoin

Bitcoin is trending as the crypto market experiences volatility, with community members debating potential support levels and whether a deeper correction is coming. Mixed sentiment abounds, as some traders anticipate a bounce while others brace for further downside, referencing historical September weakness. Broader macroeconomic concerns, including a potential government shutdown, are also being discussed as possible contributing factors.

Cipher Mining, Inc. operates as a Bitcoin mining ecosystem in the United States. The firm is developing a cryptocurrency business. The company was founded in 2021 and is headquartered in New York, NY.

Cipher Mining Inc

Cipher Mining is trending due to a recently announced $3 billion AI hosting deal with Fluidstack, backed by Google, which includes a significant equity stake. Despite the positive news, the stock's reaction is mixed as investors digest the details of an associated convertible note offering, sparking community debate about potential dilution. Some investors view this as a strategic move to expand AI capabilities, while others express concern about the near-term impact.

Amazon.com, Inc. is a multinational technology company, which engages in the provision of online retail shopping services. It operates through the following segments: North America, International, and Amazon Web Services (AWS). The North America segment offers retail sale of consumer products, including from sellers, advertising, and subscriptions services through North America-focused online and physical stores. The International segment focuses on retail sale of consumer products, including from sellers, advertising, and subscription services through internationally-focused online stores. The AWS segment is composed of global sales of compute, storage, database, and other services for start-ups, enterprises, government agencies, and academic institutions. The company was founded by Jeffrey P. Bezos in July 1994 and is headquartered in Seattle, WA.

Amazon.com Inc.

Amazon.com Inc

Amazon is trending as investors digest mixed signals, including a recent FTC settlement and a Wells Fargo upgrade, leading to debate about its near-term direction. Community discussions revolve around potential support levels, upcoming catalysts like Amazon's tech event, and its relative performance compared to other tech giants. Some traders express frustration with recent price action, while others see it as a buying opportunity, citing long-term growth potential and AWS prospects.

Intel Corp. engages in the design, manufacture, and sale of computer products and technologies. It delivers computer, networking, data storage, and communications platforms. The firm operates through the following segments: Client Computing Group (CCG), Data Center and AI (DCAI), Network and Edge (NEX), Mobileye, Accelerated Computing Systems and Graphics (AXG), Intel Foundry Services (IFS), and All Other. The CCG segment consists of platforms designed for notebooks, 2-in-1 systems, desktops, tablets, phones, wireless and wired connectivity products, and mobile communication components. The DCAI segment delivers solutions to cloud service providers and enterprise customers, along with silicon devices for communications service providers and high-performance computing customers. The NEX segment offers computing system solutions from inflexible fixed-function hardware to general-purpose compute, acceleration, and networking devices running cloud native software on programmable hardware. The Mobileye segment develops driving assistance and self-driving solutions. The AXG segment provides products and technologies designed to help customers solve the toughest computational problems. Its products include CPUs for high-performance computing and GPUs targeted for a range of workloads and platforms, from gaming and content creation on client devices to delivering media and gaming in the cloud, and the most demanding high-performance computing and AI workloads on supercomputers. The IFS segment refers to full stack solutions created from the foundry industry ecosystem. The All Other segment represents results from other non-reportable segments and corporate-related charges. The company was founded by Robert Norton Noyce and Gordon Earle Moore on July 18, 1968 and is headquartered in Santa Clara, CA.

Intel Corp.

Intel Corp

Intel is trending as reports surface about the company seeking investment from Apple and other partnerships, fueling optimism around its comeback bid and future role in AI. The community is discussing potential price targets and the impact of government and industry support, with many viewing this as a significant turning point for the stock. Bullish sentiment is high as investors speculate on potential deals with Apple and Nvidia, envisioning a resurgence of American tech leadership.

Costco Wholesale Corp. engages in the provision of operation of membership warehouses through wholly owned subsidiaries. It operates through the following geographical segments: United States, Canada, and Other International Operations. The company was founded by James D. Sinegal and Jeffrey H. Brotman in 1983 and is headquartered in Issaquah, WA.

Costco Wholesale Corp

Costco is trending amidst discussions about its valuation, potential impact from tariffs, and recent executive membership policy changes. The community is weighing whether its defensive strength justifies its high P/E ratio, especially compared to competitors, while monitoring upcoming earnings for insights on consumer spending and tariff navigation. Some traders anticipate a potential stock split or special dividend, while others point to insider selling as a bearish indicator.

Strategy, Inc. engages in the provision of enterprise analytics and mobility software. The firm designs, develops, markets, and sells software platforms through licensing arrangements and cloud-based subscriptions and related services. Its product packages include Hyper. The company was founded by Michael J. Saylor and Sanjeev K. Bansal on November 17, 1989, and is headquartered in Vienna, VA.

Strategy Inc. - Ordinary Shares - Class A

Strategy

Strategy ($MSTR) is trending as traders weigh its correlation to Bitcoin amid recent price swings, with some highlighting its potential as a leveraged play while others point to dilution risks. Community members are actively discussing key support levels and potential short squeeze opportunities, with mixed sentiment on its performance relative to direct Bitcoin ownership. Overall, the conversation revolves around $MSTR's valuation and its future trajectory in relation to the broader crypto market.

SciSparc Ltd. is a clinical stage pharmaceutical company, which focuses on creating and enhancing a portfolio of technologies and assets based on cannabinoid pharmaceuticals. The firm initiated two internal drug development programs based on repurposing an FDA approved synthetic cannabinoid (dronabinol): Joint Pharma developing THX-TS01 targeted to the treatment of TS and Brain Bright Pharma developing THX-ULD01 targeted to the high value and under-served market of MCIs. Its products include SCI-110, SCI-210, SCI-160, and CannAmide. The company was founded on August 23, 2004 and is headquartered in Tel Aviv, Israel.

SciSparc Ltd

Scisparc Ltd

SPRC is trending due to a proposed merger with AutoMax, an EV importer, which could provide SPRC with revenue and access to the Nasdaq. The community is discussing the high borrowing fees for shorts and the potential for a short squeeze. Some are also speculating about the impact of potential SEC regulations on the market.

Lithium Americas Corp. engages in the development of the Thacker Pass project. It is focused on advancing Thacker Pass to production it is located in northern Nevada. The company was founded on January 23, 2023 and is headquartered in Vancouver, Canada.

Lithium Americas Corp (NewCo)

Lithium Americas Corp

Lithium Americas Corp ($LAC) is trending due to speculation around a potential equity stake from the U.S. government as part of loan renegotiations, sparking excitement about energy independence and green/AI initiatives. The community is buzzing about the potential for a short squeeze and comparing it to previous government-backed success stories like $MP, while also debating the company's financial health and production timeline amid fluctuating lithium prices.

Tidal Trust II - YieldMax MSTR Option Income Strategy ETF

YieldMax MSTR Option Income Strategy ETF

$MSTY is trending as investors discuss its performance relative to $MSTR and $BTC.X, particularly regarding dividend payouts versus capital losses; some community members express concern over NAV erosion, while others remain optimistic about long-term gains and averaging down, viewing the dip as a buying opportunity. The ETF's sensitivity to crypto market volatility and $MSTR's performance is a key talking point.

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Will the FDA's Nod for Subcutaneous Keytruda Ease Merck's Headwinds?

FDA clears MRK's Keytruda Qlex, a subcutaneous option that promises faster treatment and new patent protection amid looming headwinds.

Retail traders kept a cautious stance on Summit Therapeutics on Tuesday after Barclays initiated coverage of the biotech with an ‘Underweight’ rating and a $13 price target.&nbsp;The stock fell 4.3% to $18.12 on Tuesday and slipped another 0.4% after hours.Barclays flagged a long regulatory path, stiff competition in lung cancer, and a rival backed by a major pharma partner as key risks.The brokerage said it still sees a “high likelihood” of approval for ivonescimab, Summit’s experimental bispecific antibody, but its models suggest only modest improvements over the current standard of care.&nbsp;The note contrasted with&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/summit-therapeutics-gets-40-dollar-price-target-from-guggenheim/chwdQXARdpT">Guggenheim’s initiation</a> earlier this month at ‘Buy’ with a $40 price target, which argued the company’s late-stage trials could offer multi-fold upside if successful.The cautious call comes just days after Summit presented&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/retail-traders-flock-to-summit-therapeutics-after-new-cancer-drug-data-shows-survival-gains/chwW19jRdqH">new follow-up data from its Phase III HARMONi trial</a> at the World Conference on Lung Cancer in Barcelona. Patients with advanced non-small cell lung cancer on ivonescimab plus chemotherapy lived a median of 16.8 months versus 14 months on chemo alone, with hazard ratios pointing to survival benefits across Western and Asian cohorts.&nbsp;Earlier results showed the study met its main goal, cutting the risk of progression or death by 48% compared with chemotherapy alone.Ivonescimab, licensed from China’s Akeso and already approved there as SMT112, has been tested in more than 2,800 patients worldwide and carries a U.S. FDA Fast Track designation.&nbsp;Summit is running additional late-stage trials, HARMONi-3 and HARMONi-7, comparing ivonescimab against Merck’s blockbuster PD-1 drug Keytruda in first-line lung cancer, with readouts expected between 2027 and 2028.On Stocktwits, retail sentiment was ‘bearish’ amid ‘low’ message volume.One user remarked that they would only consider buying Summit Therapeutics if it returned to penny-stock levels, calling it “another one added to the biotech graveyard.”<stembedurl>https://stocktwits.com/Jahlisgo/message/628908644</stembedurl>Another user said they were holding their shares following the updated brokerage reports, waiting for what they described as a future payday.<stembedurl>https://stocktwits.com/Reesh/message/628891775</stembedurl><a href="https://stocktwits.com/symbol/SMMT">Summit’s stock</a> has risen 1.5% so far in 2025.For updates and corrections, email newsroom[at]stocktwits[dot]com.

Propanc Biopharma (PPCB) tumbled 17% in after-hours trading on Monday, with activity surging to nearly 33,000 times its usual volume. (Photo credit: Getty Images)

Summit Therapeutics Stock Draws Cautious Retail Mood After Barclays ‘Underweight’ Call: ‘Added To The Biotech Graveyard’

Barclays set a $13 price target, citing a long regulatory path and stiff competition in lung cancer.

Equity

Merck Falls 14% YTD: Time to Buy, Sell or Hold the Stock?

Merck stock is down 14% this year as Keytruda-led growth gets offset by Gardasil weakness and looming patent risks, which cloud the outlook.

SMMT Stock Plummets 25% on Regional Data Differences in NSCLC Study

Summit Therapeutics plunges 25% after its HARMONi study shows sharp regional differences in lung cancer trial outcomes.

Retail traders turned their attention to Summit Therapeutics late Sunday after the company released new follow-up data from its Phase III HARMONi trial. The study is testing ivonescimab, an experimental cancer drug, together with chemotherapy in patients with advanced non-small cell lung cancer.The trial focused on people whose tumors carried Estimated Glomerular Filtration Rate (EGFR) mutations and who had already failed a third-generation EGFR therapy. In this group, past attempts with PD-1 drugs had not delivered survival gains.In fresh results presented at the World Conference on Lung Cancer in Barcelona, patients on ivonescimab plus chemotherapy lived longer on average than those on chemotherapy alone.&nbsp;The overall survival hazard ratio&nbsp;was 0.78,&nbsp;indicating an improvement from the earlier analysis. Median survival was 16.8 months with the drug compared to 14.0 months with chemotherapy.Among Western patients,&nbsp;the median overall survival&nbsp;was 17 months with ivonescimab versus 14 months for the placebo. In North America specifically, median overall survival had not yet been reached in the ivonescimab arm compared with 14 months on chemotherapy alone.&nbsp;Median survival in Asian patients was 16.7 months for ivonescimab versus 14 months for chemotherapy.The primary analysis, conducted in April, had shown a positive trend in overall survival but did not meet statistical significance. The company noted that&nbsp;the median follow-up for Western patients was shorter than their median overall survival at that time.Earlier results had already&nbsp;demonstrated that the trial met its main goal. Patients on ivonescimab plus chemotherapy were 48% less likely to see their cancer worsen or to die compared with those on chemotherapy alone.The treatment also produced better responses: 45% of patients saw their tumors shrink versus 34% on chemotherapy, and those responses lasted longer, with a median of 7.6 months compared with 4.2 months.Safety data showed the combination was generally manageable and consistent with prior studies.&nbsp;Grade 3 or higher treatment-related adverse events occurred in 50% of ivonescimab patients versus 42.2% in the chemotherapy arm. Discontinuations due to adverse events were 7.3% versus 5%, and treatment-related deaths were reported in 1.8% and 2.3% of patients, respectively. The most common events were anemia and reduced blood counts, with less than 1% of ivonescimab patients experiencing severe hemorrhage.Ivonescimab, also known as SMT112 outside China, is a first-in-class bispecific antibody targeting both PD-1 and Vascular Endothelial Growth Factor (VEGF).&nbsp;It was engineered by China’s Akeso and has been tested in more than 2,800 patients globally. The drug is already approved in China and has&nbsp;a U.S. FDA Fast Track designation in the HARMONi trial setting.On Stocktwits, retail sentiment for Summit was ‘extremely bullish’ amid ‘extremely high’ message volume.One retail user said that long-term investors in Summit had grown used to the stock falling even on positive news, but pointed out shares are still up nearly 700% over the past five years.<stembedurl>https://stocktwits.com/EB2224/message/627780145</stembedurl>Another user noted that while the day had been volatile, “the markets don’t lie” and suggested Summit CEO Robert Duggan might have more to reveal, adding that he has a reputation for frustrating short sellers. The user speculated the stock could hit $30 by the end of the day.<stembedurl>https://stocktwits.com/BooEmmy/message/627780010</stembedurl><a href="https://stocktwits.com/symbol/SMMT">Summit’s stock</a> has risen 45.6% so far in 2025.For updates and corrections, email newsroom[at]stocktwits[dot]com.

 Summit’s stock (SMMT) has risen 45.6% so far in 2025. (Photo credit: Getty Images)

Retail Traders Flock To Summit Therapeutics After New Cancer Drug Data Shows Survival Gains

The updated Phase III HARMONi trial showed Western patients on ivonescimab lived a median 17 months versus 14 months on chemotherapy.

Summit Therapeutics (SMMT) shares were in the spotlight on Thursday after Guggenheim initiated coverage of the stock with a ‘Buy’ rating and a $40 price target.The price target represents a 70% upside from the stock’s closing price on Wednesday. SMMT stock has had a good run over the past year, nearly doubling in value.Guggenheim said that it liked Summit at $3 when the market was overlooking imminent data comparing progression-free survival with Summit’s Ivonescimab versus Merck's (MRK) blockbuster drug Pembrolizumab in lung cancer. Notably, the analyst said that they still like the stock at $24.On Stocktwits, retail sentiment around <a href="https://stocktwits.com/symbol/SMMT">SMMT stock</a> fell from ‘bullish’ to ‘neutral’ territory over the past 24 hours, &nbsp;while message volume stayed at ‘low’ levels.<figure class="image"><img style="aspect-ratio:585/62;" src="https://news.stocktwits-cdn.com/Screenshot_2025_09_04_at_11_41_23_AM_png_000895180e.webp" alt="SMMT's Sentiment Meter and Message Volume as of 11:41 a.m. ET on Sept. 4, 2025 | Source: Stocktwits" width="585" height="62"><figcaption>SMMT's Sentiment Meter and Message Volume as of 11:41 a.m. ET on Sept. 4, 2025 | Source: Stocktwits</figcaption></figure>A Stocktwits user said they see sustained growth potential for the stock.<stembedurl>https://stocktwits.com/db59/message/627464707</stembedurl>Guggenheim stated that if Summit's two late-stage clinical trials, HARMONi-3 and HARMONi-7, evaluating Ivonescimab in non-small cell lung cancer (NSCLC) are successful on progression-free survival or overall survival endpoints in 2027-2028, it has high conviction that the stock still has multi-fold upside potential from today's near-$20 billion valuation.While progression-free survival (PFS) is the length of time a patient with a disease, such as cancer, lives with the disease without it getting worse, or dies, overall survival (OS) is the total length of time a patient lives from the point of diagnosis or the start of treatment until death.HARMONi-3 is intended to evaluate Ivonescimab combined with chemotherapy compared to Pembrolizumab combined with chemotherapy in patients with first-line metastatic, squamous and non-squamous NSCLC. HARMONi-7 is intended to evaluate Ivonescimab monotherapy compared to Pembrolizumab monotherapy in patients with first-line metastatic NSCLC whose tumors produce a high amount of the PD-L1 protein.SMMT stock is up 32% this year and approximately 96% over the past 12 months.&nbsp;Read also: <a href="https://stocktwits.com/news-articles/markets/equity/agios-pharma-stock-slumps-but-company-remains-top-pick-for-analyst/chwdJJlRdYs">Agios Pharma Stock Slumped 15% Today But Company Remains Top Pick For This Analyst – Find Out More</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, the Summit Therapeutics company logo is seen on a smartphone screen. (Photo Illustration by Piotr Swat/SOPA Images/LightRocket via Getty Images)

Summit Therapeutics Gets A $40 Price Target From Guggenheim: Analyst Says It Likes The Stock At $24, Just Like It Did At $3

The price target of $40 represents an upside of 70% from the stock’s closing price on Wednesday.

Summit Therapeutics drew heavy retail interest on Tuesday after its partner, Akeso, reported that ivonescimab (AK112), a closely watched lung cancer drug, helped patients live longer in a key late-stage trial.Akeso said the final analysis of the Phase III study in patients with EGFR-mutated, advanced non-squamous non-small cell lung cancer who had already failed EGFR-TKI therapy showed ivonescimab extended overall survival, meeting the trial’s main goal with a clear and meaningful benefit.&nbsp;Detailed data will be presented at an upcoming medical conference.The update came alongside Akeso’s first-half earnings and drove its Hong Kong-listed shares up as much as 5.92% on Wednesday. Meanwhile, Summit, which holds U.S. rights to ivonescimab, rose as much as 14% Tuesday on the news.&nbsp;While the drug is already approved in China, Summit is running a similar trial with a broader, global population to pave the way for an approval in the U.S.Ivonescimab has already won two approved indications in China: for EGFR-mutated NSCLC after EGFR-TKI therapy, and as monotherapy for PD-L1-positive advanced NSCLC.&nbsp;The drug has been included in clinical treatment guidelines, and Akeso has launched over 30 trials, including 13 Phase III studies and six head-to-head comparisons with PD-(L)1 therapies.Bernstein analysts led by Rebecca Liang called the survival data “a positive surprise,” noting that whether the drug could extend overall survival “has been the center of debate for AK112 since last year,” Bloomberg&nbsp;<a target="_blank" rel="noopener noreferrer nofollow" href="https://www.bloomberg.com/news/articles/2025-08-27/akeso-s-lung-cancer-drug-hits-key-goal-in-china-study">reported</a>.&nbsp;They added it could be the biggest positive catalyst for Akeso since the company announced ivonescimab had outperformed Merck &amp; Co.’s top-selling cancer drug in a separate trial.On Stocktwits, retail sentiment was ‘extremely bullish’ for Summit Therapeutics amid ‘extremely high’ message volume, while Akeso drew ‘bullish’ sentiment with ‘high’ activity.One user speculated that Summit shares could reach $35 by&nbsp;the end of the week.&nbsp;<stembedurl>https://stocktwits.com/___dog___/message/626653621</stembedurl>Another suggested the stock was still digesting the overall survival news and argued it should already be trading above $30.<stembedurl>https://stocktwits.com/BooEmmy/message/626614344</stembedurl>While&nbsp;<a href="https://stocktwits.com/symbol/SMMT">Summit’s stock</a> has risen 51.2% so far in 2025,&nbsp;<a href="https://stocktwits.com/symbol/AKESF">Akeso’s U.S.-listed shares</a> have more than tripled over the same period.&nbsp;For updates and corrections, email newsroom[at]stocktwits[dot]com.

This Image Is A Part Of A Series On Pulmonary Pathologies. (Photo By BSIP/UIG Via Getty Images)

Summit Draws Frenzied Retail Chatter After Akeso Drug Shows Survival Benefit In Lung Cancer; Retail Sees More Upside

Analysts at Bernstein called the survival data “a positive surprise,” framing it as Akeso’s biggest catalyst since the drug previously outperformed Merck’s top-selling cancer therapy.

Can Keytruda Sustain Merck's Growth Through the Rest of 2025?

MRK banks on Keytruda's soaring sales and new oncology strategies to fuel 2025 growth, even as competition and patent loss loom.

SMMT Q2 Loss Wider Than Expected, Ivonescimab Studies in Focus

Summit Therapeutics posts wider-than-expected second-quarter loss as ivonescimab trials advance in multiple lung cancer settings.

Merck Stock Down 4% Since Q2 Results: How to Play the Stock

Merck slips following its Q2 results as Gardasil sales slump. However, Keytruda, new launches and a rich pipeline bolster its long-term case.

Summit Therapeutics, Inc. is a biopharmaceutical company, that focuses on the discovery, development, and commercialization of patient, physician, caregiver, and societal-friendly medicinal therapies intended to improve quality of life, increase potential duration of life, and resolve serious unmet medical needs. The firm conducts clinical programs focusing on Clostridioides Difficile Infection (CDI). Its lead product, Ridinilazole, is an orally administered small molecule antibiotic that is in Phase III clinical trials for the treatment of CDI. The company was founded in 2003 and is headquartered in Miami, FL.

Summit Therapeutics Inc

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Fiscal Period	Estimated	Reported	Surprise	Result
Q3 '25	-$0.17	--	--	N/A
Q2 '25	-$0.09	-$0.76	-736.88%	MISSED
Q1 '25	-$0.09	-$0.09	3.25%	BEAT
Q4 '24	-$0.08	-$0.08	1.20%	BEAT
Q3 '24	-$0.07	-$0.05	25.10%	BEAT

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