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Palantir Technologies, Inc. engages in the business of building and deploying software platforms that serve as the central operating systems for its customers. It operates through the Commercial and Government segments. The Commercial segment focuses on customers working in non-government industries. The Government segment is involved in providing services to customers that are the United States government and non-United States government agencies. Its platforms are widely used in areas such as defense, intelligence, healthcare, energy, and financial services, supporting data integration, large-scale analytics, and operational decision-making. The company was founded by Alexander Ceadmon Karp, Peter Andreas Thiel, Stephen Cohen, Joseph Lonsdale, and Nathan Dale Gettings in 2003 and is headquartered in Denver, CO.

Palantir Technologies Inc - Ordinary Shares - Class A

Palantir Technologies Inc

Palantir is trending due to community discussion around earnings and a subsequent price dip, with debates focusing on valuation and the influence of Michael Burry's short position. Some are optimistic about a rebound, citing AI hype and strong fundamentals, while others express concern about overvaluation and potential downside. CEO Alex Karp's remarks about shorts on CNBC are also fueling discussion.

Sarepta Therapeutics, Inc. is a commercial-stage biopharmaceutical company, which is engaged in the discovery and development of therapeutics for the treatment of rare diseases. The company was founded on July 22, 1980, and is headquartered in Cambridge, MA.

Sarepta Therapeutics Inc

Sarepta Therapeutics is trending due to recent earnings and trial data sparking debate, with discussion focused on the impact of a failed confirmatory trial on existing PMO therapies and the future of Elevidys. The community is weighing the potential for FDA action, the significance of 'missed' data, and whether the stock is now undervalued or facing further decline. Some traders see this as an opportunity for a short squeeze.

Pfizer Inc. is a research-based global biopharmaceutical company, which engages in the discovery, development, manufacture, marketing, sales and distribution of biopharmaceutical products worldwide. The firm works across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases. The company was founded by Charles Pfizer Sr. and Charles Erhart in 1849 and is headquartered in New York, NY.

Pfizer Inc.

Pfizer Inc

Pfizer is trending amid discussions around its pursuit of Metsera and competition with Novo Nordisk in the obesity drug market, as well as an upcoming earnings report and dividend payout. The community is focused on the potential impact of the Metsera acquisition and whether Pfizer can maintain its competitive edge. Some traders are eyeing potential breakouts while others express frustration with the stock's historical performance.

Aurinia Pharmaceuticals, Inc. is a clinical stage bio-pharmaceutical company, which engages in the research, development, and commercialization of therapeutic drugs. The company was founded by Robert Foster, Richard Glickman, and Michael Martin on June 16, 1993 and is headquartered in Edmonton, Canada.

Aurinia Pharmaceuticals Inc

AUPH is trending after positive numbers sparked buyout speculation within the community, despite a generally negative market day. Community members are also closely following developments around patent extensions and potential new indications for AUR200. Some investors express frustration with management, while others remain optimistic about the company's long-term potential.

Hertz Global Holdings, Inc. engages in the vehicle rental business through the Hertz, Dollar, and Thrifty brands. It operates under the Americas Rental Car (RAC) and International Rental Car (RAC) segments. The Americas RAC segment focuses on operations in the United States, Canada, Latin America, and the Caribbean. The International RAC segment includes the provision of rental and sales of vehicles and value-added services in other locations. The company was founded in 1918 and is headquartered in Estero, FL.

Hertz Global Holdings Inc. - Ordinary Shares (New)

Hertz is trending as community members discuss a potential short squeeze amid high short interest and recent earnings. The company's turnaround efforts, including cost-cutting and diversification, are also key talking points. Bullish sentiment is building, especially with chatter around the Amazon partnership.

RAGE GUY (RAGE) is a cryptocurrency inspired by the Rage Guy meme, one of the earliest and most recognizable characters from internet rage comics. The project captures the cultural legacy of early meme history and brings it onto the blockchain in tokenized form. It is designed as a community-driven digital asset that celebrates internet culture, nostalgia, and the role memes play in shaping online communities.

Rage Guy

$RAGE is trending as the community rallies around the meme-based crypto, emphasizing retail unity and a return to OG memecoin values. Community members express strong conviction and a belief in building a lasting movement, viewing $RAGE as more than just hype. The focus is on a cult-like community and the power of memes in the crypto space.

Bitcoin is the first successful internet money based on peer-to-peer technology; whereby no central bank or authority is involved in the transaction and production of the Bitcoin currency. It was created by an anonymous individual/group under the name, Satoshi Nakamoto. The source code is available publicly as an open source project, anybody can look at it and be part of the developmental process.  Bitcoin is changing the way we see money as we speak. The idea was to produce a means of exchange, independent of any central authority, that could be transferred electronically in a secure, verifiable and immutable way. It is a decentralized peer-to-peer internet currency making mobile payment easy, very low transaction fees, protects your identity, and it works anywhere all the time with no central authority and banks.  Bitcoin is designed to have only 21 million BTC ever created, thus making it a deflationary currency. Bitcoin uses the SHA-256 hashing algorithm with an average transaction confirmation time of 10 minutes. Miners today are mining Bitcoin using ASIC chip dedicated to only mining Bitcoin, and the hash rate has shot up to peta hashes.  Being the first successful online cryptography currency, Bitcoin has inspired other alternative currencies such as Litecoin, Peercoin, Primecoin, and so on.  The cryptocurrency then took off with the innovation of the turing-complete smart contract by Ethereum which led to the development of other amazing projects such as EOS, Tron, and even crypto-collectibles such as CryptoKitties.

Bitcoin

Bitcoin is trending as the price experiences volatility, sparking debates about whether this is a healthy pullback or the start of a deeper correction. Community discussions revolve around key support levels, potential bottom fishing opportunities, and whether institutions are driving the price action. Some traders express concern about overleveraged positions and the possibility of a crypto winter.

Uber Technologies, Inc. is a technology platform, which engages in the development and operation of technology applications, networks, and product to power movement from point A to point B. The firm offers ride services and merchants delivery service providers for meal preparation, grocery, and other delivery services. It operates through the following segments: Mobility, Delivery, and Freight. The Mobility segment refers to products that connect consumers with Mobility Drivers who provide rides in a variety of vehicles, such as cars, auto rickshaws, motorbikes, minibuses, or taxis. The Delivery segment offers consumers the chance to search for and discover local restaurants, order a meal, and either pick-up at the restaurant or have the meal delivered. The Freight segment focuses on connecting Carriers with Shippers on its platform, and gives Carriers upfront, transparent pricing, and the ability to book a shipment. The company was founded by Oscar Salazar Gaitan, Travis Kalanick, and Garrett Camp in 2009 and is headquartered in San Francisco, CA.

Uber Technologies Inc

UBER is trending as investors digest mixed signals post-earnings, balancing strong performance metrics with concerns about guidance and broader market conditions. Community discussions revolve around whether the dip represents a buying opportunity, with some highlighting the potential for long-term growth driven by autonomous vehicle initiatives. Several analysts have reiterated Buy ratings, noting robust growth, while others observe that the stock price has been disconnected from fundamentals.

Dog (Bitcoin) is a fully decentralized memecoin on the Bitcoin blockchain, backed by a community dedicated to onboarding millions of people to Bitcoin.  Dog is secured by the Bitcoin blockchain and exists on Bitcoin L1, marking a significant innovation compared to Bitcoin with just BTC. Dog is a Bitcoin Runes token with a minimal on-chain footprint, native to Bitcoin, and stored in UTXOs, just like Bitcoin.   What is the project about?  Dog does not do any paid promotion and is fully decentralized just like Bitcoin. Every influencer who chooses to post about Dog either received the airdrop or bought on secondary. Dog leverages the CC0 license to ensure that Dog is not owned by any single entity but rather by everyone. This had lead to the "DOG Army" independently creating art, apps, lotteries, plushies, websites, podcast, magazines, X account, IRL meetups, clothing lines, PFP collections, Telegram groups, and TikTok/Instagram about Dog.  What makes your project unique?  Dog was airdropped in the fairest memecoin launch ever. In early 2024, the Bitcoin Ordinals ecosystem came together in a full volunteer initiative that rewarded early adopters of the Ordinals Protocol. There was no team allocation, and 100% of the supply was airdropped for free. The airdrop algorithm favored neither whales nor influencers; it was determined by the community and made open-source for maximum transparency.

Dog (Bitcoin)

$DOG is trending as community members highlight its strong ties to the Bitcoin network and its fair distribution via airdrop. Discussion centers on $DOG being the premier meme coin on Bitcoin and the growing $DOG army. The connection between $DOG and $CBLO, a public company accumulating $DOG, is also a key talking point.

Novo Nordisk A/S is a global healthcare company, which engages in the discovery, development, manufacturing and marketing of pharmaceutical products. It operates through the Diabetes and Obesity Care, and Rare Disease segments. The Diabetes and Obesity Care segment includes diabetes, obesity, cardiovascular, and emerging therapy areas. The Rare Disease segment refers to rare blood disorders, rare endocrine disorders, and hormone replacement therapy. The company was founded by Harald Pedersen and Thorvald Pedersen in 1923 is headquartered in Bagsværd, Denmark.

Novo Nordisk - ADR

Novo Nordisk A/S

Novo Nordisk is trending as it engages in a bidding war with Pfizer to acquire Metsera, a company with promising obesity drug assets; the community debates whether this acquisition strategy is the right move. Some believe Novo is strategically blocking a competitor, while others suggest focusing on share buybacks, particularly amidst concerns about market share competition with Eli Lilly. Recent messages also highlight anticipation for upcoming earnings and potential FDA approval for Novo's oral Wegovy.

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Upstream Bio (UPB) shares saw an increase in after-hours trading on Friday following the company's presentation of pharmacology modeling data, which showed investigational antibody verekitug as potentially more potent than tezepelumab by targeting the TSLP receptor rather than its ligand.Shares of the company finished at $11.36, down by 1.7%, but rose to $11.41 in after-hours trading with a 0.4% gain.Results from the European Academy of Allergy &amp; Clinical Immunology Congress demonstrated that verekitug produced lasting and thorough blockage of the TSLP/TSLPR complex, which drives critical inflammatory diseases, including severe asthma, as well as COPD and chronic rhinosinusitis with nasal polyps (CRSwNP).The FDA-approved antibody Tezspire (tezepelumab), which targets severe asthma, operates through TSLP ligand inhibition and was developed jointly by AstraZeneca and Amgen.The modeling study used a mechanistic PK/PD approach and incorporated clinical and published data.&nbsp;Simulations predicted that verekitug would lead to a greater reduction in fractional exhaled nitric oxide (FeNO)—a biomarker for airway inflammation—compared to tezepelumab.The company is looking to assess top-line Phase 2 data in CRSwNP later this year, and in severe asthma in the first half of 2026.”Verekitug is the only known monoclonal antibody in clinical development that directly targets the TSLP receptor, offering what the company describes as a more upstream and durable blockade of the inflammatory cascade.The stock moved higher after the release, with investors responding positively to the strengthened differentiation case for verekitug as it advances through multiple Phase 2 trials.&nbsp;These include the Valiant study in severe asthma, the Vibrant trial in CRSwNP, and a planned trial in COPD.Upstream Bio previously reported favorable tolerability, high subcutaneous bioavailability, and a consistent pharmacokinetic profile for verekitug in completed Phase 1 studies.On Stocktwits, retail sentiment was ‘neutral’ amid ‘high’ message volume.Upstream’s stock has declined 30.3% so far in 2025.For updates and corrections, email newsroom[at]stocktwits[dot]com.

Portrait of a doctor woman on the background of stock charts. | Image source: Getty Images

Upstream Bio Stock Gets A Boost As New Lung Inflammation Drug Shows Higher Potency

The company is progressing with multiple Phase 2 trials for its investigational treatment targeting severe respiratory diseases.

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Automotive Security Leaders Must Take Immediate Action to Mitigate the Surging Cyber Threats--Upstream Report Reveals Critical Gaps

Automotive Security Leaders Must Take Immediate Action to Mitigate the Surging Cyber Threats--Upstream Report Reveals Critical Gaps Automotive Security Leaders Must Take Immediate Action to Mitigate...

Upstream Bio, Inc. is a clinical-stage biotechnology company, which engages in the development of treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It develops verekitug, the only known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin. The company was founded in April 2021 and is headquartered in Waltham, MA.

Upstream Bio Inc.

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Current Price	$24.78
Prev Close	$25.02
Open	$24.48
Dividend Yield	0.00%
50-Day Moving Average	$19.49
Beta	1.16
Avg. Volume	353,554.13
PE Ratio	-12.20

52-Week High	$29.46
52-Week Low	$5.14
Market Capitalization	$1.35B
EPS (Annual)	-$1.43
Price to Book	3.29
Revenue Per Employee	$45,576.92
Enterprise Value/EBITDA	N/A

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Upstream Bio Inc.

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