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Avalo Therapeutics, Inc. is a clinical stage biotechnology company, which engages in the treatment of immune dysregulation by developing therapies that target the LIGHT-signaling network. It also focuses on reducing LIGHT levels which can moderate immune dysregulation in many acute and chronic inflammatory disorders. The company was founded by Blake M. Paterson, Isaac Blech, Barbara S. Slusher, and Solomon H. Snyder on January 31, 2011 and is headquartered in Wayne, PA.

Avalo Therapeutics Inc

Avalo Therapeutics is generating significant investor interest driven by high trading volumes, active momentum in its clinical-stage pipeline, and multiple analyst endorsements from firms like Guggenheim and HC Wainwright. Community discussion is focused on the high-stakes Phase 2 LOTUS trial readout expected in 2026 and ongoing debates regarding the company's financial risk profile versus the potential upside of its immunology platform.

Costco Wholesale Corp. engages in the provision of operation of membership warehouses through wholly owned subsidiaries. It operates through the following geographical segments: United States, Canada, and Other International Operations. The company was founded by James D. Sinegal and Jeffrey H. Brotman in 1983 and is headquartered in Issaquah, WA.

Costco Wholesale Corp

Costco is currently trending as investors monitor its resilience amid macroeconomic volatility and ongoing debates surrounding the impact of potential tariff refunds on retail pricing. The community remains focused on Costco's defensive strengths, with frequent discussions centered on its robust membership renewal rates, traffic growth, and valuation relative to the broader consumer staples sector.

Algorand is a scalable, secure, and decentralized digital currency and smart contract platform. Its protocol uses a variation of Proof-of-Stake (PoS) called Pure PoS (PPoS) to secure the network and reach consensus on block production. Developers can build decentralized applications (dApps) using familiar programming languages, including Python, which Algorand supports natively. Its infrastructure enables various use cases, including payment systems, digital identity solutions, supply-chain tracking, and financial services. The protocol's architecture allows for tokenization of assets and the development of smart contracts, while its technical specifications support both retail users seeking basic transaction capabilities and enterprises requiring more, complex, blockchain solutions.

Algorand

Algorand is currently a major focal point for traders due to its recent surge in social media volume and discussion surrounding its post-quantum security features. Community members remain polarized, with many debating the impact of institutional-grade infrastructure upgrades and potential regulatory shifts while long-term holders focus on accumulation during significant price volatility.

Zebec's integrated products - real time payroll apps, on-chain payments infrastructure and networked DePIN - serve companies of all sizes, merchants and individuals and help transcend the boundaries of traditional banking and diminish the role of financial intermediaries.

Zebec Network

Zebec Network is trending as the community speculates on a major upcoming partnership announcement, with many pointing to a connection with Stellar or a potential collaboration with Ripple/XRP at an upcoming industry event. Investors are actively debating the project's long-term utility in global payroll and real-world adoption, balancing high-conviction sentiment against skepticism regarding its price performance and market volatility.

Schwab Strategic Trust - Schwab US Dividend Equity ETF

Schwab US Dividend Equity ETF

Schwab US Dividend Equity ETF is capturing investor attention as they rotate toward defensive, value-oriented positions amidst broader market volatility. The community is actively debating the fund's resilience, with many investors maintaining a long-term 'buy and hold' strategy despite recent stagnant performance, while others monitor the ETF's sector diversification and dividend growth potential as a reliable hedge.

Clene, Inc. is a clinical-stage biopharmaceutical company, which focuses on the discovery, development, and commercialization of novel clean-surfaced nanotechnology therapeutics. It offers a nanotechnology drug platform for the development of a new class of orally administered neurotherapeutic drugs. The company was founded in 2013 and is headquartered in Salt Lake City, UT.

Clene Inc

Clene Inc. is trending as the community eagerly awaits definitive biomarker data and regulatory updates regarding an accelerated approval pathway for its ALS candidate, CNM-Au8. Investors are closely monitoring upcoming conference presentations and regulatory milestones, balancing high-conviction long-term sentiment against volatility driven by short interest and recent insider selling activity.

BtcUSD is a completely decentralized stablecoin issued and managed by BTCFi, a platform where users can deposit Bitcoin of various formats to use as collaterals. BtcUSD offers Bitcoin holders the opportunity to generate additional yields with their Bitcoin positions through DeFi usage.

Bitcoin USD (BTCFi)

Bitcoin is experiencing heightened volatility and intense community debate as it tests critical support levels around 60k-65k, with traders closely monitoring technical formations like bear flags and head-and-shoulders patterns. While some bulls are looking for a reclaim of key resistance zones to trigger a long-term uptrend, many participants remain cautious, pointing to equity market weakness and potential liquidity risks that could lead to further downside tests.

The Internet Computer is a decentralized cloud blockchain designed to run applications, websites, and backend systems fully on-chain. Its architecture provides robust security, resilience, and built-in multi-chain support.  A key focus of the network is enabling a “self-writing cloud,” where AI tools allow users generate applications through natural-language instructions.  Developers and users can experiment with the platform using AI app-generation tools like caffeine.ai or by writing serverless code directly through online IDEs such as icp.ninja.  The ICP token is used to pay for computation (through a burn-based model) and to participate in network governance through staking.

Internet Computer

Internet Computer (ICP) is currently a focal point for the community due to major structural updates like Mission 70aimed at reducing token inflationand increasing adoption through sovereign subnets in regions like Switzerland and Pakistan. While some users remain skeptical due to historical volatility and the project's long-term performance, many community members are highlighting the real-world utility of platforms like Caffeine.ai and the growing number of canisters as indicators that the network's fundamentals are strengthening for a future recovery.

Provides investment banking, securities and asset management services

Goldman Sachs Group, Inc.

Goldman Sachs is capturing significant attention as the firm integrates advanced AI models to automate compliance roles, while simultaneously navigating heightened market scrutiny over its past ties to Jeffrey Epstein and recent leadership resignations. The stock is experiencing intense volatility as investors weigh these corporate headwinds against the firm's strategic expansion into private credit and asset management.

Babcock & Wilcox Enterprises, Inc. engages in the provision of fossil and renewable power generation and environmental equipment. It operates through the B&W segment. The company was founded by George H. Babcock, Stephen Wilcox, Jr., and Joseph P. Manton in 1856 and is headquartered in Akron, OH.

Babcock & Wilcox Enterprises Inc

Babcock & Wilcox (BW) is experiencing significant momentum following a major $2.4 billion power infrastructure contract, with community discussions largely focused on its role in providing essential energy solutions for AI data centers. The stock is a primary focal point for investors tracking related holdings like B. Riley (RILY) and Applied Digital (APLD), as participants debate the impact of institutional backing and the potential for a long-term valuation re-rating.

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Nifty 50

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Reliance Industries Ltd.

Zomato Ltd.

Tata Consultancy Services

Tata Motors Ltd.

HDFC Bank Ltd.

ITC Ltd.

Adani Enterprises Ltd

Axis Bank Ltd

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Apple Inc.

Tesla Inc

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SELLAS Life Sciences Group (NASDAQ:SLS) Stock Price Down 7.7%  - Here's Why

SELLAS Life Sciences Group (NASDAQ:SLS) Shares Down 7.7% - What's Next...

All You Need to Know About SELLAS Life Sciences Group, Inc. (SLS) Rating Upgrade to Buy

SELLAS Life Sciences Group, Inc. (SLS) has been upgraded to a Zacks Rank #2 (Buy), reflecting growing optimism about the company's earnings prospects. This might drive the stock higher in the near term.

Wall Street Analysts Believe SELLAS Life Sciences Group, Inc. (SLS) Could Rally 63.58%: Here's is How to Trade

The consensus price target hints at a 63.6% upside potential for SELLAS Life Sciences Group, Inc. (SLS). While empirical research shows that this sought-after metric is hardly effective, an upward trend in earnings estimate revisions could mean that the stock will witness an upside in the near term.

<ul class="summary-bullets"><li>Investors weighed conflicting signals from Middle East diplomacy and braced for fresh labor market data.</li><li>AI trade tensions and regulatory risks kept Nvidia and chip-linked names under pressure.</li><li>U.S. President Trump will be holding a cabinet meeting at 10:00 am ET today.&nbsp;</li></ul>U.S. stock futures fell early Thursday as investors continued to parse the geopolitical developments in the Middle East. Amid conflicting reports, Iran is said to be reviewing a U.S. peace proposal delivered through Pakistan. Traders are also bracing for fresh macro signals with jobless claims data due later today. U.S. President Trump will be holding a cabinet meeting at 10:00 am ET today.&nbsp;As of 4:00 a.m. ET on Thursday, Dow, S&amp;P 500, and Nasdaq futures fell 0.4%, and Russell 2000 futures were down 0.6%.Retail sentiment toward the&nbsp;<a href="https://stocktwits.com/symbol/SPY">SPDR S&amp;P 500 ETF (SPY)</a>, an exchange-traded fund that tracks the S&amp;P 500 Index, and the&nbsp;<a href="https://stocktwits.com/symbol/QQQ">Invesco QQQ Trust (QQQ)</a> ETF, which tracks the Nasdaq-100 Index, has been languishing at ‘extremely bearish’ amid high trading volume.&nbsp;Trending Stocks To WatchNvidia (NVDA):&nbsp;The chipmaker remains in focus, with retail sentiment weakening to ‘bearish’ on Stocktwits. Calls are growing louder in Washington, with U.S. Senators Warren and Banks pushing to freeze export licenses over national security concerns.Meta Inc (META):&nbsp;It has lost another lawsuit alleging they made misleading claims about platform safety, adding to its growing list of legal headwinds.Destiny Tech100 (DXYZ):&nbsp;Garnering heavy retail interest as speculation around a potential SpaceX IPO grows this week.Micron (MU), Sandisk (SNDK):&nbsp;Memory stocks took a hit after reports that Google’s new AI model architecture could bring a significant impact on memory requirements.Super Micro (SMCI): The stock remained under pressure as shareholders filed a securities fraud lawsuit following recent allegations of chip smuggling.ImmunityBio (IBRX): The retail favorite biotech stock is back on traders’ radar after the company highlighted progress in its bladder cancer program and expanded trials targeting severe pneumonia and ARDS.&nbsp;Sellas Life Sciences (SLS): This pharma stock is gaining ground amid&nbsp;retail-trader speculation that Pfizer (PFE) may target the firm for an acquisition.urban-Gro (UGRO): The stock fell over 10% in early pre-market trading after surging over 400% in the previous session. Retail is bullish on the company’s new exposure to India’s fast-growing cricket economy following its merger with Flash Sports &amp; Media.Other tickers trending on&nbsp;Stocktwits&nbsp;at the time of writing included Adma Biologics (ADMA), Upstart Holdings (UPST), Moonlake Immunotherapeutics (MLTX), NextDecade Corporation (NEXT), and Alphabet Inc (GOOGL).&nbsp;Other Catalysts To WatchOn the economic front, traders will be watching for the release of continuing jobless claims data at 8:30 am ET. Also keep an eye on commentary from a whole host of Fed Governors’ speeches through the day, including Fed Vice Chair for Supervision Michael Barr.On earnings radar, watch out for quarterly reports from Pulmatrix (PULM), BioRestorative Therapies Inc (BRTX), and POET Technologies Inc (POET), among others, today.&nbsp;For updates and corrections, email newsroom[at]stocktwits[dot]com

Nasdaq, S&P 500 Futures Fall Ahead Of Jobless Claims Data: Why NVDA, META, DXYZ, IBRX, SLS Are Keeping Traders Engaged Today

Data from Stocktwits shows that traders remain ‘extremely bearish’ on SPY and QQQ. 

Equity

Data from Stocktwits shows that traders remain ‘extremely bearish’ on SPY and QQQ. 


<ul class="summary-bullets"><li>Investors compared Merck’s willingness to pay a 42% premium for mid-stage leukemia drug TERN-701 with Sellas’ AML pipeline opportunity.</li><li>Several retail investors pointed to Pfizer as a potential buyer, citing its ongoing expansion in hematologic cancers and need for post-COVID growth drivers.</li><li>Attention is focused on the Phase 3 Regal trial of GPS in AML relapse patients, which had recorded 72 of 80 required death events for final analysis as of late December.</li></ul>Shares of Sellas Life Sciences (SLS)&nbsp;jumped over 6% on Wednesday as Merck’s $6.7 billion acquisition of Terns Pharmaceuticals triggered renewed buzz on potential takeover targets across blood-cancer drug pipelines.<a href="https://stocktwits.com/symbol/SLS">SLS stock</a> has risen 41% this quarter and has surged over 300% over the past year.<h2 class="st-heading-2">Merck’s Terns Deal Spurs Leukemia Interest</h2>Merck said it would acquire Terns for $53 per share in cash, representing a 42% premium to the 90-day average before the deal’s announcement.The acquisition adds TERN-701, an oral leukemia drug currently in early-to-mid-stage clinical testing, to Merck’s blood-cancer pipeline. The treatment is being studied for patients with chronic myeloid leukemia whose disease did not respond well to earlier therapies or who could not tolerate them.Now, retail investors are drawing comparisons between Merck’s willingness to pay billions for a mid-stage leukemia asset and the perceived commercial opportunity around Sellas’ pipeline.<h2 class="st-heading-2">Retail Traders Bet On Pfizer As Potential Buyer</h2>On Stocktwits, retail sentiment for SLS has remained in the ‘bearish’ zone over the past week amid an over 350% surge in message volume this quarter. The stock’s watcher base has jumped 20% over the past year.&nbsp;<figure class="image"><img src="https://news.stocktwits-cdn.com/sls_ss_png_7ab67c1205.webp" alt="sls ss.png" width="968" height="144"><figcaption>SLS sentiment and message volume as of March 26 | Source: Stocktwits</figcaption></figure>Sentiment over the past day has increasingly centered on Pfizer as a potential acquirer following the Merck-Terns deal. One trader&nbsp;<a href="https://stocktwits.com/MarcoFla99/message/648580457">said</a>, “My $$ is on PFE to acquire SLS.”The investor pointed to Pfizer’s ongoing clinical work on Mylotarg in CD33-positive acute myeloid leukemia (AML), noting that the company is conducting a prospective surveillance study to evaluate the drug’s safety and effectiveness in newly diagnosed patients as part of its push into hematologic cancers.Another trader argued Pfizer may be seeking a major oncology win following the pandemic-era revenue decline,&nbsp;<a href="https://stocktwits.com/OnTheBalance/message/648587881">saying</a>, “They need a clear win to bury the COVID era and leave it behind… What is better than a cancer moonshot?”Another investor&nbsp;<a href="https://stocktwits.com/OnTheBalance/message/648587881">highlighted</a> motivations behind possible acquisitions, saying “PFE stock and shareholders [are] looking desperately for a powerful boost.”<h2 class="st-heading-2">Retail Traders Run Buyout Valuation Scenarios</h2>One retail investor&nbsp;<a href="https://stocktwits.com/Duncan74/message/648577739">estimated</a> that applying a typical 5x-8x peak-sales multiple to projected revenue of about $5.5 billion for Sellas’ lead AML candidate, Galinpepimut-S (GPS), and $1.2 billion for its CDK9 inhibitor, SLS-009, could imply a valuation range of roughly $33.5 billion to $53.6 billion.Another trader compared the Merck-Terns transaction directly with Sellas’ opportunity: “If TERN was acquired by MRK for 8.8b. and our product has market size smaller than TERN. our upside should be 4x-6x?”A separate user discussed potential acquisition structure scenarios,&nbsp;<a href="https://stocktwits.com/JdlawVT40/message/648584776">saying</a>, “Wouldn’t a PFE stock purchase be sweet. All long term holding period and a 6.30 dividend. Four to one share SLS.”Another trader&nbsp;<a href="https://stocktwits.com/Johnmtnb2018/message/648533707">suggested</a> the setup for a deal may already be in place: “The table is now fully set for interested pharma’s to finish a deal!” One investor also&nbsp;<a href="https://stocktwits.com/Laacy/message/648584092">outlined</a> a portfolio strategy for a possible acquisition, saying, “If PFE offers id sell my options. Keep 33% as pfizer shares if share based and sell the rest.”<h2 class="st-heading-2">GPS Catalyst Aligns With Pfizer Moves</h2>Investor attention remains focused on Sellas’ Phase 3 Regal trial evaluating GPS in AML patients whose cancer returned and then went back into remission after additional treatment. The study is designed to reach its final analysis after 80 patient death events, with 72 recorded as of Dec. 26 while the trial remained fully blinded, placing the program closer to a potential results-driven catalyst.Merck’s move to buy TERN-701 underscores continued demand for blood-cancer assets, while Pfizer has been stepping up investment in oncology as it looks to rebuild growth after the sharp decline in COVID vaccine revenues and increasing competition across several aging products.&nbsp;The company has expanded its cancer pipeline through initiatives including its $1.25 billion upfront licensing deal with 3SBio, ongoing development of Mylotarg in AML and progress with Tukysa in breast cancer.For updates and corrections, email newsroom[at]stocktwits[dot]com.Read Next:&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/sls-vs-tern-which-stock-has-more-upside-ahead-of-keytruda-patent-cliff/cZ3YKepRI16">SLS Vs. TERN: Which Pharma Stock Has More Upside As Merck Eyes $6B Cancer Bet Ahead Of Keytruda Patent Cliff</a>

SLS stock has risen 41% this quarter and has surged over 300% over the past year. (Photo credit: Getty Images)

SLS Stock Jumps After Merck's Tern Deal Sparks Buyout Buzz In Blood-Cancer Space: Retail Bets On This Big Pharma Suitor

Merck’s acquisition of Terns underscores strong big-pharma demand for blood-cancer assets, as Pfizer also expands its oncology pipeline.

Medicine pill is seen with Merck logo displayed on a screen in the background in this illustration photo taken in Poland on November 5, 2021. (Photo by Jakub Porzycki/NurPhoto via Getty Images)

SLS Vs. TERN: Which Pharma Stock Has More Upside As Merck Eyes $6B Cancer Bet Ahead Of Keytruda Patent Cliff

SLS vs TERN Stock - Analyst estimates suggest SLS may offer 73% upside, versus 16% for TERN, despite takeover momentum supporting TERN’s shares.

Analyst estimates suggest SLS may offer 73% upside, versus 16% for TERN, despite takeover momentum supporting TERN’s shares.

SELLAS Life Sciences Group (NASDAQ:SLS) Trading Down 8.5%  - Here's Why

SELLAS Life Sciences Group (NASDAQ:SLS) Shares Down 8.5% - Time to Sell...

SELLAS Life Sciences Group (NASDAQ:SLS) Trading Up 12.9% - Here's Why

SELLAS Life Sciences Group (NASDAQ:SLS) Trading Up 12.9% - Here's What Happened...

Dagco Inc. Purchases Shares of 577,540 SELLAS Life Sciences Group, Inc. $SLS

Dagco Inc. purchased a new stake in shares of SELLAS Life Sciences Group, Inc. (NASDAQ:SLS - Free Report) during the fourth quarter, according to the company in its most recent disclosure with the Securities and Exchange Commission (SEC). The fund purchased 577,540 shares of the company's stock, va...

Penny Stocks To Research - March 22nd

Kosmos Energy, Co-Diagnostics, SELLAS Life Sciences Group, JetBlue Airways, BigBear.ai, Banco Bradesco, and Bitfarms are the seven Penny stocks to watch today, according to MarketBeat's stock screener tool. Penny stocks are shares of very small companies that trade at low pricestypically under $5...

SELLAS Life Sciences Group, Inc. is a clinical stage biopharmaceutical company, which engages in the development and commercialization of immunotherapeutic for cancer indications. Its product pipeline includes galinpepimut-S. The company was founded by Angelos M. Stergiou on April 3, 2006 and is headquartered in New York, NY.

SELLAS Life Sciences Group Inc

Opendoor ($OPEN)

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Ondas Inc. ($ONDS)

The stock that proved the power of the crowd. Fueled by community energy and social momentum, this winner captivated retail investors regardless of what the "experts" or traditional fundamentals had to say.

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Debate intensifies over the extended trial duration, with many analysts tracking the final 80 events and potential for early intervention.

Investors are weighing the strategic dual value of both the lead immunotherapy candidate and the versatile CDK9 inhibitor platform.

Rising short interest against strong institutional accumulation is fueling speculation of a violent upward repricing during any catalyst event.

Investors are focused on the committee's independent power to mandate a halt for clinical efficacy if results prove overwhelming.

New abstract data suggesting efficacy independent of the p53 pathway is raising hopes for expansion into massive, untapped solid tumor markets.

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