SPDR Dow Jones Industrial Average ETF

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BioCryst Pharmaceuticals, Inc. is a biotechnology company. It engages in the provision of structure-guided drug design with the goal of developing oral small-molecule and protein therapeutics to target difficult-to-treat rare diseases. The company was founded by William M. Spencer III, Charles E. Bugg, and John A. Montgomery in 1986 and is headquartered in Durham, NC.

Biocryst Pharmaceuticals Inc.

Biocryst Pharmaceuticals is trending as heightened speculation around a potential buyout and unconfirmed M&A rumors drive significant after-hours volume and price volatility. Community members are actively debating the legitimacy of these reports, with long-term shareholders analyzing historical valuation metrics and potential takeover scenarios while others speculate on the motivations behind recent unusual trading patterns.

Veil Cash is a privacy application leveraging zk-SNARKs on Base L2, enabling verified depositors to achieve privacy and anonymity within a pool of trusted users.  Veil Cash is a non-custodial privacy protocol on Base L2. Veil Cash's goal will be enabling verified users to achieve privacy and anonymity from trusted pools.  Veil is a set of smart contracts that will allow users that are deemed as verified users to deposit into the protocol. Users can later withdraw their deposits from another address without creating a link between these two addresses.   Verified users are those who meet certain criteria based on both on-chain and off-chain data.

Veil-project

The Veil community is rallying around the project's focus on digital privacy and decentralization, often citing its multi-algorithm mining and staking capabilities as key differentiators. Investors are actively discussing the potential for a privacy-focused market surge, frequently highlighting the project's long-term utility alongside established privacy coins.

Blue Owl Capital, Inc. operates as an alternative asset management firm. It provides investors access to asset management capital solutions through its Direct Lending and GP Capital Solutions products. The company offers a platform of capital solutions to both middle market companies and large alternative asset managers. The company was founded by Doug Irving Ostrover, Michael Rees and Craig W.Packer in 2009 and is headquartered in New York, NY.

Blue Owl Capital Inc - Ordinary Shares - Class A

Blue Owl Capital is trending due to significant liquidity concerns following the restricted withdrawal access in its private credit funds, which has sparked investor anxiety over potential sector-wide fallout. The community is actively debating whether this represents an isolated incident or a broader 'canary in the coal mine' moment for private credit stability amidst rising default risks.

Roundhill ETF Trust - Roundhill Ether Covered Call Strategy ETF

oundhill Ether Covered Call Strategy ETF

Investors are closely monitoring YETH as the community debates its weekly distribution payouts versus the underlying volatility of Ethereum. While some traders leverage the fund for its income potential during range-bound market phases, others remain cautious due to concerns regarding NAV erosion and management performance.

Cardano is a blockchain platform built on academic research that enables smart contracts and decentralized applications while using significantly less energy than traditional cryptocurrencies like Bitcoin.   What sets Cardano apart is its methodical, research-driven approach — every major feature is peer-reviewed by scientists and cryptographers before being added to the network. This careful process aims to create a more secure and stable foundation compared to platforms that prioritize speed over thorough testing. The platform's native cryptocurrency, ADA, is used to send money, pay transaction fees, and participate in network governance.  Cardano uses a proof-of-stake system to process transactions, which works differently from Bitcoin's mining approach. Instead of competing to solve complex puzzles, users can "stake" their ADA — essentially locking it up temporarily — to become validators who verify transactions. The system selects validators based on how much ADA they've staked and for how long, then rewards them with additional ADA for their participation. This approach uses far less energy than traditional mining while keeping the network secure. The platform also features a two-layer design that separates basic payment transactions from smart contract operations, allowing each function to be optimized independently for better performance.   ADA holders can earn staking rewards by locking up their tokens to help secure the network, vote on proposed changes to the platform, and use ADA for international money transfers with lower fees than traditional services.  Cardano was founded in 2017 by Charles Hoskinson, who previously helped create Ethereum. Hoskinson leads Input Output Global (IOG), the technology company that builds and maintains Cardano's core software. The ecosystem operates through three organizations: IOG handles technical development, the Cardano Foundation promotes adoption and standardization, and Emurgo helps businesses integrate blockchain technology into their operations. This structure distributes responsibilities across multiple groups rather than concentrating control in a single entity.   In February 2025, major asset manager Grayscale Investments filed to create an exchange-traded fund (ETF) for Cardano with the U.S. Securities and Exchange Commission, which would allow traditional investors to buy ADA through their regular brokerage accounts without needing to set up cryptocurrency wallets.Retry

Cardano

Cardano (ADA) is currently a focal point for intense debate, as investors weigh ongoing regulatory developments like the Clarity Act against sentiment that the project is facing a long-term decline. While some community members view the current price as a prime accumulation opportunity for the long term, others are actively pivoting toward Bitcoin or expressing frustration over what they perceive as stagnant institutional interest and stalled performance.

ARK ETF Trust - ARK Autonomous Technology & Robotics ETF

ARK Autonomous Technology & Robotics ETF

ARKQ is capturing investor attention as community members debate whether emerging robotics and 'embodied AI' infrastructure will take the tech sector's leadership baton this year. The ETF remains a focal point for discussion regarding portfolio rotation into automation themes, with sentiment driven by institutional buying activity and the sector's long-term growth potential.

Chainlink is the industry-standard decentralized oracle network that solves the "oracle problem" by connecting smart contracts with real-world data. Blockchains cannot access external information on their own, so Chainlink acts as a secure bridge, enabling smart contracts to react to real-world events using verified, tamper-proof data. It is widely considered one of the first decentralized oracle networks and is the market leader in bringing off-chain data on-chain.  The platform operates through a decentralized network of nodes that fetch, validate, and deliver data to smart contracts. When a contract requests information like a stock price, a committee of independent nodes retrieves and aggregates the data to reach consensus, then delivers a single trustworthy answer. Chainlink offers a suite of services including Data Feeds for asset prices, CCIP for cross-chain token transfers and messaging, Automation for triggering smart contract functions, and Proof of Reserve for verifying asset collateralization.  Chainlink has established itself as critical infrastructure for both DeFi and institutional adoption, with partnerships including Swift, Euroclear, Mastercard, UBS, ANZ, Fidelity International, and J.P. Morgan. Its institutional products include the Chainlink Runtime Environment for tokenized asset workflows, Confidential Compute for privacy-preserving computation, and the Automated Compliance Engine for embedding regulatory rules into smart contracts.  The LINK token is the native asset used to pay node operators for services, fund subscription accounts, and incentivize network security through staking. Node operators stake LINK as collateral, which can be slashed if they provide inaccurate data. Chainlink was co-founded in 2017 by Sergey Nazarov and Steve Ellis, who co-authored the white paper with Ari Juels, and raised $32 million in its September 2017 ICO.

ChainLink

ChainLink is trending as investors debate its long-term infrastructure value versus recent price consolidation, with community sentiment split between frustration over sluggish performance and high conviction in its role as a backbone for real-world asset tokenization. Many are actively discussing potential catalysts like upcoming regulatory clarity and institutional partnerships that they believe will eventually drive a significant supply-side squeeze.

ARK ETF Trust - ARK Innovation ETF

ARK Innovation ETF

Investors are closely watching the ARK Innovation ETF as it experiences sharp volatility, with community members expressing polarized views on Cathie Wood's aggressive buying and selling patterns amid broader market rotation out of high-beta growth stocks. The ongoing discourse highlights concerns over the fund's long-term performance and its heavy exposure to volatile tech and crypto-linked assets, leading to intense debates between those betting on an innovation-led rebound and those skeptical of the fund's strategy.

AbbVie, Inc. is a research-based biopharmaceutical company, which engages in the development and sale of pharmaceutical products. It focuses on treating conditions such as chronic autoimmune diseases in rheumatology, gastroenterology, and dermatology, oncology, including blood cancers, virology, hepatitis C virus (HCV) and human immunodeficiency virus (HIV), neurological disorders, such as Parkinson's, metabolic, comprising thyroid disease and complications associated with cystic fibrosis, pain associated with endometriosis, and other serious health conditions. The company was founded on October 19, 2011 and is headquartered in North Chicago, IL.

Abbvie Inc

AbbVie Inc. is trending as investors weigh strong Q4 earnings, highlighted by robust sales growth in its immunology portfolio, against concerns over Humira's declining revenue and broader pharmaceutical sector volatility. The community is actively discussing the stock's long-term growth potential and M&A prospects, specifically focusing on the company's aggressive search for obesity drug assets to compete in the weight-loss market.

SLB Ltd. engages in the provision of energy technology. It operates through the following business segments: Digital, Reservoir Performance, Well Construction, Production Systems, and All Other. The Digital segment involves the combination of digital solutions and data products with its Asset Performance Solutions. The Reservoir Performance segment consists of technologies and services for productivity and performance optimization. The Well Construction segment includes the full portfolio of products and services for well placement and performance, drilling, and wellbore assurance. The Production Systems segment focuses on the development of technologies and provides services to production and recovery from subsurface reservoirs to the surface, into pipelines, and refineries. The company was founded by Conrad Schlumberger and Marcel Schlumberger in 1926 and is headquartered in Houston, TX.

SLB Ltd.

Schlumberger Ltd.

Schlumberger is trending as investors focus on its pivotal role in the potential revival of Venezuela's energy sector following recent geopolitical shifts. Community sentiment is mixed, with long-term holders emphasizing the company's critical technical expertise in oilfield services while short-term traders closely monitor price consolidation and volatility ahead of upcoming earnings.

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<ul class="summary-bullets"><li>The FDA issued a complete response letter regarding the application for RP1 in combination with Nivolumab for the treatment of advanced melanoma in late July.</li><li>Following months of engagement between the company and the FDA, the company subsequently resubmitted its application in October with additional information, data and analyses.</li></ul> Shares of Replimune Group Inc (REPL) closed 11% higher on Thursday as the deadline for the U.S. Food and Drug Administration’s decision on its skin cancer therapy RP1 draws close.The FDA is slated to decide on the company’s application for RP1 in the treatment of advanced melanoma by April 10. RP1 is Replimune’s lead product candidate.<h2 class="st-heading-2">RP1’s Past Issues</h2>The FDA <a href="https://stocktwits.com/news-articles/markets/equity/replimune-sarepta-capricor-stocks-surge-after-vinay-prasad-fda-exit/choXJLOR5Cg">issued</a> a complete response letter regarding the application for RP1 in combination with Nivolumab for the treatment of advanced melanoma in late July.The agency said in the letter that it is unable to approve the application in its present form and indicated that the trial conducted by the company for the drug is not considered to be an adequate and well-controlled clinical investigation that provides substantial evidence of effectiveness.Following months of engagement between the company and the FDA, the company subsequently resubmitted its application in October with additional information, data and analyses.<h2 class="st-heading-2">How Did Retail Traders React?</h2>On Stocktwits, retail sentiment around REPL stayed within the ‘bullish’ territory over the past 24 hours, while message volume rose from ‘high’ to ‘extremely high’ levels.A Stocktwits user said that shareholders are setting up to be disappointed like the last time when RP1 was denied approval.<stembedurl>https://www.stocktwits.com/TopCharts/message/649353360</stembedurl>Yet another expressed doubts about the FDA approving the drug, opining that a fresh trial would be needed for the same.<stembedurl>https://www.stocktwits.com/Steve_TheBull_Rogers/message/649347582</stembedurl>According to data from Koyfin, five of the seven analysts covering REPL stock rate it ‘Buy’ or higher while two rate it a ‘Hold’. The 12-month average price target on the stock is $12.86, representing a potential upside of about 53%. &nbsp;<a href="https://stocktwits.com/symbol/REPL">REPL stock</a> has fallen 2% over the past 12 months.&nbsp;Read More: <a href="https://stocktwits.com/news-articles/markets/equity/why-is-sbac-stock-rallying-today/cZ7UR5SRI8r">Why Is SBAC Stock Rallying Today?</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Rising stock market chart on a trading board background.

REPL Stock Rallies In Anticipation Of FDA Decision On Skin Cancer Drug

The FDA is slated to decide on the company’s application for RP1 in the treatment of advanced melanoma by April 10.

Equity

<ul class="summary-bullets"><li>The therapy also demonstrated encouraging efficacy with changes that resulted in improved laboratory markers for the disease and the resolution of anemia, the company said.&nbsp;</li><li>Beam is now looking to make an application seeking the U.S. Food and Drug Administration’s approval for the therapy as early as 2026 year-end.</li></ul>Shares of Beam Therapeutics (BEAM) rallied 3% after hours on Wednesday after the company said that its clinical trial evaluating ristoglogene autogetemcel for the treatment of sickle cell disease (SCD) with severe vaso-occlusive crises demonstrated encouraging efficacy.The company said that risto-cel, its investigational genetically modified cell therapy, demonstrated an acceptable safety profile and encouraging efficacy with changes that resulted in improved laboratory markers for the disease and the resolution of anemia. The data from the trial was published in the The New England Journal of Medicine.Sickle cell disease (SCD) is a group of inherited blood disorders caused by a genetic mutation leading to abnormal hemoglobin, which causes red blood cells to become rigid, sickle-shaped, and prone to breaking down. SCD with severe vaso-occlusive crises (VOC) involves sickle-shaped red blood cells blocking blood flow, causing intense, often bone-deep pain, ischemia, and organ damage.“Based on the totality of data generated to date from the BEACON study and the optimized treatment and manufacturing process, we believe risto-cel has the potential to be best-in-class. With an estimated 10,000 patients with SCD in the U.S. eligible for gene therapies, and significant demand expected as these treatments become more widely available, risto-cel is well positioned within this growing market,” said Amy Simon, chief medical officer of Beam.Beam is now looking to make an application seeking the U.S. Food and Drug Administration’s approval for the therapy as early as 2026 year-end. The FDA previously granted risto-cel orphan drug designation and Regenerative Medicine Advanced Therapy (RMAT) designation.<h2 class="st-heading-2">How Did Retail Traders React?</h2>On Stocktwits, retail sentiment around BEAM stock fell from ‘bullish’ to ‘neutral’ territory over the past 24 hours, while message volume fell from high to normal levels.<a href="https://stocktwits.com/symbol/BEAM">BEAM stock</a> has gained 37% over the past 12 months.&nbsp;Read More: <a href="https://stocktwits.com/news-articles/markets/equity/why-did-agpu-stock-rise-today/cZ7HyVtRIF0">Why Did AGPU Stock Rise 120% Today?</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, the Beam Therapeutics logo is displayed on the screen of a tablet. (Photo Illustration by Sheldon Cooper/SOPA Images/LightRocket via Getty Images)

Why Is BEAM Stock Edging Higher After Hours Today?

The company said that risto-cel, its investigational genetically modified cell therapy, demonstrated an acceptable safety profile in a trial. 

In this photo illustration, the ImmunityBio logo is displayed on the screen of a tablet. (Photo Illustration by Sheldon Cooper/SOPA Images/LightRocket via Getty Images)

IBRX Stock Notches Strongest Quarter Ever — But These 2 Smaller Biotech Plays Ran Even Hotter

IBRX surged 287% in the latest quarter, marking its strongest quarterly performance on record, but ANL rose 387% and ERAS gained 335%.

<ul class="summary-bullets"><li>An exposure-response analysis showed a statistically significant link between higher drug exposure and increased toxicities as well as more frequent treatment interruptions and discontinuations, the company said.</li><li>ORIC said it plans to launch its global late stage trial in metastatic castration-resistant prostate cancer patients who were previously treated with abiraterone using the 400 mg dose in the first half of 2026.</li></ul>Shares of ORIC Pharmaceuticals, Inc. (ORIC) fell 25% after hours on Tuesday after the company announced that it has selected a 400 mg once-daily dose of its investigational drug for a later stage trial after tolerability concerns emerged during an early stage study.In the early-stage trial involving certain previously treated patients with metastatic castration-resistant prostate cancer, the higher 600 mg dose of rinzimetostat produced a “modestly higher rate of adverse events and dose modifications” compared with the 400 mg level when administered with darolutamide, the company said.An exposure-response analysis showed a statistically significant link between higher drug exposure and increased toxicities as well as more frequent treatment interruptions and discontinuations, favoring the lower dose on safety grounds, it added.At the selected 400 mg dose, a grade 3 treatment-related adverse event was observed though the majority were mild, Oric said. Grade 3 treatment-related adverse events are severe, significant toxicities that are not immediately life-threatening. The company also reported one discontinuation in the early-stage &nbsp;trial. However, the company CEO Jacob M. Chacko said that the drug demonstrated a "cleaner safety profile than competitor regimens."ORIC said it plans to launch its global late stage trial in metastatic castration-resistant prostate cancer patients who were previously treated with abiraterone using the 400 mg dose in the first half of 2026. &nbsp;“Early efficacy data… are suggestive of meaningful and durable clinical benefit for rinzimetostat in combination with darolutamide compared to competitor data and historical outcomes with approved therapies,” the company said.<h2 class="st-heading-2">How Did Retail Traders React?</h2>On Stocktwits, retail sentiment around ORIC stock jumped from ‘bearish’ to ‘extremely bullish’ territory over the past 24 hours, while message volume jumped from ‘normal’ to ‘extremely high’ levels.<a href="https://stocktwits.com/symbol/ORIC">ORIC stock </a>has gained 127% over the past 12 months.&nbsp;Read More: <a href="https://stocktwits.com/news-articles/markets/equity/omer-stock-surges-after-hours-on-novo-nordisk-deal-windfall-drug-launch-optimism/cZE5fIyRIVy">OMER Stock Surges 5% After Hours On Novo Nordisk Deal Windfall And Drug Launch Optimism</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, the Oric Pharmaceuticals logo is seen displayed on a smartphone screen. (Photo Illustration by Thomas Fuller/SOPA Images/LightRocket via Getty Images)

ORIC Falls After Hours On Safety Concerns Around Prostate Cancer Candidate At Higher Doses

The company noted that a higher dose of its experimental cancer drug was associated with a higher rate of adverse events in an early-stage trial. 

<ul class="summary-bullets"><li>Biogen stated Apellis shareholders will also receive two contingent value rights as part of the all-cash deal.</li><li>This entitles Apellis shareholders to receive two payments of $2 per share, contingent on Syfovre meeting certain annual global net sales thresholds.</li><li>Biogen stated that the Apellis acquisition will add two commercialized medicines in differentiated immunology and rare diseases to its growth portfolio: Empaveli and Syfovre.</li></ul>Apellis Pharmaceuticals Inc. (APLS) shares soared 140% in Tuesday’s pre-market trade after Biogen Inc. (BIIB) announced that it has agreed to acquire the company in a $5.6 billion deal.Biogen stated that the acquisition of Apellis will bolster its rare-disease treatment portfolio and accelerate its expansion into nephrology.Retail sentiment on Stocktwits around&nbsp;<a href="https://stocktwits.com/symbol/APLS">Apellis Pharmaceuticals</a> trended in the ‘bullish’ territory with message volumes at ‘high’ levels at the time of writing.<a href="https://stocktwits.com/symbol/APLS">Biogen shares</a> were down nearly 3% at the time of writing.Biogen stated that Apellis shareholders will also receive two contingent value rights (CVRs) as part of the all-cash deal, entitling the holder to receive two payments of $2 per share, contingent on certain annual global net sales thresholds for Syfovre being met.<h2 class="st-heading-2">What Does Apellis Bring To The Table?</h2>Biogen stated that the Apellis acquisition will add two commercialized medicines in differentiated immunology and rare diseases to its growth portfolio: Empaveli and Syfovre.Syfovre is the first and only FDA-approved therapy for geographic atrophy (GA) secondary to age-related macular degeneration (AMD). The regulator approved Empaveli in 2025 as the first treatment for C3 glomerulopathy (C3G) or primary immune complex membranoproliferative glomerulonephritis (IC-MPGN) in patients aged 12 years and older.<h2 class="st-heading-2">Biogen Highlights Revenue, Earnings Boost From Apellis Acquisition</h2>Biogen stated that Empaveli and Syfovre will boost its topline immediately, noting that these two treatments achieved combined net sales of $689 million in 2025 and expect them to grow in the mid-to-high teens at least through 2028.“Consistent with our strategy, this acquisition immediately advances Biogen’s ongoing transformation. The addition of Apellis expands our growth portfolio in immunology and rare disease with two approved, best-in-class medicines that complement our existing portfolio and bolsters our near-and long-term growth potential,” said Biogen CEO Christopher A. Viehbacher.The company added that the Apellis acquisition is expected to be increasingly accretive to Biogen’s diluted earnings per share (EPS) starting in 2027. Biogen stated that it plans to update the full-year 2026 guidance when it reports its first-quarter (Q1) earnings.<a href="https://stocktwits.com/symbol/APLS">APLS stock</a> is down 32% year-to-date, while&nbsp;<a href="https://stocktwits.com/symbol/BIIB">BIIB stock</a> is up 7%. The S&amp;P Biotech ETF (XBI) is up 41% over the past 12 months, while the Vanguard Small-Cap Index Fund ETF (VB) is up 15%.Also See:&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/artl-bfrg-hkit-stocks-top-premarket-gainers-march-31-2026/cZEPAT9RIV2">ARTL, BFRG, HKIT Among Stocks Soaring Before The Bell — Top Pre-Market Gainers Today</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Representative image of a trending stock chart.

APLS Stock Soars 140% Today – Here’s Everything To Know About Apellis' Massive $5.6B Deal With Biogen

Biogen stated that the acquisition of Apellis will bolster its rare-disease treatment portfolio and accelerate its expansion into nephrology.

<ul class="summary-bullets"><li>Founder Patrick Soon-Shiong signaled balance sheet “strengthening” and a push for global expansion.</li><li>Soon-Shiong had also flagged Europe expansion talks around “immunotherapy 2.0.”</li><li>Momentum has eased over the past week after an FDA warning letter over claims suggesting Anktiva could treat cancers beyond its approved use.</li></ul>Shares of ImmunityBio, Inc. (IBRX) climbed more than 2% overnight early Tuesday after founder Patrick Soon-Shiong teased balance sheet “strengthening” and global expansion plans, as short sellers stepped back amid strong momentum for Anktiva, its lead immunotherapy.<a href="https://stocktwits.com/symbol/IBRX">IBRX stock</a> plunged nearly 10% on Monday, but is on track to post its best quarter in about six years. Shares have surged 237% so far this year, outperforming the SPDR S&amp;P Biotech ETF (XBI), which has dipped nearly 3% over the same period.&nbsp;&nbsp;<h2 class="st-heading-2">Founder Teases Balance Sheet Strengthening&nbsp;</h2>Soon-Shiong&nbsp;<a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://x.com/DrPatrick/status/2038800665481552070">took to X</a> on Tuesday and said, “Strengthening the balance sheet. Recharging for global expansion. Stay tuned.”The development comes&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/ibrx-stock-breakout-quarter-anektiva-long-covid-europe-expansion/cZERi1sRIZL">just a day</a> after Soon-Shiong signaled the company’s European expansion plans, saying he had been invited by a European health minister to discuss advancing “immunotherapy 2.0.” The effort is part of a broader push to expand natural killer cell- and CD8 T-cell-based therapies, which are immune treatments that activate the body’s virus- and cancer-fighting cells, alongside Anktiva’s global rollout.<h2 class="st-heading-2">Short Bets Retreat From Highs</h2>Meanwhile, short interest in IBRX has been steadily declining from&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/ibrx-stock-became-high-stakes-showdown-between-shorts-and-retail-bulls/cZRjSn9R4w4">record highs</a> hit in mid-February, as sentiment improved following regulatory approvals and continued expansion of Anktiva across new indications and geographies.Short positioning rose to 13.7% of the free float between Feb.13 and Feb.19, according to Koyfin data, as investors awaited a final decision from the European Commission on approval of the therapy for BCG-unresponsive non-muscle invasive bladder cancer carcinoma in situ with or without papillary tumors.The uncertainty eased later in February after the European Commission granted conditional marketing authorization across 27 European Union member states plus Iceland, Liechtenstein and Norway, expanding Anktiva’s reach to 33 countries globally, including the U.S.Short interest declined to 13.1% by Feb. 27, marking its first drop since October 2025, and has since eased further to around 12.9%. The drop followed a slew of developments supporting the therapy’s outlook beyond its initial bladder cancer indication. These include the launch of a Phase 2 study evaluating Anktiva in long COVID, expansion into programs across non-small cell lung cancer, pancreatic cancer, colorectal cancer and glioblastoma, and new trials in severe pneumonia, sepsis and acute respiratory distress syndrome.Momentum was also supported by NCCN guideline inclusion for papillary bladder cancer that no longer responds to standard BCG therapy, the company’s resubmission seeking label expansion into papillary disease, and preparations for a Saudi Arabia launch following approvals covering bladder cancer and metastatic non-small cell lung cancer.<h2 class="st-heading-2">FDA Warning Weighs On Shares</h2>The improving sentiment follows a sharp selloff over the past week after the U.S. Food and Drug Administration (FDA) issued a warning letter to ImmunityBio and Soon-Shiong, citing false and misleading promotional claims about Anktiva.The agency objected to statements in a television advertisement and a podcast appearance suggesting the therapy could treat cancers beyond its approved bladder cancer indication, including claims that it “can treat all cancers.” The FDA said the representations implied uses not supported by the drug’s labeling and requested corrective action within 15 working days.The warning came after regulators had refused to review the company’s application seeking broader label expansion, prompting ImmunityBio to resubmit it earlier this month.<h2 class="st-heading-2">How Do Stocktwits Users Feel About IBRX?</h2>On Stocktwits, retail sentiment slipped to ‘bearish’ from ‘bullish’ levels a day ago amid over a 400% surge in message volumes over the past 24 hours.<figure class="image"><img src="https://news.stocktwits-cdn.com/ibrx_png_7c546e0d33.webp" alt="ibrx.png" width="970" height="143"><figcaption>IBRX sentiment and message volume as of March 31 | Source: Stocktwits</figcaption></figure>One user&nbsp;<a href="https://stocktwits.com/BePositive1/message/649012988">said</a> Soon-Shiong could strengthen the balance sheet by boosting assets or reducing liabilities. They added that with 650 million shares and voting control, a buyout near $20 billion could cost about $7 billion, calling the idea “genius,” and said “there are a lot of players who would want a large piece of this like Elon or the Saudi’s.”<stembedurl>https://stocktwits.com/BePositive1/message/649012988</stembedurl>Another user&nbsp;<a href="https://stocktwits.com/Regener8/message/649012939">said</a>, “I’m guessing it will be $200-250 million dollars, otherwise it wouldn’t really do much strengthening. That post is annoyingly cryptic, although I think he meant it as a comfort to long shareholders and a discomfort for shorts.”<stembedurl>https://stocktwits.com/Regener8/message/649012939</stembedurl>For updates and corrections, email newsroom[at]stocktwits[dot]com.Read Next:&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/uso-batl-tpet-slide-overnight-on-signs-iran-crisis-may-be-ending-analysts-say-war-premium-fading-but-supply-risks-remain/cZEPj9HRINH">USO, BATL, TPET Slide Overnight On Signs Iran Crisis May Be Ending: Analysts Say War Premium Fading, But Supply Risks Remain</a>

IBRX Stock Gains Steam: Founder Teases Balance Sheet ‘Strengthening’ And Global Push As Bears Finally Step Back

IBRX Stock - Short interest eased to about 12.9% from a record 13.7% amid Anktiva's expansion into long COVID, multiple cancers, pneumonia, sepsis and ARDS trials.

Short interest eased to about 12.9% from a record 13.7% amid Anktiva's expansion into long COVID, multiple cancers, pneumonia, sepsis and ARDS trials.

<ul class="summary-bullets"><li>Viridian stated that the REVEAL-1 trial showed strong results, meeting its main goal and a key secondary goal at week 24 as measured by eye bulging.</li><li>The company stated that Elegrobart reduced eye bulging by about 54% in the four-week regimen and by 63% in the eight-week regimen, compared with roughly 18% on placebo.</li><li>Viridian stated that topline results from REVEAL-2, the second Phase 3 trial evaluating Elegrobart in patients with chronic thyroid eye disease, are expected in the second quarter of 2026.</li></ul>Viridian Therapeutics Inc. (VRDN) shares tanked more than 41% in Monday’s pre-market trade after the company announced results from its Phase 3 REVEAL‑1 Clinical Trial in Active Thyroid Eye Disease.Viridian stated that the REVEAL-1 trial of Elegrobart met its primary endpoint of proptosis responder rate (PRR) with a highly statistically significant treatment effect in the four-week dosing regimen.However, the company stated that while Elegrobart was generally well tolerated in the four and eight-week dosing regimens, the phase 3 trial showed low rates of hearing impairment.Retail sentiment on Stocktwits around&nbsp;<a href="https://stocktwits.com/symbol/VRDN">Viridian Therapeutics</a> trended in the ‘bullish’ territory with message volumes at ‘high’ levels at the time of writing.<h2 class="st-heading-2">What Did The Trial Reveal?</h2>Viridian stated that the REVEAL-1 trial showed strong results, meeting its main goal and a key secondary goal at week 24 as measured by eye bulging. The study also tested a different dosing schedule (every 8 weeks) versus placebo and examined other important outcomes.The company stated that Elegrobart reduced eye bulging by about 54% in the four-week regimen and by 63% in the eight-week regimen, compared with roughly 18% on placebo.However, Elegrobart showed only a slight improvement over placebo in the Clinical Activity Score (CAS), a measure of inflammation and disease activity.Viridian’s results showed that the CAS reduction to 0 or 1 was 57% in the four-week regimen and 69% in the eight-week regimen, compared with 50% in the placebo group.The company said that all complaints of adverse events in both regimens were reports of tinnitus, none of which were associated with hearing reduction.<h2 class="st-heading-2">Viridian Says Elegrobart On Track For BLA Submission In 2027</h2>The company stated that topline results from REVEAL-2, the second Phase 3 trial evaluating Elegrobart in patients with chronic thyroid eye disease, are expected in the second quarter (Q2) of 2026.Following this, Viridian plans to submit a Biologics License Application (BLA) to the U.S. FDA in Q1 2027. A BLA is a formal request submitted to the U.S. Food and Drug Administration (FDA) asking for approval to sell a biologic drug.<a href="https://stocktwits.com/symbol/VRDN">VRDN stock</a> is down 12% year-to-date, but up 87% over the past 12 months. The SPDR S&amp;P Biotech ETF (XBI) is up 40% over the past 12 months, while the iShares Russell 2000 ETF (IWM) is up 19%.Also See:&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/roma-stock-soars-100m-share-repurchase-program/cZERVIhRIZs">ROMA Stock Shot Up 10% Today – Everything To Know About Its Gigantic Share Repurchase Program</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Trading digital board showing the data on global stock market crash. | Image source: Getty Images

VRDN Stock Plummeted 41% Pre-Market Today — What Did Its Phase 3 Active Thyroid Eye Disease Trial Reveal?

Viridian stated that while Elegrobart was generally well tolerated in the four and eight-week dosing regimens, the phase 3 trial showed low rates of hearing impairment.

Dr. Patrick Soon-Shiong arrives at Trump National Golf Club Bedminster in Bedminster Township, N.J. on Saturday, Nov. 19, 2016. (Photo by Jabin Botsford/The Washington Post via Getty Images)

IBRX Stock Eyes Breakout Quarter: Anktiva Enters Phase 2 Long COVID Trial As Europe Expansion Plans Emerge

Founder Patrick Soon-Shiong said he was invited by a European health minister to discuss expanding “immunotherapy 2.0”, signaling potential expansion of Anktiva.

<ul class="summary-bullets"><li>The average 12-month price target on the stock is $18, representing a potential upside of as much as 495% from the stock’s current $3.02 trading levels.</li><li>The company is currently looking forward to initiating a late-stage trial of pemvidutide in MASH in 2026.</li><li>Truist believes that pemvidutide "could be successful in treating MASH as well as liver-related diseases AUD."</li></ul>Shares of Altimmune (ALT) traded 5% lower on Friday despite Wall Street viewing a potential upside of as much as 495% on the stock.According to data from Koyfin, nine of the 11 analysts covering the stock rate it ‘Buy’ or higher while one rates it ‘Hold’ and one has a ‘Sell’ rating on the shares.The average 12-month price target on the stock is $18, compared to the stock’s current $3.02 trading levels.<h2 class="st-heading-2">Wall Street Take</h2>Earlier this month, Truist initiated coverage of Altimmune with a ‘Buy’ rating and $12 price target. The firm believes that the company's lead candidate pemvidutide "could be successful in treating MASH."Truist is modelling peak 20,000 patients on pemvidutide, which would result in worldwide "peak adjusted/unadjusted revenue of ~$600million/$1.0billion," it said.<h2 class="st-heading-2">Altimmune Pipeline</h2>Altimmune is a clinical-stage biopharmaceutical company developing therapies for patients with serious liver diseases, including metabolic dysfunction-associated steatohepatitis (MASH). The company’s pemvidutide is in development for the treatment of alcohol use disorder (AUD) and alcohol-associated liver disease (ALD) in addition to MASH.The company is currently looking forward to initiating a late-stage trial of pemvidutide in MASH in 2026. The trial is expected to evaluate multiple pemvidutide doses over a 52-week treatment period.The company is looking forward to announcing topline data from a mid–stage trial of pemvidutide in Alcohol Use Disorder in the third quarter of 2026, and is also enrolling patients into a mid-stage trial of the drug in Alcohol-associated Liver Disease.<h2 class="st-heading-2">Retail Sentiment</h2>On Stocktwits, retail sentiment around ALT stock jumped from ‘bearish’ to ‘neutral’ territory over the past 24 hours, while message volume remained at ‘low’ levels.A Stocktwits user expressed disappointment about the stock’s downward trajectory.<stembedurl>https://www.stocktwits.com/Moemazon/message/648788986</stembedurl><a href="https://stocktwits.com/symbol/ALT">ALT stock</a> has dropped 45% over the past 12 months.Read More: <a href="https://stocktwits.com/news-articles/markets/equity/rckt-stock-dives-despite-gene-therapy-approval-wall-street-dismisses-sell-off/cZ3HfqIRImh">RCKT Stock Dives Despite Gene Therapy Approval — Wall Street Dismisses Sell-Off</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, the Altimmune logo is seen displayed on the screen of the tablet. (Photo Illustration by Sheldon Cooper/SOPA Images/LightRocket via Getty Images)

ALT Stock Has Nearly Halved In The Past Year, So Why Does Wall Street See Almost 500% Upside?

According to data from Koyfin, nine of the 11 analysts covering the stock rate it ‘Buy’ or higher while one rates it ‘Hold’ and one has a ‘Sell’ rating on the shares.

<ul class="summary-bullets"><li>Viking is developing VK2735 in both oral and subcutaneous formulations for the potential treatment of metabolic disorders such as obesity.</li><li>The company stated that the primary endpoint of the Phase 3 VANQUISH-2 study is the percentage change in body weight from baseline for participants receiving VK2735.</li><li>The company stated it expects to complete the VANQUISH studies in 2027.</li></ul>Viking Therapeutics Inc. (VKTX) on Thursday announced that it has completed enrollment in the Phase 3 trial of its obesity drug, VK2735, which is in the race to compete in the GLP-1 obesity drug market, dominated by Novo Nordisk's Ozempic and Wegovy.The company said that the Phase 3 VANQUISH-2 study will assess the efficacy and safety of VK2735 administered by subcutaneous injection once weekly for 78 weeks.Viking is developing VK2735 in both oral and subcutaneous formulations for the potential treatment of metabolic disorders such as obesity.<a href="https://stocktwits.com/symbol/VKTX">Viking Therapeutics shares</a> were up nearly 2% in Thursday’s opening trade. Retail sentiment on Stocktwits around the company trended in the ‘bearish’ territory.<h2 class="st-heading-2">What Are The Primary And Secondary Endpoints?</h2>Viking Therapeutics stated that the primary endpoint of the Phase 3 VANQUISH-2 study is the percentage change in body weight from baseline for participants receiving VK2735, compared to patients on placebo after 78 weeks of treatment.The secondary and exploratory endpoints include an evaluation of several efficacy and safety measures. This includes the percentage of patients who achieve 5%, 10%, 15% and 20% or more body weight reduction during the trial.“As with the VANQUISH-1 study, we are happy to see a study of this size enroll quickly, which we believe speaks to the enthusiasm for new obesity treatments beyond those currently available,” said Viking CEO Brian Lian.The company stated it expects to complete the VANQUISH studies in 2027.<h2 class="st-heading-2">Phase 3 Trial Update</h2>Viking also announced an update regarding its Phase 3 VANQUISH-1 study of subcutaneous VK2735 in patients who have obesity or are overweight.The company also stated that it is evaluating VK2735 in a Phase 1 study evaluating a range of potential maintenance dosing regimens. Results from the maintenance study are expected in the third quarter (Q3) of 2026.<a href="https://stocktwits.com/symbol/VKTX">VKTX stock</a> is down 6% year-to-date, but up 19% over the past 12 months. The S&amp;P Biotech ETF (XBI) is up 42% over the past 12 months, while the Vanguard Small-Cap Growth Index Fund ETF (VBK) is up 18%.Also See:&nbsp;<a href="https://stocktwits.com/news-articles/markets/equity/trump-iran-begging-for-deal-warns-get-serious-on-talks-dow-futures-fall/cZ3ru8hRIjM">Trump Says Iran ‘Begging’ For Deal, Warns Them To 'Get Serious’ On Talks — Dow Futures Fall More Than 300 Points</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, a person holds a smartphone displaying the logo of Viking Therapeutics on July 19, 2025. (Photo illustration by Cheng Xin/Getty Images)

Viking Therapeutics Moves Closer To Challenging Ozempic With Phase 3 Trial Progress

The company said that the Phase 3 VANQUISH-2 study will assess the efficacy and safety of VK2735 administered by subcutaneous injection once weekly for 78 weeks.

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