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SMX (Security Matters) Plc is a holding company, which engages in the provision of authentication solutions. It offers brand protection, authentication, and track and trace technology. The company was founded by Haggai Alon on July 1, 2022 and is headquartered in Dublin, Ireland.

SMX (Security Matters) Plc

SMX (Security Matters) PLC

SMX is trending on news of its capital runway extension to an impressive $250 million Equity Line of Credit into 2028, igniting community speculation about a significant short squeeze and a repeat of its past multi-day parabolic rallies. Investors are closely watching the small float and high volume, with discussions split between explosive potential and sustainability concerns.

NIO, Inc. is a holding company which engages in the design, manufacture, and sale of electric vehicles. Its products include the EP9 supercar and ES8 7-seater SUV. It provides users with home charging, power express valet services, and other power solutions including access to public charging, access to power mobile charging trucks, and battery swapping. It also offers other value-added services such as service package, battery payment arrangement, and vehicle financing and license plate registration. The company was founded by Bin Li and Li Hong Qin on November 28, 2014 and is headquartered in Jiading, China.

NIO Inc - ADR

NIO Inc

NIO is trending after announcing its first adjusted quarterly profit, a major turning point that bulls believe invalidates the long-standing "cash-burning machine" narrative, despite ongoing community discussion about short-term price suppression and the concurrent celebration of its 100 millionth battery swap.

Memecoin on Cronos launched by the Cro Crow community

crow with knife

Widely touted as 'the real deal' and 'king of the memes,' CAW (crow with knife) is generating significant community buzz, with users actively discussing its strong multi-chain presence on platforms like Solana and Base. The meme coin's deflationary burn mechanism and organic community growth are key drivers of its trending bullish sentiment.

SSgA Active Trust - State Street SPDR S&P 500 ETF Trust

SPY is trending due to a powerful market rally that rapidly reversed recent declines, inflicting significant losses on bearish option holders amidst widespread discussion of market manipulation and bullish momentum. The broad market strength, pushing major indices towards all-time highs, has intensified the ongoing debate between optimistic bulls and skeptical bears.

SSgA Active Trust - SPDR Dow Jones Industrial Average ETF

The SPDR Dow Jones Industrial Average ETF ($DIA) is trending as the Dow Jones Industrial Average hit a 50,000 milestone and saw a significant surge, with the community debating if this "boomer index" rally signals a genuine "melt-up" or a "blow-off top" amid a rotation away from tech-heavy sectors.

Luckin Coffee, Inc. engages in providing food and beverage items, and operates coffee retail stores. It has a pioneered a technology-driven retail network to provide coffee and other products of high quality, high convenience and high affordability to customers. The company manages pick-up stores, relax stores, and delivery kitchens. It also offers tea, snacks, and light meals through its mobile application. The company was founded by Zhi Ya Qian, Fei Yang and Jin Yi Guo on June 16, 2017 and is headquartered in Xiamen, China.

Luckin Coffee Inc - ADR

Luckin Coffee (LKNCY) is trending as a major shareholder consolidated ownership, seen by the community as a strong vote of confidence and fueling speculation about an imminent uplisting, while the reported end of aggressive price wars with competitors like Cotti Coffee is expected to significantly boost profit margins and further accelerate its rapid global store expansion.

WorldFinancial

WorldFinancial ($WLFI) is trending as it faces intensifying congressional scrutiny over a significant foreign investment and its application for a U.S. National Trust Bank Charter, igniting a polarized community debate between "scam" accusations and bullish anticipation of future utility and Real World Asset (RWA) integrations.

Reddit, Inc. operates an entertainment, social networking, and news website where registered community members can submit content. It provides online news services where users can select and rank web content. The firm also offers a personalized filter on the day's story, using previous votes to determine what new things the user might like to read. The company was founded by Steven Ladd Huffman and Alexis Ohanian on June 23, 2005 and is headquartered in San Francisco, CA.

Reddit Inc. - Ordinary Shares - Class A

Reddit Inc

Reddit (RDDT) is trending as its stock saw a sharp decline despite robust Q4 earnings and a $1 billion share buyback, fueling community discussions about perceived market manipulation, its valuation, and a bearish narrative regarding AI's potential impact, though many view it as a deep buying opportunity.

Stellantis NV engages in the designing, engineering, manufacturing, distributing, and selling of vehicles and components. It offers its products under the Abarth, Alfa Romeo, Chrysler, Citroën, Dodge, DS Automobiles, Fiat, Jeep, Lancia, Maserati, Opel, Peugeot, Ram Trucks, Vauxhall, Free2move, and Leasys brands. The company was founded on April 1, 2014 and is headquartered in Hoofddorp, the Netherlands.

Stellantis N.V

Stellantis is sharply lower after announcing a $22 billion charge to realign its EV strategy and suspending its 2026 dividend, sparking debate among investors who either see it as a painful but necessary reset or a signal of deeper troubles in the transitioning auto sector.

Arrowhead Pharmaceuticals, Inc. is a biopharmaceutical company, which engages in the development of medicines that treat intractable diseases by silencing the genes that cause them. The firms preclinical stage drug candidates include ARO-ANG3, ARO-AAT, ARO-APOC3, ARO-HIF2, ARO-HSD, ARO-Lung2, ARO-COV, and ARO-ENaC. The company was founded by Robert Bruce Stewart in 1989 and is headquartered in Pasadena, CA.

Arrowhead Pharmaceuticals Inc.

Arrowhead Pharmaceuticals is trending following the FDA approval of REDEMPLO for FCS and Breakthrough Therapy Designation for SHTG, alongside promising early clinical data for its obesity programs and the advancement of its ARO-MAPT CNS therapy. The community is optimistic about the broad potential of its RNAi platform and significant analyst upgrades, navigating discussions around recent capital raises and perceived market manipulation.

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<ul class="summary-bullets"><li>A Novo executive noted that many customers are unaware that the company already makes oral semaglutide for type 2 diabetes under the name Rybelsus, sparking the branding change.</li><li>Novo also said on Wednesday that it has filed an application with the FDA seeking approval for Ozempic tablets 25 mg in adults with type 2 diabetes.</li></ul>Danish drugmaker Novo Nordisk (NVO) said on Wednesday that the U.S. Food and Drug Administration has approved naming pill versions of some doses of its semaglutide for the treatment of type 2 diabetes as Ozempic pills.Novo has been selling oral semaglutide for diabetes since 2019. However, it was previously called Rybelsus and was available at 3 mg, 7 mg, and 14 mg doses. Ozempic pills will be available in doses 1.5 mg, 4 mg, and 9 mg.<h2 class="st-heading-2">Why The Name Change?</h2>“By bringing the oral and injectable options under the Ozempic name, we’re helping make it clear that both contain semaglutide from Novo Nordisk and are approved to treat type 2 diabetes. The medicine and how it works remain the same; this simply makes the choices clearer to understand. There’s only One Ozempic…now in two presentations.” <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.novonordisk-us.com/media/news-archive/news-details.html?id=916488">said</a> Ed Cinca, Senior Vice President of Marketing &amp; Patient Solutions at Novo Nordisk.Cinca also noted that many customers are unaware that the company already makes oral semaglutide for type 2 diabetes under the name Rybelsus, sparking the branding change.<h2 class="st-heading-2">Launch Timeline</h2>The Ozempic pill will be launched in Q2 2026. The new formulation offers the same efficacy and safety profile as the originally approved formulation, the company said, while adding that the new doses were approved based on a bioequivalence study and the clinical trial program for Rybelsus tablets.Novo got the approval of the U.S. Food and Drug Administration (FDA) for the Wegovy pill in December last year and launched it in early January. The weight-loss drug has had a great kickstart so far.Novo also said on Wednesday that it has filed an application with the FDA seeking approval for Ozempic tablets 25 mg in adults with type 2 diabetes. The company now expects the agency to provide a decision on the application by 2026-end.<h2 class="st-heading-2">Flat Growth In Diabetes Segment</h2>Novo on Tuesday said that sales from its diabetes segment remained more-or-less flat on a reported basis in 2025 at DKK 207.11 billion while sales from its obesity segment increased 26% in Danish kroner to DKK 82.35 billion.The company now expects adjusted sales to fall between 5% and 13%, and operating profit could decline by up to 13%. The company flagged concerns for the year including fierce competition, lower realized prices, and expiry of patent on the active ingredient in its best-selling Wegovy and Ozempic drugs in a few markets outside the U.S.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around NVO stock stayed within the ‘bullish’ territory while message volume increased from ‘high’ to ‘extremely high’ levels.<a href="https://stocktwits.com/symbol/NVO">NVO stock</a> has fallen 43% over the past 12 months.&nbsp;Read More: <a href="https://stocktwits.com/news-articles/markets/equity/rklb-asts-stocks-dip-amid-selloff-after-spacex-xai-merger-spurred-rally/cZbj9ElR4NO">RKLB, ASTS Stocks Dip Amid Selloff After SpaceX-xAI Merger Spurred Rally</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, the logo of Novo Nordisk is displayed on a smartphone screen on September 10, 2025 in Chongqing, China. 

Novo Nordisk To Launch Ozempic Pills Following Flat Growth In Diabetes Segment In 2025

The Ozempic pill will be launched in Q2 2026 and be available in doses 1.5 mg, 4 mg, and 9 mg.

Equity

The Ozempic pill will be launched in Q2 2026 and be available in doses 1.5 mg, 4 mg, and 9 mg.


<ul class="summary-bullets"><li>The company flagged concerns for the year including fierce competition, lower realized prices, and expiry of patent on the active ingredient in its best-selling Wegovy and Ozempic drugs in a few markets outside the U.S.&nbsp;</li><li>The updated guidance comes on the heels of the company reporting full-year 2025 net sales of DKK309.06 billion, below an analyst estimate of DKK346.97 billion.</li><li>Novo’s sales from its diabetes segment remained more-or-less flat on a reported basis in 2025 at DKK207.11 billion while sales from its obesity segment increased 26% in Danish kroner to DKK82.35 billion.</li></ul>Shares of Danish drugmaker Novo Nordisk (NVO) plummeted 14% on Tuesday after the company said that it sees fiscal 2026 adjusted sales down 5% to 13% as it gears up to face pricing headwinds and a competitive market.The company <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://ml-eu.globenewswire.com/Resource/Download/7c7c1d6f-42c0-4e8f-821c-93ff9a0858c0">flagged </a>concerns for the year including fierce competition, lower realized prices, and expiry of patent on the active ingredient in its best-selling Wegovy and Ozempic drugs in a few markets outside the U.S.Novo also sees adjusted operating profit fall as much as 13% in fiscal 2026 at constant exchange rates.<h2 class="st-heading-2">2025 Earnings</h2>The updated guidance comes on the heels of the company reporting full-year 2025 net sales of DKK309.06 billion ($48.94 billion), up 6% year-over-year on a reported basis, but below an analyst estimate of DKK346.97 billion.Diluted earnings per share for the year came in at DKK23.03, up from DKK22.63 in 2024, and below a Wall Street estimate of DKK23.4.Operating profit, meanwhile, decreased by 1% in Danish kroner to DKK127.66billion.<h2 class="st-heading-2">Executive Take</h2>CEO Mike Doustdar said that 2025 was a "challenging year” for the company.“However, we are very encouraged by the promising early uptake from the US launch of Wegovy pill, and we remain confident in our ability to drive volume growth over the coming years,” Doustdar said.“Also for this year, we look forward to regulatory decisions for next-generation treatments, such as Mim8 within haemophilia and CagriSema within obesity, as well as a number of exciting R&amp;D read-outs, including phase 3 read-outs for etavopivat and ziltivekimab," he added.Novo got the approval of the U.S. Food and Drug Administration (FDA) for the Wegovy pill in December last year and launched it in early January. The drug has had a great kickstart so far.In contrast, rival Eli Lilly and Co. (LLY) is still awaiting FDA approval on its oral weight-loss drug, giving Novo a few months of solid head start to cement its position in the market. However, Lilly is currently overtaking Novo in injectable weight loss drugs. &nbsp;<h2 class="st-heading-2">Blockbuster Drug Sales</h2>Novo said on Tuesday that sales from its diabetes segment remained more-or-less flat on a reported basis in 2025 at DKK 207.11 billion while sales from its obesity segment increased 26% in Danish kroner to DKK 82.35 billion.Sales of the company’s blockbuster diabetes drug Ozempic came in at DKK130.11 billion for the year, while Wegovy sales came in at DKK79.11 billion.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around NVO stock rose from ‘neutral’ to ‘bullish’ territory over the past 24 hours, while message volume rose from ‘low’ to ‘high’ levels.<a href="https://stocktwits.com/symbol/NVO">NVO stock</a> has dropped about 39% over the past 12 months.Read More: <a href="https://stocktwits.com/news-articles/markets/equity/tesla-continues-to-rejig-lineup-in-run-up-to-vehicle-autonomy/cZb0GTWR4mS">Tesla Continues To Rejig Lineup In Run Up To Vehicle Autonomy</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.Exchange Rate: DKK1= $0.16

Novo Nordisk Shares Tumble On 2025 Earnings Miss, Weak Sales Forecast And Competition Concerns

The drugmaker now expects fiscal 2026 adjusted sales down 5% to 13%.

<ul class="summary-bullets"><li>Novo and Aspect have been collaborating since 2023 to develop cellular medicines.</li><li>Under the deal, Aspect has acquired rights to stem cell-derived islet cell and hypoimmune cell engineering technologies from Novo Nordisk and will now lead their development.&nbsp;</li><li>Novo, in turn, will make an additional equity investment in Aspect and provide research funding.</li></ul>Danish drugmaker Novo Nordisk (NVO) said on Tuesday that it is looking to develop new medicines for diabetes as part of its new partnership with Canadian biotech firm Aspect Biosystems.Novo and Aspect have been collaborating since 2023 to develop cellular medicines. The companies <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.novonordisk.com/content/nncorp/global/en/news-and-media/news-and-ir-materials/news-details.html?id=916478">said</a> that the new partnership phase builds on the momentum achieved in the existing collaboration.<h2 class="st-heading-2">Deal Terms</h2>Under the deal, Aspect has acquired rights to stem cell-derived islet cell and hypoimmune cell engineering technologies from Novo Nordisk. This refers to technology allowing for making insulin-producing cells from stem cells for diabetes treatment and modifying cells to evade the immune system, thereby avoiding immune rejection. The privately-held company will now lead its development, manufacturing and commercialisation.Novo, in turn, will make an additional equity investment in Aspect and provide research funding. It will also retain rights to expand its role in late-stage development and commercialisation as well. &nbsp;Novo Nordisk will be eligible to receive royalties and milestone payments on future product sales from Aspect. However, the companies didn’t provide the financial terms of the agreement.<h2 class="st-heading-2">Novo On Lookout For More</h2>Last week, Novo said it is on the lookout for merger and acquisition deals to boost its drug portfolio.Novo’s CEO Mike Doustdar said during the annual JP Morgan Healthcare conference that the company will continue searching for molecules, assets, and companies that are complementary to its portfolio. Doustdar said that the company can afford any amount for an asset, provided it is worth it.Novo’s best-selling drugs now include Wegovy and Ozempic for weight loss and diabetes, respectively.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around NVO stayed within the ‘bullish’ territory over the past 24 hours, while message volume stayed at ‘high’ levels.<a href="https://stocktwits.com/symbol/NVO">NVO shares</a> have fallen 25% over the past 12 months.&nbsp;Read More: <a href="https://stocktwits.com/news-articles/markets/equity/lululemon-stock-slips-after-reportedly-removing-see-through-leggings-from-website/cmUuHw8R4OO">Lululemon Stock Slips 6% After Reportedly Removing “See-Through” Leggings From Website</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Novo Nordisk Inks Deal With Canada’s Aspect Biosystems To Find More Diabetes Meds Besides Ozempic

Novo and Aspect have been collaborating since 2023 to develop cellular medicines, and said that the new partnership phase builds on the momentum achieved in the existing collaboration.

<ul class="summary-bullets"><li>Ryanair in its post on X described Musk’ latest comments as ‘Twitshit’.</li><li>The feud between the two leaders erupted last week after O’Leary said he wouldn’t consider installing SpaceX’s Starlink internet for the budget airline’s fleet.&nbsp;</li><li>This week, Musk posted a poll asking users whether he should buy Ryanair and "restore a Ryan as their rightful ruler.”</li></ul>Ryanair has continued the online brawl between Elon Musk and its CEO Michael O’Leary as the airline in a post on X said that its CEO O’Leary will address the recent comments made by the world’s richest man Musk in a press conference on Wednesday.The airline’s official X account <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://x.com/Ryanair/status/2013651269596955135">said</a> that Ryanair CEO, Michael O’Leary will “address/undress Elon Musk’s Twitter tantrum” at a press conference on Jan. 21, describing Musk’ latest comments as ‘Twitshit’.“Musk knows even less about airline ownership rules than he does about aircraft aerodynamics,” said Michael O’Leary in the post.&nbsp;The airline also said that it is launching a “Great Idiots seat sale especially for Elon and any other idiots on X.”&nbsp;<figure class="image"><img src="https://news.stocktwits-cdn.com/RYANAIR_2_PNG_c7848ff5ec.webp" alt="The airline said that it is launching a “Great Idiots seat sale especially for Elon and any other idiots on X.”" width="591" height="612"></figure>Ryanair joined the online sparring last week. In response to a post asking what piece of propaganda it would never fall for, the airline replied bluntly, "Wi-Fi on planes."&nbsp;<h2 class="st-heading-2">Weeks Long Feud&nbsp;</h2>The feud between the two leaders erupted last week after O’Leary said he wouldn’t consider installing SpaceX’s Starlink internet for the budget airline’s fleet because of fuel costs from the weight and drag of the antenna mounted on the roof of the cabin. Musk called O’Leary ‘misinformed’ who in return called him an ‘idiot’."I would pay no attention whatsoever to Elon Musk — he's an idiot," O'Leary said, adding that while Musk is "very wealthy," he is "still an idiot."&nbsp;Musk fired back on X late last week, calling O'Leary "an utter idiot" and suggesting he be fired. That exchange prompted users to suggest that Musk simply buy the airline himself and implement the changes.This week, Musk posted a poll on X asking users whether he should buy Ryanair and "restore a Ryan as their rightful ruler." Nearly 78% of respondents voted in favor, while the rest voted against.<h2 class="st-heading-2">O’Leary Reign At Ryanair</h2>O'Leary has built the airline into the biggest budget carrier in the region over several decades at the job. He is also among the top 10 shareholders in the airline.&nbsp;Recently he was awarded a major bonus package for achieving certain performance metrics on the stock. The U.S.-listed stock of Ryanair has risen 62% over the past year.&nbsp;<h2 class="st-heading-2">Musk’s Previous Polls</h2>Musk has polled his followers in the past on various matters ranging from whether Tesla should accept Dogecoin as payment for its electric vehicles to if he should sell some stake in the carmaker.&nbsp;In 2022, he polled users on whether they wanted an edit button to edit their tweets on then called Twitter now X, shortly after revealing stake in the social media platform.&nbsp;After acquiring the platform, Musk polled whether he should step down as the head of the company. Musk later hired Linda Yaccarino to replace him as CEO in May 2023.&nbsp;<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>Retail sentiment around RYAAY trended in ‘bullish’ territory amid ‘high’ message volume.&nbsp;Retail sentiment around SPACEX trended in ‘bearish’ territory amid ‘high’ message volume.&nbsp; &nbsp;

Ryanair Boeing 737 MAX 8 as seen during taxiing, take off and flying phase in Eindhoven Airport.

Ryanair Turns Up Heat After Calling Press Briefing On Musk, Launches ‘Great Idiots Seat Sale’ Taking Aim At SpaceX Owner 

The airline’s official X account said that Ryanair CEO, Michael O’Leary will “address/undress Elon Musk’s Twitter tantrum” at a press conference on Jan. 21.

<ul class="summary-bullets"><li>If approved, Ianalumab could become the first targeted treatment for Sjögren’s disease.&nbsp;</li><li>The Breakthrough Therapy designation was granted to Novartis on the basis of clinical evidence supporting the drug’s potential.</li><li>In Novartis’ late-stage trials evaluating the efficacy and safety of Ianalumab in patients with Sjögren’s disease, the drug delivered a clinically meaningful benefit.</li></ul>Shares of Novartis (NVS) rose 1% on Friday after the U.S. Food and Drug Administration granted its drug Ianalumab a breakthrough therapy designation in the treatment of Sjögren’s disease.Sjögren’s disease is a systemic, chronic autoimmune disorder that causes inflammation and tissue damage, impacting the entire body. It primarily affects exocrine glands, leading to excessive dryness, with over 90% of patients experiencing dry eyes and dry mouth.According to Novartis, 50% of people with Sjögren’s are undiagnosed, though it is the second-most prevalent rheumatic autoimmune disease.Novartis looks to submit data from its many trials of Ianalumab with health authorities starting in early 2026 for potential approval. If approved, it could become the first targeted treatment for Sjögren’s disease, as per Novartis.<h2 class="st-heading-2">The Designation</h2>The Breakthrough Therapy designation, <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.novartis.com/news/media-releases/novartis-ianalumab-receives-fda-breakthrough-therapy-designation-sjogrens-disease">granted</a> to Novartis on the basis of clinical evidence supporting the drug’s potential, is intended to expedite the review of medicines that treat a serious or life-threatening condition. Ianalumab was previously awarded the FDA’s Fast Track designation in 2016.In Novartis’ late-stage trials that evaluated the efficacy and safety of Ianalumab in patients with Sjögren’s disease, the drug delivered a clinically meaningful benefit, showing improvement in disease activity and reductions in patient burden. Further, the drug demonstrated a favorable safety profile with an overall incidence of adverse events comparable to placebo.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around NVS stock stayed within the ‘neutral’ territory over the past 24 hours, while message volume stayed at ‘high’ levels.<a href="https://stocktwits.com/symbol/NVS">NVS stock</a> has gained nearly 48% over the past 12 months.&nbsp;Read More: <a href="https://stocktwits.com/news-articles/markets/equity/nvo-shares-rise-on-strong-kickstart-for-wegoy-pill-in-us/cmUlCCgR4Bq">NVO Shares Rise On Strong Kickstart For Wegovy Pill In US: Retail Eyes Up To $110 As ‘Fair Value’</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, the Novartis company logo is seen displayed on a smartphone screen. (Photo Illustration by Piotr Swat/SOPA Images/LightRocket via Getty Images)

NVS Stock Rises After FDA Grants Breakthrough Therapy Designation For Autoimmune Disorder Treatment

Novartis looks to submit data from its many trials of Ianalumab with health authorities starting in early 2026 for potential approval.

<ul class="summary-bullets"><li>The winding down of the said activities will impact about 365 employees across regions including Europe, the U.S. and China, the company said.&nbsp;</li><li>It will also result in the shut down of sites in the Netherlands, Switzerland, U.S. and China.</li><li>Galapagos CFO Aaron Cox had said in November that the company expects to be cash flow neutral to positive by the end of 2026 if the wind down is implemented.</li></ul> Galapagos NV (GLPG) on Monday announced that its Board of Directors has decided to initiate the wind-down of the company’s cell therapy activities, sending shares up 6% in Monday’s after hours trading.The company had announced its intent to wind down the activities after a strategic review and sale process in October but had held on acting on it until it completed communicating with work councils in the Belgium and Netherlands. The winding down of the said activities will impact about 365 employees across regions including Europe, the U.S. and China, the company <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2026/01/05/3213177/0/en/Galapagos-Announces-Board-Decision-to-Initiate-Wind-Down-of-Cell-Therapy-Activities.html">said</a>.It will also result in the shut down of sites in the Netherlands, Switzerland, the U.S. and China. The U.S. facilities to be shut down include one in Princeton and another in Pittsburgh, the company said. More details about the wind down, including details pertaining to its timeline and costs, will be provided with the company’s full year earnings in February, it added.Galapagos CFO Aaron Cox had said in November that the company expects to be cash flow neutral to positive by the end of 2026 if the wind down is implemented.<h2 class="st-heading-2">Future After Wind Down</h2>On Monday, Galapagos said that the wind-down of the cell therapy activities will position it for longer-term growth. The company will continue to manage its non-cell therapy programs and evaluate all strategic alternatives for GLPG3667, an investigational, oral, selective inhibitor of tyrosine kinase 2, to accelerate its development in dermatomyositis and potentially other severe auto-immune indications, the company said.The company will also consider resuming the partnering process for the drug, it said. Galapagos also added that it will continue to maintain its presence at its headquarters in Belgium as well as its hubs in Chicago and San Francisco.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, the retail sentiment about GLPG stayed in the ‘neutral’ territory over the past 24 hours, while message volume stayed at ‘high’ levels.<a href="https://stocktwits.com/symbol/GLPG">GLPG stock</a> has gained 15% over the past 12 months.&nbsp;Read also: <a href="https://stocktwits.com/news-articles/markets/equity/toyota-us-sales-rise-8-percent-in-q4/cmxMCZPR4Ri">US Heeds Trump To Buy A Toyota: Japanese Automaker’s US Sales Rise 8% In Q4</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

A logo of Galapagos, a European pharmaceutical research company, is pictured outside its facility on June 9, 2020 in Leiden, Netherlands. (Photo by Yuriko Nakao/Getty Images) 

Galapagos Stock Rises After Hours On Starting To Wind Down Cell Therapy Activities, Subsequent Workforce Reduction 

The company had announced its intent to wind down the activities after a strategic review and sale process in October.

<ul class="summary-bullets"><li>Brady said that the Prime members have received over €6 million in fare discounts, so “this trial has cost more money than it generates.”</li><li>All existing Prime members will continue to enjoy exclusive monthly low-fare offers until October 2026, but no new members will be allowed to sign up after Friday.</li><li>According to Ryanair’s website, the Prime members get free reserved seats, free travel insurance and access to 12 member-only seat sales and one each month.</li></ul>Ryanair (RYAAY) announced on Friday that it will close its prime member offering from November, following an eight-month trial period during which the European airline noted that the membership cost more than it generated.Chief Marketing Officer Dara Brady said that to date, Ryanair has signed up over 55,000 Prime members, generating over €4.4 million ($5.1 million) in subscription fees. However, Prime members have received over €6 million in fare discounts, so “this trial has cost more money than it generates,” Brady said,The company said that all existing Prime members will continue to enjoy exclusive monthly low-fare offers until October 2026, but no new members will be allowed to sign up after Friday.<h2 class="st-heading-2">Ryanair Prime Membership Details</h2>According to Ryanair’s website, Prime members get free reserved seats, free travel insurance, and access to 12 member-only seat sales, one each month. Prime members get the offer for £79 per annum.Ryanair noted that, based on a passenger who flew 12 times last year, the potential savings so far from the membership were £640 per year. The company added that for a passenger who flew three times last year, the potential savings so far were £415.<h2 class="st-heading-2">Brady’s View</h2>Brady noted that existing Prime members will be allowed to use their seat savings for the remainder of their 12-month membership.“This level of memberships, or subscription revenue does not justify the time and effort it takes to launch monthly exclusive Prime seat sales for our 55,000 Prime members,” Brady said.&nbsp;&nbsp;He noted that the airline has had over 207 million passengers this year and said that they would be trying to offer the lowest fares in Europe to&nbsp;all its customers, and not the subset of 55,000 Prime members.Retail sentiment on <a href="https://stocktwits.com/symbol/RYAAY">Ryanair</a> remained unchanged in the ‘bearish’ territory, with message volumes at ‘normal’ levels, according to data from Stocktwits.U.S.-listed shares of the company have gained nearly 57% this year.€1 = $1.16For updates and corrections, email newsroom[at]stocktwits[dot]com.Also See: <a href="https://stocktwits.com/news-articles/markets/equity/abercrombie-fitch-catches-retail-attention-after-barclays-raises-price-target-on-hollister-momentum/cL5abTzRELe">Abercrombie &amp; Fitch Catches Retail Attention After Barclays Raises Price Target On Hollister Momentum</a>

Ryanair Pulls Plug On Prime Membership Offering After Trial Proves Too Costly 

Chief Marketing Officer Dara Brady said that to date, Ryanair has signed up over 55,000 prime members, generating over €4.4 million in subscription fees.

<ul class="summary-bullets"><li>Both subcutaneous and oral Amycretin appeared to have a safe and well-tolerated profile in the study, Novo said.</li><li>Novo is now planning to initiate a late-stage trial of Amycretin in patients with type 2 diabetes in 2026.&nbsp;</li><li>The positive announcement comes on the heels of the company's discontinuation of late-stage trials of its GLP-1 drug, Semaglutide, in Alzheimer’s disease.</li></ul> Novo Nordisk (NVO) on Tuesday said that a mid-stage trial evaluating Amycretin in people with type 2 diabetes yielded positive outcomes in both weight loss and reduction in average blood sugar levels.NVO shares traded 3% higher in the pre-market session at the time of writing.<h2 class="st-heading-2">Study Outcomes</h2>Amycretin showed statistically significant weight loss of up to 14.5% at 36 weeks, as compared to 2.6% in patients treated with placebo, and demonstrated statistically significant reductions in average blood sugar levels, the company <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2025/11/25/3194155/0/en/Novo-Nordisk-phase-2-trial-with-amycretin-reports-significant-weight-loss-and-HbA1c-reduction-in-type-2-diabetes.html">said</a>.The trial investigated the efficacy, safety, and pharmacokinetics of once-weekly subcutaneous Amycretin and once-daily oral amycretin compared with placebo in 448 people with type 2 diabetes inadequately controlled on metformin. About 40% of the study participants also used a class of drugs known as SGLT2 inhibitors to manage their diabetes before joining the study.Amycretin belongs to the class of drugs known as GLP-1s, used to treat diabetes and obesity, similar to Novo’s blockbuster drugs Wegovy and Ozempic. Both subcutaneous and oral Amycretin appeared to have a safe and well-tolerated profile in the study, Novo said. The common side effects were gastrointestinal, and the vast majority were mild to moderate in severity, the company added.<h2 class="st-heading-2">Plans Ahead</h2>Novo is now planning to initiate a late-stage trial of Amycretin in patients with type 2 diabetes in 2026.Chief Scientific Officer Martin Holst Lange noted that this is the first time Amycretin has been evaluated in this population and added that the company is planning to test the GLP-1 compound across multiple indications starting next year.The positive announcement comes on the heels of the company's discontinuation of late-stage trials of its GLP-1 drug, Semaglutide, in Alzheimer’s disease.The company said on Monday that its late-stage trials evaluating oral Semaglutide in Alzheimer’s disease did not confirm its superiority over placebo in slowing disease progression, and it is subsequently discontinuing them.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around NVO jumped from ‘neutral’ to ‘bullish’ territory over the past 24 hours, while message volume rose from ‘low’ to ‘extremely high’ levels.<a href="https://stocktwits.com/symbol/NVO">NVO stock</a> is down by 48% this year and by about 57% over the past 12 months.&nbsp;Also See: <a href="https://stocktwits.com/news-articles/markets/equity/autl-stock-soars-pre-market-on-position-recommendation-for-cell-therapy-targeting-cancer-in-uk/cL52LfPREXA">AUTL Stock Soars Pre-market On Positive Recommendation For Cell Therapy Targeting Cancer In UK</a>For updates and corrections, email newsroom[at]stocktwits[dot]com

In this photo illustration, a Novo Nordisk logo is displayed on a smartphone with stock market percentages in the background. (Photo Illustration by Omar Marques/SOPA Images/LightRocket via Getty Images)

Novo Nordisk’s Experimental GLP-1 Drug Shows Weight Loss, Blood Sugar Levels Reduction In Study

The trial was investigating the efficacy, safety, and pharmacokinetics of once-weekly subcutaneous amycretin and once-daily oral amycretin compared to placebo in 448 people with type 2 diabetes. 

<ul class="summary-bullets"><li>Semaglutide is the active ingredient in Novo’s blockbuster drugs Wegovy and Ozempic.&nbsp;</li><li>The company said it decided to test the drug in Alzheimer’s disease based on real-world evidence and preclinical models.</li><li>The company conducted two late-stage studies in Alzheimer’s disease, and while an improvement of disease-related biomarkers was observed in both trials with Semaglutide, it did not delay the progression of the disease.</li></ul>Novo Nordisk (NVO) on Monday said that its late-stage trials evaluating oral Semaglutide in Alzheimer’s disease did not confirm its superiority over placebo in slowing disease progression.Shares of the company slumped 11% in the pre-market session at the time of writingSemaglutide is the active ingredient in Novo’s blockbuster weight-loss drug Wegovy. The company said that it decided to test the drug in Alzheimer’s based on real-world evidence studies, pre-clinical models, as well as post-hoc analyses from diabetes and obesity trials. The compound, belonging to the category known as GLP-1 drugs, is marketed as Ozempic and Rybelsus for the treatment of type 2 diabetes as well.<h2 class="st-heading-2">Trial Outcomes</h2>The company conducted two late-stage studies in Alzheimer’s disease, and while an improvement of disease-related biomarkers was observed in both trials with Semaglutide, it did not delay the progression of the disease, the company <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2025/11/24/3193328/0/en/Novo-Nordisk-A-S-Evoke-phase-3-trials-did-not-demonstrate-a-statistically-significant-reduction-in-Alzheimer-s-disease-progression.html">said</a>. The two trials enrolled a total of 3,808 adults and were aimed at evaluating the efficacy and safety of oral Semaglutide compared to placebo on top of standard of care in early-stage symptomatic Alzheimer’s disease.Alzheimer’s is a leading cause of memory loss or dementia. It is a progressive disease where symptoms gradually worsen over time. Semaglutide appears to have a safe and well-tolerated profile in the studies with patients aged 55-85 suffering from mild cognitive impairment or mild dementia due to Alzheimer’s disease, Novo noted.The company said that it is discontinuing the trials. However, the data generated will continue to provide benefits for individuals with type 2 diabetes, obesity, and related comorbidities, it added. The data from the trials will also be presented at future conferences, the company said.<h2 class="st-heading-2">Semaglutide And Its Many Indications</h2>Semaglutide is Novo's biggest asset. In the nine months through the end of September, the company reported sales of DKK 95.264 billion ($14.721.52 billion) from Ozempic, DKK 16.790 billion from Rybelsus and DKK 57.242 billion from Wegovy, togetherly accounting for about 74% of the company’s overall sales in the period.&nbsp;An approval in Alzheimer’s could have helped the company ramp revenue from the compound as its rivalry with American GLP-1 drugmaker Eli Lilly intensifies.&nbsp;The company’s drop in share price prompted a change in CEO earlier this year and layoffs.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around NVO stayed within the ‘bearish’ territory over the past 24 hours, while message volume stayed at ‘low’ levels.<a href="https://stocktwits.com/symbol/NVO">NVO stock</a> is down 45% this year and by 54% over the past 12 months.Also See: <a href="https://stocktwits.com/news-articles/markets/cryptocurrency/btc-holds-86000-crypto-market-back-above-3-trillion-xrp-doge-gain/cL5bex0REQP">Bitcoin Holds $86,000 With Crypto Market Back Above $3 Trillion – XRP, Doge Gain Ahead Of Grayscale’s New ETF Launches</a>For updates and corrections, email newsroom[at]stocktwits[dot]comExchange Rate: DKK1= $0.15

Novo Nordisk’s Blockbuster Drug Fails To Slow Alzheimer’s Disease Progression In Studies

The company said that it is discontinuing the trials.

BioNTech SE (BNTX) announced on Friday that a late-stage trial, conducted by its partner Duality Biologics in China, has met its primary endpoint of progression-free survival at a pre-specified interim analysis. The trial is evaluating Trastuzumab Pamirtecan versus Trastuzumab Emtansine in patients with certain types of breast cancer.Shares of the company traded 10% higher in the pre-market session on Friday. The <a target="_blank" rel="noopener noreferrer nofollow" href="https://investors.biontech.de/news-releases/news-release-details/biontech-and-dualitybio-announce-phase-3-trial-adc-candidate">trial</a> enrolled 228 patients with HER2-positive unresectable or metastatic breast cancer, an aggressive form of the disease that has spread and cannot be surgically removed, who previously received Trastuzumab and a taxane-based chemotherapy.On Stocktwits, retail sentiment around BNTX stock jumped from ‘bullish’ to ‘extremely bullish’ territory over the past 24 hours, while message volume rose from ‘normal’ to ‘high’ levels.<figure class="image"><img style="aspect-ratio:577/60;" src="https://news.stocktwits-cdn.com/Screenshot_2025_09_05_at_8_57_36_AM_png_5a9988a80e.webp" alt="BNTX's Sentiment Meter and Message Volume as of 8:57 a.m. ET on Sept. 5, 2025 | Source: Stocktwits" width="577" height="60"><figcaption>BNTX's Sentiment Meter and Message Volume as of 8:57 a.m. ET on Sept. 5, 2025 | Source: Stocktwits</figcaption></figure> DualityBio now plans to discuss the next steps with the Center for Drug Evaluation (CDE) of the National Medical Products Administration (NMPA) of China regarding the submission of an application for Trastuzumab Pamirtecan approval.DualityBio Global Medical Officer Hua Mu noted that breast cancer has a high incidence rate in China, with over 350,000 new cases annually.“Together with our partner BioNTech, we plan the development of Trastuzumab Pamirtecan in further tumor types towards BLA application in other regions including the United States and the European Union to maximize its potential for patients around the world,” Mu said.BioNTech also noted that this is the first positive late-stage data readout achieved in the collaboration between the two companies initiated in April 2023. The collaboration aims to accelerate the development of differentiated antibody drug-conjugate therapeutics for solid tumors.BioNTech holds global commercial rights for Trastuzumab Pamirtecan, while DualityBio has commercial rights for Mainland China, Hong Kong Special Administrative Region, and Macau Special Administrative Region.BNTX stock is down by 9% this year but up by about 15% over the past 12 months.&nbsp;Read also: <a href="https://stocktwits.com/news-articles/markets/equity/tesla-proposes-whopping-1-trillion-pay-package-for-ceo-elon-musk/chwIJkaRdpr">Tesla Proposes Whopping $1 Trillion Pay Package For CEO Elon Musk</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, the BioNTech logo is displayed on a smartphone screen. (Photo illustration by Cheng Xin/Getty Images)

Why Did BioNTech Stock Surge 10% Pre-Market Today?

DualityBio now plans to discuss the next steps with the Center for Drug Evaluation (CDE) of the National Medical Products Administration (NMPA) of China regarding the submission of an application for Trastuzumab Pamirtecan approval.

Up 5%

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Markets are hovering near key levels, making the next 5% move especially important for sentiment. A breakout higher could reinforce the bull case, while a 5% drop may signal rising risk and tighter conditions. Which comes first?

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