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nLIGHT, Inc. engages in the provision of semiconductor and fiber lasers for aerospace and defense, industrial, and microfabrication applications. It operates through the Laser Products and Advanced Development segments. The Laser Products segment designs, manufactures, and sells a range of semiconductor lasers and fiber lasers that are typically integrated into laser systems or manufacturing tools built by customers. The Advanced Development segment focuses on research, design, and prototyping of next-generation laser technologies, leveraging expertise in laser technology, development, beam control, and advanced optics. The company was founded by Scott H. Keeney, Mark DeVito, and Jason Farmer in June 2000 and is headquartered in Camas, WA.

nLIGHT Inc

nLIGHT ($LASR) is trending, with community members highlighting its potential involvement in the "Golden Dome" defense project and recent strong earnings. Some see a breakout opportunity if it can push through range highs on volume, while others discuss the company's technology and growth potential in the aerospace and defense sector. There is also discussion around possible short attacks.

IREN Ltd. is a vertically integrated data center business powering the future of Bitcoin, AI and beyond with renewable energy. It is strategically located in renewable-rich, fiber-connected regions across the US and Canada. IREN’s large-scale, grid-connected facilities are purpose-built for the next generation of power-dense computing applications. The company was founded by Daniel Roberts and William Roberts on November 6, 2018, and is headquartered in Sydney, Australia.

IREN Ltd.

IREN Limited

IREN is trending downwards, with the community discussing the potential for further declines and key support levels, possibly driven by overall market concerns and sector-specific headwinds related to data center profitability. Investors are debating whether the recent drop represents a buying opportunity or a sign of deeper issues, with discussions around the company's fundamentals versus market sentiment. The conversation includes mentions of AI bubble fears, tax-loss harvesting, and potential rate hikes, adding to the uncertainty surrounding the stock.

Broadcom Inc. is a global technology company, which designs, develops, and supplies semiconductors and infrastructure software solutions. It operates through the Semiconductor Solutions and Infrastructure Software segments. The Semiconductor Solutions segment refers to product lines and intellectual property licensing. The Infrastructure Software segment relates to mainframe, distributed and cyber security solutions, and the FC SAN business. The company was founded in 1961 and is headquartered in Palo Alto, CA.

Broadcom Inc

Broadcom ($AVGO) is trending downwards, with community chatter focused on a sharp sell-off despite recent earnings and analyst upgrades, generating discussions around potential support levels and oversold conditions. Concerns over AI revenue specifics and margin impacts, as well as broader market rotation, are cited as possible catalysts. Some traders speculate about market manipulation, while others remain bullish, citing the company's AI backlog and potential for a rebound.

AMC Robotics Corp. engages in developing and deploying AI-enabled robotics and smart security solutions, especially for warehouse automation, enterprise security, robotics patrol/incident-response and logistics automation. The company is headquartered in New York, NY.

AMC Robotics Corp.

AMCI is trending due to a significant surge in price and volume, sparking discussions about a potential short squeeze. The community is actively debating its overnight trading activity and potential for further gains, drawing comparisons to other high-flying stocks. Some traders are pointing to the company's focus on AI-powered robotics as a reason for optimism, while others are wary of a potential pump and dump.

Critical Metals Corp. engages in the mining, exploration, and development of lithium metals. It owns Wolfsberg Project and Tanbreez Project. The company was founded on October 24, 2022 and is headquartered in British Virgin Islands.

Critical Metals Corp.

Critical Metals Corp. is trending as discussions revolve around the potential of its Greenland project and its role in securing critical mineral supply chains, particularly with recent drilling results highlighting multi-commodity potential. The community is actively discussing the implications of the project's resources, including zirconium, tantalum, yttrium, and cerium, for various high-tech applications. Community members are also weighing the potential for government stakes and how the company fits into the broader context of Western nations reducing reliance on Chinese mineral resources.

Radiopharm Theranostics Ltd. operates as a pre-clinical and clinical research company. It focuses on the development of radiopharmaceutical products for diagnostic and therapeutic uses in areas of high unmet medical need. The company is founded by Paul A. Hopper in 2021 headquartered Carlton, Australia.

Radiopharm Theranostics Ltd - ADR

RADX is trending due to positive interim data from its Phase 2b trial, sparking significant community discussion around its potential as a brain metastases imaging agent. Community members are actively discussing price targets and short squeeze opportunities, while also weighing the possibility of a near-term offering. The stock's aggressive volatility and high trading volume have placed it on many traders' watchlists.

Artiva Biotherapeutics, Inc. operates as a biotechnology company for the treatment of hematologic cancers. It offers NK cell therapies for cancer. The company was founded by Thomas J. Farrell in 2019 and is headquartered in San Diego, CA.

Artiva Biotherapeutics Inc

ARTV is trending due to a recent FDA Fast Track designation for its AlloNK cell therapy in rheumatoid arthritis, sparking significant price movement and high trading volume. The community is discussing the potential for continued gains, citing analyst price target upgrades and the company's strong cash position, while also weighing the possibility of a near-term offering. Some traders are closely watching key support and resistance levels to gauge the stock's next move.

RAGE GUY (RAGE) is a cryptocurrency inspired by the Rage Guy meme, one of the earliest and most recognizable characters from internet rage comics. The project captures the cultural legacy of early meme history and brings it onto the blockchain in tokenized form. It is designed as a community-driven digital asset that celebrates internet culture, nostalgia, and the role memes play in shaping online communities.

Rage Guy

$RAGE is trending as the community aims to revive "OG Memes" and the spirit of 2021, driven by bullish market sentiment and discussions around exchange listings. Community members are actively highlighting the strong community, potential for growth, and the ongoing efforts to build and innovate within the meme space. The focus remains on conviction, community ownership, and a return to the roots of internet meme culture.

ServiceNow, Inc. engages in the provision of an end-to-end workflow automation platform for digital businesses. Its Now Platform is a cloud-based solution embedded with artificial intelligence (AI) and machine learning (ML). The company was founded by Frederic B. Luddy in June 2004 and is headquartered in Santa Clara, CA.

ServiceNow Inc

ServiceNow is trending amid discussions about AI integration, a potential rebound from recent underperformance, and a recent GSA deal.  The community is weighing the company's valuation and competitive positioning relative to peers, along with strong potential for AI-driven growth. Technical analysis suggests a potential breakout, with some eyeing price targets, while others express concerns about momentum and market manipulation.

Mask Network is the core product of Dimension, which is positioned to become the bridge that connects internet users from Web 2.0 to Web 3.0. The foundational technology of Mask Network is a peer-to-peer encrypted messaging application, with new functions continuously being created around this foundation. We at Mask Network are strong believers in the ownership economy. People should own what they produce, people should own their data, their attention and the virtual space they choose to contribute to.  Mask Network integrates decentralized social messaging, borderless payment network, and decentralized file storage and sharing to provide a safe and convenient portal for users to jump right into the continent of decentralized finance and then the new world of Web 3.0.

Mask Network

Mask Network (MASK) is trending as traders discuss its recent gains and potential as an AI-related asset, drawing comparisons to other high-performing tokens. Community members are actively monitoring its price action, identifying key levels, and speculating on further upside potential, with some anticipating a significant breakout soon. The discussions also touch on the broader context of Web3 and decentralized social media, where Mask Network aims to empower users.

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<ul class="summary-bullets"><li>Brady said that the Prime members have received over €6 million in fare discounts, so “this trial has cost more money than it generates.”</li><li>All existing Prime members will continue to enjoy exclusive monthly low-fare offers until October 2026, but no new members will be allowed to sign up after Friday.</li><li>According to Ryanair’s website, the Prime members get free reserved seats, free travel insurance and access to 12 member-only seat sales and one each month.</li></ul>Ryanair (RYAAY) announced on Friday that it will close its prime member offering from November, following an eight-month trial period during which the European airline noted that the membership cost more than it generated.Chief Marketing Officer Dara Brady said that to date, Ryanair has signed up over 55,000 Prime members, generating over €4.4 million ($5.1 million) in subscription fees. However, Prime members have received over €6 million in fare discounts, so “this trial has cost more money than it generates,” Brady said,The company said that all existing Prime members will continue to enjoy exclusive monthly low-fare offers until October 2026, but no new members will be allowed to sign up after Friday.<h2 class="st-heading-2">Ryanair Prime Membership Details</h2>According to Ryanair’s website, Prime members get free reserved seats, free travel insurance, and access to 12 member-only seat sales, one each month. Prime members get the offer for £79 per annum.Ryanair noted that, based on a passenger who flew 12 times last year, the potential savings so far from the membership were £640 per year. The company added that for a passenger who flew three times last year, the potential savings so far were £415.<h2 class="st-heading-2">Brady’s View</h2>Brady noted that existing Prime members will be allowed to use their seat savings for the remainder of their 12-month membership.“This level of memberships, or subscription revenue does not justify the time and effort it takes to launch monthly exclusive Prime seat sales for our 55,000 Prime members,” Brady said.&nbsp;&nbsp;He noted that the airline has had over 207 million passengers this year and said that they would be trying to offer the lowest fares in Europe to&nbsp;all its customers, and not the subset of 55,000 Prime members.Retail sentiment on <a href="https://stocktwits.com/symbol/RYAAY">Ryanair</a> remained unchanged in the ‘bearish’ territory, with message volumes at ‘normal’ levels, according to data from Stocktwits.U.S.-listed shares of the company have gained nearly 57% this year.€1 = $1.16For updates and corrections, email newsroom[at]stocktwits[dot]com.Also See: <a href="https://stocktwits.com/news-articles/markets/equity/abercrombie-fitch-catches-retail-attention-after-barclays-raises-price-target-on-hollister-momentum/cL5abTzRELe">Abercrombie &amp; Fitch Catches Retail Attention After Barclays Raises Price Target On Hollister Momentum</a>

Ryanair Boeing 737 MAX 8 as seen during taxiing, take off and flying phase in Eindhoven Airport.

Ryanair Pulls Plug On Prime Membership Offering After Trial Proves Too Costly 

Chief Marketing Officer Dara Brady said that to date, Ryanair has signed up over 55,000 prime members, generating over €4.4 million in subscription fees.

Equity

Chief Marketing Officer Dara Brady said that to date, Ryanair has signed up over 55,000 prime members, generating over €4.4 million in subscription fees.


<ul class="summary-bullets"><li>Both subcutaneous and oral Amycretin appeared to have a safe and well-tolerated profile in the study, Novo said.</li><li>Novo is now planning to initiate a late-stage trial of Amycretin in patients with type 2 diabetes in 2026.&nbsp;</li><li>The positive announcement comes on the heels of the company's discontinuation of late-stage trials of its GLP-1 drug, Semaglutide, in Alzheimer’s disease.</li></ul> Novo Nordisk (NVO) on Tuesday said that a mid-stage trial evaluating Amycretin in people with type 2 diabetes yielded positive outcomes in both weight loss and reduction in average blood sugar levels.NVO shares traded 3% higher in the pre-market session at the time of writing.<h2 class="st-heading-2">Study Outcomes</h2>Amycretin showed statistically significant weight loss of up to 14.5% at 36 weeks, as compared to 2.6% in patients treated with placebo, and demonstrated statistically significant reductions in average blood sugar levels, the company <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2025/11/25/3194155/0/en/Novo-Nordisk-phase-2-trial-with-amycretin-reports-significant-weight-loss-and-HbA1c-reduction-in-type-2-diabetes.html">said</a>.The trial investigated the efficacy, safety, and pharmacokinetics of once-weekly subcutaneous Amycretin and once-daily oral amycretin compared with placebo in 448 people with type 2 diabetes inadequately controlled on metformin. About 40% of the study participants also used a class of drugs known as SGLT2 inhibitors to manage their diabetes before joining the study.Amycretin belongs to the class of drugs known as GLP-1s, used to treat diabetes and obesity, similar to Novo’s blockbuster drugs Wegovy and Ozempic. Both subcutaneous and oral Amycretin appeared to have a safe and well-tolerated profile in the study, Novo said. The common side effects were gastrointestinal, and the vast majority were mild to moderate in severity, the company added.<h2 class="st-heading-2">Plans Ahead</h2>Novo is now planning to initiate a late-stage trial of Amycretin in patients with type 2 diabetes in 2026.Chief Scientific Officer Martin Holst Lange noted that this is the first time Amycretin has been evaluated in this population and added that the company is planning to test the GLP-1 compound across multiple indications starting next year.The positive announcement comes on the heels of the company's discontinuation of late-stage trials of its GLP-1 drug, Semaglutide, in Alzheimer’s disease.The company said on Monday that its late-stage trials evaluating oral Semaglutide in Alzheimer’s disease did not confirm its superiority over placebo in slowing disease progression, and it is subsequently discontinuing them.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around NVO jumped from ‘neutral’ to ‘bullish’ territory over the past 24 hours, while message volume rose from ‘low’ to ‘extremely high’ levels.<a href="https://stocktwits.com/symbol/NVO">NVO stock</a> is down by 48% this year and by about 57% over the past 12 months.&nbsp;Also See: <a href="https://stocktwits.com/news-articles/markets/equity/autl-stock-soars-pre-market-on-position-recommendation-for-cell-therapy-targeting-cancer-in-uk/cL52LfPREXA">AUTL Stock Soars Pre-market On Positive Recommendation For Cell Therapy Targeting Cancer In UK</a>For updates and corrections, email newsroom[at]stocktwits[dot]com

In this photo illustration, a Novo Nordisk logo is displayed on a smartphone with stock market percentages in the background. (Photo Illustration by Omar Marques/SOPA Images/LightRocket via Getty Images)

Novo Nordisk’s Experimental GLP-1 Drug Shows Weight Loss, Blood Sugar Levels Reduction In Study

The trial was investigating the efficacy, safety, and pharmacokinetics of once-weekly subcutaneous amycretin and once-daily oral amycretin compared to placebo in 448 people with type 2 diabetes. 

<ul class="summary-bullets"><li>Semaglutide is the active ingredient in Novo’s blockbuster drugs Wegovy and Ozempic.&nbsp;</li><li>The company said it decided to test the drug in Alzheimer’s disease based on real-world evidence and preclinical models.</li><li>The company conducted two late-stage studies in Alzheimer’s disease, and while an improvement of disease-related biomarkers was observed in both trials with Semaglutide, it did not delay the progression of the disease.</li></ul>Novo Nordisk (NVO) on Monday said that its late-stage trials evaluating oral Semaglutide in Alzheimer’s disease did not confirm its superiority over placebo in slowing disease progression.Shares of the company slumped 11% in the pre-market session at the time of writingSemaglutide is the active ingredient in Novo’s blockbuster weight-loss drug Wegovy. The company said that it decided to test the drug in Alzheimer’s based on real-world evidence studies, pre-clinical models, as well as post-hoc analyses from diabetes and obesity trials. The compound, belonging to the category known as GLP-1 drugs, is marketed as Ozempic and Rybelsus for the treatment of type 2 diabetes as well.<h2 class="st-heading-2">Trial Outcomes</h2>The company conducted two late-stage studies in Alzheimer’s disease, and while an improvement of disease-related biomarkers was observed in both trials with Semaglutide, it did not delay the progression of the disease, the company <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2025/11/24/3193328/0/en/Novo-Nordisk-A-S-Evoke-phase-3-trials-did-not-demonstrate-a-statistically-significant-reduction-in-Alzheimer-s-disease-progression.html">said</a>. The two trials enrolled a total of 3,808 adults and were aimed at evaluating the efficacy and safety of oral Semaglutide compared to placebo on top of standard of care in early-stage symptomatic Alzheimer’s disease.Alzheimer’s is a leading cause of memory loss or dementia. It is a progressive disease where symptoms gradually worsen over time. Semaglutide appears to have a safe and well-tolerated profile in the studies with patients aged 55-85 suffering from mild cognitive impairment or mild dementia due to Alzheimer’s disease, Novo noted.The company said that it is discontinuing the trials. However, the data generated will continue to provide benefits for individuals with type 2 diabetes, obesity, and related comorbidities, it added. The data from the trials will also be presented at future conferences, the company said.<h2 class="st-heading-2">Semaglutide And Its Many Indications</h2>Semaglutide is Novo's biggest asset. In the nine months through the end of September, the company reported sales of DKK 95.264 billion ($14.721.52 billion) from Ozempic, DKK 16.790 billion from Rybelsus and DKK 57.242 billion from Wegovy, togetherly accounting for about 74% of the company’s overall sales in the period.&nbsp;An approval in Alzheimer’s could have helped the company ramp revenue from the compound as its rivalry with American GLP-1 drugmaker Eli Lilly intensifies.&nbsp;The company’s drop in share price prompted a change in CEO earlier this year and layoffs.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around NVO stayed within the ‘bearish’ territory over the past 24 hours, while message volume stayed at ‘low’ levels.<a href="https://stocktwits.com/symbol/NVO">NVO stock</a> is down 45% this year and by 54% over the past 12 months.Also See: <a href="https://stocktwits.com/news-articles/markets/cryptocurrency/btc-holds-86000-crypto-market-back-above-3-trillion-xrp-doge-gain/cL5bex0REQP">Bitcoin Holds $86,000 With Crypto Market Back Above $3 Trillion – XRP, Doge Gain Ahead Of Grayscale’s New ETF Launches</a>For updates and corrections, email newsroom[at]stocktwits[dot]comExchange Rate: DKK1= $0.15

In this photo illustration, the logo of Novo Nordisk is displayed on a smartphone screen on September 10, 2025 in Chongqing, China. 

Novo Nordisk’s Blockbuster Drug Fails To Slow Alzheimer’s Disease Progression In Studies

The company said that it is discontinuing the trials.

BioNTech SE (BNTX) announced on Friday that a late-stage trial, conducted by its partner Duality Biologics in China, has met its primary endpoint of progression-free survival at a pre-specified interim analysis. The trial is evaluating Trastuzumab Pamirtecan versus Trastuzumab Emtansine in patients with certain types of breast cancer.Shares of the company traded 10% higher in the pre-market session on Friday. The <a target="_blank" rel="noopener noreferrer nofollow" href="https://investors.biontech.de/news-releases/news-release-details/biontech-and-dualitybio-announce-phase-3-trial-adc-candidate">trial</a> enrolled 228 patients with HER2-positive unresectable or metastatic breast cancer, an aggressive form of the disease that has spread and cannot be surgically removed, who previously received Trastuzumab and a taxane-based chemotherapy.On Stocktwits, retail sentiment around BNTX stock jumped from ‘bullish’ to ‘extremely bullish’ territory over the past 24 hours, while message volume rose from ‘normal’ to ‘high’ levels.<figure class="image"><img style="aspect-ratio:577/60;" src="https://news.stocktwits-cdn.com/Screenshot_2025_09_05_at_8_57_36_AM_png_5a9988a80e.webp" alt="BNTX's Sentiment Meter and Message Volume as of 8:57 a.m. ET on Sept. 5, 2025 | Source: Stocktwits" width="577" height="60"><figcaption>BNTX's Sentiment Meter and Message Volume as of 8:57 a.m. ET on Sept. 5, 2025 | Source: Stocktwits</figcaption></figure> DualityBio now plans to discuss the next steps with the Center for Drug Evaluation (CDE) of the National Medical Products Administration (NMPA) of China regarding the submission of an application for Trastuzumab Pamirtecan approval.DualityBio Global Medical Officer Hua Mu noted that breast cancer has a high incidence rate in China, with over 350,000 new cases annually.“Together with our partner BioNTech, we plan the development of Trastuzumab Pamirtecan in further tumor types towards BLA application in other regions including the United States and the European Union to maximize its potential for patients around the world,” Mu said.BioNTech also noted that this is the first positive late-stage data readout achieved in the collaboration between the two companies initiated in April 2023. The collaboration aims to accelerate the development of differentiated antibody drug-conjugate therapeutics for solid tumors.BioNTech holds global commercial rights for Trastuzumab Pamirtecan, while DualityBio has commercial rights for Mainland China, Hong Kong Special Administrative Region, and Macau Special Administrative Region.BNTX stock is down by 9% this year but up by about 15% over the past 12 months.&nbsp;Read also: <a href="https://stocktwits.com/news-articles/markets/equity/tesla-proposes-whopping-1-trillion-pay-package-for-ceo-elon-musk/chwIJkaRdpr">Tesla Proposes Whopping $1 Trillion Pay Package For CEO Elon Musk</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, the BioNTech logo is displayed on a smartphone screen. (Photo illustration by Cheng Xin/Getty Images)

Why Did BioNTech Stock Surge 10% Pre-Market Today?

DualityBio now plans to discuss the next steps with the Center for Drug Evaluation (CDE) of the National Medical Products Administration (NMPA) of China regarding the submission of an application for Trastuzumab Pamirtecan approval.

Sanofi (SNY) announced on Thursday that its experimental drug, Amlitelimab, met all primary and key secondary endpoints in a late-stage study in adults and adolescents with atopic dermatitis (AD).The <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.sanofi.com/en/media-room/press-releases/2025/2025-09-04-05-00-00-3144170">study</a> enrolled 601 adults and adolescents aged 12 years and older with moderate-to-severe AD. Amlitelimab, dosed every four weeks or every 12 weeks, demonstrated statistically significant and clinically meaningful efficacy in skin clearance and disease severity compared to placebo at week 24. Furthermore, a progressive increase in efficacy was observed during the treatment period in patients who were dosed every four weeks as well as in those who were dosed every 12 weeks, the company said.The most common treatment-emergent adverse events, such as upper respiratory tract infection, were more common in the placebo arm compared to the Amlitelimab-treated arms of the study, it said.Shares of the company, however, traded 9% lower in the premarket session at the time of writing.According to a Reuters <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.reuters.com/business/healthcare-pharmaceuticals/sanofi-sheds-13-billion-value-weak-trial-results-eczema-drug-2025-09-04/">report</a>, Jefferies analysts opined that the trial results fell short of those from an earlier trial and of rival biologic drugs. However, the drug's safety profile and convenient 12-week dosing regimen could still support its use.JPMorgan, meanwhile, noted that the data confirmed that Amlitelimab is less effective than Sanofi’s approved drug Dupixent, Reuters added. On Stocktwits, retail sentiment around <a href="https://stocktwits.com/symbol/SNY">SNY stock</a> jumped from ‘neutral’ to ‘bullish’ territory over the past 24 hours, while message volume rose from ‘low’ to ‘high’ levels.<figure class="image"><img style="aspect-ratio:578/61;" src="https://news.stocktwits-cdn.com/Screenshot_2025_09_04_at_7_50_44_AM_png_2f5aa98d10.webp" alt="SNY's Sentiment Meter and Message Volume as of 7:51 a.m. ET on Sept. 4, 2025 | Source: Stocktwits" width="578" height="61"><figcaption>SNY's Sentiment Meter and Message Volume as of 7:51 a.m. ET on Sept. 4, 2025 | Source: Stocktwits</figcaption></figure>Sanofi’s Dupixent is approved to treat atopic dermatitis in addition to asthma, chronic spontaneous urticaria, and other diseases. In the second quarter, Dupixent sales increased by 21.1% to €3.8 billion ($4.43 billion), and the company was expecting Amlitelimab to complement the blockbuster drug.The firm now looks forward to sharing additional late-stage results from the clinical development program of Amlitelimab in atopic dermatitis, said Houman Ashrafian, Executive Vice President, Head of Research &amp; Development at Sanofi.SNY stock is up 3% this year but down approximately 15% over the past 12 months.Read also: <a href="https://stocktwits.com/news-articles/markets/equity/fda-says-no-advisory-commitee-meeting-required-for-aquestive-oral-epinephrine-film/chwd20pRdYB">FDA Says No Advisory Committee Meeting Needed For Aquestive’s Oral Epinephrine Film</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.Exchange Rate: €1= $1.17

Photo taken on April 15, 2025 shows the pharmaceutical factory of pharmaceutical company Sanofi in Hangzhou, Zhejiang province, China. (Photo credit should read CFOTO/Future Publishing via Getty Images)

Sanofi’s New Experimental Eczema Drug Meets Goals Of Late-stage Trial, But Wall Street Expected More

Amlitelimab, dosed every four weeks or every 12 weeks, demonstrated statistically significant and clinically meaningful efficacy in skin clearance and disease severity compared to placebo at week 24, the company said. 

A Delaware federal judge on Friday reportedly said that Novartis (NVS) cannot block India-based drugmaker MSN Pharmaceuticals from launching a generic version of its heart failure drug Entresto before its patent expires late next year.The judge rejected Novartis’ argument that the generic would infringe on one of the company’s patents, Reuters <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.reuters.com/legal/litigation/novartis-loses-bid-block-us-entresto-generic-through-2026-2025-07-11/">reported</a>. U.S. District Judge Richard Andrews also denied Novartis’ request to block the generic from launching until after the patent expires in November 2026.NYSE-listed shares of <a href="https://stocktwits.com/symbol/NVS">Novartis</a> were trading 2% lower at the time of writing.Novartis told Reuters in a statement that it plans to appeal.The company told the court in a filing on Friday that MSN may receive the U.S. Food and Drug Administration’s approval for the generic as soon as July 16 and launch it soon after, cutting into the market for Entresto.Entresto is a prescription medicine used to treat adults with long-lasting (chronic) heart failure to help reduce the risk of death and hospitalization. It was Novartis’s best-selling brand in the first quarter.The company reported $2.26 billion in net sales for the drug, marking a growth of 22% at constant currency. The drug, in fact, accounted for over 17% of the company’s overall net sales in the period.The company said in April that the drug had sustained, robust, demand-led growth globally in the quarter, including in China and Japan, with increased penetration in hypertension.On Stocktwits, retail sentiment around Novartis remained unmoved in the ‘neutral’ territory over the past 24 hours while message volume stayed unchanged at ‘normal’ levels.<figure class="image"><img style="aspect-ratio:622/66;" src="https://news.stocktwits-cdn.com/Screenshot_2025_07_11_at_2_12_01_PM_png_5d097b2dd4.webp" alt="NVS's Sentiment Meter and Message Volume as of 2:10 p.m. ET on July 11, 2025 | Source: Stocktwits" width="622" height="66"><figcaption>NVS's Sentiment Meter and Message Volume as of 2:10 p.m. ET on July 11, 2025 | Source: Stocktwits</figcaption></figure>NVS stock is up by about 25% this year and by about 10% over the past 12 months.Read Next: <a target="_blank" rel="noopener noreferrer nofollow" href="https://CMS’s Initial Proposal To Cover Renal Denervation A Win For Medtronic, Says Analysts">CEL-SCI Stock Soars On Imminent Partnership With Saudi Arabian Pharma Company For Cancer Drug: Retail’s Thrilled</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, the Novartis company logo is seen displayed on a smartphone screen. (Photo Illustration by Piotr Swat/SOPA Images/LightRocket via Getty Images)

Novartis Fails To Block Heart Failure Drug’s Generic From Launching Through 2026: Report

Novartis’ heart failure drug Entresto accounted for over 17% of the company’s overall net sales in the first quarter of 2025.

Novartis (NVS) on Tuesday said that Swiss authorities have approved its Coartem Baby as the first malaria medicine for newborns and young infants.<a href="https://stocktwits.com/symbol/NVS">Novartis</a> developed the treatment, also known as Riamet Baby in some geographies, in collaboration with Medicines for Malaria Venture (MMV).The company <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.novartis.com/news/media-releases/novartis-receives-approval-first-malaria-medicine-newborn-babies-and-young-infants">said</a> that it now expects rapid approval for the treatment in eight African countries, including Burkina Faso, Côte d'Ivoire, Kenya, Malawi, Mozambique, Nigeria, Uganda, and Tanzania. &nbsp;Malaria is a life-threatening disease caused by a parasite and spread to humans by some types of mosquitoes. Novartis cited WHO data and noted that there were 263 million cases of malaria and 597,000 deaths in 2023, almost all of them in Africa.&nbsp;The company said it intends to introduce the infant-friendly treatment on a largely not-for-profit basis where malaria is endemic. According to Novartis, some 30 million babies are born in areas of malaria risk in Africa every year.The new approval is for the treatment of malaria in infants weighing between 2kg and 5kg. Novartis said there were no approved malaria treatments for infants weighing less than 4.5kg until now, leaving a treatment gap. Furthermore, malaria vaccines are also not approved for the youngest babies, the company noted.The pediatric formulation of the treatment is dissolvable, including in breast milk, and has a sweet cherry flavor to make it easier to administer.“The approval of Coartem Baby provides a necessary medicine with an optimized dose to treat an otherwise neglected group of patients and offers a valuable addition to the antimalarial toolbox,” CEO of MMV Martin Fitchet said.On Stocktwits, retail sentiment around Novartis is trending in the “bullish” territory, coupled with “high” message volume.<figure class="image"><img style="aspect-ratio:1250/130;" src="https://news.stocktwits-cdn.com/Screenshot_2025_07_08_at_7_32_02_AM_png_2a581d344f.webp" alt="NVS's Sentiment Meter and Message Volume as of 7:30 a.m. ET on July 8, 2025 | Source: Stocktwits" width="1250" height="130"><figcaption>NVS's Sentiment Meter and Message Volume as of 7:30 a.m. ET on July 8, 2025 | Source: Stocktwits</figcaption></figure>NVS stock is up by about 26% this year and by 13% over the past 12 months.Read Next: <a href="https://stocktwits.com/news-articles/markets/equity/musk-ally-isaacman-reacts-to-trump-s-political-jabs-says-nasa-without-a-confirmed-leader-not-ideal-for-america/chFvNyDR5g4">Musk Ally Isaacman Reacts To Trump’s Political Jabs, Says NASA Without A Confirmed Leader ‘Not Ideal For... America’</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Novartis Gets Swiss Authority Nod For First Malaria Drug In Newborns, Young Infants

The company said that it now expects rapid approval for the treatment in eight African countries, including Burkina Faso, Côte d'Ivoire, Kenya, Malawi, Mozambique, Nigeria, Uganda, and Tanzania. 

Medicine company Novartis (NVS) said on Thursday that a late-stage trial evaluating its drug Cosentyx in adults with newly diagnosed or relapsing giant cell arteritis failed to meet its primary goal of sustained remission. &nbsp;Cosentyx was evaluated in combination with a 26-week steroid taper and compared to placebo plus a 52-week steroid taper in the trial. The drug, however, did not demonstrate a statistically significant improvement in sustained remission at week 52 compared to placebo.The company <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.novartis.com/news/media-releases/novartis-provides-update-phase-iii-gcaptain-study-cosentyx-giant-cell-arteritis-gca">said</a> that it will share a full evaluation of the trial data at a later date.Shares of Novartis were trading 1% lower in the pre-market session.Giant cell arteritis (GCA) is the most common form of systemic vasculitis, a group of rare autoimmune diseases characterized by inflammation of blood vessels. GCA primarily affects people over 50 years of age and has the potential to cause irreversible vision loss and life-threatening aortic aneurysms.Cosentyx, launched in 2015, is already approved for use in adults with multiple conditions such as psoriatic arthritis, moderate to severe plaque psoriasis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, and hidradenitis suppurativa.It is also approved in pediatric patients with moderate to severe plaque psoriasis, enthesitis-related arthritis, and juvenile psoriatic arthritis.In the first quarter of 2025, Cosentyx brought in $1,534 million in net sales, marking a growth of 18% at constant currency, as sales grew mainly in the U.S., emerging markets, and Europe.Cosentyx, in fact, accounted for about 12% of the company’s overall net sales in the quarter.On Stocktwits, retail sentiment around <a href="https://stocktwits.com/symbol/NVS">Novartis</a> jumped from ‘neutral’ to ‘bullish’ over the past 24 hours while message volume remained at ‘high’ levels.<figure class="image"><img style="aspect-ratio:627/57;" src="https://news.stocktwits-cdn.com/Screenshot_2025_07_03_082008_png_2cf306955c.webp" alt="NVS's Sentiment Meter and Message Volume as of 8:20 a.m. ET on July 3, 2025 | Source: Stocktwits" width="627" height="57"><figcaption>NVS's Sentiment Meter and Message Volume as of 8:20 a.m. ET on July 3, 2025 | Source: Stocktwits</figcaption></figure>NVS stock is up by over 27% this year and by about 16% over the past 12 months.Read Next: <a href="https://stocktwits.com/news-articles/markets/equity/alibaba-targets-1.5-billion-from-bond-sale-linked-to-health-arm/chFjAFkRcmI">Alibaba Targets $1.5B From Bond Sale Linked To Health Arm: Retail’s Buoyant</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Novartis’ Blockbuster Drug Fails Late-Stage Trial In Disease Causing Blood Vessel Inflammation, But Retail Turns Bullish

Giant cell arteritis (GCA) is the most common form of systemic vasculitis, a group of rare autoimmune diseases characterized by inflammation of blood vessels.

U.S. District Judge Mark Pittman in Fort Worth, Texas, reportedly upheld the U.S. Food and Drug Administration's (FDA) decision on Wednesday to remove Novo Nordisk's popular drugs, Ozempic and Wegovy, from its shortage list.Pittman said that the FDA had appropriately weighed supply and demand data for the drugs and properly removed them from the shortage list while rejecting a challenge brought by compounding pharmacies who sought to continue making copies of the drugs, Reuters <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.reuters.com/business/healthcare-pharmaceuticals/us-judge-upholds-fdas-removal-ozempic-wegovy-drug-shortage-list-2025-06-18/">reported</a>.Compounders are allowed to produce copies of drugs only when they are declared to be in short supply by the FDA. In February, the FDA announced that the semaglutide injection product shortage had been resolved, preventing compounders from manufacturing copies of Wegovy and Ozempic, as semaglutide is the active ingredient in them.Semaglutide injection products were first added to the FDA’s drug shortage list in 2022, paving the way for compounders to replicate them.Late last month, Novo Nordisk said that it had filed nearly 120 lawsuits across 34 states against compounders and other entities making false and misleading claims about their “semaglutide" drugs.The company also announced a $199-per-month limited-time offer for self-paying patients new to its weight loss drug, Wegovy, to encourage patients who previously used compounded versions of the drug to transition to Wegovy.On Stocktwits, retail sentiment around Novo Nordisk shares rose from ‘neutral’ to ‘bullish’ territory over the past 24 hours while message volume fell from ‘high’ to ‘normal’ levels.<figure class="image"><img style="aspect-ratio:629/65;" src="https://news.stocktwits-cdn.com/Screenshot_2025_06_18_at_12_40_07_PM_png_8852be04e7.webp" alt="NVO's Sentiment Meter and Message Volume as of 12:40 p.m. ET on June 18, 2025 | Source: Stocktwits" width="629" height="65"><figcaption>NVO's Sentiment Meter and Message Volume as of 12:40 p.m. ET on June 18, 2025 | Source: Stocktwits</figcaption></figure> <a href="https://stocktwits.com/symbol/NVO">NVO stock</a> is down by about 15% this year and by about 47% over the past 12 months.Read Next: <a href="https://stocktwits.com/news-articles/markets/equity/tmc-stock-surges-to-near-4-year-high-after-opening-the-door-to-cashless-exercise-of-class-b-warrants/chlsB67RR2h">TMC Stock Surges To Near 4-Year High After Opening The Door To Cashless Exercise Of Class B Warrants</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

Ozempic manufactured by Novo Nordisk packaging is seen in this illustration photo taken in a pharmacy in Krakow, Poland on December 7, 2023. (Photo by Jakub Porzycki/NurPhoto via Getty Images)

US Judge Upholds FDA Decision To Remove Wegovy, Ozempic From Shortage List In Move Against Compounding Pharmacies

The judge said that the FDA had appropriately weighed supply and demand data for the drugs and properly removed them from the shortage list, Reuters reported. 

Danish drugmaker Novo Nordisk (NVO) <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.novonordisk.com/content/nncorp/global/en/news-and-media/news-and-ir-materials/news-details.html?id=916348">announced</a> on Thursday that it plans to initiate a late-stage development program with its experimental drug Amycretin for adults with obesity or those who are overweight, starting in the first quarter of 2026.Shares of NVO traded 3% higher on Thursday.The decision to advance the study of Amycretin into the late stage is based on feedback received from regulators following mid-stage studies.Amycretin is a single molecule that operates as both GLP-1 receptor agonist and amylin receptor agonist.While GLP-1 receptor agonists work by mimicking the natural hormone GLP-1, Amylin receptor agonists mimic the effects of the natural hormone amylin, reducing appetite. The drug is developed for subcutaneous and oral administration.The company’s popular weight-loss drug Wegovy’s active component is Semaglutide, another GLP-1 receptor agonist.In the first quarter, Wegovy experienced an 85% increase in sales to DKK 17.36 billion ($2.69 billion), while the company’s overall sales within its obesity care segment grew 67% to DKK 18.42 billion.However, last month, the company said that Lars Fruergaard Jørgensen will <a href="https://stocktwits.com/news-articles/markets/equity/novo-nordisk-ceo-to-step-down/chiw5m5Rbno">step down</a> as CEO as per a mutual agreement with the Novo Nordisk board.The board stated that the change is being made in light of Novo Nordisk's recent market challenges, the company’s declining share price since mid-2024, and discussions with the Novo Nordisk Foundation.<a href="https://stocktwits.com/symbol/NVO">NVO stock</a> has fallen by about 8% this year and by about 44% over the past 12 months.On Stocktwits, retail sentiment around Novo Nordisk stayed unmoved within the ‘bullish’ territory over the past 24 hours while message volume remained ‘high’.<figure class="image"><img style="aspect-ratio:628/64;" src="https://news.stocktwits-cdn.com/Screenshot_2025_06_12_at_2_12_25_PM_png_81063cab85.webp" alt="Screenshot 2025-06-12 at 2.12.25 PM.png" width="628" height="64"><figcaption>NVO's Sentiment Meter and Message Volume as of 2:10 p.m. ET on Jun 12, 2025 | Source: Stocktwits</figcaption></figure>Read Next: <a href="https://stocktwits.com/news-articles/markets/equity/google-cloud-teams-up-with-databricks-to-scale-gemini-enterprise-adoption/chlgdNHRRGd">Google Cloud Teams Up With Databricks To Scale Gemini Enterprise Adoption</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.(Exchange Rate: 1 DKK= 0.16 USD)

Novo Nordisk’s Plan To Start Late-Stage Trial Of Investigational Obesity Drug Amycretin In 2026 Gets Retail Talking

The decision to advance the study of subcutaneous and oral Amycretin into the late stage is based on feedback received from regulators following mid-stage studies.

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