Connect Biopharma (NASDAQ:CNTB) delivered a potentially important clinical catalyst today, announcing positive preliminary topline results from its global Phase 2 Seabreeze STAT COPD study evaluating rademikibart as an add-on treatment for acute exacerbations in adults with COPD and type 2 inflammation. The company reported an 81% reduction in treatment failure, an 85% reduction in new moderate-to-severe COPD exacerbations, and a 100% reduction in new emergency-department visits or hospitalizations for new exacerbations through four weeks versus placebo, with statistically significant p-values for all three measures. Rademikibart was also reported to have been well tolerated, with fewer adverse events and serious adverse events than placebo and no new safety signals.