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Amgen, Inc. is a biotechnology company, which engages in the discovery, development, manufacture, and marketing of human therapeutics. The company was founded by William K. Bowes, Jr., Franklin Pitcher Johnson, Jr., George B. Rathmann, and Joseph Rubinfeld on April 8, 1980 and is headquartered in Thousand Oaks, CA.

AMGEN Inc.

Amgens IMDELLTRAIMFINZI combination is drawing attention after Phase 3 results showed a substantial survival benefit in first-line small-cell lung cancer, strengthening discussion of the companys oncology pipeline. Traders are also citing Repathas strong sales growth, while weighing those growth drivers against biosimilar pressure.

Icahn Enterprises LP is a holding company. It operates through the following segments: Investment, Automotive, Energy, Food Packaging, Real Estate, Home Fashion, Pharma, and Holding Company. The Investment segment consists of various private investment funds. The Automotive segment holds ownership in Icahn Automotive Group, LLC. The Energy segment refers to petroleum refining and marketing businesses. The Food Packaging segment involves the production and sale of cellulosic, fibrous, and plastic casings for the processed meat and poultry industry. The Real Estate segment offers rental real estate, property development, and resort activities. The Home Fashion segment deals with manufacturing, sourcing, marketing, distributing, and selling home fashion consumer products. The Pharma segments operate through Vivus, Inc., a specialized pharmaceutical company. The Holding Company segment manages acquisition and investment in operating businesses. The company was founded on February 17, 1987 and is headquartered in Sunny Isles Beach, FL.

Icahn Enterprises L P - Unit

Icahn Enterprises, L.P.

IEP is drawing attention after a sharp selloff that traders say lacks an obvious fresh headline; speculation includes short-selling or positioning, while others worry about the distribution, debt obligations, and portfolio decisions. The cause of the decline remains uncertain, and some holders are waiting for earnings or management updates for clarity.

Klarna Group Plc is a global digital bank and flexible payments provider. It operates through an AI-powered payments and commerce network that empowers people to pay smarter, with a mission to be available everywhere, for everything. The company was founded by Gustav Erik Niklas Adalberth, Karl Anders Victor Jacobsson, and Sebastian Marcin Siemiatkowski in 2005 and is headquartered in London, the United Kingdom.

Klarna Group plc

Klarnas steep selloff is being linked by traders to reduced growth guidance amid weakness in Germany and heavier investment, with frustration over the stocks persistent underperformance. Bulls argue that improving profitability and expansion through Apple, JPMorgan and other partnerships could support longer-term growth, while skeptics remain concerned about execution and returns.

Zscaler, Inc. engages in the provision of a cloud-based internet security platform. It offers Zero Trust Exchange, Zscaler Client Connector, Zscaler Internet Access, Zscaler Private Access, Zscaler B2B, Zscaler Cloud Protection, and Zscaler Digital Experience. The company was founded by Jagtar Singh Chaudhry and K. Kailash in September 2007 and is headquartered in San Jose, CA.

Zscaler Inc

A broad cybersecurity rally tied to headlines about AI-discovered software vulnerabilities is lifting Zscaler, with traders viewing expanding AI-related risks as a potential tailwind for security spending. Bulls point to breakout momentum and possible short covering, while some caution the stock may be overextended.

AstraZeneca Plc is a global, science-led biopharmaceutical company focused on the discovery, development, and commercialization of prescription medicines. Its portfolio spans oncology, rare diseases, and biopharmaceuticals, including cardiovascular, renal & metabolism, and respiratory & immunology. The company was founded in 1913 and is headquartered in Cambridge, the United Kingdom.

Astrazeneca plc

AstraZeneca PLC

Reports of a possible AstraZenecaBristol Myers Squibb merger sparked debate over financing, dilution and integration risks, with traders linking the speculation to pressure on AZN shares. Subsequent reports that no talks had taken place eased some concerns, though the merger chatter remains unconfirmed.

Helus Pharma, Inc. operates as a clinical-stage biopharmaceutical company on a mission to create safe and effective psychedelic-based therapeutics to address the large unmet need for new and innovative treatment options for people who suffer from mental health conditions. It is currently developing CYB003, a proprietary deuterated psilocybin analog for the treatment of major depressive disorder and CYB004, a proprietary deuterated DMT molecule for generalized anxiety disorder and has a research pipeline of investigational psychedelic-based compounds. The company was founded by Paul Glavine, Eric So, and John Kanakis on October 13, 2016 and is headquartered in Toronto, Canada.

Helus Pharma Inc.

Attention centers on Heluss pivotal Phase 3 APPROACH readout for HLP003, its investigational add-on treatment for major depressive disorder, expected in Q4 2026. Bulls point to earlier Phase 2 results and the option for patients to remain on antidepressants, while skeptics emphasize the binary trial risk and potential financing-related dilution.

Carvana Co. is a holding company and an eCommerce platform, which engages in the buying and selling of used cars. The company was founded by Ernest Garcia, III, Benjamin Huston and Ryan Keeton in 2012 and is headquartered in Tempe, AZ.

Carvana Co. - Ordinary Shares - Class A

Carvana Co.

A sustained selloff has intensified debate over Carvanas financing-dependent business, with traders citing credit quality, debt, higher borrowing costs, and used-car market pressure as risks ahead of Q3 results. Bears see further downside, while some bulls expect a rebound or short-covering move; no specific new catalyst is consistently confirmed.

Hut 8 Corp. engages in the development and operation of data centers at scale, supporting AI, high-performance computing (HPC), ASIC compute, and other energy-intensive technology applications. It operates through the following segments: Power, Digital Infrastructure, Compute, and Others. The Power segment manages the origination, development, and management of powered land and energy infrastructure. The Digital Infrastructure refers to the development, ownership, and operation of facilities designed to support next-generation, energy-intensive technology application. The Compute segment deals with operating businesses that deploy and monetize compute assets across next-generation energy-intensive technology. The Others segment offers equipment sales and repairs. The company was founded on January 27, 2023 and is headquartered in Miami, FL.

Hut 8 Corp

Hut 8 is drawing attention amid a sharp, volatile selloff in bitcoin miners and AI data-center stocks, as traders weigh Bitcoin weakness, financing costs and concerns about execution of the companys data-center pivot. The debate pits fears over capital needs and delayed returns against confidence in its longer-term AI infrastructure opportunity and upcoming earnings update.

Chevron Corp. engages in the provision of oil and gas energy solutions. It provides crude oil and natural gas, manufactures transportation fuels, lubricants, petrochemicals, and additives, and develops technologies that enhance business and the industry. It operates through the Upstream and Downstream segments. The Upstream segment consists of the exploration, development, and production of crude oil and natural gas, the liquefaction, transportation, and regasification associated with liquefied natural gas, the transporting of crude oil by major international oil export pipelines, the processing, transporting, storage, and marketing of natural gas, and a gas-to-liquids plant. The Downstream segment consists of the refining of crude oil into petroleum products, the marketing of crude oil and refined products, the transporting of crude oil and refined products by pipeline, marine vessel, motor equipment, and rail car, and the manufacturing and marketing of commodity petrochemicals and plastics for industrial uses and fuel & lubricant additives. The company was founded on September 10, 1879 and is headquartered in Houston, TX.

Chevron Corp.

Chevrons breakout to fresh highs, alongside rising crude prices and geopolitical supply concerns, is driving attention as traders position around the upcoming earnings report. The community is broadly bullish on the momentum, though some see the report and elevated oil-driven expectations as risks to sustaining the advance.

Snowflake, Inc. engages in the provision of cloud data warehousing software. The firm offers Data Cloud, an ecosystem where Snowflake customers, partners, data providers, and data consumers can break down data silos and derive value from data. Its platform supports a range of use cases including data warehousing, data lakes, data engineering, data science, data application development, and data sharing. The cloud-native architecture consists of layers across storage, compute, and cloud services. The storage layer ingests structured and semi-structured data to create a unified data record. The compute layer provides dedicated resources to enable users to access common data sets for many use cases without latency. The cloud services layer optimizes each use case's performance requirements with no administration. The company was founded by Marcin Zukowski, Thierry Cruanes, and Benoit Dageville on July 23, 2012 and is headquartered in Menlo Park, CA.

Snowflake Inc

Traders are focused on SNOWs rebound after a sharp pullback, with bullish options positioning and attention to whether support holds. Some see room for further recovery on Snowflakes growth story, while skeptics question its valuation and whether the bounce will last.

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Sagimet Biosciences Stock Soars After Positive Data For Experimental Drug In Acne Study

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Dimensional ETF Trust - Dimensional US Core Equity Market ETF

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<ul class="summary-bullets"><li>The trial was conducted by &nbsp;Sagimet’s license partner for China, Ascletis Bioscience Co., in 480 patients with moderate to severe acne vulgaris.</li><li>The company said that once daily oral 50 mg Denifanstat achieved highly statistically significant and clinically meaningful improvements across all primary and secondary efficacy endpoints in the study.&nbsp;</li><li>Ascletic said in October that it plans to submit a new drug application to China National Medical Products Administration for Denifanstat for the treatment of moderate-to-severe acne soon. &nbsp;</li></ul>Shares of Sagimet Biosciences Inc. (SGMT) soared 22% by Friday afternoon after its Denifanstat drug yielded positive results in the treatment of acne in a late-stage trial.The trial was conducted by Sagimet’s license partner for China, Ascletis Bioscience Co., in 480 patients with moderate to severe acne vulgaris. It was aimed at evaluating the safety and efficacy of Denifanstat in acne treatment.<h2 class="st-heading-2">Trial Takeaways</h2>Acne vulgaris is a common skin condition caused by clogged hair follicles from oil and dead skin cells, which can result in whiteheads, blackheads, pimples, and in severe cases, painful nodules and cysts.The company <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://ir.sagimet.com/news-releases/news-release-details/denifanstat-achieved-all-endpoints-treatment-moderate-severe">said</a> that once daily oral 50 mg Denifanstat achieved highly statistically significant and clinically meaningful improvements across all primary and secondary efficacy endpoints. Primary endpoints included the percentage change in total lesion count, and the percentage change in inflammatory lesion count, among others.At week 12, treatment success rates with Denifanstat were more than double those of placebo, with marked reductions in both inflammatory and non-inflammatory lesions, it noted.Furthermore, the drug was generally well-tolerated, the company added.<h2 class="st-heading-2">Plans Ahead</h2>Ascletis said in October that it plans to soon submit a new drug application to China National Medical Products Administration for Denifanstat for the treatment of moderate-to-severe acne.Sagimet, meanwhile, is studying the drug in the treatment of metabolic dysfunction associated steatohepatitis, a serious form of liver disease, characterized by fat buildup, inflammation, and liver cell damage.<h2 class="st-heading-2">How Did Stocktwits Users React?</h2>On Stocktwits, retail sentiment around<a href="https://stocktwits.com/symbol/SGMT"> SGMT stock</a> jumped from ‘bearish’ to ‘bullish’ territory over the past 24 hours, while message volume increased from ‘normal’ to ‘extremely high’ levels.<figure class="image"><img style="aspect-ratio:622/59;" src="data:image/png;base64,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" width="622" height="59" alt="SGMT's Sentiment Meter and Message Volume as of 2:15 p.m. ET on Oct. 24, 2025 | Source: Stocktwits"><figcaption>SGMT's Sentiment Meter and Message Volume as of 2:15 p.m. ET on Oct. 24, 2025 | Source: Stocktwits</figcaption></figure>A Stocktwits user sounded positive on the stock, citing the size of the Chinese market.<stembedurl>https://stocktwits.com/Mikrus36/message/633613843</stembedurl>SGMT stock has nearly doubled this year.&nbsp;Read also: <a href="https://stocktwits.com/news-articles/markets/equity/gm-reportedly-lays-off-over-200-employees-days-after-raising-2025-earnings-guidance/cLGJFcKR3tb">GM Reportedly Lays Off Over 200 Employees Days After Raising 2025 Earnings Guidance</a>For updates and corrections, email newsroom[at]stocktwits[dot]com.

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The trial was conducted by  Sagimet’s license partner for China, Ascletis Bioscience Co., in 480 patients with moderate to severe acne vulgaris.

Sagimet Biosciences Inc

Vanguard Extended Market ETF

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What do you think the S&amp;P 500&#39;s ($SPY) return will be next week?

Current Price	$52.40
Prev Close	$52.70
Open	$52.40
Dividend Yield	N/A
50-Day Moving Average	$52.93
Beta	N/A
Avg. Volume	580,372.89
PE Ratio	N/A

52-Week High	$53.95
52-Week Low	$43.68
Market Capitalization	N/A
EPS (Annual)	N/A
Price to Book	N/A
Revenue Per Employee	N/A

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