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Bitcoin is the world's first decentralized cryptocurrency, created in 2009 by the pseudonymous Satoshi Nakamoto. It enables peer-to-peer electronic cash transactions without intermediaries like banks or governments, operating on a blockchain secured by Proof of Work mining and the SHA-256 cryptographic algorithm.   With a fixed supply cap of 21 million coins and programmatic halvings every four years that reduce miner rewards, Bitcoin is designed as a deflationary digital asset often called "digital gold." Its value stems from solving the double-spending problem without trusted intermediaries, creating the first truly scarce digital asset with censorship resistance and permissionless access that no government, corporation, or individual can control.  Bitcoin operates as a decentralized peer-to-peer network where transactions are recorded on a public ledger called the blockchain, distributed across thousands of computers globally. Transactions are grouped into blocks added approximately every 10 minutes through mining, where specialized computers compete to solve complex mathematical puzzles.   Bitcoin has achieved mainstream adoption through multiple vectors. The January 2024 SEC approval of 11 spot Bitcoin ETFs opened Bitcoin investment to traditional finance participants, and corporations like Strategy (formerly MicroStrategy) are using Bitcoin as a treasury reserve asset to protect against currency debasement, offering MSTR holders amplified exposure to Bitcoin.   The Bitcoin ecosystem continues to evolve with innovations like Ordinals, which emerged in January 2023 to enable NFT-like functionality directly on Bitcoin, and BRC-20 tokens, an experimental standard for creating fungible tokens using Ordinal inscriptions. BTCFi (Bitcoin Finance) represents emerging financial applications extending beyond Bitcoin's traditional role, with protocols like Babylon allowing Bitcoin holders to stake BTC to secure Proof of Stake chains.

Bitcoin

Bitcoin is trending as the price experiences volatility, prompting discussions about potential bottom levels and future price movements. Community members are debating whether this is a buying opportunity or a sign of further decline, with some expressing concerns about market manipulation and potential liquidations. Broader conversations include the impact of external factors and historical trends on Bitcoin's performance.

Strategy, Inc. engages in the provision of enterprise analytics and mobility software. The firm designs, develops, markets, and sells software platforms through licensing arrangements and cloud-based subscriptions and related services. Its product packages include Hyper. The company was founded by Michael J. Saylor and Sanjeev K. Bansal on November 17, 1989, and is headquartered in Vienna, VA.

Strategy Inc. - Ordinary Shares - Class A

Strategy

Strategy is trending downwards amidst Bitcoin's recent volatility, sparking debates about its correlation with BTC and potential risks. Community discussions range from concerns about margin calls and possible delisting to speculation on a potential bottom, with some traders eyeing a bounce while others foresee further declines. The stock's performance is closely tied to Bitcoin's price movements and Michael Saylor's strategy, leading to heightened uncertainty and a wide range of opinions.

Bitmine Immersion Technologies, Inc. is a blockchain technology company, which engages in industrial scale digital asset mining, equipment sales, and hosting operations. It operates through the Cryptocurrency Mining Industry segment. The company was founded on August 16, 1995 and is headquartered in Las Vegas, NV.

BitMine Immersion Technologies Inc

Bitmine Immersion Technologies Inc

BMNR is trending amidst broader crypto market volatility and ahead of an earnings report, with community members debating the influence of figures like Tom Lee and speculating about potential staking strategies. Discussions include unrealized losses, potential liquidations, and whether the stock is undervalued relative to its Ethereum holdings. Some traders express frustration and accuse key figures of misleading investors, while others see a buying opportunity amid the dip.

Ripple is the catchall name for the cryptocurrency platform, the transactional protocol for which is actually XRP, in the same fashion as Ethereum is the name for the platform that facilitates trades in Ether. Like other cryptocurrencies, Ripple is built atop the idea of a distributed ledger network which requires various parties to participate in validating transactions, rather than any singular centralized authority. That facilitates transactions all over the world, and transfer fees are far cheaper than the likes of bitcoin. Unlike other cryptocurrencies, XRP transfers are effectively immediate, requiring no typical confirmation time.  Ripple was originally founded by a single company, Ripple Labs, and continues to be backed by it, rather than the larger network of developers that continue bitcoin’s development. It also doesn’t have a fluctuating amount of its currency in existence. Where bitcoin has a continually growing pool with an eventual maximum, and Ethereum theoretically has no limit, Ripple was created with all of its 100 billion XRP tokens right out of the gate. That number is maintained with no mining and most of the tokens are owned and held by Ripple Labs itself — around 60 billion at the latest count.  Even at the recently reduced value of around half a dollar per XRP, that means Ripple Labs is currently sitting on around $20 billion worth of the cryptocurrency (note: Ripple’s price crashed hard recently, and may be worth far less than $60 billion by time you read this). It holds 55 billion XRP in an escrow account, which allows it to sell up to a billion per month if it so chooses in order to fund new projects and acquisitions. Selling such an amount would likely have a drastic effect on the cryptocurrency’s value, and isn’t something Ripple Labs plans to do anytime soon.  In actuality, Ripple Labs is looking to leverage the technology behind XRP to allow for faster banking transactions around the world. While Bitcoin and other cryptocurrencies are built on the idea of separating financial transactions from the financial organizations of traditional currencies, Ripple is almost the opposite in every sense.  XRP by Ripple price can be found on this page alongside the market capitalization and additional stats.

Ripple

XRP is trending as the community discusses the potential impact of newly launched ETFs and the upcoming ISO 20022 standard implementation, while also navigating overall market volatility and price fluctuations. Community debates center on whether XRP can decouple from Bitcoin's influence and realize its utility for payments and tokenization. Some traders express frustration with recent price action, while others remain optimistic about long-term potential, particularly with institutional adoption.

Webull Corp. engages in the provision of financial services. It offers trading, wealth management product distribution, market data and information, user community, and investor education. The company was founded by An Quan Wang in 2016 and is headquartered in St. Petersburg, FL.

Webull Corp. - Ordinary Shares - Class A

Webull Corp

Webull (BULL) is trending following an earnings beat, with the community debating whether it can break through market pressures. Bullish investors hope for upgrades and institutional buying, while others express concerns about market conditions and potential dilution. Some compare Webull to Robinhood, anticipating a similar growth trajectory.

Robinhood Markets, Inc is a financial services platform, which engages in the provision of retail brokerage and offers trading in U.S. listed stocks and Exchange Traded Funds, related options, and cryptocurrency trading, as well as cash management, which includes debit cards services. The company was founded by Vladimir Tenev and Baiju Prafulkumar Bhatt in 2013 and is headquartered in Menlo Park, CA.

Robinhood Markets Inc - Ordinary Shares - Class A

Robinhood Markets Inc

HOOD is trending amidst a recent dip, sparking debates about oversold conditions and potential for a rebound. Community members are weighing bullish and bearish scenarios, influenced by factors like Bitcoin's performance and broader market trends. Some traders discuss strategies like buying the dip or selling covered calls, while others speculate on future price movements and potential impacts of upcoming economic data.

Micron Technology, Inc. engages in the provision of innovative memory and storage solutions. It operates through the following segments: Compute and Networking Business Unit (CNBU), Mobile Business Unit (MBU), Embedded Business Unit (EBU), and Storage Business Unit (SBU). The CNBU segment includes memory products and solutions sold into client, cloud server, enterprise, graphics, and networking markets. The MBU segment is involved in memory and storage products sold into smartphone and other mobile-device markets. The EBU segment focuses on memory and storage products sold into automotive, industrial, and consumer Markets. The SBU segment consists of SSDs and component-level solutions sold into enterprise and cloud, client, and consumer storage markets. The company was founded by Ward D. Parkinson, Joseph Leon Parkinson, Dennis Wilson, and Doug Pitman on October 5, 1978 and is headquartered in Boise, ID.

Micron Technology Inc.

Micron Technology Inc

Micron is trending amid volatility, with investors reacting to a UBS price target increase and broader market concerns. Community discussions revolve around whether the recent selloff presents a buying opportunity or signals an overbought condition, especially with Nvidia's earnings on the horizon. Sentiment is mixed as some anticipate a continued rally driven by AI memory demand, while others foresee a deeper correction.

Blockchain-on-Blockchain (BOB) is a new blockchain built on top of another blockchain called ICP. It's like a special layer on an existing system. BOB creates a secure digital record book that uses ICP's network for safety. BOB uses a system called 'proof-of-on-chain-work': You deploy your own smart contract (canister) at bob.fun. This program solves math problems (hashes). Main computers (mother nodes) give out these problems. Miners solve the problems and tell the mother node. If correct, the mother node adds a new block to the blockchain. The winning miner gets BOB tokens as a reward.

$BOB is gaining attention as a token built on the $ICP blockchain, with the community drawing comparisons to an early-stage $BTC and highlighting its capped supply and upcoming halving event. Some community members are swapping $ICP for $BOB, citing its potential for higher gains and its role in driving network revenue for $ICP. Discussions also focus on its multi-chain availability and mining pool developments.

Super Micro Computer, Inc. engages in the distribution and manufacture of information technology solutions and other computer products. Its products include twin solutions, MP servers, GPU and coprocessor, MicroCloud, AMD solutions, power supplies, SuperServer, storage, motherboards, chassis, super workstations, accessories, SuperRack and server management products. The company was founded by Charles Liang, Yih-Shyan Liaw, Sara Liu, and Chiu-Chu Liu Liang in September 1993 and is headquartered in San Jose, CA.

Super Micro Computer Inc

SMCI is trending due to positive sentiment surrounding the AI sector, fueled by strong earnings from key partner Nvidia and the anticipation of increased demand for AI infrastructure. Community members are discussing the potential for a short squeeze given the stock's oversold conditions and significant short interest, while also acknowledging the volatility and historical underperformance of the stock relative to its peers. Recent news of authorized chip exports to Saudi Arabia and the UAE further supports discussions around SMCI's growth potential within the expanding AI landscape.

Oracle Corp. engages in the provision of products and services that address aspects of corporate information technology environments, including applications and infrastructure technologies. It operates through the following business segments: Cloud and License, Hardware, and Services. The Cloud and License segment markets, sells, and delivers enterprise applications and infrastructure technologies through cloud and on-premise deployment models including cloud services and license support offerings. The Hardware segment provides infrastructure technologies including Oracle Engineered Systems, servers, storage, industry-specific hardware, operating systems, virtualization, management, and other hardware-related software. The Services segment offers consulting, advanced support, and education services. The company was founded by Lawrence Joseph Ellison, Robert Nimrod Miner, and Edward A. Oates on June 16, 1977 and is headquartered in Austin, TX.

Oracle Corp.

ORCL is trending as investors debate the company's AI strategy and significant debt, with concerns amplified by insider selling. Community members are discussing the potential impact on Oracle's valuation and ability to compete in the AI infrastructure space. Recent analyst actions and overall market sentiment are adding to the volatility.

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Leerink Partnrs Reduces Earnings Estimates for enGene

enGene Holdings Inc. (NASDAQ:ENGN - Free Report) - Leerink Partnrs decreased their FY2030 earnings estimates for shares of enGene in a research report issued to clients and investors on Thursday...

Leerink Partnrs Brokers Reduce Earnings Estimates for enGene

enGene Holdings Inc. (NASDAQ:ENGN - Free Report) - Investment analysts at Leerink Partnrs decreased their FY2026 earnings per share estimates for shares of enGene in a report released on Tuesday...

Leerink Partnrs Estimates enGene FY2030 Earnings

enGene Holdings Inc. (NASDAQ:ENGN - Free Report) - Research analysts at Leerink Partnrs issued their FY2030 earnings estimates for shares of enGene in a research report issued on Tuesday, November...

enGene (NASDAQ:ENGN) Price Target Raised to $19.00 at Morgan Stanley

Morgan Stanley lifted their price target on shares of enGene from $18.00 to $19.00 and gave the stock an "overweight" rating in a research note on Wednesday...

enGene (NASDAQ:ENGN) Given New $21.00 Price Target at Citizens Jmp

Citizens Jmp boosted their target price on shares of enGene from $18.00 to $21.00 and gave the stock a "market outperform" rating in a report on Wednesday...

enGene Announces Pricing of $130 Million Public Offering of Common Shares and Pre-Funded Warrants

enGene Holdings Inc. (Nasdaq: ENGN, enGene or the Company), a clinical-stage, non-viral genetic medicines company, today announced the pricing of its previously announced underwritten public offering...

enGene Announces Proposed Public Offering of Common Shares

enGene Holdings Inc. (Nasdaq: ENGN, enGene or the Company), a clinical-stage, non-viral genetic medicines company, today announced that it has commenced an underwritten public offering of its common...

enGene (NASDAQ:ENGN) Upgraded at Raymond James Financial

Raymond James Financial raised shares of enGene from an "outperform" rating to a "strong-buy" rating and set a $27.00 price objective for the company in a report on Tuesday...

<ul class="summary-bullets"><li>The study was evaluating the experimental drug in certain high-risk, Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) patients.&nbsp;</li><li>Engene said on Tuesday that preliminary data from the pivotal cohort of its mid-stage trial shows that out of 37 patients evaluated at six months, 62% had a complete response rate.</li></ul><p><br>Shares of enGene Holdings Inc. (ENGN) jumped 39% on Tuesday morning after the company said that its Detalimogene voraplasmid demonstrated an improved complete response rate of 62% at six months in a study. &nbsp;</p><p>The study was <a class="st-link-external" target="_blank" rel="noopener noreferrer nofollow" href="https://engene.com/detalimogene-demonstrates-improved-complete-response-rate-of-62-at-6-months/">evaluating</a> the experimental drug in certain high-risk, Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) patients.</p><p>NMIBC occurs when cancer cells grow in the tissues that line the interior of the bladder, but the cancer has not yet penetrated the muscle of the bladder wall. Patients suffering from high-risk NMIBC who are unresponsive to the standard of care, Bacillus Calmette-Guérin (BCG), face high rates of disease recurrence, and the standard treatment is often radical cystectomy, which involves removing the bladder.</p><h2 class="st-heading-2">What Does The Study Show?</h2><p>Engene said on Tuesday that preliminary data from the pivotal cohort of its mid-stage trial shows that out of 37 patients evaluated at six months, 62% had a complete response rate, and all five patients who completed the 9-month assessment had a complete response.</p><p>Complete response rate is the percentage of patients whose cancer disappears completely after treatment, a measure often used in cancer research to evaluate a therapy's effectiveness.</p><p>The patients in the cohort were evaluated under an amended protocol adopted in the fourth quarter of 2024 and designed to align the trial with the American Urological Association’s Guidelines. Before the protocol amendment, the complete response rate at 6 months was only 41%.</p><p>The company is now looking forward to submitting an application for approval of the cancer therapy to the U.S. Food and Drug Administration in the second half of 2026 and is hopeful for approval in 2027.</p><h2 class="st-heading-2">Safety Concerns</h2><p>According to Engene, the company has enrolled 125 patients in the pivotal cohort of its trial, and 42% of them experienced a treatment-related adverse event. However, only 1.6% experienced dose interruptions due to treatment-related adverse events, and only 0.8% experienced dose discontinuations.</p><p>Overall, the data demonstrates a favorable tolerability profile, the company said.</p><h2 class="st-heading-2">How Did Stocktwits Users React?</h2><p>On Stocktwits, retail sentiment around <a href="https://stocktwits.com/symbol/ENGN">ENGN stock</a> jumped from ‘neutral’ to ‘extremely bullish’ territory over the past 24 hours while message volume rose from ‘low’ to ‘extremely high’ levels.</p><p>ENGN stock is up by 25% this year.&nbsp;</p><p>Also See: <a href="https://stocktwits.com/news-articles/markets/equity/hesai-technology-wins-exclusive-lidar-contract-for-li-auto-next-gen-evs/cLPdnQdREPg">Hesai Technology Wins Exclusive Lidar Contract For Li Auto’s Next-Gen EVs</a></p><p><i>For updates and corrections, email newsroom[at]stocktwits[dot]com</i></p>

Rising stock market chart on a trading board background.

ENGN Stock Soars On Hopeful Data From Bladder Cancer Study

The company is now looking forward to submitting an application for approval of the cancer therapy to the U.S. Food and Drug Administration in the second half of 2026. 

Equity

The company is now looking forward to submitting an application for approval of the cancer therapy to the U.S. Food and Drug Administration in the second half of 2026. 


Detalimogene Demonstrates Improved Complete Response Rate of 62% at 6 Months

enGene Holdings Inc. (Nasdaq: ENGN or enGene or the Company), a clinical-stage, non-viral genetic medicines company, today reported additional preliminary data from the pivotal cohort of its ongoing...

enGene Holdings, Inc. is a clinical-stage biotechnology company, which engages in developing gene therapies. It is developing non-viral gene therapies based on its novel and proprietary dually derived chitosan, or DDX, gene delivery platform, which allows localized delivery of multiple gene cargos directly to mucosal tissues and other organs. The company was founded by Anthony T. Cheung on April 24, 2023 and is headquartered in Saint-Laurent, Canada.

Current Price	$6.60
Prev Close	$6.76
Open	$6.85
Dividend Yield	0.00%
50-Day Moving Average	$7.44
Beta	0.26
Avg. Volume	349,781.39
PE Ratio	-3.48

52-Week High	$11.14
52-Week Low	$2.65
Market Capitalization	$436.55M
EPS (Annual)	-$1.46
Price to Book	1.68
Revenue Per Employee	$0.00
Enterprise Value/EBITDA	N/A

ENGN
enGene Holdings Inc

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