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Pyth Network is a decentralised oracle network designed to provide real-time financial market data to decentralised applications (dApps) across multiple blockchains. It allows developer to secure smart contracts with reliable, low-latency market data from institutional sources, and build apps with high-fidelity oracle feeds designed for mission-critical systems.

Pyth Network

Pyth Network is trending as the community discusses potential revenue generation and real-world asset (RWA) adoption. Some users are speculating on partnerships and integrations with other projects. Bullish sentiment is fueled by discussions of on-chain matrix rewards and treasury mechanics.

"What's Updog?" is a Community Led token.

UpDog

$UPDOG.X is trending as the community rallies around the long-standing joke and the coin's presence on the Solana network. Community members are actively engaging in the 'What's UpDog?' meme, celebrating its resilience and unique place as the only UPDOG on the Jupiter Strict List.

BlackBerry Ltd. engages in the provision of intelligent security software and services. It operates through the following segments: Cybersecurity, Internet of Things (IoT), and Licensing and Other. The Cybersecurity segment includes the brand Cylance, BlackBerry Spark, AtHoc, and SecuSUITE. The IoT segment focuses on software licenses, support, maintenance, and professional services. The Licensing and Other segment involves the intellectual property licensing arrangements and settlement awards. The company was founded by Michael Lazaridis, James Laurence Balsillie, and Douglas E. Fregin on March 7, 1984 and is headquartered in Waterloo, Canada.

BlackBerry Ltd

BlackBerry is trending as investors discuss its partnerships with major tech companies like AMD and Nvidia, particularly regarding QNX's role in automotive and robotics. Community members are highlighting the company's potential for growth and a possible breakout, fueled by anticipation for upcoming earnings. The conversation also includes discussions around technical analysis, market manipulation, and BlackBerry's long-term prospects as a software and cybersecurity player.

Moonlake Immunotherapeutics operates as a clinical-stage biotechnology company. It offers tri-specific Nanobody, Sonelokimab to address significant unmet needs in inflammatory skin and joint diseases. The company was founded by Kristian Reich, Jorge Santos da Silva, and Arnout Ploos van Amstel in 2021 and is headquartered in Zug, Switzerland.

MoonLake Immunotherapeutics - Ordinary Shares - Class A

MoonLake Immunotherapeutics is trending due to positive Phase 2 trial results for their hidradenitis suppurativa treatment, sonelokimab, which has sparked considerable excitement and discussion within the biotech community. Community members are actively debating the potential for a buyout, comparing the company's prospects to competitors, and analyzing the implications of a possible public offering. The stock's movement is also influenced by discussions about short squeezes and technical indicators.

Memecoin on Cronos launched by the Cro Crow community

crow with knife

Enthusiastic community members are actively promoting $CAW.X, a memecoin known as "crow with knife", across various chains. The community emphasizes its deflationary nature and strong social presence, encouraging others to join and "caw caw" their way to potential gains. Mentions of "layer zero burn mechanism in place" and "crow with knife is the only option" highlight key community talking points.

ResMed, Inc. engages in providing digital health and cloud-connected medical devices. Its digital health technologies and cloud-connected medical devices transform care for people with sleep apnea, chronic obstructive pulmonary disease, or COPD, and other chronic diseases. The firm operates through the Sleep and Respiratory Care and Software as a Service segments. The Sleep and Respiratory Care segment engages in the sleep and respiratory disorders sector of the medical device industry. The Software as a Service segment provides business management software as a service to out-of-hospital health providers. The company was founded by Peter C. Farrell in June 1989 and is headquartered in San Diego, CA.

Resmed Inc.

Resmed ($RMD) is trending as the community speculates about potential partnerships or a buyout of Incannex ($IXHL), fueled by the presence of a ResMed representative on Incannex's advisory board and upcoming phase 2 results for Incannex's sleep apnea pill.  The community believes positive trial outcomes could make Incannex a compelling acquisition target in the competitive sleep apnea treatment market, while others believe a strategic alliance is more likely. Some traders are closely watching for a formal announcement during ResMed's earnings call.

Blockchain-on-Blockchain (BOB) is a new blockchain built on top of another blockchain called ICP. It's like a special layer on an existing system. BOB creates a secure digital record book that uses ICP's network for safety. BOB uses a system called 'proof-of-on-chain-work': You deploy your own smart contract (canister) at bob.fun. This program solves math problems (hashes). Main computers (mother nodes) give out these problems. Miners solve the problems and tell the mother node. If correct, the mother node adds a new block to the blockchain. The winning miner gets BOB tokens as a reward.

BOB.X is trending as users discuss its potential as the next BTC.X, highlighting its capped supply and upcoming halving event. Community members are also excited about its multi-chain availability and integration within the ICP.X ecosystem.

Linea is the Layer 2 built from first principles to strengthen Ethereum and the entire ETH economy. Every aspect of its design—from its productive ETH burn mechanics, and capital efficient native yield, to its underlying Ethereum-equivalent zk tech—amplifies the value and utility of Ethereum Mainnet. All of this is backed by the largest ecosystem fund in the space, managed by the most trusted Ethereum builders. With institutional-grade infrastructure, and deep integration across DeFi, Linea is the best chain for ETH capital, where every transaction and every block strengthens Ethereum. Linea is where Ethereum wins.

Linea

Linea is trending as the community discusses its potential integration with SWIFT, a global banking network, with some suggesting it could be a competitor to Ripple ($XRP.X). There is excitement around the possibilities for the Ethereum ecosystem and Linea's role in it, with some users highlighting its newness and potential for growth.

Marathon Petroleum Corp. engages in the refining, marketing, and transportation of petroleum products. It operates through the Refining and Marketing, and Midstream segments. The Refining and Marketing segment includes refining crude oil and other feedstocks, purchasing ethanol, and refined products for resale and distribution of refined products. The Midstream segment refers to transportation, storing, distribution, and marketing of crude oil and refined products. The company was founded in 1887 and is headquartered in Findlay, OH.

Marathon Petroleum Corp

Marathon Petroleum is trending amid unusual options activity and high trading volume, suggesting bullish sentiment among some investors. Community members are actively discussing potential ROI from call options, while recent reports highlight the company's solid financial position and potential as a 'refiner cash cow' given disruptions in global oil markets.

Ouster, Inc. engages in the provision of high resolution digital lidar sensors that offer advanced 3D vision to machinery, vehicles, robots, and fixed infrastructure assets. The company was founded by Angus Pacala and Mark Frichtl on June 30, 2015 and is headquartered in San Francisco, CA.

Ouster Inc - Ordinary Shares - Class A

OUST is trending as investors react to news of increasing adoption of its lidar technology in diverse sectors like traffic management (Utah deployment) and security, and a potential breakout into the $100B security market. Bullish sentiment is fueled by consecutive quarters of revenue growth, zero debt, and growing cash reserves, with some community members anticipating a rise to $50. Discussions also highlight OUST as a key player in the physical AI space and a potential acquisition target.

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Madrigal Gets Conditional Nod for MASH Drug Rezdiffra in EU

MDGL wins EU nod for Rezdiffra as the first and only approved MASH therapy. The drug's launch in Europe is expected in the fourth quarter of 2025.

Madrigal (MDGL) Reports Q2 Loss, Tops Revenue Estimates

Madrigal (MDGL) delivered earnings and revenue surprises of +45.40% and +32.00%, respectively, for the quarter ended June 2025. Do the numbers hold clues to what lies ahead for the stock?

MDGL Stock Soars 11% on New Patent Protecting Rezdiffra Dosing Rights

Madrigal Pharmaceuticals stock jumps 11% after securing a new U.S. patent for Rezdiffra's dosing, reinforcing exclusivity through 2044.

Madrigal (MDGL) Moves 10.9% Higher: Will This Strength Last?

Madrigal (MDGL) was a big mover last session on higher-than-average trading volume. The latest trend in earnings estimate revisions might not help the stock continue moving higher in the near term.

​Short interest in Madrigal Pharmaceuticals rose to a four-month high, Ortex data showed, as bearish positions increased despite recent signs of stabilization in the stock following a multi-session decline.Madrigal’s stock closed at $294.64 on Friday, down $4.93 or 1.65%Short interest as a percentage of free float climbed to 38.9% from 34.8%, marking the highest level since early January,&nbsp;as per a report on The Fly. The days-to-cover ratio edged lower by 30 basis points to 6.7.The increase came as Madrigal shares found some support over the past two trading sessions, following four consecutive days of losses. The stock is down 6.1% year-to-date.The build in short positions follows Madrigal’s first-quarter earnings report last week. The company reported a net loss of $3.32 per share, narrower than analysts’ expectations for a $3.79 loss.&nbsp;Revenue for the quarter came in at $137.25 million, above the $114.19 million consensus estimate.CEO Bill Sibold said the company has delivered Rezdiffra to more than 17,000 patients since its approval as the first FDA-approved treatment for MASH, a progressive liver disease associated with metabolic dysfunction.&nbsp;He added that providers have reported improvements in liver stiffness, fat, enzymes, LDL, and triglyceride levels.On Saturday, Madrigal announced two-year results from the open-label compensated MASH cirrhosis arm of its Phase 3 MAESTRO-NAFLD-1 trial.&nbsp;Patients treated with Rezdiffra showed statistically significant improvements in liver stiffness, fat, fibrosis biomarkers, liver volume, and clinically significant portal hypertension (CSPH) risk scores.Among patients with CSPH at baseline, 65% moved into lower-risk categories by year two. Of those with probable CSPH, 57% moved to the no/low-risk category, while 14% progressed to confirmed CSPH.&nbsp;The safety profile remained consistent with previous studies. Rezdiffra was well-tolerated, with a low rate of discontinuation due to adverse events.&nbsp;The most common side effects were diarrhea, COVID-19, and nausea. Two deaths occurred during the study but were not attributed to the drug.On Stocktwits, sentiment was 'bullish' amid ‘high’ message volume.One user anticipated a rise in Madrigal stock on Monday, expressing confidence in the stock's upward momentum.&nbsp;<stembedurl>https://stocktwits.com/Wallst45/message/614200620</stembedurl>Another user echoed a similar sentiment, highlighting the potential demand for Rezdiffra, suggesting that both patients with MASH and healthcare providers would likely favor the treatment due to its lack of side effects.<stembedurl>https://stocktwits.com/BrenFal0919/message/614192080</stembedurl>The stock has declined 6.1% so far in 2025.For updates and corrections, email newsroom[at]stocktwits[dot]com.

In this photo illustration, Madrigal Pharmaceuticals logo is seen on a smartphone screen. (Photo Illustration by Pavlo Gonchar/SOPA Images/LightRocket via Getty Images)

Madrigal Pharma Short Interest Reaches 4-Month High: Retail Investors Still Bullish On Stock

Despite soaring short interest, retail sentiment remains bullish, with investors optimistic about the company’s positive trial results and the continued demand for its FDA-approved treatment, Rezdiffra.

Equity

Companies developing therapies for metabolic steatohepatitis (MASH) saw strong gains even as Novo Nordisk (<a class="mention" data-mention="$NVO" data-symbol-id="NVO" href="https://stocktwits.com/symbol/NVO" target="_blank">$NVO</a>) announced that its GLP-1 drug, semaglutide, demonstrated “superior improvement” in treating the liver disease in its phase 3 ESSENCE trial.&nbsp;Shares of Madrigal Pharmaceuticals (<a class="mention" data-mention="$MDGL" data-symbol-id="MDGL" href="https://stocktwits.com/symbol/MDGL" target="_blank">$MDGL</a>), which received FDA approval earlier this year for its MASH drug, Rezdiffra, rose by 18% following the announcement, with 89Bio (<a class="mention" data-mention="$ETNB" data-symbol-id="ETNB" href="https://stocktwits.com/symbol/ETNB" target="_blank">$ETNB</a>) and Akero Therapeutics (<a class="mention" data-mention="$AKRO" data-symbol-id="AKRO" href="https://stocktwits.com/symbol/AKRO" target="_blank">$AKRO</a>) seeing gains of 15% and 4%, respectively.Novo Nordisk’s ESSENCE trial, a 240-week, double-blind study involving 1,200 adults with MASH and moderate to advanced liver fibrosis, achieved its primary endpoints.&nbsp;After 72 weeks, patients receiving a weekly dose of 2.4 mg semaglutide showed significant liver fibrosis improvement without worsening steatohepatitis, as well as steatohepatitis resolution with no worsening of liver fibrosis, compared to those on placebo.&nbsp;"We are very pleased about the ESSENCE clinical trial results and the potential of semaglutide to help people living with MASH. Among people with overweight or obesity, one in three live with MASH. This has a serious impact on their health and represents a significant unmet need," said Martin Holst Lange, Novo’s executive vice president.The FDA has yet to approve GLP-1 drugs for MASH, though several early trials have shown promise in reversing the disease’s initial stages.&nbsp;In March, Madrigal’s Rezdiffra became the first FDA-approved treatment for MASH with moderate to advanced liver scarring.&nbsp;On Thursday, Madrigal reported robust quarterly earnings, driven by Rezdiffra sales, which led to raised price targets and positive analyst notes.&nbsp;Canaccord boosted its target on Madrigal to $394, citing confidence in continued revenue growth, while UBS increased its target to $441, highlighting an “underappreciated opportunity” in MASH and potential validation from Novo’s findings.<figure class="image"><a href="https://stocktwits.com/symbol/MDGL"><img style="aspect-ratio:1314/320;" src="https://st-everywhere-cms-prod.s3.us-east-1.amazonaws.com/MDGL_sentiment_and_message_volume_Nov_1_69ab9366a3.png" alt="MDGL sentiment and message volume Nov 1.png" width="1314" height="320"></a><figcaption>MDGL sentiment and message volume Nov 1 as of 1:30 pm ET | source: Stocktwits</figcaption></figure>On Stocktwits, retail sentiment for MDGL remained ‘extremely bullish’ as of Friday afternoon amid a spike in message volume, with many fixated on Thursday’s strong results.<stembedurl>https://stocktwits.com/GXD_Texas/message/590911195</stembedurl>Some were also penciling in the next resistance levels for the stock that broke out over $300 this week.<stembedurl>https://stocktwits.com/TheProphetOfProfit/message/590910821</stembedurl>Madrigal’s stock has surged over 33% year-to-date, significantly outperforming broader market benchmarks.For updates and corrections, email&nbsp;<a target="_blank" rel="noopener noreferrer nofollow" href="mailto:newsroom@stocktwits.com">newsroom@stocktwits.com</a>Read next: <a href="https://stocktwits.com/news-articles/markets/equity/epix-stock-falls-after-drug-trial-fails/cJEYt4ERBm">Essa Pharma Stock Crashes After Lead Drug Candidate Trial Flops: Retail Hopes Fade</a>

On Thursday, Madrigal reported robust quarterly earnings, driven by Rezdiffra sales, which led to raised price targets and positive analyst notes.

Madrigal Pharma Stock Soars Despite Novo Nordisk’s ‘Superior’ MASH Trial Results: Retail Bullish On Earnings Beat

In March, Madrigal’s Rezdiffra became the first FDA-approved treatment for MASH with moderate to advanced liver scarring.

Thinking of Buying Madrigal Pharmaceuticals Stock? Eli Lilly Would Like to Have a Word.

Thinking of Buying Madrigal Pharmaceuticals Stock? Eli Lilly Would Like to Have a Word...

Madrigal Pharmaceuticals's Options Frenzy: What You Need to Know

Madrigal Pharmaceuticals, Inc. (NASDAQ:MDGL) Director Sells $2,832,280.00 in Stock

Madrigal Pharmaceuticals, Inc. (NASDAQ:MDGL - Get Free Report) Director Richard S. Levy sold 11,000 shares of the firm's stock in a transaction dated Monday, April 1st. The shares were sold at an...

Madrigal Pharmaceuticals Inc Director James Daly Sells 32,489 Shares

Madrigal Pharmaceuticals, Inc. engages in the development and commercialization of innovative therapeutic candidates for the treatment of cardiovascular, metabolic, and liver diseases. Its lead product, MGL-3196, is used for the treatment of non-alcoholic steatohepatitis and familial hypercholesterolemia. The company was founded by Rebecca A. Taub, Frederick Bernard Craves, and Edward Chiang on March 10, 2000 and is headquartered in West Conshohocken, PA.

Madrigal Pharmaceuticals Inc

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