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Moonlake Immunotherapeutics operates as a clinical-stage biotechnology company. It offers tri-specific Nanobody, Sonelokimab to address significant unmet needs in inflammatory skin and joint diseases. The company was founded by Kristian Reich, Jorge Santos da Silva, and Arnout Ploos van Amstel in 2021 and is headquartered in Zug, Switzerland.

MoonLake Immunotherapeutics - Ordinary Shares - Class A

MoonLake Immunotherapeutics

MoonLake Immunotherapeutics is trending following positive Phase 2 S-OLARIS trial results for sonelokimab in axial spondyloarthritis, which showcased clinically meaningful benefits and objective evidence of disease modification, positioning it as a potential best-in-class therapy. The strong clinical data and a robust cash position are driving community discussions about its significant undervaluation, potential for a short squeeze, and anticipation of further positive updates at its upcoming Investor Day.

SSgA Active Trust - State Street SPDR S&P 500 ETF Trust

SPDR S&P 500 ETF Trust is trending due to renewed global trade uncertainty, as President Trump's re-imposed 15% worldwide tariffs draw international pushback from the EU and India. The market community is deeply split between predictions of a significant market downturn and expectations for underlying resilience to absorb the news, with upcoming Nvidia earnings also in focus.

First Majestic Silver Corp. engages in the production, development, exploration and acquisition of mineral properties. It owns and operates producing mines in México including the La Encantada Silver Mine, La Parrilla Silver Mine, San Martin Silver Mine, La Guitarra Silver Mine, Del Toro Silver Mine, Santa Elena Silver & Gold Mine, and San Dimas Silver & Gold Mine. The company was founded by Keith Neumeyer on September 26, 1979 and is headquartered in Vancouver, Canada.

First Majestic Silver Corporation

First Majestic Silver Corporation is trending due to its strong financial performance, marked by record revenue and treasury position, which has fueled community excitement and multi-year highs. Investors are particularly focused on the company's unique position as a pure-play silver miner with its own mint, allowing it to capture premiums amid a broader rally in precious metals and anticipated supply dynamics.

Ripple is the catchall name for the cryptocurrency platform, the transactional protocol for which is actually XRP, in the same fashion as Ethereum is the name for the platform that facilitates trades in Ether. Like other cryptocurrencies, Ripple is built atop the idea of a distributed ledger network which requires various parties to participate in validating transactions, rather than any singular centralized authority. That facilitates transactions all over the world, and transfer fees are far cheaper than the likes of bitcoin. Unlike other cryptocurrencies, XRP transfers are effectively immediate, requiring no typical confirmation time.  Ripple was originally founded by a single company, Ripple Labs, and continues to be backed by it, rather than the larger network of developers that continue bitcoin’s development. It also doesn’t have a fluctuating amount of its currency in existence. Where bitcoin has a continually growing pool with an eventual maximum, and Ethereum theoretically has no limit, Ripple was created with all of its 100 billion XRP tokens right out of the gate. That number is maintained with no mining and most of the tokens are owned and held by Ripple Labs itself — around 60 billion at the latest count.  Even at the recently reduced value of around half a dollar per XRP, that means Ripple Labs is currently sitting on around $20 billion worth of the cryptocurrency (note: Ripple’s price crashed hard recently, and may be worth far less than $60 billion by time you read this). It holds 55 billion XRP in an escrow account, which allows it to sell up to a billion per month if it so chooses in order to fund new projects and acquisitions. Selling such an amount would likely have a drastic effect on the cryptocurrency’s value, and isn’t something Ripple Labs plans to do anytime soon.  In actuality, Ripple Labs is looking to leverage the technology behind XRP to allow for faster banking transactions around the world. While Bitcoin and other cryptocurrencies are built on the idea of separating financial transactions from the financial organizations of traditional currencies, Ripple is almost the opposite in every sense.  XRP by Ripple price can be found on this page alongside the market capitalization and additional stats.

Ripple

XRP is experiencing strong community debate fueled by the anticipated U.S. Clarity for Digital Assets Act, with Ripple's CEO suggesting a high chance of passage by April, exciting bulls who foresee institutional adoption. However, skeptics caution against past failed catalysts, token dilution, and perceived market manipulation, viewing current price movements as opportunities for swing traders.

Lizard

LIZARD CRYPTO is trending due to active community efforts to boost its viral status, driven by a meme contest and social media buzz, with many anticipating significant growth and potential major exchange listings for the meme coin, while others remain skeptical.

Karman Holdings, Inc. engages in the design, testing, manufacturing, and sale of dependable missile systems. It offers Payload Protection & Deployment Systems, Aerodynamic Interstage Systems, and Propulsion Systems. The company was founded on August 20, 2020 and is headquartered in Huntington Beach, CA.

Karman Holdings Inc.

Karman Holdings Ord Shs

Karman Holdings is generating buzz amid its strong financial performance, which includes exceeding revenue expectations, securing major defense contracts, and strategic acquisitions in the space and defense sectors. While the stock has seen recent volatility, the community views current dips as a significant buying opportunity, highlighting its critical role in advanced missile and hypersonic technologies.

Cardano is a blockchain platform built on academic research that enables smart contracts and decentralized applications while using significantly less energy than traditional cryptocurrencies like Bitcoin.   What sets Cardano apart is its methodical, research-driven approach — every major feature is peer-reviewed by scientists and cryptographers before being added to the network. This careful process aims to create a more secure and stable foundation compared to platforms that prioritize speed over thorough testing. The platform's native cryptocurrency, ADA, is used to send money, pay transaction fees, and participate in network governance.  Cardano uses a proof-of-stake system to process transactions, which works differently from Bitcoin's mining approach. Instead of competing to solve complex puzzles, users can "stake" their ADA — essentially locking it up temporarily — to become validators who verify transactions. The system selects validators based on how much ADA they've staked and for how long, then rewards them with additional ADA for their participation. This approach uses far less energy than traditional mining while keeping the network secure. The platform also features a two-layer design that separates basic payment transactions from smart contract operations, allowing each function to be optimized independently for better performance.   ADA holders can earn staking rewards by locking up their tokens to help secure the network, vote on proposed changes to the platform, and use ADA for international money transfers with lower fees than traditional services.  Cardano was founded in 2017 by Charles Hoskinson, who previously helped create Ethereum. Hoskinson leads Input Output Global (IOG), the technology company that builds and maintains Cardano's core software. The ecosystem operates through three organizations: IOG handles technical development, the Cardano Foundation promotes adoption and standardization, and Emurgo helps businesses integrate blockchain technology into their operations. This structure distributes responsibilities across multiple groups rather than concentrating control in a single entity.   In February 2025, major asset manager Grayscale Investments filed to create an exchange-traded fund (ETF) for Cardano with the U.S. Securities and Exchange Commission, which would allow traditional investors to buy ADA through their regular brokerage accounts without needing to set up cryptocurrency wallets.Retry

Cardano

Cardano is trending following news of Coinbase expanding its lending platform to include ADA and founder Charles Hoskinson's vision for blockchain-powered social applications. This is fueling intense debate among the community, with some viewing current price levels as a significant accumulation opportunity while others express skepticism about its future.

BtcUSD is a completely decentralized stablecoin issued and managed by BTCFi, a platform where users can deposit Bitcoin of various formats to use as collaterals. BtcUSD offers Bitcoin holders the opportunity to generate additional yields with their Bitcoin positions through DeFi usage.

Bitcoin USD (BTCFi)

Bitcoin is trending amidst significant volatility, as technical support levels are tested following recent ETF outflows and profit-taking, fueling a divided community discussion between deeper corrections and long-term accumulation opportunities. Ongoing developments in institutional adoption, like the South Dakota House Bill 1155, continue to shape the narrative around its maturing role as a reserve asset.

Invesco Capital Management LLC - Invesco QQQ Trust Series 1

QQQ is trending as the market processes conflicting signals from the Supreme Court's tariff invalidation and President Trump's immediate counter-announcement of new global duties, creating trade policy uncertainty. Community sentiment is sharply divided between those anticipating a market dump given economic concerns and upcoming tech earnings, and others noting its surprising resilience to negative news.

JFrog Ltd. engages in the provision of an end-to-end, hybrid, universal development operations platform that powers and controls the software supply chain, which enables organizations to continuously and securely deliver software updates across any system. It operates through the following geographical segments: United States, Israel, India, and Rest of World. The firm is also involved in creating software delivered without friction from developer to device. The company was founded by Frederic Simon, Shlomi Ben Haim, and Yoav Landman in 2008 and is headquartered in Sunnyvale, CA.

JFrog Ltd

JFrog ($FROG) is trending following a significant sell-off after Anthropic's Claude Code Security preview, sparking a divided community discussion between those fearing AI disruption and others, including analysts, who view the extreme market reaction as an excessive overcorrection and a buying opportunity for the company's core DevSecOps value.

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Compugen (CGEN) Reports Q1 Loss, Misses Revenue Estimates

Mersana Therapeutics, Inc. (MRSN) Reports Q1 Loss, Lags Revenue Estimates

MeiraGTx Holdings PLC (MGTX) Reports Q1 Loss, Misses Revenue Estimates

Shares of Affimed N.V. (AFMD) were in the spotlight on Monday morning after the company received a notice from Nasdaq indicating a compliance issue with its stock price.Affirmed <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2025/04/21/3064526/0/en/Affimed-Announces-Receipt-of-NASDAQ-Deficiency-Notice-Regarding-Minimum-Bid-Price-Requirement.html">said</a> that the Nasdaq notice indicated the bid price for the company’s common shares had closed below the minimum $1.00 per share requirement for continued listing on the bourse.Affirmed, headquartered in Mannheim, Germany, stated that it has been granted an initial period of 180 calendar days, or until October 13, 2025, to regain compliance.The company said that if it fails to regain compliance with the Minimum Bid Price Rule during the period, it may consider applying to transfer its securities from The Nasdaq Global Select Market to The Nasdaq Capital Market, provided that it meets the requirements.Affirmed also added that there is no assurance that Nasdaq would grant the company’s request for continued listing in the case.In the meantime, the firm intends to monitor the bid price of its common shares and consider available options to regain compliance with the Minimum Bid Price Rule.Affimed is a clinical-stage company aimed at developing treatments for cancer. In December, the company announced positive updates from a trial of its AFM24 in combination with atezolizumab in Non-Small Cell Lung Cancer patients.AFM24 is an innate cell engager molecule that activates the innate immune system to kill cancer cells.On Stocktwits, retail sentiment regarding Affimed remained unchanged within ‘neutral’ territory over the past 24 hours, while message volume remained at ‘extremely low’ levels.<figure class="image"><img style="aspect-ratio:648/146;" src="https://news.stocktwits-cdn.com/Screenshot_2025_04_21_at_7_06_18_AM_png_68fb6a412b.webp" alt="AFMD's Sentiment Meter and Message Volume as of 7:20 a.m. ET on April 21, 2025 | Source: Stocktwits" width="648" height="146"><figcaption>AFMD's Sentiment Meter and Message Volume as of 7:20 a.m. ET on April 21, 2025 | Source: Stocktwits</figcaption></figure><a href="https://stocktwits.com/symbol/AFMD">AFMD stock</a> is down by about 46% so far this year and by over 85% over the past 12 months.Also See: <a href="https://stocktwits.com/news-articles/markets/equity/dhl-freezes-shipments-worth-over-800-to-us-consumers-amid-rising-trade-tensions/chQiW2kRbQO">DHL Freezes Shipments Worth Over $800 To US Consumers Amid Rising Trade Tensions</a>For updates and corrections, email newsroom[at]stocktwits[dot]com&nbsp;

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Affimed Receives Nasdaq Deficiency Notice Over Low Share Price: Retail’s In Wait-And-Wait Mode

The company has been granted an initial period of 180 calendar days, or until October 13, 2025, to regain compliance with Nasdaq’s Minimum Bid Price Rule.

Equity

Affimed NV is a clinical-stage immuno-oncology company, which engages in the discovery and development of cancer immunotherapies. The company’s proprietary ROCK platform enables a tumor-targeted approach to recognize and kill a range of hematologic and solid tumors, enabling a broad pipeline of wholly-owned and partnered single agent and combination therapy programs. It operates through the Germany and USA geographical segments. The company was founded in 2000 and is headquartered in Mannheim, Germany.

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