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Bitcoin is the world's first decentralized cryptocurrency, created in 2009 by the pseudonymous Satoshi Nakamoto. It enables peer-to-peer electronic cash transactions without intermediaries like banks or governments, operating on a blockchain secured by Proof of Work mining and the SHA-256 cryptographic algorithm.   With a fixed supply cap of 21 million coins and programmatic halvings every four years that reduce miner rewards, Bitcoin is designed as a deflationary digital asset often called "digital gold." Its value stems from solving the double-spending problem without trusted intermediaries, creating the first truly scarce digital asset with censorship resistance and permissionless access that no government, corporation, or individual can control.  Bitcoin operates as a decentralized peer-to-peer network where transactions are recorded on a public ledger called the blockchain, distributed across thousands of computers globally. Transactions are grouped into blocks added approximately every 10 minutes through mining, where specialized computers compete to solve complex mathematical puzzles.   Bitcoin has achieved mainstream adoption through multiple vectors. The January 2024 SEC approval of 11 spot Bitcoin ETFs opened Bitcoin investment to traditional finance participants, and corporations like Strategy (formerly MicroStrategy) are using Bitcoin as a treasury reserve asset to protect against currency debasement, offering MSTR holders amplified exposure to Bitcoin.   The Bitcoin ecosystem continues to evolve with innovations like Ordinals, which emerged in January 2023 to enable NFT-like functionality directly on Bitcoin, and BRC-20 tokens, an experimental standard for creating fungible tokens using Ordinal inscriptions. BTCFi (Bitcoin Finance) represents emerging financial applications extending beyond Bitcoin's traditional role, with protocols like Babylon allowing Bitcoin holders to stake BTC to secure Proof of Stake chains.

Bitcoin

Bitcoin is experiencing significant downward pressure from geopolitical tensions, particularly surrounding new tariff threats and potential international conflicts, combined with aggressive "whale" selling that has broken key support levels. This confluence of events is fueling a sharp community debate, with bears pointing to ongoing market manipulation and even conspiratorial links as reasons for further declines, while bulls advocate for buying the dip amidst a recurring pattern of weekend sell-offs.

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SPY is experiencing pre-market volatility, fueled by discussions around new global tariffs following a Supreme Court ruling, escalating cartel violence in Mexico, and a sharp Bitcoin drop. The community is actively debating whether these factors signal a "bloody Monday" or a "fake dip" ahead of NVIDIA's anticipated earnings.

Ethereum is a global, open-source platform for decentralized applications. In other words, it is a decentralized blockchain platform that enables developers to build and deploy smart contracts and applications without central authority control. Unlike Bitcoin, which primarily functions as digital currency, Ethereum operates as a programmable global computer where developers can create any type of decentralized service.   The platform hosts over $14 billion in DeFi applications with hundreds of thousands of active users across financial protocols, NFT marketplaces, and gaming platforms. Its transition to Proof of Stake in September 2022 reduced energy consumption by over 99%, addressing environmental concerns while strengthening network security.  The network operates through thousands of independent validator nodes that process transactions and execute smart contracts on the Ethereum Virtual Machine. Smart contracts are self-executing programs written in Solidity that automatically carry out agreements when conditions are met, eliminating intermediaries like banks or brokers.   Validators stake ETH as collateral to propose and validate blocks, earning rewards for honest participation while facing penalties for malicious behavior. The EIP-1559 upgrade introduced a dynamic base fee mechanism that burns ETH with each transaction, creating deflationary pressure during high network activity when more ETH is burned than issued to validators.  Vitalik Buterin proposed Ethereum in 2013, but seven co-founders helped build it, including Gavin Wood who created Solidity and the EVM technical specification, and Joseph Lubin who founded ConsenSys. The project launched in July 2015 after raising over $18 million through crowdfunding, quickly becoming the largest blockchain developer community. Major milestones include the 2020 Beacon Chain launch, the 2021 London hard fork implementing fee burning, and the 2022 Merge to Proof of Stake.   Ether (ETH) serves multiple functions: paying transaction fees (gas), staking to secure the network and earn 3-5% annual yields, serving as collateral in DeFi protocols, and purchasing NFTs and digital assets. The asset is increasingly adopted by traditional institutions, with publicly traded companies adding ETH to corporate treasuries to generate staking yields while maintaining blockchain exposure, and in 2024, the SEC approved spot Ethereum ETFs, allowing traditional investors to gain exposure through conventional brokerage accounts.  Ethereum's roadmap focuses on dramatically increasing transaction capacity to over 100,000 per second, reducing confirmation times, and enhancing decentralization while maintaining security against future threats like quantum computing.

Ethereum

Ethereum is trending amid a significant price plunge that has sparked widespread despair and accusations of market manipulation across the community, though some investors are actively accumulating, citing strong institutional interest and record staking figures.

Solana is a high-performance Layer 1 blockchain designed for mass adoption by providing a fast, secure, and low-cost environment for decentralized applications. It distinguishes itself by scaling globally without the use of complex sharding or multiple layers, instead maintaining a single, unified ledger to avoid liquidity fragmentation. This architecture allows it to process thousands of transactions per second with sub-second finality, often at a cost of less than a penny per transaction.  The network operates on a unique hybrid model that combines Proof of Stake with an innovation called Proof of History, which functions as a decentralized clock to timestamp transactions. This system reduces the need for constant node communication, allowing the Sealevel engine to run non-conflicting smart contracts in parallel across multiple CPU cores. Further efficiency is gained through the Gulf Stream protocol, which reduces confirmation times by forwarding transactions to validators before the current block is finished.  Founded in 2017 by Anatoly Yakovenko, Solana is now supported by the Switzerland-based Solana Foundation and significant institutional investors like Andreessen Horowitz and Polychain Capital. The platform’s native token, SOL, serves as the primary currency for paying transaction fees, participating in network governance, and securing the system through staking.   Solana has also seen significant institutional adoption ranging from spot Solana ETFs to major partnerships including Visa's 2025 launch of USDC settlement on the network and the tokenization of public equity by firms like Galaxy Digital.

Solana

Solana is a top trending topic as it garners significant institutional interest, marked by recent spot ETF inflows and companies leveraging staking loans for liquidity. The community remains polarized, with many accumulating and staking amidst bearish price predictions, while others highlight the network's strategic pivot towards global finance and real-world applications.

Moonlake Immunotherapeutics operates as a clinical-stage biotechnology company. It offers tri-specific Nanobody, Sonelokimab to address significant unmet needs in inflammatory skin and joint diseases. The company was founded by Kristian Reich, Jorge Santos da Silva, and Arnout Ploos van Amstel in 2021 and is headquartered in Zug, Switzerland.

MoonLake Immunotherapeutics - Ordinary Shares - Class A

MoonLake Immunotherapeutics

MoonLake Immunotherapeutics is trending following robust positive Phase 2 data for sonelokimab in axial spondyloarthritis, highlighting an 81% ASAS40 response and suggesting disease-modifying potential. The community is eagerly discussing this strong clinical validation, coupled with a solid financial position and significant institutional share repurchases, fueling anticipation for a potential short squeeze and re-valuation ahead of its upcoming Investor Day.

Uniting the six native Japanese dog breeds. Kendu is the keeper of peace, the preserver of life, and the protector of unity. Join the pack!!

Kendu

Kendu is trending due to its exceptionally active and resilient community, which is relentlessly building a permissionless brand through 20+ real-world initiatives like energy drinks and street art. This strong collective conviction, emphasizing continuous building and 'buying the dip' even in a down market, positions Kendu as a unique long-term play in the crypto space.

Microsoft Corp. engages in the development and support of software, services, devices, and solutions. It operates through the following segments: Productivity and Business Processes, Intelligent Cloud, and More Personal Computing. The Productivity and Business Processes segment is composed of products and services relating to productivity, communication, and information services such as Office Commercial, Office Consumer, LinkedIn, and Dynamics business solutions. The Intelligent Cloud segment consists of public, private, and hybrid server products and cloud services for businesses and developers, as well as enterprise and partner services. The More Personal Computing segment refers to products and services including Windows operating system, Windows cloud services, Surface, HoloLens, personal computer accessories, Xbox hardware, Xbox Cloud Gaming, Microsoft News, and Microsoft Edge. The company was founded by Paul Gardner Allen and William Henry Gates, III in 1975 and is headquartered in Redmond, WA.

Microsoft Corporation

Microsoft Corp

Microsoft is trending with a recent substantial insider buy signaling potential undervaluation, fueling optimism among those who believe the stock is oversold. However, a significant portion of the community remains highly bearish, citing concerns over its extensive AI investments, particularly OpenAI's substantial cash burn, and underperformance relative to other tech giants.

Synthetix is a decentralized perpetual futures protocol built on Ethereum Mainnet. Synthetix uses a hybrid design — off-chain order matching on a high-performance CLOB with on-chain settlement — to deliver low latency, deep liquidity, and MEV-resistant execution while keeping custody and finality on Ethereum. Traders get CEX-like performance with on-chain security and composability. The protocol’s liquidity is provided by the Synthetix Liquidity Provider (SLP) vault and backstopped by staked SNX collateral, which underwrites the issuance of the sUSD stablecoin and the solvency of the SLP vault.

Synthetix Network 

Synthetix Network (SNX) is trending due to community excitement surrounding its expanded presence on major platforms, the highly anticipated $1 million trading competition, and the launch of its Perps V3 on Ethereum Mainnet, alongside notable updates to its tokenomics.

Invesco Capital Management LLC - Invesco QQQ Trust Series 1

QQQ is trending as the market grapples with significant uncertainty following the Supreme Court's ruling on prior tariffs and the subsequent announcement of new global tariffs, leading to sharply divided community sentiment between expectations of a downturn and continued dip-buying. Investors are also closely watching upcoming NVIDIA earnings as a potential major catalyst for the tech-heavy index.

What is the project about? Pepe is a community based meme token surround the iconic meme Pepe the frog. Pepe aims to leverage the power of such an iconic meme to become the most memeable memecoin in existence.   What makes your project unique? Pepe is here to make memecoins great again. Ushering in a new paradigm for memecoins, Pepe represents the memecoin in it's purest simplicity. With zero taxes, liquidity locked forever, and contract immutable, Pepe is for the people, forever. Pepe is about culture, rallying together a community to have fun and enjoy memes, fueled purely by memetic power.   History of your project. Pepe was stealth launched on Friday, April 14th, 2023.   What’s next for your project? Pepe will focus on developing a tight-knit community around the token and building resources to enrich the communities knowledge and success in crypto through a token gated group, newsletter, and more tools.   What can your token be used for? Pepe can be used to speculate on the power of memes, and does not pretend to be anything more.

Pepe

PEPE is trending as the crypto community actively buys perceived dips, fueled by strong HODLing sentiment and anticipation of a broader meme coin season. Many are discussing "loading the boat" and awaiting a significant price run, often using the "feels good man" meme.

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Compugen (CGEN) Reports Q1 Loss, Misses Revenue Estimates

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Shares of Affimed N.V. (AFMD) were in the spotlight on Monday morning after the company received a notice from Nasdaq indicating a compliance issue with its stock price.Affirmed <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.globenewswire.com/news-release/2025/04/21/3064526/0/en/Affimed-Announces-Receipt-of-NASDAQ-Deficiency-Notice-Regarding-Minimum-Bid-Price-Requirement.html">said</a> that the Nasdaq notice indicated the bid price for the company’s common shares had closed below the minimum $1.00 per share requirement for continued listing on the bourse.Affirmed, headquartered in Mannheim, Germany, stated that it has been granted an initial period of 180 calendar days, or until October 13, 2025, to regain compliance.The company said that if it fails to regain compliance with the Minimum Bid Price Rule during the period, it may consider applying to transfer its securities from The Nasdaq Global Select Market to The Nasdaq Capital Market, provided that it meets the requirements.Affirmed also added that there is no assurance that Nasdaq would grant the company’s request for continued listing in the case.In the meantime, the firm intends to monitor the bid price of its common shares and consider available options to regain compliance with the Minimum Bid Price Rule.Affimed is a clinical-stage company aimed at developing treatments for cancer. In December, the company announced positive updates from a trial of its AFM24 in combination with atezolizumab in Non-Small Cell Lung Cancer patients.AFM24 is an innate cell engager molecule that activates the innate immune system to kill cancer cells.On Stocktwits, retail sentiment regarding Affimed remained unchanged within ‘neutral’ territory over the past 24 hours, while message volume remained at ‘extremely low’ levels.<figure class="image"><img style="aspect-ratio:648/146;" src="https://news.stocktwits-cdn.com/Screenshot_2025_04_21_at_7_06_18_AM_png_68fb6a412b.webp" alt="AFMD's Sentiment Meter and Message Volume as of 7:20 a.m. ET on April 21, 2025 | Source: Stocktwits" width="648" height="146"><figcaption>AFMD's Sentiment Meter and Message Volume as of 7:20 a.m. ET on April 21, 2025 | Source: Stocktwits</figcaption></figure><a href="https://stocktwits.com/symbol/AFMD">AFMD stock</a> is down by about 46% so far this year and by over 85% over the past 12 months.Also See: <a href="https://stocktwits.com/news-articles/markets/equity/dhl-freezes-shipments-worth-over-800-to-us-consumers-amid-rising-trade-tensions/chQiW2kRbQO">DHL Freezes Shipments Worth Over $800 To US Consumers Amid Rising Trade Tensions</a>For updates and corrections, email newsroom[at]stocktwits[dot]com&nbsp;

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Affimed Receives Nasdaq Deficiency Notice Over Low Share Price: Retail’s In Wait-And-Wait Mode

The company has been granted an initial period of 180 calendar days, or until October 13, 2025, to regain compliance with Nasdaq’s Minimum Bid Price Rule.

Equity

Affimed NV is a clinical-stage immuno-oncology company, which engages in the discovery and development of cancer immunotherapies. The company’s proprietary ROCK platform enables a tumor-targeted approach to recognize and kill a range of hematologic and solid tumors, enabling a broad pipeline of wholly-owned and partnered single agent and combination therapy programs. It operates through the Germany and USA geographical segments. The company was founded in 2000 and is headquartered in Mannheim, Germany.

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